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TMEM72 Gene

protein-coding   GIFtS: 32

GC10P044731
transmembrane protein 72
(Previous name: chromosome 10 open reading frame 127 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C10orf127)
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Aliases &
Descriptions
for TMEM72

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
C10orf127 2
DKFZp686M0585 2
KSP37 1, 2, 3
MGC157906 2
bA285G1.3 1, 2
Descriptions
Kidney-specific secretory protein of 37 kDa 2, 3
chromosome 10 open reading frame 127 1
transmembrane protein 72 2
External Ids
HGNC: 316581
Entrez Gene: 6432362
UniProtKB: A0PK053
Ensembl: ENSG000001877837
Search outside databases for aliases for TMEM72 gene

Summaries
for TMEM72

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for TMEM72

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.21   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.21

TMEM72 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P044731:     (about GC identifiers)

Start:
 44,726,770 bp from pter
End:
 44,752,456 bp from pter
Size:
 25,687 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000010.9  NT_033985.6  

Proteins
for TMEM72

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: TMM72_HUMAN, A0PK05 (See protein sequence)
Recommended Name: Transmembrane protein 72  
Size: 275 amino acids; 29891 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A1L181
Alternative splicing: 2 isoforms:  A0PK05-1   A0PK05-2   

REFSEQ proteins: NP_001116848.1  

ENSEMBL proteins: 
ENSP00000374234 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
About this table

Antibodies for TMEM72: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for TMEM72

Assays for TMEM72: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for TMEM72

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: A0PK05

Gene Function
for TMEM72

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:		Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Applied Biosystems Silencer® siRNAs for TMEM72

              Sigma-Aldrich siRNA for TMEM72  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001123376
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001123376
                                 untagged cDNA clone in CMV expression vector: NM_001123376 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001123376

Pathways & Interactions
for TMEM72

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

Drugs & Compounds
for TMEM72

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TMEM72

Transcripts
for TMEM72

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Sigma-Aldrich siRNA for TMEM72  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001123376  

REFSEQ mRNAs for TMEM72 gene: 

NM_001123376.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001123376  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001123376
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001123376
                                 untagged cDNA clone in CMV expression vector: NM_001123376 

Additional cDNA sequence: 

AB235418.1 BC029135.1 BC127789.1 BC127790.1 

4 DOTS entries:

DT.95140578  DT.121228252  DT.121228421  DT.121228315 

Unigene Cluster for TMEM72:

Transmembrane protein 72
Hs.292788  [show with all ESTs]
Unigene Representative Sequence: AB235418


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000389583  

Expression
for TMEM72

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TMEM72 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for TMEM72

1 / 2

3 probe-sets matching TMEM72 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
66634_at2 U95-C 1 1.00 1.00 1.00 1.00 -- -- -- -- --

1558324_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1558323_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  TMEM72 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GCCAGCCTCT

SOURCE GeneReport for Unigene cluster: Hs.292788

Orthologs
for TMEM72

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for TMEM72 gene from 5 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 TMEM721   -- transmembrane protein 72 98.51(n)
98.73(a)		 746671  XM_001154517.1  XP_001154517.1 
cow
(Bos taurus)		 TMEM721   -- transmembrane protein 72 86.81(n)
87.23(a)		 513137  XM_590780.3  XP_590780.3 
rat
(Rattus norvegicus)		 Tmem721   -- transmembrane protein 72 84.61(n)
84.73(a)		 362424  XM_342744.3  XP_342745.3 
mouse
(Mus musculus)		 Tmem721, 5 65
 transmembrane protein 721, 5 84.36(n)1
84.36(a)1		 3197761  NM_178768.41  NP_848883.21 
 AK0338565  AK0490485  (see all 12)
zebrafish
(Danio rerio)		 LOC5623211   -- hypothetical protein LOC562321 51.17(n)
41.15(a)		 562321  XM_685710.2  XP_690802.1 
About this table        Species with no ortholog for TMEM72

ENSEMBL Gene Tree for TMEM72

Paralogs
for TMEM72

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for TMEM72

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/136 NCBI SNPs in TMEM72 are shown (see all 136 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 52)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs22818411,2
C,F,H,O44726614(+) GTTAAT/CTGCCA 1 -- ng5113Minor allele frequency- C:0.38EA NA EU WA 2470
--
rs70747941,2
A,C,F,H44726083(+) AGCTAC/GAGGGA 1 -- ng5111Minor allele frequency- G:0.04EU EA WA NA 980
rs70676921,2
A,C,F,H44750705(+) CCCACG/ACTGGC 1 -- ng314Minor allele frequency- A:0.31EU EA WA 420
--
rs22818401,2
A,C,F,H44726297(+) TCTGCG/ATGGCG 1 -- ng515Minor allele frequency- A:0.48EA EU WA 1910
rs70845111,2
C,F,H44750962(+) TACTCC/TCAACC 1 -- ng314Minor allele frequency- T:0.04EU EA WA 418
rs122493781,2
C,F,H44750611(+) GAGGAC/TGCTCA 1 -- ut317Minor allele frequency- T:0.09EU EA WA NA 560
--
rs112392771,2
H44724843(+) TTCCCG/AACCCA 1 -- ng514Minor allele frequency- A:0.00EU EA WA 416
rs171572621,2
C,F,H44750159(+) AAGCGG/AAAGAA 1 R/R syn1 ese3 trp311Minor allele frequency- A:0.01NA EU EA WA 978
rs174174421,2
F,H44750468(+) CTCGCC/TGAAGG 1 A/A syn17Minor allele frequency- T:0.35NA EU EA WA 562
rs8722081,2
A,C,F,H,O44747058(-) CCAAAT/CAGTCA 1 -- int112Minor allele frequency- C:0.23EU EA WA NA 1048
About this table

HapMap Linkage Disequilibrium images for TMEM72 (up to first 250kb)

Disorders & Mutations
for TMEM72

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for TMEM72

(Possibly Related Articles in Doctor's Guide)
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   --

Publications
for TMEM72

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

3 PubMed articles for TMEM72 gene:

Search for TMEM72

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing TMEM72

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 643236 HGNC: 31658 Ensembl:ENSG00000187783 euGenes: HUgn643236 ECgene: TMEM72
H-InvDB: TMEM72

Other Databases showing TMEM72

(According to HUGE)
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   --

Specialized Databases showing TMEM72

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for TMEM72

(Available from WIS Yeda, Salk, Tufts)
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  --

Services
for TMEM72

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for TMEM72:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TMEM72-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for TMEM72 Browse antibodies at Sigma-Aldrich
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