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C10orf125 Gene

protein-coding   GIFtS: 41

GC10M135018
chromosome 10 open reading frame 125
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for C10orf125

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
FLJ26016 1, 2
MGC149258 2
Descriptions
chromosome 10 open reading frame 125 2
hypothetical protein LOC282969 2
External Ids
HGNC: 247331
Entrez Gene: 2829692
UniProtKB: A2VDF03
Ensembl: ENSG000001488037
Search outside databases for aliases for C10orf125 gene

Previous GC identifers: GC10M134642 GC10M135057

Summaries
for C10orf125

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for C10orf125

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf125 gene  

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

C10orf125 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M135018:     (about GC identifiers)

Start:
 135,018,648 bp from pter
End:
 135,021,519 bp from pter
Size:
 2,872 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000010.9  NT_017795.18  

Proteins
for C10orf125

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: CJ125_HUMAN, A2VDF0 (See protein sequence)
Recommended Name: Protein fucU homolog  
Size: 154 amino acids; 16765 Da
Sequence caution: Sequence=CAH70284.1; Type=Erroneous gene model prediction; Sequence=CAH70285.1;
Type=Erroneous gene model prediction;
Secondary accessions: A1L300 Q5VWY2 Q5VWY3 Q6ZPD2
Alternative splicing: 2 isoforms:  A2VDF0-1   A2VDF0-2   

REFSEQ proteins (2 alternative transcripts): 
NP_001091953.1  NP_940874.2  


ENSEMBL proteins: 
ENSP00000357540 ENSP00000357539 ENSP00000278025 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
              OriGene Purified Recombinant Human Protein: C10orf125 


Antibodies for C10orf125: 
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for C10orf125

Assays for C10orf125: 
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Browse Kits and Assays available from Millipore
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Protein Domains/
Families
for C10orf125

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR007721 RbsD_FucU


   GeneDecks  C10orf125 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry A2VDF0

ProtoNet protein and cluster: A2VDF0

UniProtKB/Swiss-Prot: CJ125_HUMAN, A2VDF0
Similarity: Belongs to the rbsD / fucU family

Gene Function
for C10orf125

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (C10orf125)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001098483

              Applied Biosystems Silencer® siRNAs for C10orf125

              Sigma-Aldrich siRNA for C10orf125  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001098483
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001098483
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001098483 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001098483

Pathways & Interactions
for C10orf125

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008643 carbohydrate transport IEA--
About this table

Drugs & Compounds
for C10orf125

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf125

Transcripts
for C10orf125

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (C10orf125)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001098483

              Sigma-Aldrich siRNA for C10orf125  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001098483  NM_198472  

REFSEQ mRNAs for C10orf125 gene (2 alternative transcripts): 

NM_001098483.1   NM_198472.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001098483  NM_198472  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001098483
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001098483
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001098483 

Additional cDNA sequence: 

AK129527.1 AK310070.1 BC129818.1 BC129819.1 

5 DOTS entries:

DT.75100305  DT.101979068  DT.427390  DT.100745610  DT.100017152 

24/27 AceView cDNA sequences (see all 27 ):

AI333356 BU849497 BE646025 BX119427 AI682430 CK299563 BM797299 BM009909 
CD365619 AA371739 AK129527 NM_198472 AI657157 BQ277643 T48398 BI197701 
BU597947 BQ189431 AI269186 BE675283 BF206345 CB048432 AI992343 AA715323 

highest scoring ESTs for C10orf125:

AI471699 AK129527 AA371739 BE675283 BF206345 BI197701 BM009909 BQ277643 BU849497 BX119427 

Unigene Cluster for C10orf125:

Chromosome 10 open reading frame 125
Hs.155823  [show with all ESTs]
Unigene Representative Sequence: BQ277643


GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf125 (see all 7 )

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1:              -     -     -                       -                 -                     
SP2:              -     -                             -                 -     -               
SP3:                          -                       -                 -     -               
SP4:              -     -     -     -                 -                 -     -               
SP5:                                                  -                                       

About this scheme

ECgene alternative splicing isoforms for C10orf125

3 Ensembl transcripts including schematic representations:
ENST00000368552  ENST00000368551  ENST00000278025  

Expression
for C10orf125

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C10orf125 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for C10orf125

1 / 2 / 3

3 probe-sets matching C10orf125 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
83579_at2, 3 U95-E 1 0.75 1.00 1.00 1.00 AI471699 0.80 1.00 0.91 1

230259_at2, 3 U133-B 1 1.00 1.00 -- -- AI471699 0.80 1.00 0.91 1

230259_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  C10orf125 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GAGCTGGTGC

SOURCE GeneReport for Unigene cluster: Hs.155823

Orthologs
for C10orf125

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for C10orf125 gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 LOC4916961   -- hypothetical LOC491696 83.96(n)
85.71(a)		 491696  XM_548817.1  XP_548817.1 
chimpanzee
(Pan troglodytes)		 LOC4508531   -- hypothetical LOC450853 99.5(n)
99.25(a)		 450853  XM_001145826.1  XP_001145826.1 
cow
(Bos taurus)		 MGC1520071   -- hypothetical protein LOC613571 83.78(n)
82.43(a)		 613571  NM_001076278.1  NP_001069746.1 
rat
(Rattus norvegicus)		 RGD13111861   -- similar to RIKEN cDNA 1810014F10 gene 80.7(n)
81.58(a)		 293587  XM_215110.3  XP_215110.2 
mouse
(Mus musculus)		 1810014F10Rik1, 5 75
 RIKEN cDNA 1810014F10 gene1, 5 79.61(n)1
80.92(a)1		 690641  NM_026928.21  NP_081204.21 
 AB0944805  AI8379845  (see all 10)
About this table        Species with no ortholog for C10orf125

ENSEMBL Gene Tree for C10orf125

Paralogs
for C10orf125

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for C10orf125

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/29 NCBI SNPs in C10orf125 are shown (see all 29 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 44)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs733901441,2
--135022416(+) AAAAAA/GTTCTG 1 -- ng310--------
--
rs741641571,2
--135023191(+) TGGAAA/GCCTCA 1 -- ng310--------
rs10570971,2
--135018747(-) GGGCTC/TTAGGG 1 -- ut31 ese30--------
--
rs733901501,2
--135023468(+) AATCAG/TATTAT 1 -- ng310--------
--
rs723079061,2
--135021593(+) AGGCG-/GGGGGGC 1 -- ng310--------
--
rs733895451,2
--135018497(+) CCTTGC/GTGTCC 1 -- ng510--------
--
rs559984241,2
--135023012(+) AGAATC/TGCTTG 1 -- ng310--------
rs412833351,2
--135018657(+) TTGGAA/CTCTTG 1 -- ut310--------
--
rs20961691,2
--135022842(+) cctgtA/Gatccc 1 -- ng310--------
--
rs343953841,2
--135018162(-) AGGGG-/GTGCCT 1 -- ng510--------
About this table

HapMap Linkage Disequilibrium images for C10orf125 (up to first 250kb)

Disorders & Mutations
for C10orf125

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for C10orf125

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for C10orf125

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

5 PubMed articles for C10orf125 gene:

Search for C10orf125

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing C10orf125

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 282969 HGNC: 24733 AceView: C10orf125 Ensembl:ENSG00000148803 euGenes: HUgn282969
ECgene: C10orf125 H-InvDB: C10orf125

Other Databases showing C10orf125

(According to HUGE)
About This Section

   --

Specialized Databases showing C10orf125

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for C10orf125

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for C10orf125

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for C10orf125:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Millipore Target Screening & Profiling Services


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 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for C10orf125

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