V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

C10orf92 Gene

protein-coding   GIFtS: 38

GC10M134471
chromosome 10 open reading frame 92
(Previous names: chromosome 10 open reading frame 123, chromosome 10 open reading frame 124 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: C10orf123, C10orf124)
Services    

Aliases &
Descriptions
for C10orf92

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
C10orf123 2
C10orf124 2
DKFZp434A1721 1, 2
FLJ46273 2
bA288G11.4 1, 2
bA288G11.5 1, 2
bB137A17.2 1, 2
Descriptions
TPR repeat-containing protein C10orf93 2
chromosome 10 open reading frame 123 1
chromosome 10 open reading frame 124 1
chromosome 10 open reading frame 92 2
hypothetical protein LOC54777 2
External Ids
HGNC: 252471
Entrez Gene: 547772
UniProtKB: Q8IYW23
Ensembl: ENSG000001080467
Search outside databases for aliases for C10orf92 gene

Previous GC identifer: GC10M134057

Summaries
for C10orf92

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for C10orf92

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf92 gene  

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

C10orf92 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M134471:     (about GC identifiers)

Start:
 134,471,886 bp from pter
End:
 134,521,226 bp from pter
Size:
 49,341 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000010.9  NT_017795.18  

Proteins
for C10orf92

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: CJ092_HUMAN, Q8IYW2 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf92  
Size: 876 amino acids; 95496 Da
Secondary accessions: Q5JSF7 Q9NTQ5

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_060079.4  

    ENSEMBL proteins: 
    ENSP00000263170 ENSP00000357577 ENSP00000357576 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for C10orf92: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for C10orf92

    Assays for C10orf92: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for C10orf92

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8IYW2

    Gene Function
    for C10orf92

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (C10orf92)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017609

                  Applied Biosystems Silencer® siRNAs for C10orf92

                  Sigma-Aldrich siRNA for C10orf92  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for C10orf92
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_017609
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_017609
                                     untagged cDNA clone in CMV expression vector: NM_017609 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_017609

    Pathways & Interactions
    for C10orf92

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    Drugs & Compounds
    for C10orf92

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for C10orf92

    Transcripts
    for C10orf92

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (C10orf92)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017609

                  Sigma-Aldrich siRNA for C10orf92  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_017609  

    REFSEQ mRNAs for C10orf92 gene: 

    NM_017609.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_017609  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_017609
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_017609
                                     untagged cDNA clone in CMV expression vector: NM_017609 

    Additional cDNA sequence: 

    AL122111.1 BC034223.1 

    10 DOTS entries:

    DT.40278889  DT.121216501  DT.100001562  DT.97822306  DT.100666814  DT.101971547  DT.102819557  DT.121272319 
    DT.121272320  DT.40197736 

    15 AceView cDNA sequences:

    CA950562 BU790542 CA950326 BG773134 F32670 AK128150 BG708430 AL122111 
    BU790245 NM_017609 CA310952 BC034223 BX282676 BE502197 AI656413 

    highest scoring ESTs for C10orf92:

    BC034223 BG773134 AI656413 AL122111 BE502197 F32670 M79226 NM_017609 AK128150 BG708430 

    Unigene Cluster for C10orf92:

    Chromosome 10 open reading frame 92
    Hs.298038  [show with all ESTs]
    Unigene Representative Sequence: NM_017609


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000263170  ENST00000368588  ENST00000368587  

    Expression
    for C10orf92

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    C10orf92 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for C10orf92

    1 / 2 / 3

    3 probe-sets matching C10orf92 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		69556_at2, 3 U95-E 1 1.00 1.00 1.00 1.00 M79226 0.60 1.00 0.82 1

    		220539_at2, 3 U133-A 1 1.00 1.00 -- -- NM_017609 0.60 1.00 0.82 1

    		220539_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.298038

    Orthologs
    for C10orf92

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for C10orf92 gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 LOC6079411   -- hypothetical protein LOC607941 73.4(n)
    65.06(a)    		 607941  XM_844804.1  XP_849897.1 
    cow
    (Bos taurus)    		 LOC5141171   -- similar to Uncharacterized protein C10orf92 75.39(n)
    65.07(a)    		 514117  XM_591917.3  XP_591917.3 
    rat
    (Rattus norvegicus)    		 LOC6805821   -- hypothetical protein LOC680582 69.62(n)
    58.87(a)    		 680582  XM_001057880.1  XP_001057880.1 
    mouse
    (Mus musculus)    		 E030019B06Rik1, 5 75
    		 RIKEN cDNA E030019B06 gene1, 5 69.64(n)1
    58.69(a)1    		 2121241  XM_133957.71  XP_133957.61 
     AK0869985  BC1168825  (see all 7)
    zebrafish
    (Danio rerio)    		 LOC7979571   -- similar to mCG55818 51.09(n)
    35.04(a)    		 797957  XM_001338374.2  XP_001338410.2 
    About this table        Species with no ortholog for C10orf92

    ENSEMBL Gene Tree for C10orf92

    Paralogs
    for C10orf92

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for C10orf92

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/427 NCBI SNPs in C10orf92 are shown (see all 427 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 129)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs48804331,2
    		A,C,F,H134496978(+) GTCTGC/TGACCA 1 T/A mis1 ese313Minor allele frequency- T:0.34EU EA WA NA 1270
    rs108703411,2
    		A,C,F,H134509616(+) TTGGCA/GCCGGA 1 C/R mis1 ese34Minor allele frequency- G:0.15EU EA WA 410
    rs22544191,2
    		A,C,F,H134473949(-) GAAACG/AGTGCG 1 S/G mis112Minor allele frequency- A:0.26EA EU WA NA 2568
    rs37505871,2
    		C,F,H134476283(-) AACTTG/TCAAGG 1 L/F mis1 ese39Minor allele frequency- T:0.07EA EU WA 2338
    rs123569781,2
    		C,F,H134498269(+) TGGTTC/TCTACC 1 E/K mis14Minor allele frequency- T:0.06EU EA WA 420
    --
    rs122506321,2
    		A,H134521940(+) GGGGGC/TGACCC 1 -- ng314Minor allele frequency- T:0.00EU EA WA 380
    rs359810391,2
    		F134472091(+) TGCCTT/GGCGGG 1 Q/K mis11Minor allele frequency- G:0.05NA 76
    --
    rs122447101,2
    		A134521886(+) GGGGTG/TGCCCC 1 -- ng310--------
    --
    rs122535481,2
    		A134521899(+) GTTGGA/GGGCAG 1 -- ng310--------
    --
    rs48804511,2
    		A134521789(+) GTTGGA/GGGCAG 1 -- ng310--------
    About this table

    HapMap Linkage Disequilibrium images for C10orf92 (up to first 250kb)

    Disorders & Mutations
    for C10orf92

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		   --

    Medical News
    for C10orf92

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for C10orf92

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		6 PubMed articles for C10orf92 gene:

    Search for C10orf92

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C10orf92

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 54777 HGNC: 25247 AceView: C10orf92 Ensembl:ENSG00000108046 euGenes: HUgn54777
    ECgene: C10orf92 H-InvDB: C10orf92

    Other Databases showing C10orf92

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing C10orf92

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for C10orf92

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for C10orf92

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for C10orf92:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for C10orf92-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for C10orf92 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Search for Recombinant Proteins
     Search for Antibodies
     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Search for Recombinant Proteins
     Search for Antibodies
     Search OriGene for C10orf92
     Search Tocris compounds for C10orf92




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for C10orf92

    GeneCards Homepage    -    Last full update: 1 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    C10orf92 Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com