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C10orf122 Gene

protein-coding   GIFtS: 34

GC10M127255
chromosome 10 open reading frame 122
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ27500 2
MGC157877 2
MGC157878 2
bA383C5.1 1, 2
Descriptions
chromosome 10 open reading frame 122 2
hypothetical protein LOC387718 2
External Ids
HGNC: 316531
Entrez Gene: 3877182
UniProtKB: Q5VZQ53
Ensembl: ENSG000001750187
Search outside databases for aliases for C10orf122 gene

Previous GC identifer: GC10M126919

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.13

C10orf122 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M127255:     (about GC identifiers)

Start:
127,334,459 bp from pter
End:
127,361,665 bp from pter
Size:
27,207 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000010.9  NT_035040.4  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ122_HUMAN, Q5VZQ5 (See protein sequence)
Recommended Name: Putative uncharacterized protein C10orf122  
Size: 186 amino acids; 21545 Da
Secondary accessions: Q0P5T8

REFSEQ proteins: NP_001121674.1  

ENSEMBL proteins: 
ENSP00000357811 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for C10orf122: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for C10orf122

Assays for C10orf122: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q5VZQ5

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (C10orf122)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Applied Biosystems Silencer® siRNAs for C10orf122

              Sigma-Aldrich siRNA for C10orf122  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001128202
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001128202
                                 untagged cDNA clone in CMV expression vector: NM_001128202 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001128202

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf122

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (C10orf122)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Sigma-Aldrich siRNA for C10orf122  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001128202  

REFSEQ mRNAs for C10orf122 gene: 

NM_001128202.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001128202  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001128202
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001128202
                                 untagged cDNA clone in CMV expression vector: NM_001128202 

Additional cDNA sequence: 

AK131010.1 BC062717.1 BC127766.1 BC127767.1 CR611441.1 

3 DOTS entries:

DT.100840844  DT.101979384  DT.40127575 

9 AceView cDNA sequences:

CR611441 BC062717 AW086452 AK131010 BX336391 AW082215 AA977508 BQ429237 
BX390366 

highest scoring ESTs for C10orf122:

AW082215 BX390366 AA977508 AW086452 BC062717 BQ429237 BX336390 BX336391 CR611441 AK131010 

Unigene Cluster for C10orf122:

Chromosome 10 open reading frame 122
Hs.148259  [show with all ESTs]
Unigene Representative Sequence: BC062717


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000368821  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C10orf122 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for C10orf122

1 / 2 / 3

3 probe-sets matching C10orf122 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

54143_at2, 3 U95-C 2 1.00 0.97 1.00 1.00 AA977508 0.60 0.83 0.73 1

244789_at2, 3 U133-B 1 1.00 1.00 -- -- AW082215 0.40 1.00 0.76 1

244789_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TGTAAATAAA

SOURCE GeneReport for Unigene cluster: Hs.148259
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for C10orf122 gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
mouse
(Mus musculus)
4930404H21Rik5 7 RIKEN cDNA 4930404H21 gene   -- BC100509 
About this table        Species with no ortholog for C10orf122

ENSEMBL Gene Tree for C10orf122
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


5 NCBI SNPs in C10orf122 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs94229151,2
C,F,H127340476(+) GGGCTC/GTTTTG 1 E/Q mis1 ese315Minor allele frequency- G:0.01EU EA WA NA 1394
--
rs127798931,2
H127339650(+) GGTTAT/GTCACT 1 T/N mis1 ese34Minor allele frequency- G:0.00EU EA WA 404
--
rs127798911,2
H127339648(+) CTGGTT/GATTCA 1 H/N mis1 ese34Minor allele frequency- G:0.00EU EA WA 406
rs413075831,2
--127334479(+) AGAAAC/TAACCT 1 V/I mis10--------
rs617469631,2
--127334504(+) AACCTA/GACTTT 2 V/V syn10--------
About this table
The following additional 210 SNP(s) have been found in Applied Biosystems data source:
(Click for Applied Biosystems TaqMan ® Genotyping Assay)


 rs7077188 rs192711 rs7920745 rs2031793 rs212385 rs2016626 rs12780889
 rs12254965 rs1368531 rs1433279 rs4307635 rs12776905 rs7081122 rs7084723
 rs12773467 rs4638222 rs17153407 rs7098714 rs297250 rs2043356 rs17153231
 rs11244607 rs297222 rs7079241 rs17153272 rs11244576 rs10901413 rs7924056
 rs7076513 rs12217538 rs11244574 rs297236 rs11244611 rs297240 rs1384609
 rs9422804 rs17153249 rs11244573 rs2128640 rs11244596 rs17153269 rs7096815
 rs11598514 rs11244590 rs9422904 rs10901411 rs297256 rs9422941 rs12775517
 rs2046295 rs297223 rs9422775 rs1483018 rs2046296 rs11244609 rs7475605
 rs9422803 rs297252 rs11814317 rs9422778 rs9422902 rs297248 rs297241
 rs7068548 rs9422916 rs9422921 rs9422913 rs7085846 rs17153397 rs10794012
 rs11244592 rs11244585 rs7071037 rs297255 rs7078320 rs11244586 rs9422923
 rs2304264 rs927956 rs11244568 rs9422905 rs7896345 rs297251 rs1433278
 rs3829921 rs1483017 rs1041235 rs17153402 rs297227 rs4962476 rs12358853
 rs7069510 rs9422782 rs7895499 rs186127 rs11244577 rs9422776 rs7074413
 rs7922891 rs12261644 rs7070447 rs11244608 rs11816452 rs10510147 rs7080402
 rs297243 rs7896595 rs9422908 rs10901409 rs28438583 rs1026895 rs4615940
 rs3814625 rs7906923 rs297238 rs12767691 rs11244589 rs11244588 rs1433277
 rs11244565 rs12257291 rs17153404 rs7072444 rs4962475 rs17153386 rs5014172
 rs9422942 rs913372 rs2365818 rs297244 rs9422787 rs1560749 rs1055284
 rs927955 rs7074309 rs11244601 rs167216 rs12413009 rs11244597 rs1865136
 rs17153200 rs297226 rs12219308 rs4962312 rs9422922 rs7097445 rs2274530
 rs9422906 rs7083854 rs12255553 rs17153228 rs5014547 rs17153224 rs1384610
 rs1836047 rs11244587 rs7070291 rs7098701 rs297245 rs9422940 rs12220188
 rs9422788 rs9422903 rs7916886 rs11598551 rs4456175 rs11812808 rs2569919
 rs9422917 rs927957 rs7920648 rs9422914 rs297253 rs7084502 rs12245845
 rs11244569 rs5014171 rs7092281 rs7073875 rs3740184 rs7075103 rs7075452
 rs17153417 rs12220827 rs12768111 rs297242 rs10510145 rs5022290 rs7082982
 rs172465 rs1076001 rs2569916 rs3858290 rs7080804 rs2840248 rs12242997
 rs297257 rs297239 rs7100966 rs9422789 rs11814225 rs7917291 rs11813947
 rs12411576 rs1368532 rs12414594 rs9422907 rs9422780 rs297237 rs10901416

HapMap Linkage Disequilibrium images for C10orf122 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

3 PubMed articles for C10orf122 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 387718 HGNC: 31653 AceView: C10orf122 Ensembl:ENSG00000175018 euGenes: HUgn387718
ECgene: C10orf122 H-InvDB: C10orf122
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for C10orf122:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for C10orf122-related products

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 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for C10orf122 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for C10orf122

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