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C10orf120 Gene

protein-coding   GIFtS: 34

GC10M124447
chromosome 10 open reading frame 120
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
OTTHUMP00000020665 2
bA318C4.1 1, 2
Descriptions
chromosome 10 open reading frame 120 2
hypothetical protein LOC399814 2
External Ids
HGNC: 257071
Entrez Gene: 3998142
UniProtKB: Q5SQS83
Ensembl: ENSG000001835597
Search outside databases for aliases for C10orf120 gene

Previous GC identifer: GC10M123998

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf120 gene  

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.13

C10orf120 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M124447:     (about GC identifiers)

Start:
124,432,189 bp from pter
End:
124,449,332 bp from pter
Size:
17,144 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ120_HUMAN, Q5SQS8 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf120  
Size: 335 amino acids; 39268 Da

REFSEQ proteins: NP_001010912.1  

ENSEMBL proteins: 
ENSP00000357903 ENSP00000331012 


Human Recombinant Proteins 
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Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for C10orf120: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for C10orf120

Assays for C10orf120: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q5SQS8

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (C10orf120)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001010912

              Applied Biosystems Silencer® siRNAs for C10orf120

              Sigma-Aldrich siRNA for C10orf120  
                     Sigma-Aldrich shRNA for C10orf120  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001010912
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001010912
                                 untagged cDNA clone in CMV expression vector: NM_001010912 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001010912

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf120

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (C10orf120)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001010912

              Sigma-Aldrich siRNA for C10orf120  
                     Sigma-Aldrich shRNA for C10orf120  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001010912  

REFSEQ mRNAs for C10orf120 gene: 

NM_001010912.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001010912  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001010912
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001010912
                                 untagged cDNA clone in CMV expression vector: NM_001010912 

Additional cDNA sequence: 

BC065903.1 BC140922.1 

1 DOTS entry:

DT.97767719 

4 AceView cDNA sequences:

AL704711 BC065903 BQ432763 BQ438467 

highest scoring ESTs for C10orf120:

AL704711 BC065903 BQ438467 BQ432763 NM_001010912 CR735246 

Unigene Cluster for C10orf120:

Chromosome 10 open reading frame 120
Hs.363649  [show with all ESTs]
Unigene Representative Sequence: BC065903


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000368907  ENST00000329446  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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C10orf120 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for C10orf120

1Data from GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: CGTAAAGCAA

SOURCE GeneReport for Unigene cluster: Hs.363649
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for C10orf120 gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LOC4778531   -- hypothetical LOC477853 74.75(n)
62.12(a)
477853  XM_535045.2  XP_535045.2 
chimpanzee
(Pan troglodytes)
LOC7427171   -- hypothetical protein LOC742717 99.1(n)
98.21(a)
742717  XM_001160071.1  XP_001160071.1 
cow
(Bos taurus)
C26H10orf1201   -- chromosome 10 open reading frame 120 ortholog 73.33(n)
60.9(a)
617773  NM_001076476.1  NP_001069944.1 
rat
(Rattus norvegicus)
LOC4992761   -- similar to RIKEN cDNA 1700022C21 65.55(n)
50.46(a)
499276  XM_574574.2  XP_574574.2 
mouse
(Mus musculus)
4933402N03Rik1, 5 75
RIKEN cDNA 4933402N03 gene1, 5 65.93(n)1
52.85(a)1
2339181  NM_173409.31  NP_775585.11 
 AK0163715  AK0166255  (see all 9)
About this table        Species with no ortholog for C10orf120

ENSEMBL Gene Tree for C10orf120
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/36 NCBI SNPs in C10orf120 are shown (see all 36 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 44)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs109029291,2
A,C,F,H124450059(+) TCAAAG/AGTGTG 1 -- ng31 tfbs312Minor allele frequency- A:0.21EU EA WA NA 1052
rs29475941,2
A,C,F,H124447442(+) CTTTGT/CGGGGA 1 T/A mis18Minor allele frequency- C:0.22EU EA WA 838
rs30194971,2
C,F,H124446757(-) catttG/Ttcctc 1 -- ng513Minor allele frequency- T:0.27EU EA 300
rs112483911,2
C,F,H124446855(+) catgaG/Agaacc 1 -- ng518Minor allele frequency- A:0.06EU EA WA 834
--
rs30194961,2
A,C124446942(-) aaaacA/Gacaat 1 -- ng510--------
rs414480481,2
C,F124449238(-) TGACAC/AAATGG 1 K/T mis18Minor allele frequency- A:0.08EU EA WA 838
rs29013431,2
A,C,F,H,O124447896(+) TAGTCC/TGGAGA 1 P/P syn1 ese311Minor allele frequency- T:0.42EU EA WA NA 1110
rs118135971,2
A,C,F,H124449129(+) AACGGC/TGAAGC 1 S/S syn1 ese38Minor allele frequency- N:0.00EA NA EU WA 628
--
rs79229361,2
A,C124448512(+) GCGGGC/TGCCTG 1 -- int10--------
--
rs109029221,2
A124448725(+) CAATGG/TGAGTC 1 -- int10--------
About this table

HapMap Linkage Disequilibrium images for C10orf120 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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3 PubMed articles for C10orf120 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 399814 HGNC: 25707 AceView: C10orf120 Ensembl:ENSG00000183559 euGenes: HUgn399814
ECgene: C10orf120 H-InvDB: C10orf120
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for C10orf120:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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  Invitrogen Antibodies  Invitrogen Assays
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for C10orf120-related products

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 Millipore Preclinical / Clinical Development Services
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 Predesigned and custom siRNAs for C10orf120 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for C10orf120 Browse small molecules at Sigma-Aldrich
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