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C10orf12 Gene

protein-coding GIFtS: 40

GC10P098731

chromosome 10 open reading frame 12
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DKFZP564P1916 ^¹
DKFZp564P1916 ^²
FLJ13022 ^¹, ²

Descriptions
chromosome 10 open reading frame 12 ^²
hypothetical protein LOC26148 ^²

External Ids
HGNC: 23420¹
Entrez Gene: 26148²
UniProtKB: Q8N655³
Ensembl: ENSG00000155640⁷

Search outside databases for aliases for C10orf12 gene

Previous GC identifer: GC10P098405

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the C10orf12 gene

Entrez Gene cytogenetic band: 10q24.1 Ensembl cytogenetic band: 10q24.1 HGNC cytogenetic band: 10q24.2

C10orf12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P098731: (about GC identifiers)

Start:	98,731,031 bp from pter
End:	98,735,575 bp from pter
Size:	4,545 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ012_HUMAN, Q8N655 (See protein sequence)

Recommended Name: Uncharacterized protein C10orf12

Size: 1247 amino acids; 137223 Da

Secondary accessions: Q9H945 Q9Y457

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_056467.2

ENSEMBL proteins:

ENSP00000286067

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for C10orf12:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for C10orf12

Assays for C10orf12:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8N655

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf12)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015652

Applied Biosystems Silencer® siRNAs for C10orf12

Sigma-Aldrich siRNA for C10orf12

Sigma-Aldrich shRNA for C10orf12

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015652
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015652
untagged cDNA clones in CMV expression vector (see all 2): NM_015652

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015652

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Interacting proteins for C10orf12 (Q8N655²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
EHMT2 Q96KQ7² MINT-66766
ENSG00000206376 Q96KQ7² MINT-66766
-- Q9BWA2² MINT-68173
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf12

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf12)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015652

Sigma-Aldrich siRNA for C10orf12

Sigma-Aldrich shRNA for C10orf12

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015652

REFSEQ mRNAs for C10orf12 gene:

NM_015652.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015652

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015652
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015652
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_015652

Additional cDNA sequence:

AK023084.1 AK126886.1 AL049938.1 BC024315.1 BC031482.1

6 DOTS entries:

DT.442872 DT.40305424 DT.427894 DT.413462 DT.91707703 DT.100747223

24/43 AceView cDNA sequences (see all 43 ):

BX279707 AI310447 AL042599 AK126886 CA313138 NM_015652 AL049938 AA777765

BG232093 N73475 BC031482 AK023084 AI571097 AU130389 BC024315 AA627752

AA304931 BG257177 BQ365522 AL042598 CB139673 BQ723372 AI655077 BG257754

highest scoring ESTs for C10orf12:

AL042599 AL049938 AI702215 AA304931 AA627752 AI310447 AI571097 AI655077 AI902741 AI902742

Unigene Clusters for C10orf12:

Chromosome 10 open reading frame 12

Hs.14555 [show with all ESTs], Hs.427927 [show with all ESTs]

Unigene Representative Sequences: AK025166, NM_015652

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000286067

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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C10orf12 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for C10orf12

¹ / ² / ³

7 probe-sets matching C10orf12 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
58234_at²^{, 3}	U95-B	1	1.00	1.00	0.72	1.21	AI702215	0.80	1.00	0.91	1
35612_at²^{, 3}	U95-A	2	1.00	0.97	0.74	0.79	AL049938	1.00	0.90	0.95	1
87999_at²^{, 3}	U95-D	2	0.94	0.94	0.87	1.00	AL042598	0.80	0.88	0.84	1
226892_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK025166	0.60	1.00	0.82	1
219601_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_015652	0.60	0.83	0.73	1
226892_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219601_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks C10orf12 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.14555 Hs.427927
Expression variation in blood from EXPOLDB for C10orf12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for C10orf12 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LOC450647¹	--	similar to Chromosome 10 open reading frame 12	99.6(n) 99.28(a)	450647 XM_507956.2 XP_507956.2
mouse (Mus musculus)	Gm340⁵	19	predicted gene 340	--	AK145489
chicken (Gallus gallus)	C10orf12¹	--	chromosome 10 open reading frame 12	55.7(n) 47.59(a)	428970 XM_426527.2 XP_426527.2
zebrafish (Danio rerio)	wu:fc17b08¹	--	wu:fc17b08	44.3(n) 33.01(a)	556205 XM_678958.3 XP_684050.3
tropical clawed frog (Silurana tropicalis)	Str.17506²	--	Transcribed sequences	73.87(n)	BX758120.1

About this table Species with no ortholog for C10orf12

ENSEMBL Gene Tree for C10orf12

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for C10orf12 gene

ENSG00000215273²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/29 NCBI SNPs in C10orf12 are shown (see all 29 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7900672^1,2	A,C,F,H	98729103(+)	`ACACCG/AACTGC`	1	--	ng5¹		8	EU EA WA	836
	rs7082522^1,2	A,C,F,H	98732078(+)	`TCACCT/CTCCTG`	1	P/L	mis¹ ese³		8	EU EA WA	838
	rs3829856^1,2	C,F,H	98732740(+)	`TTGAAA/CTCAAA`	1	I/L	mis¹		11	EU EA WA NA	1038
	rs7894200^1,2	C,F,H	98732803(+)	`GGACAA/CCACCT`	1	T/P	mis¹ ese³		4	EU EA WA	406
	rs11188980^1,2	C,F,H	98731283(+)	`GGGGAA/GCTCAT`	1	N/S	mis¹		8	EU EA WA	838
	rs7895159^1,2	A,H	98733283(+)	`CTAGGG/CCACCA`	1	P/A	mis¹ ese³		4	EU EA WA	416
	rs35128733^1,2	C,F	98732324(-)	`GATTTT/CCTGAG`	1	G/E	mis¹		5	NA EU EA WA	498
--	rs7900727^1,2	A,H	98729372(+)	`CTTGAA/GTAAAG`	1	--	ng5¹ tfbs³		4	EU EA WA	414
	rs7894545^1,2	A,H	98732977(+)	`AGTTAC/GGAGGA`	1	R/G	mis¹ ese³		4	EU EA WA	418
	rs34104025^1,2	C,F	98732338(-)	`CATTGG/CGGAAC`	1	A/P	mis¹		5	NA EU EA WA	498

About this table

HapMap Linkage Disequilibrium images for C10orf12 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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9 PubMed articles for C10orf12 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)⁴ Matsuoka S.... Elledge S.J. (2007)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 26148	HGNC: 23420	AceView: C10orf12	Ensembl:ENSG00000155640	euGenes: HUgn26148
ECgene: C10orf12	H-InvDB: C10orf12

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for C10orf12
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for C10orf12:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for C10orf12-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for C10orf12		Browse antibodies at Sigma-Aldrich
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	Recombinant & Natural Proteins

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for C10orf12

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C10orf12 Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for C10orf12

Summaries
for C10orf12

Genomic Location
for C10orf12

Proteins
for C10orf12

Protein Domains/
Families
for C10orf12

Gene Function
for C10orf12

Pathways & Interactions
for C10orf12

Drugs & Compounds
for C10orf12

Transcripts
for C10orf12

Expression
for C10orf12

Orthologs
for C10orf12

Paralogs
for C10orf12

SNPs/Variants
for C10orf12

Disorders & Mutations
for C10orf12

Medical News
for C10orf12

Publications
for C10orf12

Search for C10orf12

Genome Databases showing C10orf12

Other Databases showing C10orf12

Specialized Databases showing C10orf12

Licensable Technologies
for C10orf12

Services
for C10orf12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

C10orf12 Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor C10orf12

Summariesfor C10orf12

Genomic Locationfor C10orf12

Proteinsfor C10orf12

Protein Domains/Familiesfor C10orf12

Gene Functionfor C10orf12

Pathways & Interactionsfor C10orf12

Drugs & Compoundsfor C10orf12

Transcriptsfor C10orf12

Expression for C10orf12

Orthologsfor C10orf12

Paralogsfor C10orf12

SNPs/Variantsfor C10orf12

Disorders & Mutationsfor C10orf12

Medical Newsfor C10orf12

Publicationsfor C10orf12

Search for C10orf12

Genome Databases showing C10orf12

Other Databases showing C10orf12

Specialized Databases showing C10orf12

Licensable Technologiesfor C10orf12

Servicesfor C10orf12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for C10orf12

Summaries
for C10orf12

Genomic Location
for C10orf12

Proteins
for C10orf12

Protein Domains/
Families
for C10orf12

Gene Function
for C10orf12

Pathways & Interactions
for C10orf12

Drugs & Compounds
for C10orf12

Transcripts
for C10orf12

Expression
for C10orf12

Orthologs
for C10orf12

Paralogs
for C10orf12

SNPs/Variants
for C10orf12

Disorders & Mutations
for C10orf12

Medical News
for C10orf12

Publications
for C10orf12

Licensable Technologies
for C10orf12

Services
for C10orf12