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C10orf12 Gene

protein-coding   GIFtS: 44
GCID: GC10P098731

Chromosome 10 Open Reading Frame 12

  Search for C10orf12
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 10 Open Reading Frame 121 2
Uncharacterized Protein C10orf122

External Ids:    HGNC: 234201   Entrez Gene: 261482   Ensembl: ENSG000001556407   UniProtKB: Q8N6553   

Export aliases for C10orf12 gene to outside databases

Previous GC identifers: GC10P098405 GC10P092369


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C10orf12 Gene:
C10orf12 (chromosome 10 open reading frame 12) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the C10orf12 gene promoter:
         TBP   Egr-1   Roaz   Evi-1   RORalpha1   POU2F1   POU2F1a   HSF2   Cart-1   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C10orf12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C10orf12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q24.2

C10orf12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C10orf12 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P098731:  view genomic region     (about GC identifiers)

Start:
98,741,041 bp from pter      End:
98,745,585 bp from pter
Size:
4,545 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CJ012_HUMAN, Q8N655 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf12  
Size: 1247 amino acids; 137223 Da
Sequence caution: Sequence=BAB14396.1; Type=Erroneous initiation;
Secondary accessions: Q9H945 Q9Y457

Explore the universe of human proteins at neXtProt for C10orf12: NX_Q8N655

Explore proteomics data for C10orf12 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys813
  • Modification sites at PhosphoSitePlus

  • See C10orf12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056467.2  
    ENSEMBL proteins: 
     ENSP00000286067  

    C10orf12 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028104 DUF4553

    Graphical View of Domain Structure for InterPro Entry Q8N655

    ProtoNet protein and cluster: Q8N655


    C10orf12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C10orf12
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    hsa-miR-3910 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-302e hsa-miR-1297 hsa-miR-520a-3p hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidC10orf12 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C10orf12
    Interactions:

        Search GeneGlobe Interaction Network for C10orf12

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for C10orf12 (Q8N6552, 3 ENSP000002860674) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206376Q96KQ72, 3MINT-66766 I2D: score=5 
    ENSG00000232045Q96KQ72, 3MINT-66766 I2D: score=5 
    ENSG00000236759Q96KQ72, 3MINT-66766 I2D: score=5 
    ENSG00000238134Q96KQ72, 3MINT-66766 I2D: score=5 
    ENSG00000227333Q96KQ72, 3, ENSP000003973234MINT-66766 I2D: score=5 STRING: ENSP00000397323
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C10orf12 (CJ012)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for C10orf12 gene: 
    NM_015652.2  

    Unigene Clusters for C10orf12:

    Chromosome 10 open reading frame 12
    Hs.14555  [show with all ESTs], Hs.427927  [show with all ESTs]
    Unigene Representative Sequences: AK025166, NM_015652
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000286067(uc001kmv.3)
    miRNA
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    hsa-miR-3910 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-302e hsa-miR-1297 hsa-miR-520a-3p hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidC10orf12 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for C10orf12
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      QuantiTect SYBR Green Assays in human, mouse, rat C10orf12
      QuantiFast Probe-based Assays in human, mouse, rat C10orf12

    Additional mRNA sequence: 

    AK023084.1 AK126886.1 AL049938.1 BC024315.1 BC031482.1 

    5 DOTS entries:

    DT.442872  DT.40305424  DT.427894  DT.100747223  DT.91707703 

    Selected AceView cDNA sequences (see all 43):

    BG232093 BC031482 AK023084 AU130389 BX279707 BC024315 AL049938 AK126886 
    AA777765 N73475 NM_015652 CA313138 AI571097 AL042599 AI310447 CB139673 
    BQ365521 BE907891 BI517661 AV760888 BP356121 AI655077 AL042598 BQ723372 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C10orf12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTTTTTCA
    C10orf12 Expression
    About this image

    C10orf12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C10orf12 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.14555 Hs.427927
        Custom PCR Arrays for C10orf12
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C10orf12 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm3405 predicted gene 340   --   19 (34.97 cM) 41582370 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    79(a)
    42(a)
    many → 1
    many → 1
    6(21966798-21967118)
    6(21965976-21966506)
    lizard
    (Anolis carolinensis)
    Reptilia C10orf126
    chromosome 10 open reading frame 12
    39(a)
    1 ↔ 1
    GL343239.1(2009759-2013901)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.175062 Transcribed sequences 73.87(n)    BX758120.1 
    zebrafish
    (Danio rerio)
    Actinopterygii C1H10orf126
    chromosome 10 open reading frame 12
    10(a)
    1 ↔ 1
    1(22347318-22370015) ENSDARG00000070098


    ENSEMBL Gene Tree for C10orf12 (if available)
    TreeFam Gene Tree for C10orf12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C10orf12 gene

    C10orf12 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for C10orf12
    PGOHUM00000263125


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C10orf12 (see all 253)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs79006721,2
    C,F,A,H--98739113(+) ACACCG/AACTGC 1 -- us2k115Minor allele frequency- A:0.13NS EA NA WA 1608
    rs1918038561,2
    --98739249(+) TCTGCA/GCTAAG 1 -- us2k10--------
    rs1140363981,2
    F--98739334(+) TGATTG/ATAAAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1840133021,2
    --98739346(+) GTGTAC/TTGAAG 1 -- us2k10--------
    rs122196141,2
    C,H--98739367(+) ATGTAG/ACAAGT 1 -- us2k14Minor allele frequency- A:0.00NS EA 420
    rs79007271,2
    A,H--98739382(+) CTTGAA/GTAAAG 1 -- us2k1 tfbs34Minor allele frequency- G:0.00NS EA 414
    rs1891420581,2
    --98739420(+) GGCCTA/GTACAG 1 -- us2k10--------
    rs1489640961,2
    C--98739453(+) CTCCTC/TACTTA 1 -- us2k10--------
    rs1470567051,2
    --98739603(+) TCTTAA/GAACTG 1 -- us2k10--------
    rs1147650731,2
    C,F--98739608(+) AAACTG/CTTAAG 1 -- us2k11Minor allele frequency- C:0.19WA 118

    HapMap Linkage Disequilibrium report for C10orf12 (98741041 - 98745585 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for C10orf12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831951CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C10orf12
    DNA2.0 Custom Variant and Variant Library Synthesis for C10orf12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C10orf12 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with C10orf12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL cross-linking and affinity purification. (PubMed id 24550272)1, 3 Alekseyenko A.A....Kuroda M.I. (Proc. Natl. Acad. Sci. U.S.A. 2014)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26148 HGNC: 23420 AceView: C10orf12 Ensembl:ENSG00000155640 euGenes: HUgn26148
    ECgene: C10orf12 H-InvDB: C10orf12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C10orf12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C10orf12 gene:
    Search GeneIP for patents involving C10orf12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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