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Aliases for C10orf12 Gene

Aliases for C10orf12 Gene

  • Chromosome 10 Open Reading Frame 12 2 3
  • Ligand Dependent Nuclear Receptor Corepressor 5
  • LCOR 5

External Ids for C10orf12 Gene

Previous GeneCards Identifiers for C10orf12 Gene

  • GC10P098405
  • GC10P098731
  • GC10P092369
  • GC10P096981

Summaries for C10orf12 Gene

GeneCards Summary for C10orf12 Gene

C10orf12 (Chromosome 10 Open Reading Frame 12) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf12 Gene

Genomics for C10orf12 Gene

Regulatory Elements for C10orf12 Gene

Enhancers for C10orf12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C10orf12 on UCSC Golden Path with GeneCards custom track

Promoters for C10orf12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C10orf12 on UCSC Golden Path with GeneCards custom track

Genomic Location for C10orf12 Gene

Chromosome:
10
Start:
96,832,260 bp from pter
End:
96,995,959 bp from pter
Size:
163,700 bases
Orientation:
Plus strand

Genomic View for C10orf12 Gene

Genes around C10orf12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf12 Gene

Proteins for C10orf12 Gene

  • Protein details for C10orf12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N655-CJ012_HUMAN
    Recommended name:
    Uncharacterized protein C10orf12
    Protein Accession:
    Q8N655
    Secondary Accessions:
    • Q9H945
    • Q9Y457

    Protein attributes for C10orf12 Gene

    Size:
    1247 amino acids
    Molecular mass:
    137223 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14396.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C10orf12 Gene

Post-translational modifications for C10orf12 Gene

  • Ubiquitination at Lys 813
  • Modification sites at PhosphoSitePlus

Other Protein References for C10orf12 Gene

No data available for DME Specific Peptides for C10orf12 Gene

Domains & Families for C10orf12 Gene

Protein Domains for C10orf12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C10orf12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C10orf12: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C10orf12 Gene

Function for C10orf12 Gene

Gene Ontology (GO) - Molecular Function for C10orf12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C10orf12: view

Phenotypes for C10orf12 Gene

GenomeRNAi human phenotypes for C10orf12:
genes like me logo Genes that share phenotypes with C10orf12: view

Animal Model Products

CRISPR Products

miRNA for C10orf12 Gene

miRTarBase miRNAs that target C10orf12

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C10orf12 Gene

Localization for C10orf12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C10orf12 Gene COMPARTMENTS Subcellular localization image for C10orf12 gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for C10orf12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with C10orf12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C10orf12 Gene

Pathways & Interactions for C10orf12 Gene

SuperPathways for C10orf12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C10orf12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf12 Gene

Drugs & Compounds for C10orf12 Gene

No Compound Related Data Available

Transcripts for C10orf12 Gene

mRNA/cDNA for C10orf12 Gene

Unigene Clusters for C10orf12 Gene

Chromosome 10 open reading frame 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf12 Gene

No ASD Table

Relevant External Links for C10orf12 Gene

GeneLoc Exon Structure for
C10orf12
ECgene alternative splicing isoforms for
C10orf12

Expression for C10orf12 Gene

mRNA expression in normal human tissues for C10orf12 Gene

Protein differential expression in normal tissues from HIPED for C10orf12 Gene

This gene is overexpressed in Breast (30.0), Cervix (20.1), and Amniocyte (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C10orf12 Gene



NURSA nuclear receptor signaling pathways regulating expression of C10orf12 Gene:

C10orf12

SOURCE GeneReport for Unigene cluster for C10orf12 Gene:

Hs.14555
genes like me logo Genes that share expression patterns with C10orf12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C10orf12 Gene

Orthologs for C10orf12 Gene

This gene was present in the common ancestor of animals.

Orthologs for C10orf12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LCOR 34
  • 83.51 (n)
  • 77.03 (a)
LCOR 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LCOR 34
  • 85.86 (n)
  • 80.84 (a)
LCOR 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lcor 34
  • 72.24 (n)
  • 62.57 (a)
oppossum
(Monodelphis domestica)
Mammalia LCOR 35
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lcor 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LCOR 35
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C10H10ORF12 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves LCOR 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LCOR 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17506 34
zebrafish
(Danio rerio)
Actinopterygii lcor 35
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eip93F 35
  • 2 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mbr-1 35
  • 8 (a)
OneToMany
Species where no ortholog for C10orf12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C10orf12 Gene

ENSEMBL:
Gene Tree for C10orf12 (if available)
TreeFam:
Gene Tree for C10orf12 (if available)

Paralogs for C10orf12 Gene

No data available for Paralogs for C10orf12 Gene

Variants for C10orf12 Gene

Sequence variations from dbSNP and Humsavar for C10orf12 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11188980 - 96,981,536(+) GGGGA(A/G)CTCAT reference, missense
rs7082522 - 96,982,331(+) TCACC(C/T)TCCTG reference, missense
rs34104025 - 96,982,591(-) CATTG(C/G)GGAAC reference, missense
rs3829856 - 96,982,993(+) TTGAA(A/C)TCAAA reference, missense
rs35128733 - 96,982,577(-) GATTT(C/T)CTGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for C10orf12 Gene

Variant ID Type Subtype PubMed ID
nsv1052931 CNV gain 25217958
nsv1110852 OTHER inversion 24896259
nsv831951 CNV gain 17160897

Variation tolerance for C10orf12 Gene

Residual Variation Intolerance Score: 49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.01; 74.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C10orf12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf12 Gene

Disorders for C10orf12 Gene

Relevant External Links for C10orf12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C10orf12

No disorders were found for C10orf12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf12 Gene

Publications for C10orf12 Gene

  1. Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL cross-linking and affinity purification. (PMID: 24550272) Alekseyenko A.A. … Kuroda M.I. (Proc. Natl. Acad. Sci. U.S.A. 2014) 2 3 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 65

Products for C10orf12 Gene

Sources for C10orf12 Gene

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