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C10orf119 Gene

protein-coding GIFtS: 46

GC10M121578

chromosome 10 open reading frame 119
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ13081 ^¹, ²
FLJ36756 ^²
MCM-BP ^¹, ²
MCMBP ^¹, ², ⁵
OTTHUMP00000020612 ^²

Descriptions
MCM-binding protein ^²
chromosome 10 open reading frame 119 ^²
minichromosome maintenance complex binding protein ^²
minichromosome maintenance complex-binding protein ^²

External Ids
HGNC: 25782¹
Entrez Gene: 79892²
UniProtKB: Q9BTE3³
Ensembl: ENSG00000197771⁷

Search outside databases for aliases for C10orf119 gene

Previous GC identifer: GC10M121254

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for C10orf119:

DNA replication is a carefully orchestrated process involving many proteins that assemble at

origins of replication. Among these are the 6 proteins of the minichromosome maintenance (MCM)

complex (e.g., MCM2; MIM 116945), which form a hexamer. Each MCM subunit performs an essential

function in initiation and elongation of DNA replication. MCMBP can replace MCM2 in the MCM

complex, thus forming an alternative MCM hexamer (Sakwe et al., 2007 [PubMed 17296731]).[supplied

by OMIM]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the C10orf119 gene

Entrez Gene cytogenetic band: 10q26.11 Ensembl cytogenetic band: 10q26.11 HGNC cytogenetic band: 10q26.13

C10orf119 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M121578: (about GC identifiers)

Start:	121,578,962 bp from pter
End:	121,622,384 bp from pter
Size:	43,423 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CJ119_HUMAN, Q9BTE3 (See protein sequence)

Recommended Name: UPF0557 protein C10orf119

Size: 642 amino acids; 72980 Da

Secondary accessions: Q6IA56 Q9BVT9 Q9H916

Alternative splicing: 2 isoforms: Q9BTE3-1 Q9BTE3-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_079110.1

ENSEMBL proteins:

ENSP00000353098 ENSP00000358073

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

About this table

Antibodies for C10orf119:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for C10orf119

Assays for C10orf119:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9BTE3

ProtoNet protein and cluster: Q9BTE3

UniProtKB/Swiss-Prot: CJ119_HUMAN, Q9BTE3

Similarity: Belongs to the UPF0557 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf119)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024834

Applied Biosystems Silencer® siRNAs for C10orf119

Sigma-Aldrich siRNA for C10orf119

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for C10orf119
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_024834
Myc/DDK tagged cDNA clone in CMV expression vector: NM_024834
untagged cDNA clone in CMV expression vector: NM_024834

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024834

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for C10orf119 (Q9BTE3²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
DDIT3 P35638² MINT-67504
About this table
1 Gene Ontology (GO) biological process term (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf119

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf119)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024834

Sigma-Aldrich siRNA for C10orf119

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_024834

REFSEQ mRNAs for C10orf119 gene:

NM_024834.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_024834

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024834
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024834
                                 untagged cDNA clone in CMV expression vector: NM_024834

Additional cDNA sequence:

AK001928.1 AK023143.1 AK094075.1 BC000935.2 BC004183.2 BC007219.1 CR457299.1 CR609239.1

12 DOTS entries:

DT.95174649 DT.455894 DT.99994077 DT.100792020 DT.100792019 DT.40107482 DT.101978008 DT.91986611

DT.100792024 DT.92439730 DT.97799962 DT.97846578

24/301 AceView cDNA sequences (see all 301 ):

BG528848 BU156525 AI278309 CA449737 BE465947 BU618658 AW771502 CD367418

AA829470 AA973972 AL135399 AI917203 BM739371 BU069493 AW771521 AI434568

BU618799 BM807043 BQ231534 BP337967 BU902327 N66098 AA305344 AI631297

highest scoring ESTs for C10orf119:

AI818209 AK023143 AL518068 AL536159 AW410333 BC004183 BC007219 BE546476 BE561984 BF514239

Unigene Cluster for C10orf119:

Chromosome 10 open reading frame 119

Hs.124246 [show with all ESTs]

Unigene Representative Sequence: NM_024834

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf119 (see all 7 )

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17a	·
SP1:			-								-		-				-		-				-										-												-
SP2:											-		-										-										-												-
SP3:											-		-										-										-												-
SP4:																							-
SP5:

ExUns:	17b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for C10orf119

2 Ensembl transcripts including schematic representations:

ENST00000360003 ENST00000369077

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C10orf119 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for C10orf119

¹ / ² / ³

7 probe-sets matching C10orf119 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45243_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AI818209	0.80	1.00	0.91	1
233028_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK001928	0.60	1.00	0.82	1
222464_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BC004183	0.80	1.00	0.91	1
217905_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024834	0.60	1.00	0.82	1
233028_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222464_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217905_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGCTTTTGA

SOURCE GeneReport for Unigene cluster: Hs.124246

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for C10orf119 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LOC450781¹	--	similar to Chromosome 10 open reading frame 119	99.64(n) 100(a)	450781 XM_508075.2 XP_508075.2
cow (Bos taurus)	C26H10ORF119¹	--	chromosome 10 open reading frame 119 ortholog	90.94(n) 96.72(a)	514863 XM_592775.3 XP_592775.3
rat (Rattus norvegicus)	RGD1306730¹	--	similar to cDNA sequence BC025641	82.88(n) 90.99(a)	309009 NM_001039608.1 NP_001034697.1
mouse (Mus musculus)	1110007A13Rik^{1, 5}	7⁵	RIKEN cDNA 1110007A13 gene^{1, 5}	85.25(n)¹ 92.99(a)¹	210711¹ NM_145955.3¹ NP_666067.1¹ AA445754⁵ AI845990⁵ (see all 15)
chicken (Gallus gallus)	C10orf119¹	--	chromosome 10 open reading frame 119	79.39(n) 84.07(a)	423933 NM_001012912.1 NP_001012930.1

About this table Species with no ortholog for C10orf119

ENSEMBL Gene Tree for C10orf119

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/275 NCBI SNPs in C10orf119 are shown (see all 275 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 107)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2456715^1,2	A,C,F,H	121623528(+)	`tcaaaG/Caggtg`	1	--	ng3¹		4		EU EA WA	418
--	rs6881^1,2	A,C,F,H	121579392(-)	`TGTAAC/ATTGTA`	1	--	ut3¹		5		MN EU EA	670
	rs3808956^1,2	C,F,H	121622790(+)	`CCGGCC/TCGAAA`	1	--	ng3¹		5		EA EU WA	1720
	rs10550^1,2	F,H	121579764(-)	`ATCAAA/GTAACT`	1	--	ut3¹		6		MN EU EA WA	790
--	rs10787995^1,2	A,C	121624296(+)	`CTTACA/GTTAGC`	1	--	ng3¹		0	--	--	--	--
	rs2475318^1,2	A	121622477(-)	`TCCAAA/GATGgc`	1	--	ng3¹		0	--	--	--	--
	rs12778411^1,2	F	121580043(+)	`AGGGGG/CTATTG`	1	--	ut3¹		2		MN EA	1252
	rs12777827^1,2	C	121579903(+)	`TTGTAC/TGAGGC`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs28362484^1,2	F	121580840(-)	`CTGGT-/GTAACAC`	1	--	ut3¹		2		MN EA	1252
	rs12772291^1,2	C,F,H	121588163(+)	`TTTCAA/GATGGT`	1	L/L	syn¹		5		EU EA WA NA	496

About this table

HapMap Linkage Disequilibrium images for C10orf119 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 610909

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

9 PubMed articles for C10orf119 gene:

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)⁴ Cantin G.T....Yates J.R. III (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Identification and characterization of a novel component of the human minichromosome maintenance complex. (PubMed id 17296731)³ Sakwe A.M....Frappier L. (2007)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)³ Brandenberger R.... Stanton L.W. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 79892	HGNC: 25782	AceView: C10orf119	Ensembl:ENSG00000197771	euGenes: HUgn79892
ECgene: C10orf119	H-InvDB: C10orf119

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for C10orf119
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for C10orf119:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for C10orf119-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for C10orf119		Browse antibodies at Sigma-Aldrich
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	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
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Search Novus for antibodies for C10orf119

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C10orf119 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for C10orf119

Summaries
for C10orf119

Genomic Location
for C10orf119

Proteins
for C10orf119

Protein Domains/
Families
for C10orf119

Gene Function
for C10orf119

Pathways & Interactions
for C10orf119

Drugs & Compounds
for C10orf119

Transcripts
for C10orf119

Expression
for C10orf119

Orthologs
for C10orf119

Paralogs
for C10orf119

SNPs/Variants
for C10orf119

Disorders & Mutations
for C10orf119

Medical News
for C10orf119

Publications
for C10orf119

Search for C10orf119

Genome Databases showing C10orf119

Other Databases showing C10orf119

Specialized Databases showing C10orf119

Licensable Technologies
for C10orf119

Services
for C10orf119

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

C10orf119 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor C10orf119

Summariesfor C10orf119

Genomic Locationfor C10orf119

Proteinsfor C10orf119

Protein Domains/Familiesfor C10orf119

Gene Functionfor C10orf119

Pathways & Interactionsfor C10orf119

Drugs & Compoundsfor C10orf119

Transcriptsfor C10orf119

Expression for C10orf119

Orthologsfor C10orf119

Paralogsfor C10orf119

SNPs/Variantsfor C10orf119

Disorders & Mutationsfor C10orf119

Medical Newsfor C10orf119

Publicationsfor C10orf119

Search for C10orf119

Genome Databases showing C10orf119

Other Databases showing C10orf119

Specialized Databases showing C10orf119

Licensable Technologiesfor C10orf119

Servicesfor C10orf119

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for C10orf119

Summaries
for C10orf119

Genomic Location
for C10orf119

Proteins
for C10orf119

Protein Domains/
Families
for C10orf119

Gene Function
for C10orf119

Pathways & Interactions
for C10orf119

Drugs & Compounds
for C10orf119

Transcripts
for C10orf119

Expression
for C10orf119

Orthologs
for C10orf119

Paralogs
for C10orf119

SNPs/Variants
for C10orf119

Disorders & Mutations
for C10orf119

Medical News
for C10orf119

Publications
for C10orf119

Licensable Technologies
for C10orf119

Services
for C10orf119