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C10orf118 Gene

protein-coding GIFtS: 46

GC10M115871

chromosome 10 open reading frame 118
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ10188 ^¹, ²
FLJ35301 ^¹, ²
MGC118918 ^²
MGC129699 ^²
OTTHUMP00000020523 ^²

Descriptions
CTCL tumor antigen HD-CL-01/L14-2 ^³
CTCL tumor antigen L14-2 ^²
chromosome 10 open reading frame 118 ^²

External Ids
HGNC: 24349¹
Entrez Gene: 55088²
UniProtKB: Q7Z3E2³
Ensembl: ENSG00000165813⁷

Search outside databases for aliases for C10orf118 gene

Previous GC identifer: GC10M115547

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for C10orf118

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the C10orf118 gene

Entrez Gene cytogenetic band: 10q25.3 Ensembl cytogenetic band: 10q25.3 HGNC cytogenetic band: 10q26.11

C10orf118 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M115871: (about GC identifiers)

Start:	115,871,964 bp from pter
End:	115,924,354 bp from pter
Size:	52,391 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ118_HUMAN, Q7Z3E2 (See protein sequence)

Recommended Name: Uncharacterized protein C10orf118

Size: 898 amino acids; 103687 Da

Sequence caution: Sequence=AAH70368.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.

Potential poly-A sequence starting in position 212; Sequence=AAM44457.1; Type=Miscellaneous

discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 792;

Secondary accessions: Q2M2V6 Q6NS91 Q7RTP1 Q8N117 Q8N3G3 Q8N6C2 Q9NWA3

Alternative splicing: 2 isoforms: Q7Z3E2-1 Q7Z3E2-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_060487.2

ENSEMBL proteins:

ENSP00000358293 ENSP00000358291 ENSP00000358292

Human Recombinant Proteins

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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for C10orf118:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for C10orf118
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for C10orf118

Assays for C10orf118:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q7Z3E2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf118)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018017

Applied Biosystems Silencer® siRNAs for C10orf118

Sigma-Aldrich siRNA for C10orf118

Sigma-Aldrich shRNA for C10orf118

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for C10orf118
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_018017
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018017
untagged cDNA clones in CMV expression vector (see all 2): AF273054

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018017

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for C10orf118 (Q7Z3E2²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
SMAD3 P84022² MINT-51240
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf118

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf118)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018017

Sigma-Aldrich siRNA for C10orf118

Sigma-Aldrich shRNA for C10orf118

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018017

REFSEQ mRNAs for C10orf118 gene:

NM_018017.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018017

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018017
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018017
                                 untagged cDNA clones in CMV expression vector (see all 2): AF273054

Additional cDNA sequence:

AF273054.1 AK001050.1 AK024739.1 AK057508.1 AK092620.1 AK094498.1 AK307517.1 AL834368.1

BC020842.1 BC022229.1 BC070368.1 BC100670.1 BC103499.1 BC103504.1 BC105632.1 BC107430.1

BC152306.1 BX537964.1

8 DOTS entries:

DT.100716575 DT.304234 DT.92418292 DT.92057946 DT.121229321 DT.121229338 DT.97782920 DT.95336207

24/135 AceView cDNA sequences (see all 135 ):

BK001329 CB178647 AI862150 CK430370 CA436334 AI292113 CD703085 AI984325

AW235859 BE221489 BX537964 BC022229 AX747632 AW291511 AI093252 NM_018017

AA885835 AA456660 BX111831 CB995224 CB992135 BX091088 BE222725 AI991475

highest scoring ESTs for C10orf118:

AA934755 AI143965 AI223129 AI655195 AI672382 AK092620 AW172285 BC020842 BC070368 BE568568

Unigene Cluster for C10orf118:

Chromosome 10 open reading frame 118

Hs.159066 [show with all ESTs]

Unigene Representative Sequence: NM_018017

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf118 (see all 9 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16a	·	16b	^	17a	·	17b	·
SP1:																	-																				-								-
SP2:									-		-						-
SP3:									-		-		-		-		-
SP4:											-
SP5:

ExUns:	17c	·	17d	^	18	^	19
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for C10orf118

3 Ensembl transcripts including schematic representations:

ENST00000369287 ENST00000369285 ENST00000369286

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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C10orf118 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for C10orf118

¹ / ² / ³

11 probe-sets matching C10orf118 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
77246_at²^{, 3}	U95-E	1	1.00	1.00	0.84	0.98	T62566	0.80	1.00	0.91	1
52409_at²^{, 3}	U95-C	1	1.00	1.00	0.93	1.31	AI672382	0.80	1.00	0.91	1
83890_at²^{, 3}	U95-E	1	1.00	1.00	0.92	0.38	AI655195	0.80	1.00	0.91	1
86286_at²^{, 3}	U95-E	1	1.00	1.00	0.08	0.33	AA934755	0.80	1.00	0.91	1
89177_at²^{, 3}	U95-E	1	1.00	1.00	0.95	1.37	R64659	0.80	1.00	0.91	1
229399_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF438440	0.60	1.00	0.82	1
219844_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_018017	0.60	1.00	0.82	1
227701_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AK024739	0.60	1.00	0.82	1
229399_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219844_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227701_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks C10orf118 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGTCAGGGAC

SOURCE GeneReport for Unigene cluster: Hs.159066

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for C10orf118 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC477825¹	--	similar to CTCL tumor antigen L14-2	91.82(n) 92.19(a)	477825 XM_535019.2 XP_535019.2
chimpanzee (Pan troglodytes)	LOC450749¹	--	CTCL tumor antigen L14-2	99.7(n) 99.11(a)	450749 XM_508047.2 XP_508047.2
mouse (Mus musculus)	A630007B06Rik^{1, 5}	19⁵	RIKEN cDNA A630007B06 gene^{1, 5}	83.91(n)¹ 84.39(a)¹	213993¹ NM_170757.1¹ NP_739563.1¹ AA265784⁵ AA387073⁵ (see all 21)
chicken (Gallus gallus)	C10orf118¹	--	chromosome 10 open reading frame 118	73.86(n) 75(a)	423905 XM_421767.2 XP_421767.2
zebrafish (Danio rerio)	LOC557112¹	--	tolloid-like 1	67.33(n) 73.07(a)	557112 XM_680114.3 XP_685206.2

About this table Species with no ortholog for C10orf118

ENSEMBL Gene Tree for C10orf118

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/236 NCBI SNPs in C10orf118 are shown (see all 236 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 74)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1061159^1,2	A,C,F,H,O	115912764(-)	`AGACAC/TAGGCT`	1	T/I	mis¹ ese³		17		MN EA NA EU WA	1598
	rs7095762^1,2	A,C,F,H	115900918(+)	`TAGTTG/TATCTC`	1	Q/K	mis¹		8		EU EA WA	838
	rs12782946^1,2	C,F,H	115912482(+)	`GTACTC/TGATGT`	1	R/Q	mis¹ ese³		17		NA EU EA WA	1580
	rs17091403^1,2	C,F,H	115923895(+)	`GCCGAC/TGCCTC`	1	--	ut5¹ ese³		7		NA EU EA WA	520
--	rs11596871^1,2	A,C	115873240(+)	`TAGAGC/TCCAAA`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs12571485^1,2	C	115925231(+)	`ttttcA/Gtgaaa`	1	--	ng3¹		0	--	--	--	--
	rs660101^1,2	A,C,F,H,O	115886441(-)	`GAGAAC/GTTTTC`	1	--	int¹		4		EU EA WA	418
	rs11594867^1,2	A,C,F,H	115876853(+)	`ACTACA/GTCCTA`	1	--	int¹		8		EU EA WA NA	776
	rs7902873^1,2	A,C,F,H	115884949(+)	`CCTAGG/CTTTTA`	1	--	int¹		13		NS EU EA WA	942
	rs727168^1,2	A,C,F,H	115898800(+)	`GTTGGG/CAGGAA`	1	--	int¹ trp³		5		MN EU EA WA	602

About this table

HapMap Linkage Disequilibrium images for C10orf118 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10 PubMed articles for C10orf118 gene:

Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. (PubMed id 12783626)^{2, 3, 4} Oduru S....Williams S.C. (2003)
SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma. (PubMed id 14996095)^{3, 4} Hartmann T.B.... Eichmueller S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
The LIFEdb database in 2006. (PubMed id 16381901)³ Mehrle A....Wiemann S. (2006)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)³ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)³ Wiemann S.... Poustka A. (2001)
DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)³ Hartley J.L....Brasch M.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 55088	HGNC: 24349	AceView: C10orf118	Ensembl:ENSG00000165813	euGenes: HUgn55088
ECgene: C10orf118	H-InvDB: C10orf118

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for C10orf118	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for C10orf118
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for C10orf118:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for C10orf118-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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	Predesigned and custom siRNAs for C10orf118		Antibodies for C10orf118
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C10orf118 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for C10orf118

Summaries
for C10orf118

Genomic Location
for C10orf118

Proteins
for C10orf118

Protein Domains/
Families
for C10orf118

Gene Function
for C10orf118

Pathways & Interactions
for C10orf118

Drugs & Compounds
for C10orf118

Transcripts
for C10orf118

Expression
for C10orf118

Orthologs
for C10orf118

Paralogs
for C10orf118

SNPs/Variants
for C10orf118

Disorders & Mutations
for C10orf118

Medical News
for C10orf118

Publications
for C10orf118

Search for C10orf118

Genome Databases showing C10orf118

Other Databases showing C10orf118

Specialized Databases showing C10orf118

Licensable Technologies
for C10orf118

Services
for C10orf118

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

C10orf118 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor C10orf118

Summariesfor C10orf118

Genomic Locationfor C10orf118

Proteinsfor C10orf118

Protein Domains/Familiesfor C10orf118

Gene Functionfor C10orf118

Pathways & Interactionsfor C10orf118

Drugs & Compoundsfor C10orf118

Transcriptsfor C10orf118

Expression for C10orf118

Orthologsfor C10orf118

Paralogsfor C10orf118

SNPs/Variantsfor C10orf118

Disorders & Mutationsfor C10orf118

Medical Newsfor C10orf118

Publicationsfor C10orf118

Search for C10orf118

Genome Databases showing C10orf118

Other Databases showing C10orf118

Specialized Databases showing C10orf118

Licensable Technologiesfor C10orf118

Servicesfor C10orf118

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for C10orf118

Summaries
for C10orf118

Genomic Location
for C10orf118

Proteins
for C10orf118

Protein Domains/
Families
for C10orf118

Gene Function
for C10orf118

Pathways & Interactions
for C10orf118

Drugs & Compounds
for C10orf118

Transcripts
for C10orf118

Expression
for C10orf118

Orthologs
for C10orf118

Paralogs
for C10orf118

SNPs/Variants
for C10orf118

Disorders & Mutations
for C10orf118

Medical News
for C10orf118

Publications
for C10orf118

Licensable Technologies
for C10orf118

Services
for C10orf118