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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C10orf114 Gene

protein-coding GIFtS: 36
GCID: GC10M021781

chromosome 10 open reading frame 114

Search for C10orf114
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 10 Open Reading Frame 114¹ ²
BA418C1.3¹
Putative Uncharacterized Protein C10orf114²

External Ids:	HGNC: 31448¹	Entrez Gene: 399726²	Ensembl: ENSG00000204682⁷	UniProtKB: Q5T4H9³

Export aliases for C10orf114 gene to outside databases

Previous GC identifers: GC10M021787 GC10M021823 GC10M021445

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008705.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C10orf114 gene promoter:
Max1 GATA-3 HTF Hand1 Nkx2-5 E47 GATA-1 GATA-2
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C10orf114

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.31 Ensembl cytogenetic band: 10p12.31 HGNC cytogenetic band: 10p12.31

C10orf114 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C10orf114 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M021781: view genomic region (about GC identifiers)

Start:	21,781,587 bp from pter	End:	21,786,213 bp from pter
Size:	4,627 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CJ114_HUMAN, Q5T4H9 (See protein sequence)

Recommended Name: Putative uncharacterized protein C10orf114

Size: 136 amino acids; 14851 Da

Secondary accessions: A1L4M3

Explore the universe of human proteins at neXtProt for C10orf114: NX_Q5T4H9

C10orf114 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001010911.1

ENSEMBL proteins:

ENSP00000366317

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q5T4H9

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C10orf114

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for C10orf114 (ENSP00000366317⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GPX7	ENSP00000354677⁴	STRING: ENSP00000354677
LRRC7	ENSP00000035383⁴	STRING: ENSP00000035383
PHTF1	ENSP00000358617⁴	STRING: ENSP00000358617
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269
--	ENSP00000402148⁴	STRING: ENSP00000402148

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C10orf114
Search CenterWatch for drugs/clinical trials and news about C10orf114 / CJ114

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for C10orf114 gene:

NM_001010911.2

Unigene Cluster for C10orf114:

Chromosome 10 open reading frame 114

Hs.315568 [show with all ESTs]

Unigene Representative Sequence: BC040880

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000377113(uc001iqn.4)

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Additional cDNA sequence:

BC040880.1 BC130594.1 BC132974.1

3 DOTS entries:

DT.97838178 DT.100694692 DT.91935310

24/30 AceView cDNA sequences (see all 30):

AI597615 BM678461 BX387127 BM713771 CR596294 BU621529 BQ188628 BM548798

BM563843 BC040880 BX327844 BQ007522 BM558275 BQ184250 BF982799 BF034738

BM805029 CB989480 BX327685 BE783770 BX337043 BX354661 BQ071016 BE874831

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C10orf114 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGGGTTCGG

About this image

C10orf114 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C10orf114 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C10orf114

SOURCE GeneReport for Unigene cluster: Hs.315568

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for C10orf114 gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	A930004D18Rik⁵	RIKEN cDNA A930004D18 gene	--		2 (12.82 cM) 18025193

ENSEMBL Gene Tree for C10orf114 (if available)
TreeFam Gene Tree for C10orf114 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190338924^1,2		--	21783075(+)	`TTTCCC/TGAGTC`	1	--	int¹		0	--	--	--	--
rs182082942^1,2		--	21783108(+)	`CTACAC/GTTCCT`	1	--	int¹		0	--	--	--	--
rs185842435^1,2		--	21783116(+)	`CCTGCA/CCGGTG`	1	--	int¹		0	--	--	--	--
rs76842060^1,2	F,	--	21783209(+)	`AACGAG/CAAAGC`	1	--	int¹		1		EA	120
rs190417754^1,2		--	21783267(+)	`GGCGGC/GACCCC`	1	--	int¹		0	--	--	--	--
rs143514816^1,2		--	21783428(+)	`AGTTTA/CTGTCT`	1	--	ut3¹		0	--	--	--	--
rs74120969^1,2	C,F,	--	21783430(+)	`TTTCTG/CTCTTT`	1	--	ut3¹		3		WA CSA	122
rs180679369^1,2		--	21783571(+)	`ACAGTC/GTAAAA`	1	--	ut3¹		0	--	--	--	--
rs12770228^1,2	C,F,H,	--	21783634(+)	`CCCCTG/AGGGTG`	1	--	ut3¹ ese³		20		NS EA NA WA	2226
rs35106872^1,2	C,	--	21783752(+)	`CCCCAA/GGCCTG`	1	--	ut3¹		8		NA WA CSA	249

HapMap Linkage Disequilibrium report for C10orf114 (21781587 - 21786213 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C10orf114
1 CNV: 48505

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C10orf114 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C10orf114)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 399726	HGNC: 31448	AceView: C10orf114	Ensembl:ENSG00000204682	euGenes: HUgn399726
ECgene: C10orf114	H-InvDB: C10orf114

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C10orf114	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C10orf114 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C10orf114 gene:
Search GeneIP for patents involving C10orf114

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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C10orf114 Gene

chromosome 10 open reading frame 114

Aliases
for C10orf114 gene

Summaries
for C10orf114 gene

Genomic Views
for C10orf114 gene

Proteins
for C10orf114 gene

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for C10orf114 gene

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for C10orf114 gene

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for C10orf114 gene

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for C10orf114 gene

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for C10orf114 gene

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for C10orf114 gene

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C10orf114 Gene

chromosome 10 open reading frame 114

Aliasesfor C10orf114 gene

Summariesfor C10orf114 gene

Genomic Viewsfor C10orf114 gene

Proteinsfor C10orf114 gene

Protein Domains /Familiesfor C10orf114 gene

Functionfor C10orf114 gene

Pathways & Interactionsfor C10orf114 gene

Drugs & Compoundsfor C10orf114 gene

Transcriptsfor C10orf114 gene

Expression for C10orf114 gene

Orthologsfor C10orf114 gene

Paralogsfor C10orf114 gene

Genomic Variantsfor C10orf114 gene

Disorders / Diseasesfor C10orf114 gene

Publicationsfor C10orf114 gene

External Searches for C10orf114 gene

Genome Databases showing C10orf114 gene

Other Databases showing C10orf114 gene

Specialized Databases showing C10orf114 gene

Intellectual Propertyfor C10orf114 gene

Productsfor C10orf114 gene

View Random Gene

Aliases
for C10orf114 gene

Summaries
for C10orf114 gene

Genomic Views
for C10orf114 gene

Proteins
for C10orf114 gene

Protein Domains /
Families
for C10orf114 gene

Function
for C10orf114 gene

Pathways & Interactions
for C10orf114 gene

Drugs & Compounds
for C10orf114 gene

Transcripts
for C10orf114 gene

Expression
for C10orf114 gene

Orthologs
for C10orf114 gene

Paralogs
for C10orf114 gene

Genomic Variants
for C10orf114 gene

Disorders / Diseases
for C10orf114 gene

Publications
for C10orf114 gene

Intellectual Property
for C10orf114 gene

Products
for C10orf114 gene