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C10orf114 Gene

protein-coding   GIFtS: 34

GC10M021823
chromosome 10 open reading frame 114
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
OTTHUMP00000019273 2
bA418C1.3 1, 2
Descriptions
chromosome 10 open reading frame 114 2
hypothetical protein LOC399726 2
External Ids
HGNC: 314481
Entrez Gene: 3997262
UniProtKB: Q5T4H93
Ensembl: ENSG000002046827
Search outside databases for aliases for C10orf114 gene

Previous GC identifer: GC10M021787

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf114 gene  

Entrez Gene cytogenetic band: 10p12.31   Ensembl cytogenetic band:  10p12.31   HGNC cytogenetic band: 10p12.31

C10orf114 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M021823:     (about GC identifiers)

Start:
21,823,427 bp from pter
End:
21,826,197 bp from pter
Size:
2,771 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000010.9  NT_008705.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CJ114_HUMAN, Q5T4H9 (See protein sequence)
Recommended Name: Putative uncharacterized protein C10orf114  
Size: 136 amino acids; 14851 Da
Secondary accessions: A1L4M3

REFSEQ proteins: NP_001010911.1  

ENSEMBL proteins: 
ENSP00000366317 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for C10orf114: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for C10orf114

Assays for C10orf114: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q5T4H9

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (C10orf114)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001010911

              Applied Biosystems Silencer® siRNAs for C10orf114

              Sigma-Aldrich siRNA for C10orf114  
                     Sigma-Aldrich shRNA for C10orf114  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001010911
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001010911
                                 untagged cDNA clone in CMV expression vector: NM_001010911 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001010911

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf114

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (C10orf114)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001010911

              Sigma-Aldrich siRNA for C10orf114  
                     Sigma-Aldrich shRNA for C10orf114  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001010911  

REFSEQ mRNAs for C10orf114 gene: 

NM_001010911.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001010911  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001010911
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001010911
                                 untagged cDNA clone in CMV expression vector: NM_001010911 

Additional cDNA sequence: 

BC040880.1 BC130594.1 BC132974.1 CR596294.1 

3 DOTS entries:

DT.97838178  DT.100694692  DT.91935310 

24/30 AceView cDNA sequences (see all 30 ):

BU621529 AI597615 BM713771 BM678461 BX387127 CR596294 BQ007522 BM558275 
BM563843 BC040880 CB989480 BF982799 BX327844 BF034738 BQ184250 BM805029 
BQ188628 BM548798 BE783770 BX337043 BX327685 BX354661 BQ071016 BE874831 

highest scoring ESTs for C10orf114:

BC040880 BF982799 BM558275 BM805029 AI597615 BE879219 BF034738 BF983576 BM563843 BM678461 

Unigene Cluster for C10orf114:

Chromosome 10 open reading frame 114
Hs.315568  [show with all ESTs]
Unigene Representative Sequence: BC040880


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000377113  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C10orf114 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for C10orf114

1 / 2 / 3

2 probe-sets matching C10orf114 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

1555923_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1555922_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TAGGGTTCGG

SOURCE GeneReport for Unigene cluster: Hs.315568
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for C10orf114 gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
mouse
(Mus musculus)
A930004D18Rik5 2 RIKEN cDNA A930004D18 gene   -- AU022051 
About this table        Species with no ortholog for C10orf114

ENSEMBL Gene Tree for C10orf114
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/16 NCBI SNPs in C10orf114 are shown (see all 16 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 16)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs127702281,2
C,F,H21823640(+) CCCCTG/AGGGTG 1 -- ut31 ese34Minor allele frequency- A:0.10EU EA WA 420
rs110127241,2
F,H21824728(+) GAACCC/GGGTGG 1 R/P mis1 ese34Minor allele frequency- G:0.01EU EA WA 418
--
rs115993371,2
--21824527(+) TCGCCC/GGGAAT 1 -- ut31 ese30--------
--
rs346535181,2
--21827715(+) CTTTT-/TAAGTG 1 -- ng310--------
--
rs352171261,2
--21827373(+) TGAGG-/GATGAG 1 -- ng310--------
--
rs105477161,2
--21824509(+) GACTT-/ACTC  
        
AACCT
1 -- ut310--------
--
rs127717011,2
--21824848(+) CAGCTA/CCGGGG 1 G/V mis1 ese30--------
--
rs345855301,2
--21827740(+) ATTTT-/TCTCAT 1 -- ng310--------
--
rs561051371,2
--21826616(+) TCCCCC/TTTTAG 1 -- ng310--------
--
rs735925751,2
--21826189(+) CTGGTC/TCTCAA 1 -- ut510--------
About this table

HapMap Linkage Disequilibrium images for C10orf114 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

4 PubMed articles for C10orf114 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 399726 HGNC: 31448 AceView: C10orf114 Ensembl:ENSG00000204682 euGenes: HUgn399726
ECgene: C10orf114 H-InvDB: C10orf114
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for C10orf114:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for C10orf114-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
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 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for C10orf114 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for C10orf114 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for C10orf114

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