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C10orf112 Gene

protein-coding   GIFtS: 37

GC10P019564
chromosome 10 open reading frame 112
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for C10orf112

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
FLJ60310 2
bA265G8.2 1, 2
Descriptions
chromosome 10 open reading frame 112 2
novel MAM domain containing protein 2
External Ids
HGNC: 243311
Entrez Gene: 3408952
UniProtKB: Q5VYJ53
Ensembl: ENSG000002047407
Search outside databases for aliases for C10orf112 gene

Previous GC identifers: GC10P019397 GC10P019432

Summaries
for C10orf112

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for C10orf112

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf112 gene  

Entrez Gene cytogenetic band: 10p12.33   Ensembl cytogenetic band:  10p12.33   HGNC cytogenetic band: 10p12.33

C10orf112 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P019564:     (about GC identifiers)

Start:
 19,585,919 bp from pter
End:
 19,896,508 bp from pter
Size:
 310,590 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000010.9  NT_008705.15  

Proteins
for C10orf112

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: CJ112_HUMAN, Q5VYJ5 (See protein sequence)
Recommended Name: MAM and LDL-receptor class A domain-containing protein C10orf112 precursor  
Size: 1229 amino acids; 136444 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=CAH71834.1; Type=Erroneous gene model prediction;

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2




    • ENSEMBL proteins: 
    ENSP00000366476 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for C10orf112: 
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    Search Novus for antibodies for C10orf112

    Assays for C10orf112: 
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    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for C10orf112

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro domains/families:
     IPR002172 LDL_rcpt_classA_cys-rich
     IPR000998 MAM


       GeneDecks  C10orf112 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q5VYJ5

    ProtoNet protein and cluster: Q5VYJ5

    UniProtKB/Swiss-Prot: CJ112_HUMAN, Q5VYJ5
    Similarity: Contains 7 LDL-receptor class A domains
    Similarity: Contains 4 MAM domains

    Gene Function
    for C10orf112

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (C10orf112)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                    Browse Origene for 29mer shRNA kit in GFP-retroviral vector

                  Applied Biosystems Silencer® siRNAs for C10orf112

                  Sigma-Aldrich siRNA for C10orf112  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                    Browse Origene for untagged/tagged cDNA clones in CMV expression vector

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                    Browse Origene genome-wide validated SYBR primer pairs

    Pathways & Interactions
    for C10orf112

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    Drugs & Compounds
    for C10orf112

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for C10orf112

    Transcripts
    for C10orf112

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (C10orf112)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                    Browse Origene for 29mer shRNA kit in GFP-retroviral vector

                  Sigma-Aldrich siRNA for C10orf112  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    XM_295865  

                    Browse Origene for untagged/tagged cDNA clones in CMV expression vector

    Additional cDNA sequence: 

    AK297683.1 XM_295865.6 

    6 DOTS entries:

    DT.40119356  DT.406111  DT.121294367  DT.91763880  DT.121238926  DT.121294378 

    1 AceView cDNA sequence:

    BX483505 

    highest scoring ESTs for C10orf112:

    AA425507 BX097779 AA425379 AW340797 BG186270 BG192521 DA538731 DB087413 DV080615 DV080616 

    Unigene Cluster for C10orf112:

    Chromosome 10 open reading frame 112
    Hs.662505  [show with all ESTs]
    Unigene Representative Sequence: XM_295865


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000377265  

    Expression
    for C10orf112

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    C10orf112 expression in normal and diseased human tissues

    1 / 2 / 3

    3 probe-sets matching C10orf112 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		42166_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AA846789 0.60 0.83 0.73 1

    		242660_at2, 3 U133-B 1 1.00 1.00 -- -- AA846789 0.60 0.83 0.73 1

    		242660_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.662505

    Orthologs
    for C10orf112

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for C10orf112 gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    chimpanzee
    (Pan troglodytes)    		 LOC4660201   -- hypothetical LOC466020 98.56(n)
    98.32(a)    		 466020  XM_521422.2  XP_521422.2 
    cow
    (Bos taurus)    		 LOC5242401   -- similar to hCG2042429 86.57(n)
    83.74(a)    		 524240  XM_602561.3  XP_602561.3 
    rat
    (Rattus norvegicus)    		 RGD15636521   -- similar to novel MAM domain containing protein 81.08(n)
    78.55(a)    		 291332  XM_225591.4  XP_225591.4 
    chicken
    (Gallus gallus)    		 C10orf1121   -- chromosome 10 open reading frame 112 67.18(n)
    59.17(a)    		 420512  XM_418614.2  XP_418614.2 
    zebrafish
    (Danio rerio)    		 LOC5618491   -- similar to predicted protein 59.19(n)
    50.3(a)    		 561849  XM_685251.3  XP_690343.3 
    About this table        Species with no ortholog for C10orf112

    ENSEMBL Gene Tree for C10orf112

    Paralogs
    for C10orf112

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for C10orf112

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1867 NCBI SNPs in C10orf112 are shown (see all 1867 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 1262)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs71004031,2
    		A,C,F,H19660445(+) ACTGCG/ATTGCC 1 V/I mis111Minor allele frequency- A:0.45NA EU EA WA 970
    rs108273061,2
    		A,C,F,H19681041(+) CACTGC/TAGAAC 1 V/A mis116Minor allele frequency- N:0.00EA NA EU WA 1474
    rs71003821,2
    		A,C,F,H19660413(+) TACTGC/ATCATG 1 A/D mis111Minor allele frequency- A:0.36NA EU EA WA 974
    --
    rs107639751,2
    		A,C,F,H19718503(+) ATTTCA/GTATCT 1 V/I mis14Minor allele frequency- G:0.10EU EA WA 412
    rs110091551,2
    		A,C,F,H19585704(+) GGTAAT/CTTTCA 1 -- ng5115Minor allele frequency- C:0.46EU EA WA NA 1400
    rs16097461,2
    		A,C,F,H19676875(-) AAACTA/CTTTAT 1 K/N mis110Minor allele frequency- C:0.46EU EA WA 1014
    rs110091491,2
    		C,F,H19583991(+) AACGTG/AGTTAC 1 -- ng514Minor allele frequency- A:0.02EU EA WA 412
    rs122514791,2
    		C,F,H19584132(+) AAGGCA/GGGTCA 1 -- ng517Minor allele frequency- G:0.07EU EA WA NA 562
    rs127713331,2
    		C,F,H19716567(+) AAAATG/AAGTGT 1 K/E mis14Minor allele frequency- A:0.11EU EA WA 404
    rs110091501,2
    		C,F,H19584007(+) CCAGTC/GTGTCT 1 -- ng5111Minor allele frequency- G:0.13EU EA WA NA 942
    About this table

    HapMap Linkage Disequilibrium images for C10orf112 (up to first 250kb)

    Disorders & Mutations
    for C10orf112

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		   --

    Medical News
    for C10orf112

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for C10orf112

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		4 PubMed articles for C10orf112 gene:

    Search for C10orf112

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C10orf112

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 340895 HGNC: 24331 AceView: C10orf112.1 Ensembl:ENSG00000204740 euGenes: HUgn340895
    ECgene: C10orf112 H-InvDB: C10orf112

    Other Databases showing C10orf112

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing C10orf112

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for C10orf112

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for C10orf112

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for C10orf112:
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



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     Search Novus for antibodies for C10orf112

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