C10orf112 Gene
protein-coding GIFtS: 35
GCID: GC10P019432
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chromosome 10 open reading frame 112
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Aliases
for C10orf112 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 10 Open Reading Frame 1121 2 | | BA265G8.21 | | MAM And LDL-Receptor Class A Domain-Containing Protein C10orf1122 | | MAM And LDL-Receptor Class A Domain-Containing Protein C10orf112-Like2 | | Novel MAM Domain Containing Protein2 |
Export aliases for C10orf112 gene to outside databasesPrevious GC identifers: GC10P019397 GC10P019564 GC10P019154 |
Summaries
for C10orf112 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C10orf112 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C10orf112 gene promoter:
Oct-B1 FOXD1 Nkx2-5 C/EBPalpha Evi-1 AREB6 Nkx6-1 Cart-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C10orf112
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C10orf112 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p12.31 Ensembl cytogenetic band: 10p12.31 HGNC cytogenetic band: 10p12.31C10orf112 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P019432: view genomic region
(about GC identifiers)
Start:
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19,392,544 bp from pter |
End:
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20,079,330 bp from pter |
Size:
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686,787 bases |
Orientation:
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plus strand |
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Proteins
for C10orf112 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CJ112_HUMAN, Q5VYJ5 (See
protein sequence)Recommended Name: MAM and LDL-receptor class A domain-containing protein C10orf112 Size: 1473 amino acids; 163994 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=CAX12812.1; Type=Erroneous gene model prediction; Sequence=CAX14912.1; Type=Erroneous genemodel prediction; Sequence=CAX14966.1; Type=Erroneous gene model prediction; Sequence=CAX15055.1; Type=Erroneous genemodel prediction;
Secondary accessions: B7ZBP2Explore the universe of human proteins at neXtProt for C10orf112: NX_Q5VYJ5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VYJ5
C10orf112 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000366477 ENSP00000404330 ENSP00000366476 ENSP00000403218 ENSP00000412763 ENSP00000391253
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
C10orf112 for ontologies About GeneDecksing
C10orf112 Antibody Products:
Assay Products for C10orf112: |
Protein
Domains /
Families
for C10orf112 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C10orf112 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VYJ5ProtoNet protein and cluster: Q5VYJ5 UniProtKB/Swiss-Prot: CJ112_HUMAN, Q5VYJ5Similarity: Contains 8 LDL-receptor class A domainsSimilarity: Contains 6 MAM domains |
Function
for C10orf112 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf112 |
|
Pathways & Interactions
for C10orf112 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C10orf112
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for C10orf112 (ENSP000003664774) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for C10orf112 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C10orf112
Search CenterWatch for drugs/clinical trials and news about C10orf112 / CJ112 
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Transcripts
for C10orf112 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C10orf112 gene: NM_001142308.1 Unigene Cluster for C10orf112: Chromosome 10 open reading frame 112 Hs.646734 [show with all ESTs]Unigene Representative Sequence: AK2976838 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377266 ENST00000441070 ENST00000492202 ENST00000377265 ENST00000480707
ENST00000418367 ENST00000454679 ENST00000455457(uc010qcq.1 uc010qcr.1)
Additional cDNA sequence: AK297683.1 4 DOTS entries: DT.40119356 DT.406111 DT.121294367 DT.91763880 1 AceView cDNA sequence: BX483505
GeneLoc Exon Structure
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Expression
for C10orf112 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C10orf112 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See C10orf112 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C10orf112
SOURCE GeneReport for Unigene cluster: Hs.646734
SABiosciences Custom PCR Arrays for C10orf112
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C10orf112 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C10orf112 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C10orf112 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf112 |
Orthologs
for C10orf112 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for C10orf112 gene from 2/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
BX005319.36 |
-- |
39(a) |
1 ↔ 1 |
7(44364516-44414566) |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
12(a) |
possible ortholog |
GroupUn.320(38529-42048) |
Species with no ortholog for C10orf112
ENSEMBL Gene Tree for C10orf112 (if available)
TreeFam Gene Tree for C10orf112 (if available) |
Paralogs
for C10orf112 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C10orf112 gene
- MAMDC42 MDGA22 MDGA12 MAMDC22
2 SIMAP similar genes for C10orf112 using alignment to 6 protein entries: CJ112_HUMAN (see all proteins):NRP1 VLDLR
C10orf112 for paralogs About GeneDecksing
|
Genomic Variants
for C10orf112 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C10orf112 |
|
Disorders
/ Diseases
for C10orf112 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C10orf112 for disorders About GeneDecksing
1  disease for C10orf112: About MalaCardsblindness
Human Genome Epidemiology (HuGE) Navigator: C10orf112 (2 documents)
Export disorders for C10orf112 gene to outside databases
|
Publications
for C10orf112 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C10orf112 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C10orf112) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Predicted gene sequence C10orf112 is transcribed, exhibits tissue-specific expression, and may correspond to AD7. (PubMed id 19103277)1, 3 Zubenko G.S. and Hughes H.B. (2009)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- D10S1423 identifies a susceptibility locus for Alzhei mer's disease (AD7) in a prospective, longitudinal, double-blind study of asymp tomatic individuals: results at 14 years. (PubMed id 19591129)1 Zubenko G.S....Zubenko W.N. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)
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External Searches for C10orf112 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing C10orf112 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C10orf112 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C10orf112 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C10orf112 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for C10orf112 gene:
Search GeneIP for patents involving C10orf112
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C10orf112 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C10orf112 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C10orf112 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C10orf112 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C10orf112 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C10orf112 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C10orf112 |
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 | | | C10orf112 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf112 |
|  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C10orf112 |
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