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C10orf107 Gene

protein-coding   GIFtS: 35

GC10P063092
chromosome 10 open reading frame 107
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
Em:AC022398.2 1
MGC44593 1, 2
bA63A2.1 1, 2
Descriptions
chromosome 10 open reading frame 107 2
hypothetical protein LOC219621 2
External Ids
HGNC: 286781
Entrez Gene: 2196212
UniProtKB: Q8IVU93
Ensembl: ENSG000001833467
Search outside databases for aliases for C10orf107 gene

Previous GC identifer: GC10P062768

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf107 gene  

Entrez Gene cytogenetic band: 10q21.2   Ensembl cytogenetic band:  10q21.2   HGNC cytogenetic band: 10q21.3

C10orf107 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P063092:     (about GC identifiers)

Start:
63,092,725 bp from pter
End:
63,196,107 bp from pter
Size:
103,383 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000010.9  NT_008583.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ107_HUMAN, Q8IVU9 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf107  
Size: 208 amino acids; 23883 Da
Secondary accessions: Q5T1B8

REFSEQ proteins: NP_775825.1  

ENSEMBL proteins: 
ENSP00000328698 ENSP00000374290 ENSP00000378692 


Human Recombinant Proteins 
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for C10orf107: 
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for C10orf107

Assays for C10orf107: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8IVU9

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (C10orf107)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173554

              Applied Biosystems Silencer® siRNAs for C10orf107

              Sigma-Aldrich siRNA for C10orf107  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for C10orf107
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_173554
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_173554
                                 untagged cDNA clone in CMV expression vector: NM_173554 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_173554

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf107

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (C10orf107)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173554

              Sigma-Aldrich siRNA for C10orf107  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_173554  

REFSEQ mRNAs for C10orf107 gene: 

NM_173554.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_173554  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_173554
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_173554
                                 untagged cDNA clone in CMV expression vector: NM_173554 

Additional cDNA sequence: BC041932.1 

3 DOTS entries:

DT.95299408  DT.92417783  DT.100737276 

23 AceView cDNA sequences:

AW166758 BM975643 BF445773 BM979467 AW274577 BG216140 BM993294 NM_173554 
CB993053 BC041932 BM979310 BI603606 BI918915 BG719544 BI560158 CF453859 
BG211750 BG772138 BG719614 BG708671 BG212285 AA715315 BI602540 

highest scoring ESTs for C10orf107:

BC041932 BM993294 AW166758 AW274577 BF445773 BG211750 BG216140 BG708671 BG772138 BI602540 

Unigene Cluster for C10orf107:

Chromosome 10 open reading frame 107
Hs.673160  [show with all ESTs]
Unigene Representative Sequence: BC041932


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf107

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:        -                                       
SP2:              -                                 

About this scheme

ECgene alternative splicing isoforms for C10orf107

3 Ensembl transcripts including schematic representations:
ENST00000330194  ENST00000389639  ENST00000395277  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C10orf107 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for C10orf107

1Data from GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.673160
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for C10orf107 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LOC4890011   -- hypothetical LOC489001 89.56(n)
84.62(a)
489001  XM_546119.2  XP_546119.2 
chimpanzee
(Pan troglodytes)
LOC7456871   -- similar to Chromosome 10 open reading frame 107 98.72(n)
98.08(a)
745687  XM_001165444.1  XP_001165444.1 
rat
(Rattus norvegicus)
RGD13067391   -- similar to RIKEN cDNA 1700040L02 78.69(n)
75(a)
361834  XM_342127.3  XP_342128.3 
mouse
(Mus musculus)
1700040L02Rik1, 5 105
RIKEN cDNA 1700040L02 gene1, 5 77.72(n)1
74.52(a)1
732871  NM_028491.11  NP_082767.11 
 AK0066615  AK0296225  (see all 6)
chicken
(Gallus gallus)
C10orf1071   -- chromosome 10 open reading frame 107 60.89(n)
44.13(a)
423662  XM_421543.1  XP_421543.2 
About this table        Species with no ortholog for C10orf107

ENSEMBL Gene Tree for C10orf107
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/638 NCBI SNPs in C10orf107 are shown (see all 638 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 261)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs70956431,2
A,C,F,H63090944(+) CCTACA/GAAACA 1 -- ng514Minor allele frequency- G:0.29EU EA WA 418
rs124147291,2
C,F,H63091248(+) AGTGGC/AGATCA 1 -- ng514Minor allele frequency- A:0.11EU EA WA 414
rs19926251,2
A,C,F,H,O63190704(+) GGTTTC/TACCAT 1 F/F syn117Minor allele frequency- T:0.13EA EU WA NA 2950
rs123592461,2
H63111033(+) TATTCA/GAAATT 1 S/S syn14Minor allele frequency- G:0.00EU EA WA 416
rs23938301,2
A,C,F,H,O63134935(+) CCTTAT/CCTGGT 1 -- int111Minor allele frequency- C:0.22EU EA WA NA 978
rs21661221,2
A,C,F,H,O63193080(+) ATAAGC/TTTTTT 1 -- int17Minor allele frequency- T:0.21EU EA WA NA 560
rs26756121,2
A,C,F,H,O63193272(+) TGAGTC/TGTGTA 1 -- int17Minor allele frequency- T:0.40NA EU EA WA 560
rs21207021,2
A,C,F,H,O63192664(+) ATTCCT/AAGTTG 1 -- int17Minor allele frequency- A:0.40EU EA WA NA 558
rs23938331,2
A,C,F,H,O63115322(-) CCTGCG/ACCAAC 1 -- int17Minor allele frequency- A:0.22EU EA WA NA 558
rs20536411,2
A,C,F,H,O63193501(+) CATGAG/AATCAT 1 -- int17Minor allele frequency- A:0.09EU EA WA NA 562
About this table

HapMap Linkage Disequilibrium images for C10orf107 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

Human Genome Epidemiology Navigator: C10orf107 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

4 PubMed articles for C10orf107 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 219621 HGNC: 28678 AceView: C10orf107 Ensembl:ENSG00000183346 euGenes: HUgn219621
ECgene: C10orf107 H-InvDB: C10orf107
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for C10orf107:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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