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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C10orf107 Gene

protein-coding   GIFtS: 41
GCID: GC10P063422

Chromosome 10 Open Reading Frame 107

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 10 Open Reading Frame 1071 2
bA63A2.12
Uncharacterized Protein C10orf1072

External Ids:    HGNC: 286781   Entrez Gene: 2196212   Ensembl: ENSG000001833467   UniProtKB: Q8IVU93   

Export aliases for C10orf107 gene to outside databases

Previous GC identifers: GC10P062768 GC10P063092 GC10P057411


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C10orf107 Gene: 
C10orf107 (chromosome 10 open reading frame 107) is a protein-coding gene. Diseases associated with C10orf107 include hypertension, and alzheimer's disease.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C10orf107 gene promoter:
         Nkx3-1 v4   POU2F1   POU2F1b   POU2F1a   POU2F1c   HNF-3beta   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C10orf107

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C10orf107


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.2   Ensembl cytogenetic band:  10q21.2   HGNC cytogenetic band: 10q21.3

C10orf107 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C10orf107 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P063422:  view genomic region     (about GC identifiers)

Start:
63,422,719 bp from pter      End:
63,526,524 bp from pter
Size:
103,806 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CJ107_HUMAN, Q8IVU9 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf107  
Size: 208 amino acids; 23883 Da
Secondary accessions: Q5T1B8

Explore the universe of human proteins at neXtProt for C10orf107: NX_Q8IVU9

Explore proteomics data for C10orf107 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IVU9

  • C10orf107 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C10orf107 Protein Expression
    REFSEQ proteins: NP_775825.1  
    ENSEMBL proteins: 
     ENSP00000328698   ENSP00000374290  

    Human Recombinant Protein Products for C10orf107: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8IVU9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for C10orf107:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for C10orf107 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C10orf107

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for C10orf107 (ENSP000003286984) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WDR63ENSP000002946644STRING: ENSP00000294664
    ALG6ENSP000003601494STRING: ENSP00000360149
    C1orf141ENSP000003600454STRING: ENSP00000360045
    DKK1ENSP000003630814STRING: ENSP00000363081
    ENSG00000137345ENSP000002598914STRING: ENSP00000259891
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C10orf107 (CJ107)

    Search CenterWatch for drugs/clinical trials and news about C10orf107 / CJ107

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C10orf107 gene: 
    NM_173554.2  

    Unigene Cluster for C10orf107:

    Chromosome 10 open reading frame 107
    Hs.673160  [show with all ESTs]
    Unigene Representative Sequence: BC041932
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330194(uc010qik.2) ENST00000389639

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    hsa-miR-548p hsa-miR-576-5p hsa-miR-3611 hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidC10orf107 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of C10orf107 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C10orf107
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    Additional mRNA sequence: BC041932.1 

    3 DOTS entries:

    DT.95299408  DT.92417783  DT.100737276 

    23 AceView cDNA sequences:

    AW166758 NM_173554 BM975643 CB993053 BM979310 BG216140 BM979467 BM993294 
    BF445773 AW274577 BC041932 BI918915 CF453859 BG719544 BI560158 BI603606 
    BG211750 BG719614 BG708671 BG772138 BG212285 AA715315 BI602540 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf107    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:        -                                       
    SP2:              -                                 


    ECgene alternative splicing isoforms for C10orf107

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C10orf107 expression in normal human tissues (normalized intensities)      C10orf107 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    C10orf107 Expression
    About this image


    C10orf107 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Epithelium (Respiratory System)    fully expand to see all 2 entries
             bronchial epithelial cells   
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Liver Bud
     
     Heart (Cardiovascular System)

    See C10orf107 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C10orf107

    SOURCE GeneReport for Unigene cluster: Hs.673160
        SABiosciences Custom PCR Arrays for C10orf107
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf107

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C10orf107 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1700040L02Rik1 , 5 RIKEN cDNA 1700040L02 gene1, 5 77.56(n)1
    74.52(a)1
      10 (35.40 cM)5
    732871  NM_028491.11  NP_082767.11 
     684309535 
    chicken
    (Gallus gallus)
    Aves C6H10orf1071 chromosome 6 open reading frame, human C10orf107 61.05(n)
    44.21(a)
      423662  XM_421543.2  XP_421543.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    52(a)
    34(a)
    many → 1
    many → 1
    GL343204.1(3497445-3506904)
    GL343204.1(3554375-3563123)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1376959882   -- 74.92(n)    137695988 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1945081 zgc:194508 49.92(n)
    35.82(a)
      100004673  NM_001177463.1  NP_001170934.1 


    ENSEMBL Gene Tree for C10orf107 (if available)
    TreeFam Gene Tree for C10orf107 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2069 SNPs in C10orf107 are shown (see all 2069)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1465459101,2
    C--63420746(+) ACCTAC/TAAAAG 1 -- us2k10--------
    rs70956431,2
    C,F,A,H--63420938(+) CCTACA/GAAACA 1 -- us2k121Minor allele frequency- G:0.33NS EA NA WA CSA 2346
    rs1834138921,2
    --63420964(+) AGATAA/GCCATC 1 -- us2k10--------
    rs1409600171,2
    --63421074(+) GAAATA/GGCAGC 1 -- us2k10--------
    rs1884691861,2
    --63421089(+) TTAAAC/TGCCTG 1 -- us2k10--------
    rs1917292111,2
    --63421137(+) CGTTAC/GAGAAA 1 -- us2k10--------
    rs1502092011,2
    --63421202(+) TACCTC/TGAAGA 1 -- us2k10--------
    rs124147291,2
    C,F,H--63421242(+) AGTGGC/AGATCA 1 -- us2k120Minor allele frequency- A:0.11NS EA NA WA CSA 2344
    rs1838645431,2
    --63421243(+) GTGGCG/TATCAG 1 -- us2k10--------
    rs1867396971,2
    C--63421292(+) GTGGCC/TTTTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C10orf107 (63422719 - 63526524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for C10orf107:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2737507CNV Deletion23290073
    esv1510214CNV Insertion17803354
    dgv42n21CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for C10orf107:    About MalaCards
    hypertension    alzheimer's disease


    C10orf107 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): C10orf107
    Human Genome Epidemiology (HuGE) Navigator: C10orf107 (6 documents)

    Export disorders for C10orf107 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C10orf107 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with C10orf107)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (2011)
    2. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    6. Genetic association with overall survival of taxane-tr eated lung cancer patients - a genome-wide association study in human lymphoblas toid cell lines followed by a clinical association study. (PubMed id 23006423)1 Niu N....Wang L. (2012)
    7. Discovery and replication of novel blood pressure gen etic loci in the Women's Genome Health Study. (PubMed id 21045733)1 Ho J.E....Chasman D.I. (2011)
    8. Common variants in or near FGF5, CYP17A1 and MTHFR ge nes are associated with blood pressure and hypertension in Chinese Hans. (PubMed id 20852445)1 Liu C....Lin X. (2011)
    9. Confirmation of top polymorphisms in hypertension gen ome wide association study among Han Chinese. (PubMed id 20542020)1 Niu W....Zhu D. (2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219621 HGNC: 28678 AceView: C10orf107 Ensembl:ENSG00000183346 euGenes: HUgn219621
    ECgene: C10orf107 H-InvDB: C10orf107

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C10orf107 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C10orf107 gene:
    Search GeneIP for patents involving C10orf107

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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