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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C10orf107 Gene

protein-coding   GIFtS: 40
GCID: GC10P063422

chromosome 10 open reading frame 107
 Explore 2 diseases affiliated with
C10orf107 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C10orf107    

Aliases
for C10orf107 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 10 Open Reading Frame 1071 2
BA63A2.11
Em:AC022398.21
MGC445931
Uncharacterized Protein C10orf1072

External Ids:    HGNC: 286781   Entrez Gene: 2196212   Ensembl: ENSG000001833467   UniProtKB: Q8IVU93   

Export aliases for C10orf107 gene to outside databases

Previous GC identifers: GC10P062768 GC10P063092 GC10P057411


Summaries
for C10orf107 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C10orf107 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C10orf107 gene promoter:
         Nkx3-1 v4   POU2F1   POU2F1b   POU2F1a   POU2F1c   HNF-3beta   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C10orf107

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C10orf107


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.2   Ensembl cytogenetic band:  10q21.2   HGNC cytogenetic band: 10q21.3

C10orf107 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C10orf107 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P063422:  view genomic region     (about GC identifiers)

Start:
 63,422,719 bp from pter      End:
 63,526,524 bp from pter
Size:
 103,806 bases      Orientation:
 plus strand

Proteins
for C10orf107 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CJ107_HUMAN, Q8IVU9 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf107  
Size: 208 amino acids; 23883 Da
Secondary accessions: Q5T1B8

Explore the universe of human proteins at neXtProt for C10orf107: NX_Q8IVU9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IVU9

    • C10orf107 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_775825.1  
    ENSEMBL proteins: 
     ENSP00000328698   ENSP00000374290  

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    Uscn Proteins for C10orf107


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    Protein Domains /
    Families
    for C10orf107 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8IVU9


    Function
    for C10orf107 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Inhib. RNA
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    1 GenomeRNAi human phenotype for C10orf107:
     Decreased viability of wild-ty 


    Pathways & Interactions
    for C10orf107 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C10orf107

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for C10orf107 (ENSP000003286984) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WDR63ENSP000002946644STRING: ENSP00000294664
    ALG6ENSP000003601494STRING: ENSP00000360149
    C1orf141ENSP000003600454STRING: ENSP00000360045
    DKK1ENSP000003630814STRING: ENSP00000363081
    PRUNEENSP000002716204STRING: ENSP00000271620
    About this table

    Drugs & Compounds
    for C10orf107 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C10orf107
    Search CenterWatch for drugs/clinical trials and news about C10orf107 / CJ107 

    Transcripts
    for C10orf107 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
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    About This Section
    REFSEQ mRNAs for C10orf107 gene: 
    NM_173554.2  

    Unigene Cluster for C10orf107:

    Chromosome 10 open reading frame 107
    Hs.673160  [show with all ESTs]
    Unigene Representative Sequence: BC041932
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330194(uc010qik.2) ENST00000389639

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    hsa-miR-548p hsa-miR-576-5p hsa-miR-3611 hsa-miR-548n
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: BC041932.1 

    3 DOTS entries:

    DT.95299408  DT.92417783  DT.100737276 

    23 AceView cDNA sequences:

    AW166758 BM979467 NM_173554 BM979310 BM993294 BM975643 CB993053 AW274577 
    BF445773 BC041932 BG216140 BI603606 BG719544 BI560158 CF453859 BG211750 
    BI918915 BG719614 BG772138 BG708671 BG212285 AA715315 BI602540 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf107    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:        -                                       
    SP2:              -                                 


    ECgene alternative splicing isoforms for C10orf107

    Expression
    for C10orf107 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C10orf107 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    C10orf107 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeInterscapular Brown Adipose DepotAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See C10orf107 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C10orf107

    SOURCE GeneReport for Unigene cluster: Hs.673160
        SABiosciences Custom PCR Arrays for C10orf107
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf107

    Orthologs
    for C10orf107 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for C10orf107 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia 1700040L02Rik1 , 5 RIKEN cDNA 1700040L02 gene1, 5 77.56(n)1
    74.52(a)1    		   10 (35.40 cM)5
    732871  NM_028491.11  NP_082767.11 
     684309535 
    chicken
    (Gallus gallus)    		 Aves C6H10orf1071 chromosome 6 open reading frame, human C10orf107 61.05(n)
    44.21(a)    		   423662  XM_421543.2  XP_421543.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 51(a)
    34(a)
    		 many → 1
    many → 1
    		 GL343204.1(3497445-3506904)
    GL343204.1(3554375-3563123)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia 1376959882   -- 74.92(n)    137695988 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1945081 zgc:194508 49.92(n)
    35.82(a)    		   100004673  NM_001177463.1  NP_001170934.1 


    ENSEMBL Gene Tree for C10orf107 (if available)
    TreeFam Gene Tree for C10orf107 (if available) 

    Paralogs
    for C10orf107 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C10orf107 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1769 NCBI SNPs in C10orf107 are shown (see all 1769)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1465459101,2
    		--63420746(+) ACCTAC/TAAAAG 1 -- us2k10--------
    rs70956431,2
    		C,F,A,H,--63420938(+) CCTACA/GAAACA 1 -- us2k121Minor allele frequency- G:0.33NS EA NA WA CSA 2346
    rs1834138921,2
    		--63420964(+) AGATAA/GCCATC 1 -- us2k10--------
    rs1409600171,2
    		--63421074(+) GAAATA/GGCAGC 1 -- us2k10--------
    rs1884691861,2
    		--63421089(+) TTAAAC/TGCCTG 1 -- us2k10--------
    rs1917292111,2
    		--63421137(+) CGTTAC/GAGAAA 1 -- us2k10--------
    rs1502092011,2
    		--63421202(+) TACCTC/TGAAGA 1 -- us2k10--------
    rs124147291,2
    		C,F,H,--63421242(+) AGTGGC/AGATCA 1 -- us2k120Minor allele frequency- A:0.11NS EA NA WA CSA 2344
    rs1838645431,2
    		--63421243(+) GTGGCG/TATCAG 1 -- us2k10--------
    rs1867396971,2
    		--63421292(+) GTGGCC/TTTTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C10orf107 (63422719 - 63526524 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for C10orf107: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for C10orf107 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    C10orf107 for disorders           About GeneDecksing

    2 diseases for C10orf107:    About MalaCards
    alzheimer's disease    hypertension

    Human Genome Epidemiology (HuGE) Navigator: C10orf107 (6 documents)

    Export disorders for C10orf107 gene to outside databases

    Publications
    for C10orf107 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C10orf107 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with C10orf107)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1 Wain L.V....van Duijn C.M. (2011)
    4. Discovery and replication of novel blood pressure gen etic loci in the Women's Genome Health Study. (PubMed id 21045733)1 Ho J.E....Chasman D.I. (2011)
    5. Common variants in or near FGF5, CYP17A1 and MTHFR ge nes are associated with blood pressure and hypertension in Chinese Hans. (PubMed id 20852445)1 Liu C....Lin X. (2011)
    6. Confirmation of top polymorphisms in hypertension gen ome wide association study among Han Chinese. (PubMed id 20542020)1 Niu W....Zhu D. (2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1 Newton-Cheh C....Munroe P.B. (2009)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)

    External Searches for C10orf107 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C10orf107 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219621 HGNC: 28678 AceView: C10orf107 Ensembl:ENSG00000183346 euGenes: HUgn219621
    ECgene: C10orf107 H-InvDB: C10orf107

    Other Databases showing C10orf107 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C10orf107 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C10orf107 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C10orf107 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C10orf107 gene:
    Search GeneIP for patents involving C10orf107

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for C10orf107 gene

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    Advanced Cell Diagnostics
    About This Section

     
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