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Aliases for C10orf105 Gene

Aliases for C10orf105 Gene

  • Chromosome 10 Open Reading Frame 105 2 3 5

External Ids for C10orf105 Gene

Previous GeneCards Identifiers for C10orf105 Gene

  • GC10U900452
  • GC10M073142
  • GC10M073472
  • GC10M067465

Summaries for C10orf105 Gene

GeneCards Summary for C10orf105 Gene

C10orf105 (Chromosome 10 Open Reading Frame 105) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf105 Gene

Genomics for C10orf105 Gene

Regulatory Elements for C10orf105 Gene

Enhancers for C10orf105 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F071762 0.9 FANTOM5 ENCODE 19.2 -32.2 -32167 14.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 ZNF2 ZNF207 ZNF143 FOS VSIR CDH23 C10orf105 PSAP SPOCK2
GH10F071887 1.7 FANTOM5 Ensembl ENCODE 13.1 -152.1 -152148 5.5 HDGF PKNOX1 CREB3L1 ARNT SIN3A ZNF2 FOS ZNF263 SP3 REST PSAP C10orf105 VSIR DNAJB12 DDIT4 ENSG00000230526 GC10M071945
GH10F072232 0.9 ENCODE 13 -495.0 -495007 0.9 HDGF ATF1 PKNOX1 MCM5 NCOA1 REST TBX21 SMARCA4 HMBOX1 NBN C10orf105 DNAJB12 RPL15P14 NUDT13 ENSG00000200170 GC10M072248
GH10F072241 1.4 VISTA FANTOM5 Ensembl ENCODE 13 -516.0 -515977 25.2 MLX CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 ECD ANAPC16 DNAJC9 ENSG00000272599 ASCC1 DNAJB12 DDIT4 C10orf105 ENSG00000200170 RPL17P50
GH10F072133 0.8 Ensembl ENCODE 13 -396.9 -396880 2.6 TBP PKNOX1 ATF1 TBL1XR1 BMI1 FEZF1 CBX5 ETV6 FOS CREM C10orf105 ANAPC16 ASCC1 ENSG00000200170 ENSG00000200294 RPL15P14 GC10P072223 SPOCK2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C10orf105 on UCSC Golden Path with GeneCards custom track

Genomic Location for C10orf105 Gene

Chromosome:
10
Start:
71,711,701 bp from pter
End:
71,737,824 bp from pter
Size:
26,124 bases
Orientation:
Minus strand

Genomic View for C10orf105 Gene

Genes around C10orf105 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf105 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf105 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf105 Gene

Proteins for C10orf105 Gene

  • Protein details for C10orf105 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEF2-CJ105_HUMAN
    Recommended name:
    Uncharacterized protein C10orf105
    Protein Accession:
    Q8TEF2

    Protein attributes for C10orf105 Gene

    Size:
    133 amino acids
    Molecular mass:
    14519 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C10orf105 Gene

Post-translational modifications for C10orf105 Gene

No Post-translational modifications

Other Protein References for C10orf105 Gene

No data available for DME Specific Peptides for C10orf105 Gene

Domains & Families for C10orf105 Gene

Protein Domains for C10orf105 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C10orf105: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C10orf105 Gene

Function for C10orf105 Gene

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C10orf105 Gene

Localization for C10orf105 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf105 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C10orf105 Gene COMPARTMENTS Subcellular localization image for C10orf105 gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for C10orf105 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C10orf105: view

Pathways & Interactions for C10orf105 Gene

SuperPathways for C10orf105 Gene

No Data Available

Interacting Proteins for C10orf105 Gene

Gene Ontology (GO) - Biological Process for C10orf105 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf105 Gene

Transcripts for C10orf105 Gene

mRNA/cDNA for C10orf105 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C10orf105 Gene

Chromosome 10 open reading frame 105:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf105 Gene

No ASD Table

Relevant External Links for C10orf105 Gene

GeneLoc Exon Structure for
C10orf105
ECgene alternative splicing isoforms for
C10orf105

Expression for C10orf105 Gene

mRNA expression in normal human tissues for C10orf105 Gene

mRNA differential expression in normal tissues according to GTEx for C10orf105 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x7.7), Brain - Hypothalamus (x7.2), Brain - Nucleus accumbens (basal ganglia) (x6.3), Brain - Hippocampus (x5.8), Brain - Amygdala (x5.7), Whole Blood (x4.5), and Brain - Substantia nigra (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of C10orf105 Gene:

C10orf105

SOURCE GeneReport for Unigene cluster for C10orf105 Gene:

Hs.568788
genes like me logo Genes that share expression patterns with C10orf105: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C10orf105 Gene

Orthologs for C10orf105 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C10orf105 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf105 34
  • 99.75 (n)
C10orf105 35
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C28H10orf105 34
  • 86.45 (n)
C10orf105 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4H10orf105 34
  • 82.79 (n)
C10orf105 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm17455 34 16 35
  • 74.48 (n)
rat
(Rattus norvegicus)
Mammalia LOC100361018 34
  • 73.96 (n)
lizard
(Anolis carolinensis)
Reptilia C10orf105 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492846 34
  • 62.11 (n)
Species where no ortholog for C10orf105 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C10orf105 Gene

ENSEMBL:
Gene Tree for C10orf105 (if available)
TreeFam:
Gene Tree for C10orf105 (if available)

Paralogs for C10orf105 Gene

No data available for Paralogs for C10orf105 Gene

Variants for C10orf105 Gene

Sequence variations from dbSNP and Humsavar for C10orf105 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs121908347 Pathogenic 71,739,772(+) CTCCA(C/G)GTGGG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs121908350 Pathogenic 71,732,151(+) TCAAC(C/T)AGGGC intron-variant, nc-transcript-variant, reference, stop-gained
rs121908351 Pathogenic 71,732,292(+) CCATC(A/G)ACAAC intron-variant, nc-transcript-variant, reference, missense
rs397517323 Pathogenic 71,725,422(+) TGATG(C/T)GAGGG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, stop-gained
rs397517326 Pathogenic 71,730,517(+) TCACA(C/T)AGCAG intron-variant, nc-transcript-variant, reference, synonymous-codon, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for C10orf105 Gene

Variant ID Type Subtype PubMed ID
nsv470963 CNV loss 18288195
nsv831910 CNV loss 17160897

Variation tolerance for C10orf105 Gene

Gene Damage Index Score: 2.07; 37.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C10orf105 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf105

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf105 Gene

Disorders for C10orf105 Gene

Relevant External Links for C10orf105

Genetic Association Database (GAD)
C10orf105
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C10orf105

No disorders were found for C10orf105 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf105 Gene

Publications for C10orf105 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C10orf105 Gene

Sources for C10orf105 Gene

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