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C10orf104 Gene

protein-coding GIFtS: 38

GC10P073645

chromosome 10 open reading frame 104
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ33728 ^¹, ²
OTTHUMP00000060576 ^²
bA570G20.3 ^¹, ²

Descriptions
chromosome 10 open reading frame 104 ^²
hypothetical protein LOC119504 ^²

External Ids
HGNC: 26976¹
Entrez Gene: 119504²
UniProtKB: Q96DE5³
Ensembl: ENSG00000166295⁷

Search outside databases for aliases for C10orf104 gene

Previous GC identifer: GC10P073321

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the C10orf104 gene

Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.2

C10orf104 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P073645: (about GC identifiers)

Start:	73,645,812 bp from pter
End:	73,665,624 bp from pter
Size:	19,813 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_008583.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ104_HUMAN, Q96DE5 (See protein sequence)

Recommended Name: UPF0448 protein C10orf104

Size: 110 amino acids; 11667 Da

REFSEQ proteins: NP_775744.1

ENSEMBL proteins:

ENSP00000299381

Human Recombinant Proteins

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OriGene Purified Recombinant Human Protein: C10orf104

Antibodies for C10orf104:

	Browse Antibodies Central at Invitrogen
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	Search Novus for antibodies for C10orf104

Assays for C10orf104:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
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	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q96DE5

UniProtKB/Swiss-Prot: CJ104_HUMAN, Q96DE5

Similarity: Belongs to the UPF0448 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf104)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173473

Applied Biosystems Silencer® siRNAs for C10orf104

Sigma-Aldrich siRNA for C10orf104

Sigma-Aldrich shRNA for C10orf104

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_173473
Myc/DDK tagged cDNA clone in CMV expression vector: NM_173473
untagged cDNA clones in CMV expression vector (see all 2): NM_173473

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_173473

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf104

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf104)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173473

Sigma-Aldrich siRNA for C10orf104

Sigma-Aldrich shRNA for C10orf104

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_173473

REFSEQ mRNAs for C10orf104 gene:

NM_173473.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_173473

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_173473
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_173473
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_173473

Additional cDNA sequence:

AF085974.1 AK023981.1 AK091047.1 BC009530.1 CR598398.1 CR607060.1 CR615306.1 CR618642.1

CR625345.1

24/29 DOTS entries (see all 29 ):

DT.100038624 DT.456242 DT.86838897 DT.100038625 DT.121298978 DT.92327556 DT.100773647 DT.100822176

DT.100822163 DT.121299050 DT.91642226 DT.95156635 DT.100822175 DT.92416030 DT.100822181 DT.429295

DT.100822174 DT.121298975 DT.121298980 DT.208458 DT.92449643 DT.92449645 DT.92449652 DT.75114396

24/510 AceView cDNA sequences (see all 510 ):

BQ438143 BU617881 AA232284 AA699453 AA909205 BF222154 AI092491 BE221228

N40166 AA699966 BU618154 BM699267 AW070969 CA844207 CA943019 CA418323

AI313465 CB135073 F19260 BM998029 CD724246 AA937208 AW151876 CD513155

highest scoring ESTs for C10orf104:

AI041673 AI310514 N51587 AA034078 AA039371 AA039446 AA040035 AA040829 AA092097 AA115585

Unigene Cluster for C10orf104:

Chromosome 10 open reading frame 104

Hs.426296 [show with all ESTs]

Unigene Representative Sequence: NM_173473

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf104 (see all 11 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	·	5d	·	5e	·	5f	·	5g	·	5h
SP1:													-		-		-		-				-		-
SP2:											-		-		-		-		-				-		-
SP3:															-		-		-				-		-
SP4:																			-				-		-
SP5:											-		-		-		-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for C10orf104

1 Ensembl transcript including schematic representation:

ENST00000299381

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C10orf104 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for C10orf104

¹ / ² / ³

13 probe-sets matching C10orf104 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
48988_at²^{, 3}	U95-C	1	1.00	1.00	0.99	0.91	AI310514	1.00	1.00	1.00	1
50851_at²^{, 3}	U95-B	1	1.00	1.00	0.95	0.78	AA541762	0.80	1.00	0.91	1
59706_s_at²^{, 3}	U95-C	1	1.00	1.00	0.98	1.14	AI041673	1.00	1.00	1.00	1
45238_at²^{, 3}	U95-B	1	0.94	1.00	0.95	1.01	AA034078	0.80	1.00	0.91	1
64149_at²^{, 3}	U95-C	1	0.88	1.00	0.98	1.16	N51587	1.00	1.00	1.00	1
229145_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA541762	0.80	1.00	0.91	1
224665_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE874771	0.80	0.88	0.84	1
224664_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE962336	0.40	1.00	0.76	1
224667_x_at²^{, 3}	U133-B	31	1.00	0.71	--	--	AK023981	0.80	1.00	0.91	1
229145_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224665_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224664_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224667_x_at²	U133Plus2	31	1.00	0.71	--	--	--	--	--	--	--

GeneDecks C10orf104 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: CCAAATGCTG

SOURCE GeneReport for Unigene cluster: Hs.426296

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for C10orf104 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC608342¹	--	hypothetical protein LOC608342	96.06(n) 100(a)	608342 XM_845475.1 XP_850568.1
chimpanzee (Pan troglodytes)	LOC736866¹	--	hypothetical protein LOC736866	76.09(n) 72.73(a)	736866 XM_001136981.1 XP_001136981.1
cow (Bos taurus)	C28H10orf104¹	--	chromosome 10 open reading frame 104 ortholog	94.24(n) 99.09(a)	540089 NM_001014960.1 NP_001014960.1
mouse (Mus musculus)	D10Ertd641e^{1, 5}	10 (30.00 cM)⁵	DNA segment, Chr 10, ERATO Doi 641, expressed^{1, 5}	90(n)¹ 100(a)¹	52717¹ NM_025514.2¹ NP_079790.1¹ AI840598⁵ AK009172⁵ (see all 13)
chicken (Gallus gallus)	C10orf104¹	--	chromosome 10 open reading frame 104	82.12(n) 99.09(a)	423708 XM_421587.2 XP_421587.2

About this table Species with no ortholog for C10orf104

ENSEMBL Gene Tree for C10orf104

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/109 NCBI SNPs in C10orf104 are shown (see all 109 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 32)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11000229^1,2	F,H	73663524(+)	`CAGAAA/GTCCTG`	1	--	ut3¹ ese³		4		EU EA WA	414
--	rs6480601^1,2	A,C	73664771(+)	`ttagcC/Tcagtg`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs4293052^1,2	F,H	73664074(+)	`gccAAT/Attttt`	1	--	ut3¹		3		EU EA	280
	rs1136518^1,2	A	73663066(+)	`GGAATA/GTTTTG`	1	--	ut3¹		0	--	--	--	--
--	rs11553570^1,2	H	73653704(-)	`CAGCTG/AAGGAG`	1	L/S	mis¹ ese³		4		EU EA WA	392
--	rs12572740^1,2	C	73664906(+)	`cgagaC/Ttctgt`	1	--	ut3¹ ese³		0	--	--	--	--
	rs9275^1,2	C,F,H	73662868(-)	`GAAGAC/G/TGGGGT`	2	P/P	syn¹ trp³		8		MN EU EA WA NA	740
	rs4554797^1,2	A,C,F,H	73658270(+)	`TTACTG/AAACTT`	1	--	int¹		4		EU EA WA	412
	rs10823909^1,2	A,C,F,H	73659190(+)	`TGTAAT/CACCTG`	1	--	int¹		8		EU EA WA	840
	rs7918833^1,2	A,C,F,H	73657898(+)	`ATCTCA/GAAAGG`	1	--	int¹		4		EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for C10orf104 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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5 PubMed articles for C10orf104 gene:

The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{2, 3} Ota T....Sugano S. (2004)
RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1. (PubMed id 18851979)³ Chibi M....Pugh D.J. (2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 119504	HGNC: 26976	AceView: C10orf104	Ensembl:ENSG00000166295	euGenes: HUgn119504
ECgene: C10orf104	H-InvDB: C10orf104

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for C10orf104
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for C10orf104:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for C10orf104-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Millipore Target Screening & Profiling Services

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C10orf104 Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for C10orf104

Summaries
for C10orf104

Genomic Location
for C10orf104

Proteins
for C10orf104

Protein Domains/
Families
for C10orf104

Gene Function
for C10orf104

Pathways & Interactions
for C10orf104

Drugs & Compounds
for C10orf104

Transcripts
for C10orf104

Expression
for C10orf104

Orthologs
for C10orf104

Paralogs
for C10orf104

SNPs/Variants
for C10orf104

Disorders & Mutations
for C10orf104

Medical News
for C10orf104

Publications
for C10orf104

Search for C10orf104

Genome Databases showing C10orf104

Other Databases showing C10orf104

Specialized Databases showing C10orf104

Licensable Technologies
for C10orf104

Services
for C10orf104

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

C10orf104 Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor C10orf104

Summariesfor C10orf104

Genomic Locationfor C10orf104

Proteinsfor C10orf104

Protein Domains/Familiesfor C10orf104

Gene Functionfor C10orf104

Pathways & Interactionsfor C10orf104

Drugs & Compoundsfor C10orf104

Transcriptsfor C10orf104

Expression for C10orf104

Orthologsfor C10orf104

Paralogsfor C10orf104

SNPs/Variantsfor C10orf104

Disorders & Mutationsfor C10orf104

Medical Newsfor C10orf104

Publicationsfor C10orf104

Search for C10orf104

Genome Databases showing C10orf104

Other Databases showing C10orf104

Specialized Databases showing C10orf104

Licensable Technologiesfor C10orf104

Servicesfor C10orf104

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for C10orf104

Summaries
for C10orf104

Genomic Location
for C10orf104

Proteins
for C10orf104

Protein Domains/
Families
for C10orf104

Gene Function
for C10orf104

Pathways & Interactions
for C10orf104

Drugs & Compounds
for C10orf104

Transcripts
for C10orf104

Expression
for C10orf104

Orthologs
for C10orf104

Paralogs
for C10orf104

SNPs/Variants
for C10orf104

Disorders & Mutations
for C10orf104

Medical News
for C10orf104

Publications
for C10orf104

Licensable Technologies
for C10orf104

Services
for C10orf104