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Aliases for C10orf10 Gene

Aliases for C10orf10 Gene

  • Chromosome 10 Open Reading Frame 10 2 3
  • Decidual Protein Induced By Progesterone 2 3 4
  • Fasting-Induced Gene Protein 3 4
  • Fasting Induced 2 3
  • DEPP 3 4
  • FIG 3 4
  • Fat-Specific Expressed Gene 2
  • Fasting-Induced Protein 3
  • Fat-Specific Expressed 3
  • Fseg 3

External Ids for C10orf10 Gene

Previous GeneCards Identifiers for C10orf10 Gene

  • GC10M044755
  • GC10M044791
  • GC10M045466
  • GC10M041996

Summaries for C10orf10 Gene

Entrez Gene Summary for C10orf10 Gene

  • The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. [provided by RefSeq, Jul 2008]

GeneCards Summary for C10orf10 Gene

C10orf10 (Chromosome 10 Open Reading Frame 10) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C10orf10 Gene

  • May play a role in autophagy.

Gene Wiki entry for C10orf10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf10 Gene

Genomics for C10orf10 Gene

Regulatory Elements for C10orf10 Gene

Genomic Location for C10orf10 Gene

44,970,981 bp from pter
44,978,882 bp from pter
7,902 bases
Minus strand

Genomic View for C10orf10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C10orf10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf10 Gene

Proteins for C10orf10 Gene

  • Protein details for C10orf10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein DEPP
    Protein Accession:
    Secondary Accessions:
    • B2R6A1
    • O94997
    • Q5T735
    • Q76MX8

    Protein attributes for C10orf10 Gene

    212 amino acids
    Molecular mass:
    23406 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI13066.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for C10orf10 Gene

Proteomics data for C10orf10 Gene at MOPED

Post-translational modifications for C10orf10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C10orf10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C10orf10 Gene

Domains & Families for C10orf10 Gene

Protein Domains for C10orf10 Gene


Suggested Antigen Peptide Sequences for C10orf10 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C10orf10: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C10orf10 Gene

Function for C10orf10 Gene

Molecular function for C10orf10 Gene

UniProtKB/Swiss-Prot Function:
May play a role in autophagy.
UniProtKB/Swiss-Prot Induction:
By progesterone, testosterone and, to a much lower extent, estrogen. Up-regulated by hypoxia (at protein level).

Phenotypes for C10orf10 Gene

genes like me logo Genes that share phenotypes with C10orf10: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C10orf10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for C10orf10 Gene

Localization for C10orf10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf10 Gene

Cytoplasm. Note=May localize to aggresomes.

Subcellular locations from

Jensen Localization Image for C10orf10 Gene COMPARTMENTS Subcellular localization image for C10orf10 gene
Compartment Confidence
mitochondrion 4
nucleus 2
cytosol 1
extracellular 1
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for C10orf10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with C10orf10: view

Pathways & Interactions for C10orf10 Gene

SuperPathways for C10orf10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C10orf10 Gene


No data available for Pathways by source and SIGNOR curated interactions for C10orf10 Gene

Drugs & Compounds for C10orf10 Gene

No Compound Related Data Available

Transcripts for C10orf10 Gene

mRNA/cDNA for C10orf10 Gene

Unigene Clusters for C10orf10 Gene

Chromosome 10 open reading frame 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C10orf10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf10 Gene

No ASD Table

Relevant External Links for C10orf10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C10orf10 Gene

mRNA expression in normal human tissues for C10orf10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C10orf10 Gene

This gene is overexpressed in Adipose - Subcutaneous (x5.4).

SOURCE GeneReport for Unigene cluster for C10orf10 Gene Hs.93675

mRNA Expression by UniProt/SwissProt for C10orf10 Gene

Tissue specificity: Expressed in various tissues, including pancreas, placenta, ovary, testis and kidney.
genes like me logo Genes that share expression patterns with C10orf10: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for C10orf10 Gene

Orthologs for C10orf10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C10orf10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC613715 35
  • 76.6 (n)
  • 66.83 (a)
C28H10ORF10 36
  • 67 (a)
(Canis familiaris)
Mammalia C28H10orf10 35
  • 77.08 (n)
  • 67.31 (a)
C10orf10 36
  • 67 (a)
(Mus musculus)
Mammalia 8430408G22Rik 35
  • 71.71 (n)
  • 60.49 (a)
8430408G22Rik 16
8430408G22Rik 36
  • 60 (a)
(Pan troglodytes)
Mammalia C10H10orf10 35
  • 98.27 (n)
  • 96.7 (a)
C10orf10 36
  • 97 (a)
(Rattus norvegicus)
Mammalia LOC500300 35
  • 70.24 (n)
  • 61.46 (a)
(Monodelphis domestica)
Mammalia C10orf10 36
  • 42 (a)
Species with no ortholog for C10orf10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C10orf10 Gene

Gene Tree for C10orf10 (if available)
Gene Tree for C10orf10 (if available)

Paralogs for C10orf10 Gene

No data available for Paralogs for C10orf10 Gene

Variants for C10orf10 Gene

Structural Variations from Database of Genomic Variants (DGV) for C10orf10 Gene

Variant ID Type Subtype PubMed ID
nsv831846 CNV Loss 17160897
nsv526734 CNV Loss 19592680

Variation tolerance for C10orf10 Gene

Residual Variation Intolerance Score: 80.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 26.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C10orf10 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for C10orf10 Gene

Disorders for C10orf10 Gene

Relevant External Links for C10orf10

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C10orf10: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf10 Gene

Publications for C10orf10 Gene

  1. A novel protein Depp, which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor. (PMID: 16123073) Watanabe H. … Fujita J. (Mol. Hum. Reprod. 2005) 2 23 67
  2. The c10orf10 gene product is a new link between oxidative stress and autophagy. (PMID: 24530860) Stepp M.W. … Zelko I.N. (Biochim. Biophys. Acta 2014) 2 67
  3. Insulin-mediated regulation of decidual protein induced by progesterone (DEPP) in adipose tissue and liver. (PMID: 19937567) Kuroda Y. … Shimomura I. (Horm. Metab. Res. 2010) 2 67
  4. Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells. (PMID: 15977181) Shin D. … Anderson D.J. (Dev. Dyn. 2005) 23 67
  5. C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma. (PMID: 25261981) Salcher S. … Obexer P. (Mol. Cancer 2014) 67

Products for C10orf10 Gene

Sources for C10orf10 Gene

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