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Aliases for C10orf10 Gene

Aliases for C10orf10 Gene

  • Chromosome 10 Open Reading Frame 10 2 3 5
  • Decidual Protein Induced By Progesterone 2 3 4
  • Fasting-Induced Gene Protein 3 4
  • Fasting Induced 2 3
  • DEPP 3 4
  • FIG 3 4
  • Fat-Specific Expressed Gene 2
  • Fasting-Induced Protein 3
  • Fat-Specific Expressed 3
  • Protein DEPP 3
  • Fseg 3

External Ids for C10orf10 Gene

Previous GeneCards Identifiers for C10orf10 Gene

  • GC10M044755
  • GC10M044791
  • GC10M045466
  • GC10M041996

Summaries for C10orf10 Gene

Entrez Gene Summary for C10orf10 Gene

  • The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. [provided by RefSeq, Jul 2008]

GeneCards Summary for C10orf10 Gene

C10orf10 (Chromosome 10 Open Reading Frame 10) is a Protein Coding gene. Diseases associated with C10orf10 include Vlcad Deficiency.

UniProtKB/Swiss-Prot for C10orf10 Gene

  • May play a role in autophagy.

Gene Wiki entry for C10orf10 Gene

Additional gene information for C10orf10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf10 Gene

Genomics for C10orf10 Gene

Regulatory Elements for C10orf10 Gene

Enhancers for C10orf10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H044989 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.8 -15.1 -15077 9.7 FOXA2 MLX ARID4B DMAP1 YY1 ATF7 RUNX3 PAF1 SP5 REST C10orf25 ENSG00000223462 C10orf10 PIR39907
GH10H045726 1.1 ENCODE 9.7 -748.4 -748447 1.5 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF143 ZNF207 FOS SP3 PARGP1 WASHC2C AGAP4 LOC105378289 ZFAND4 ENSG00000273363 AGAP10P C10orf10 ALOX5 FAM21FP
GH10H044971 2 FANTOM5 Ensembl ENCODE dbSUPER 0.7 -1.0 -961 16.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 C10orf25 ZNF22 TMEM72-AS1 RASSF4 FAM21FP ENSG00000223462 ENSG00000234504 WASHC2C TMEM72 CEP164P1
GH10H045235 0.7 FANTOM5 ENCODE 1.7 -257.2 -257195 0.4 IKZF1 FOS ENSG00000227683 C10orf10 CUBNP2 ENSG00000278531
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C10orf10 on UCSC Golden Path with GeneCards custom track

Promoters for C10orf10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000027449 882 1201 PKNOX1 ARID4B DMAP1 ZNF2 RARA ZNF121 SLC30A9 ZNF766 GLIS2 ZNF143

Genomic Locations for C10orf10 Gene

Genomic Locations for C10orf10 Gene
chr10:44,970,981-44,978,882
(GRCh38/hg38)
Size:
7,902 bases
Orientation:
Minus strand
chr10:45,466,429-45,474,330
(GRCh37/hg19)

Genomic View for C10orf10 Gene

Genes around C10orf10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf10 Gene

Proteins for C10orf10 Gene

  • Protein details for C10orf10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTK1-DEPP_HUMAN
    Recommended name:
    Protein DEPP
    Protein Accession:
    Q9NTK1
    Secondary Accessions:
    • B2R6A1
    • O94997
    • Q5T735
    • Q76MX8

    Protein attributes for C10orf10 Gene

    Size:
    212 amino acids
    Molecular mass:
    23406 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI13066.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for C10orf10 Gene

Post-translational modifications for C10orf10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C10orf10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C10orf10 Gene

Domains & Families for C10orf10 Gene

Gene Families for C10orf10 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C10orf10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C10orf10 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C10orf10: view

No data available for UniProtKB/Swiss-Prot for C10orf10 Gene

Function for C10orf10 Gene

Molecular function for C10orf10 Gene

UniProtKB/Swiss-Prot Function:
May play a role in autophagy.
UniProtKB/Swiss-Prot Induction:
By progesterone, testosterone and, to a much lower extent, estrogen. Up-regulated by hypoxia (at protein level).
genes like me logo Genes that share phenotypes with C10orf10: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C10orf10 Gene

Localization for C10orf10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf10 Gene

Cytoplasm. Note=May localize to aggresomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C10orf10 gene
Compartment Confidence
mitochondrion 5
nucleus 4
extracellular 2
peroxisome 2
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C10orf10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
genes like me logo Genes that share ontologies with C10orf10: view

Pathways & Interactions for C10orf10 Gene

SuperPathways for C10orf10 Gene

No Data Available

Interacting Proteins for C10orf10 Gene

Gene Ontology (GO) - Biological Process for C10orf10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf10 Gene

Drugs & Compounds for C10orf10 Gene

No Compound Related Data Available

Transcripts for C10orf10 Gene

mRNA/cDNA for C10orf10 Gene

Unigene Clusters for C10orf10 Gene

Chromosome 10 open reading frame 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf10 Gene

No ASD Table

Relevant External Links for C10orf10 Gene

GeneLoc Exon Structure for
C10orf10
ECgene alternative splicing isoforms for
C10orf10

Expression for C10orf10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C10orf10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C10orf10 Gene

This gene is overexpressed in Adipose - Subcutaneous (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of C10orf10 Gene:

C10orf10

SOURCE GeneReport for Unigene cluster for C10orf10 Gene:

Hs.93675

mRNA Expression by UniProt/SwissProt for C10orf10 Gene:

Q9NTK1-DEPP_HUMAN
Tissue specificity: Expressed in various tissues, including pancreas, placenta, ovary, testis and kidney.

Evidence on tissue expression from TISSUES for C10orf10 Gene

  • Nervous system(5)
  • Intestine(4.7)
  • Lung(4.6)
  • Pancreas(4.4)
  • Liver(3.5)
  • Heart(3.1)
  • Kidney(2.8)
  • Stomach(2.8)
  • Muscle(2.6)
  • Thyroid gland(2.5)
  • Adrenal gland(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with C10orf10: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for C10orf10 Gene

Orthologs for C10orf10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C10orf10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf10 33
  • 98.27 (n)
C10orf10 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C28H10orf10 33
  • 77.08 (n)
C10orf10 34
  • 67 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC613715 33
  • 76.6 (n)
C28H10ORF10 34
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 8430408G22Rik 33 16 34
  • 71.71 (n)
rat
(Rattus norvegicus)
Mammalia LOC500300 33
  • 70.24 (n)
oppossum
(Monodelphis domestica)
Mammalia C10orf10 34
  • 42 (a)
OneToOne
Species where no ortholog for C10orf10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C10orf10 Gene

ENSEMBL:
Gene Tree for C10orf10 (if available)
TreeFam:
Gene Tree for C10orf10 (if available)

Paralogs for C10orf10 Gene

No data available for Paralogs for C10orf10 Gene

Variants for C10orf10 Gene

Sequence variations from dbSNP and Humsavar for C10orf10 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1001161369 -- 44,975,959(+) GAGGC(C/T)GGGCC intron-variant, downstream-variant-500B
rs1001230161 -- 44,976,253(+) GGAAA(C/T)TGGGT intron-variant, downstream-variant-500B
rs1001450998 -- 44,975,997(+) CCTTG(C/G/T)TGGGT intron-variant, downstream-variant-500B
rs1002398081 -- 44,979,881(+) GGCTG(A/G)GGGGC intron-variant, upstream-variant-2KB
rs1003351331 -- 44,979,048(+) AGAGG(C/G)AGGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C10orf10 Gene

Variant ID Type Subtype PubMed ID
nsv831846 CNV loss 17160897
nsv526734 CNV loss 19592680
esv3576560 CNV gain 25503493

Variation tolerance for C10orf10 Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 26.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C10orf10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf10 Gene

Disorders for C10orf10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C10orf10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
vlcad deficiency
  • very long-chain acyl-coenzyme a dehydrogenase deficiency
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C10orf10

Human Genome Epidemiology (HuGE) Navigator
C10orf10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C10orf10
genes like me logo Genes that share disorders with C10orf10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C10orf10 Gene

Publications for C10orf10 Gene

  1. A novel protein Depp, which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor. (PMID: 16123073) Watanabe H … Fujita J (Molecular human reproduction 2005) 2 3 4 22 60
  2. The c10orf10 gene product is a new link between oxidative stress and autophagy. (PMID: 24530860) Stepp MW … Zelko IN (Biochimica et biophysica acta 2014) 2 3 4 60
  3. C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy. (PMID: 28545464) Salcher S … Obexer P (Molecular cancer 2017) 2 3 60
  4. FoxO regulates expression of decidual protein induced by progesterone (DEPP) in human endothelial cells. (PMID: 21510935) Chen S … Li H (FEBS letters 2011) 3 4 60
  5. Insulin-mediated regulation of decidual protein induced by progesterone (DEPP) in adipose tissue and liver. (PMID: 19937567) Kuroda Y … Shimomura I (Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2010) 2 3 60

Products for C10orf10 Gene

Sources for C10orf10 Gene

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