C10orf10 Gene
protein-coding GIFtS : 49
GCID: GC10 M045466
chromosome 10 open reading frame 10
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Aliasesfor C10orf10 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Chromosome 10 Open Reading Frame 10 1 2 Fasting-Induced Gene Protein2 3 FIG1 2 3 Fasting Induced2 DEPP1 2 Fasting-Induced Protein2 Decidual Protein Induced By Progesterone2 3 Protein DEPP2
Export aliases for C10orf10 gene to outside databases Previous GC identifers: GC10M044755 GC10M044791 GC10M041996
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Summariesfor C10orf10 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for C10orf10 : The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. (provided by RefSeq, Jul 2008) Gene Wiki entry for C10orf10
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Genomic Viewsfor C10orf10 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000010.10 NC_018921.1 NT_033985.7 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the C10orf10 gene promoter: Bach1 USF1 RFX1 p53 ATF-2 Tal-1beta USF-1 FOXJ2 (long isoform) FOXJ2 ITF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for C10orf10 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C10orf10
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10q11.21 Ensembl cytogenetic band: 10q11.21 HGNC cytogenetic band: 10q11.21 C10orf10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10M045466: view genomic region
(about GC identifiers )
Start:
45,466,429 bp from pter
End:
45,474,330 bp from pter
Size:
7,902 bases
Orientation:
minus strand
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Proteinsfor C10orf10 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DEPP_HUMAN, Q9NTK1 (See
protein sequence )Recommended Name: Protein DEPP Size : 212 amino acids; 23406 Da
Developmental stage : High levels in first trimester deciduas. Higher levels in the endometria during secretory phasethan the proliferative phase, especially after the mid-secretory phase
Sequence caution : Sequence=CAI13066.1; Type=Erroneous gene model prediction;
Secondary accessions : B2R6A1 O94997 Q5T735 Q76MX8Explore the universe of human proteins at neXtProt for C10orf10: NX_Q9NTK1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NTK1 C10orf10 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_008952.1 ENSEMBL proteins: ENSP00000298295 ENSP00000414494 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005739 mitochondrion
IDA --
C10orf10 for ontologies About GeneDecksing C10orf10 Antibody Products: Assay Products for C10orf10:
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Protein
Domains / Familiesfor C10orf10 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
C10orf10 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9NTK1 ProtoNet protein and cluster: Q9NTK1
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Functionfor C10orf10 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DEPP_HUMAN, Q9NTK1 Induction : By progesterone, testosterone and, to a much lower extent, estrogen
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C10orf10 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C10orf10 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C10orf10 (NM_007021 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C10orf10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C10orf10
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf10
1 GenomeRNAi human phenotype for C10orf10 :Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for 8430408G22Rik) :
C10orf10 for phenotypes About GeneDecksing
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Pathways & Interactionsfor C10orf10 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C10orf10 STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)5/9 Interacting proteins for C10orf10 (Q9NTK1 2 , 3 ENSP00000298295 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 9 )Interactant Interaction Details GeneCard External ID(s) CCDC85B Q15834 2 , 3 , ENSP00000311695 4 MINT-67111 I2D:
score=5 STRING: ENSP00000311695 KRT15 P19012 2 , 3 , ENSP00000254043 4 MINT-66290 I2D:
score=5 STRING: ENSP00000254043 QKI Q96PU8 2 , 3 , ENSP00000354951 4 MINT-2869299 I2D:
score=3 STRING: ENSP00000354951 KRT19 P08727 2 , 3 , ENSP00000355124 4 MINT-67060 I2D:
score=5 STRING: ENSP00000355124 PLSCR1 O15162 2 , 3 , ENSP00000345494 4 MINT-67216 I2D:
score=5 STRING: ENSP00000345494
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Drugs & Compoundsfor C10orf10 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for C10orf10 Search CenterWatch for drugs/clinical trials and news about C10orf10 / DEPP
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Transcriptsfor C10orf10 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
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Vector BioLabs ,
Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for C10orf10 gene: NM_007021.3 Unigene Cluster for C10orf10:
Chromosome 10 open reading frame 10 Hs.93675 [show with all ESTs ] Unigene Representative Sequence: AB022718 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000496638 ENST00000298295 (uc001jbr.4 ) ENST00000448778 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C10orf10 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C10orf10 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C10orf10 (NM_007021 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C10orf10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C10orf10
Additional cDNA sequence: AB022718.1 AB025244.1 AK002191.1 AK098476.1 AK300839.1 AK312496.1 AL136653.1 BC011402.1
24/27 DOTS entries (see all 27 ): DT.40260675 DT.100856347
DT.95139113 DT.121228485 DT.100720213 DT.121228387 DT.100856357 DT.121228377 DT.97808897 DT.100051879 DT.121228410 DT.121228327 DT.121228232 DT.121228319 DT.121228322 DT.121228466 DT.121228487 DT.100059701 DT.100831109 DT.121228235 DT.121228237 DT.121228246 DT.121228355 DT.121228380 24/442 AceView cDNA sequences (see all 442 ):
AW339117 BX361324 BM717861 CR616425 AI288275 CB265668 BP373338 F16325 BM680464 BQ932506 BM707740 BX458618 H27107 CA390725 BQ652049 CA414997 AK098476 AI282593 BG056582 CR592377 CR618606 BQ549348 CA941395 BQ651833 GeneLoc Exon Structure
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Expression for C10orf10 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section C10orf10 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTCAGGGTCC
About this image C10orf10 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See C10orf10 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for C10orf10 SOURCE GeneReport for Unigene cluster: Hs.93675 UniProtKB/Swiss-Prot: DEPP_HUMAN, Q9NTK1 Tissue specificity : Expressed in various tissues, including pancreas, placenta, ovary, testis and kidney SABiosciences Custom PCR Arrays for C10orf10 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C10orf10Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat C10orf10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C10orf10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C10orf10 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf10
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Orthologsfor C10orf10 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of human and mouse.
Orthologs for C10orf10 gene from 1/6 species (see all 6 ) About this table
ENSEMBL Gene Tree for C10orf10 (if available)TreeFam Gene Tree for C10orf10 (if available)
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Paralogsfor C10orf10 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor C10orf10 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 10 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for C10orf10 (45466429 - 45474330 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for C10orf10: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C10orf10
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Disorders
/ Diseasesfor C10orf10 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
C10orf10 for disorders About GeneDecksing
OMIM gene information: 611309
OMIM disorders : --2 diseases for C10orf10 : About MalaCards alzheimer's disease ataxia Human Genome Epidemiology (HuGE) Navigator: C10orf10 (3 documents) Export disorders for C10orf10 gene to outside databases
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Publicationsfor C10orf10 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for C10orf10 gene, integrated from 9 sources (see all 19 ): (articles sorted by number of sources associating them with C10orf10) Utopia : connect your pdf to the dynamic world of online information
A novel protein Depp, which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor. (PubMed id 16123073) 1 , 2 , 9 Watanabe H.... Fujita J. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054) 1 , 2 Deloukas P.... Rogers J. (2004) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 1 , 2 Wiemann S.... Poustka A. (2001) Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells. (PubMed id 15977181) 1 , 9 Shin D. and Anderson D.J. (2005) FoxO regulates expression of decidual protein induced by progesterone (DEPP) in human endothelial cells. (PubMed id 21510935) 1 Chen S....Li H. (2011) Association between CETP Taq1B and LIPC -514C/T polym orphisms with the serum lipid levels in a group of Tehran's population: a cross sectional study. (PubMed id 20822508) 1 Kashani Farid M.A....Siassi F. (2010) Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624) 1 Hendrickson S.L....O'Brien S.J. (2010) Insulin-mediated regulation of decidual protein induc ed by progesterone (DEPP) in adipose tissue and liver. (PubMed id 19937567) 1 Kuroda Y....Shimomura I. (2010)
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External Searches for C10orf10 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing C10orf10 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing C10orf10 gene
(According to HUGE )
About This Section --
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Specialized Databases showing C10orf10 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for C10orf10 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for C10orf10 gene: Search GeneIP for patents involving C10orf10 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor C10orf10 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C10orf10 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C10orf10 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C10orf10 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat C10orf10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C10orf10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C10orf10
C10orf10 Proteins, Antibodies, CLIAs, and ELISAs
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Aliases for C10orf10
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Disorders / Diseases for C10orf10
Domains / Families for C10orf10
Drugs / Compounds for C10orf10
Expression for C10orf10
Function for C10orf10
Genomic Views for C10orf10
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