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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C10orf10 Gene

protein-coding   GIFtS: 49
GCID: GC10M045466

chromosome 10 open reading frame 10

 Explore 2 diseases affiliated with
C10orf10 via our new
 Human Malady Compendium 
Biological research products
for C10orf10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Chromosome 10 Open Reading Frame 101 2     Fasting-Induced Gene Protein2 3
FIG1 2 3     Fasting Induced2
DEPP1 2     Fasting-Induced Protein2
Decidual Protein Induced By Progesterone2 3     Protein DEPP2

External Ids:    HGNC: 233551   Entrez Gene: 110672   Ensembl: ENSG000001655077   OMIM: 6113095   UniProtKB: Q9NTK13   

Export aliases for C10orf10 gene to outside databases

Previous GC identifers: GC10M044755 GC10M044791 GC10M041996


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for C10orf10:
The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains
a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal.
Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. (provided
by RefSeq, Jul 2008)

Gene Wiki entry for C10orf10


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_033985.7  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C10orf10 gene promoter:
         Bach1   USF1   RFX1   p53   ATF-2   Tal-1beta   USF-1   FOXJ2 (long isoform)   FOXJ2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC10orf10 promoter sequence
   Search SABiosciences Chromatin IP Primers for C10orf10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C10orf10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.21   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.21

C10orf10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C10orf10 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M045466:  view genomic region     (about GC identifiers)

Start:
45,466,429 bp from pter      End:
45,474,330 bp from pter
Size:
7,902 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DEPP_HUMAN, Q9NTK1 (See protein sequence)
Recommended Name: Protein DEPP  
Size: 212 amino acids; 23406 Da
Developmental stage: High levels in first trimester deciduas. Higher levels in the endometria during secretory phase
than the proliferative phase, especially after the mid-secretory phase
Sequence caution: Sequence=CAI13066.1; Type=Erroneous gene model prediction;
Secondary accessions: B2R6A1 O94997 Q5T735 Q76MX8

Explore the universe of human proteins at neXtProt for C10orf10: NX_Q9NTK1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NTK1

  • C10orf10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008952.1  
    ENSEMBL proteins: 
     ENSP00000298295   ENSP00000414494  

    Human Recombinant Protein Products: 
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    Uscn Proteins for C10orf10

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--


    C10orf10 for ontologies           About GeneDecksing



    C10orf10 Antibody Products: 
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    Uscn ELISAs and CLIAs for C10orf10


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    C10orf10 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR020133 Decidual_prot_progesterone_ind

    Graphical View of Domain Structure for InterPro Entry Q9NTK1

    ProtoNet protein and cluster: Q9NTK1


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DEPP_HUMAN, Q9NTK1
    Induction: By progesterone, testosterone and, to a much lower extent, estrogen

    miRNA
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    hsa-miR-635
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf10

    1 GenomeRNAi human phenotype for C10orf10:
     Increased gamma-H2AX phosphory 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for 8430408G22Rik):
     normal 

    C10orf10 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C10orf10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for C10orf10 (Q9NTK12, 3 ENSP000002982954) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-67111 I2D: score=5 STRING: ENSP00000311695
    KRT15P190122, 3, ENSP000002540434MINT-66290 I2D: score=5 STRING: ENSP00000254043
    QKIQ96PU82, 3, ENSP000003549514MINT-2869299 I2D: score=3 STRING: ENSP00000354951
    KRT19P087272, 3, ENSP000003551244MINT-67060 I2D: score=5 STRING: ENSP00000355124
    PLSCR1O151622, 3, ENSP000003454944MINT-67216 I2D: score=5 STRING: ENSP00000345494
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C10orf10
    Search CenterWatch for drugs/clinical trials and news about C10orf10 / DEPP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C10orf10 gene: 
    NM_007021.3  

    Unigene Cluster for C10orf10:

    Chromosome 10 open reading frame 10
    Hs.93675  [show with all ESTs]
    Unigene Representative Sequence: AB022718
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496638 ENST00000298295(uc001jbr.4) ENST00000448778

    miRNA
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    OriGene 3'-UTR Clone: C10orf10
    Browse OriGene MicroRNA Expression Plasmids
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate C10orf10:
    hsa-miR-635
    SwitchGear 3'UTR luciferase reporter plasmidC10orf10 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C10orf10 (see all 4)
    OriGene shRNA RFP: C10orf10
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C10orf10 (see all 3)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C10orf10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C10orf10

    Additional cDNA sequence: 

    AB022718.1 AB025244.1 AK002191.1 AK098476.1 AK300839.1 AK312496.1 AL136653.1 BC011402.1 

    24/27 DOTS entries (see all 27):

    DT.40260675  DT.100856347  DT.95139113  DT.121228485  DT.100720213  DT.121228387  DT.100856357  DT.121228377 
    DT.97808897  DT.100051879  DT.121228410  DT.121228327  DT.121228232  DT.121228319  DT.121228322  DT.121228466 
    DT.121228487  DT.100059701  DT.100831109  DT.121228235  DT.121228237  DT.121228246  DT.121228355  DT.121228380 

    24/442 AceView cDNA sequences (see all 442):

    AW339117 BX361324 BM717861 CR616425 AI288275 CB265668 BP373338 F16325 
    BM680464 BQ932506 BM707740 BX458618 H27107 CA390725 BQ652049 CA414997 
    AK098476 AI282593 BG056582 CR592377 CR618606 BQ549348 CA941395 BQ651833 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C10orf10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCAGGGTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    C10orf10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSertoli cellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Syncytiotrophoblast-like cells (Generation of syncyt...)

    See C10orf10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C10orf10

    SOURCE GeneReport for Unigene cluster: Hs.93675

    UniProtKB/Swiss-Prot: DEPP_HUMAN, Q9NTK1
    Tissue specificity: Expressed in various tissues, including pancreas, placenta, ovary, testis and kidney

        SABiosciences Custom PCR Arrays for C10orf10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for C10orf10 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 8430408G22Rik1 , 5 RIKEN cDNA 8430408G22 gene1, 5 71.71(n)1
    60.49(a)1
      6 (53.83 cM)5
    2133931  NM_001166580.11  NP_001160052.11 
     1166506845 


    ENSEMBL Gene Tree for C10orf10 (if available)
    TreeFam Gene Tree for C10orf10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/130 NCBI SNPs in C10orf10 are shown (see all 130    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37400981,2
    C,F,H,--45471222(-) GAGGTC/TAATGG 2 -- int1 ds500125Minor allele frequency- T:0.40EA NS NA WA CSA 4204
    rs1873557781,2
    --45471260(+) AGCCCC/GGGGAT 2 -- ds5001 int10--------
    rs1931407211,2
    --45471273(+) TCTCCC/TCAAAC 2 -- ds5001 int10--------
    rs37400971,2
    C,F,--45471278(-) TGGCAG/CTTTGA 2 -- ds5001 int112Minor allele frequency- C:0.40EA NA WA CSA 1872
    rs1856211121,2
    --45471304(+) AGCGAC/GGTGGC 2 -- int1 ds50010--------
    rs750319491,2
    --45471388(+) TTGCAG/AAAGGG 2 -- int1 ds50011Minor allele frequency- A:0.01WA 118
    rs9147011,2
    C,F,A,H,--45471422(+) AAGCCC/TGGACC 2 -- ds5001 int112Minor allele frequency- T:0.41NA EA WA 1888
    rs1427016931,2
    C,--45471447(+) TTGGT-/GGGTGG 2 -- ds5001 int10--------
    rs1876852611,2
    --45471470(+) TCTCCC/TGAGGA 2 -- int1 ds50010--------
    rs1461576461,2
    --45471520(+) CACACA/GTTTGC 2 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for C10orf10 (45466429 - 45474330 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for C10orf10: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C10orf10
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C10orf10 for disorders           About GeneDecksing

    OMIM gene information: 611309    OMIM disorders: --

    2 diseases for C10orf10:    About MalaCards
    alzheimer's disease    ataxia

    Human Genome Epidemiology (HuGE) Navigator: C10orf10 (3 documents)

    Export disorders for C10orf10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C10orf10 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with C10orf10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel protein Depp, which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor. (PubMed id 16123073)1, 2, 9 Watanabe H.... Fujita J. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    6. Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells. (PubMed id 15977181)1, 9 Shin D. and Anderson D.J. (2005)
    7. FoxO regulates expression of decidual protein induced by progesterone (DEPP) in human endothelial cells. (PubMed id 21510935)1 Chen S....Li H. (2011)
    8. Association between CETP Taq1B and LIPC -514C/T polym orphisms with the serum lipid levels in a group of Tehran's population: a cross sectional study. (PubMed id 20822508)1 Kashani Farid M.A....Siassi F. (2010)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    10. Insulin-mediated regulation of decidual protein induc ed by progesterone (DEPP) in adipose tissue and liver. (PubMed id 19937567)1 Kuroda Y....Shimomura I. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11067 HGNC: 23355 AceView: C10orf10 Ensembl:ENSG00000165507 euGenes: HUgn11067
    ECgene: C10orf10 H-InvDB: C10orf10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C10orf10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C10orf10 gene:
    Search GeneIP for patents involving C10orf10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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