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Aliases for BZW2 Gene

Aliases for BZW2 Gene

  • Basic Leucine Zipper And W2 Domains 2 2 3 5
  • HSPC028 3
  • MSTP017 3
  • MST017 3

External Ids for BZW2 Gene

Previous GeneCards Identifiers for BZW2 Gene

  • GC07P016330
  • GC07P016430
  • GC07P016458
  • GC07P016652
  • GC07P016572

Summaries for BZW2 Gene

GeneCards Summary for BZW2 Gene

BZW2 (Basic Leucine Zipper And W2 Domains 2) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is BZW1.

UniProtKB/Swiss-Prot for BZW2 Gene

  • May be involved in neuronal differentiation.

Gene Wiki entry for BZW2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BZW2 Gene

Genomics for BZW2 Gene

Regulatory Elements for BZW2 Gene

Enhancers for BZW2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BZW2 on UCSC Golden Path with GeneCards custom track

Promoters for BZW2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BZW2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BZW2 Gene

16,646,131 bp from pter
16,706,523 bp from pter
60,393 bases
Plus strand

Genomic View for BZW2 Gene

Genes around BZW2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BZW2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BZW2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BZW2 Gene

Proteins for BZW2 Gene

  • Protein details for BZW2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Basic leucine zipper and W2 domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A4D123
    • Q3B779
    • Q96JW5
    • Q9H3F7

    Protein attributes for BZW2 Gene

    419 amino acids
    Molecular mass:
    48162 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI07758.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for BZW2 Gene


neXtProt entry for BZW2 Gene

Proteomics data for BZW2 Gene at MOPED

Post-translational modifications for BZW2 Gene

  • Ubiquitination at Lys 117 and Lys 232
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BZW2 Gene

Domains & Families for BZW2 Gene

Protein Domains for BZW2 Gene

Suggested Antigen Peptide Sequences for BZW2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 W2 domain.
  • Belongs to the BZW family.
  • Contains 1 W2 domain.
  • Belongs to the BZW family.
genes like me logo Genes that share domains with BZW2: view

No data available for Gene Families for BZW2 Gene

Function for BZW2 Gene

Molecular function for BZW2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in neuronal differentiation.

Phenotypes for BZW2 Gene

genes like me logo Genes that share phenotypes with BZW2: view

Animal Models for BZW2 Gene

MGI Knock Outs for BZW2:
  • Bzw2 tm1b(KOMP)Mbp

Animal Model Products

miRNA for BZW2 Gene

miRTarBase miRNAs that target BZW2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BZW2 Gene

Localization for BZW2 Gene

Subcellular locations from

Jensen Localization Image for BZW2 Gene COMPARTMENTS Subcellular localization image for BZW2 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
plasma membrane 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BZW2 Gene

Pathways & Interactions for BZW2 Gene

SuperPathways for BZW2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BZW2 Gene


No data available for Pathways by source and SIGNOR curated interactions for BZW2 Gene

Drugs & Compounds for BZW2 Gene

No Compound Related Data Available

Transcripts for BZW2 Gene

Unigene Clusters for BZW2 Gene

Basic leucine zipper and W2 domains 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BZW2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - - - - - - - - -
SP9: - - -
SP10: -
SP11: - - - - - - - - - -
SP12: - - - - -
SP13: - - - -
SP14: - - - - - -
SP15: - - - - - -

ExUns: 16

Relevant External Links for BZW2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BZW2 Gene

mRNA expression in normal human tissues for BZW2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BZW2 Gene

This gene is overexpressed in Heart - Left Ventricle (x7.9) and Muscle - Skeletal (x5.4).

Protein differential expression in normal tissues from HIPED for BZW2 Gene

This gene is overexpressed in Bone (41.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BZW2 Gene

SOURCE GeneReport for Unigene cluster for BZW2 Gene Hs.487635

genes like me logo Genes that share expression patterns with BZW2: view

Protein tissue co-expression partners for BZW2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for BZW2 Gene

Orthologs for BZW2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BZW2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BZW2 35
  • 94.51 (n)
  • 99.28 (a)
BZW2 36
  • 99 (a)
(Canis familiaris)
Mammalia BZW2 35
  • 95.07 (n)
  • 100 (a)
BZW2 36
  • 100 (a)
(Mus musculus)
Mammalia Bzw2 35
  • 91.73 (n)
  • 99.05 (a)
Bzw2 16
Bzw2 36
  • 99 (a)
(Pan troglodytes)
Mammalia BZW2 35
  • 99.84 (n)
  • 100 (a)
BZW2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Bzw2 35
  • 91.57 (n)
  • 98.81 (a)
(Monodelphis domestica)
Mammalia BZW2 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
-- 36
  • 89 (a)
-- 36
  • 97 (a)
(Gallus gallus)
Aves BZW2 35
  • 84.15 (n)
  • 94.12 (a)
BZW2 36
  • 94 (a)
(Anolis carolinensis)
Reptilia BZW2 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bzw2 35
  • 79 (n)
  • 89.95 (a)
(Danio rerio)
Actinopterygii bzw2 35
  • 74.94 (n)
  • 84.03 (a)
zgc55580 35
bzw2 36
  • 84 (a)
fruit fly
(Drosophila melanogaster)
Insecta exba 36
  • 50 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G65220 35
  • 46.4 (n)
  • 34 (a)
(Oryza sativa)
Liliopsida Os11g0414000 35
  • 47.48 (n)
  • 33.5 (a)
Species with no ortholog for BZW2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BZW2 Gene

Gene Tree for BZW2 (if available)
Gene Tree for BZW2 (if available)

Paralogs for BZW2 Gene

Paralogs for BZW2 Gene Pseudogenes for BZW2 Gene

genes like me logo Genes that share paralogs with BZW2: view

Variants for BZW2 Gene

Sequence variations from dbSNP and Humsavar for BZW2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs35233079 - 16,674,484(+) TGATG(A/C)CCTTG nc-transcript-variant, reference, missense
rs818495 -- 16,672,389(+) cttag(C/G)tttct intron-variant
rs818496 -- 16,685,367(-) ACTTT(A/T)CTGAG intron-variant
rs818497 -- 16,684,148(-) CTACA(A/T)GTATA intron-variant
rs818498 -- 16,684,033(-) ATCTT(C/T)ATACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BZW2 Gene

Variant ID Type Subtype PubMed ID
nsv830912 CNV Gain 17160897
nsv887759 CNV Gain 21882294
nsv437016 CNV Loss 16327808
esv2665677 CNV Deletion 23128226
nsv517565 CNV Loss 19592680
esv25168 CNV Loss 19812545
nsv887760 CNV Gain 21882294

Variation tolerance for BZW2 Gene

Residual Variation Intolerance Score: 18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.03; 80.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BZW2 Gene

Disorders for BZW2 Gene

Relevant External Links for BZW2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BZW2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BZW2 Gene

Publications for BZW2 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R. … Green R.C. (Alzheimers Dement 2014) 3

Products for BZW2 Gene

Sources for BZW2 Gene