Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BZW2 Gene

protein-coding   GIFtS: 52
GCID: GC07P016652

Basic Leucine Zipper And W2 Domains 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Basic Leucine Zipper And W2 Domains 21 2
MST0172
MSTP0172
Basic Leucine Zipper And W2 Domain-Containing Protein 22

External Ids:    HGNC: 188081   Entrez Gene: 289692   Ensembl: ENSG000001362617   UniProtKB: Q9Y6E23   

Export aliases for BZW2 gene to outside databases

Previous GC identifers: GC07P016330 GC07P016430 GC07P016458 GC07P016572


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for BZW2 Gene: 
BZW2 (basic leucine zipper and W2 domains 2) is a protein-coding gene. Diseases associated with BZW2 include neuronitis. An important paralog of this gene is BZW1.

UniProtKB/Swiss-Prot: BZW2_HUMAN, Q9Y6E2
Function: May be involved in neuronal differentiation (By similarity)

Gene Wiki entry for BZW2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BZW2 gene promoter:
         HOXA9B   HOXA9   USF1   AP-1   USF2   USF-1:USF-2   USF-1   Meis-1a   MRF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): BZW2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BZW2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BZW2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.1   Ensembl cytogenetic band:  7p21.1   HGNC cytogenetic band: 7p21.3

BZW2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BZW2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P016652:  view genomic region     (about GC identifiers)

Start:
16,685,756 bp from pter      End:
16,746,148 bp from pter
Size:
60,393 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 16,738,882-16,799,268     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BZW2_HUMAN, Q9Y6E2 (See protein sequence)
Recommended Name: Basic leucine zipper and W2 domain-containing protein 2  
Size: 419 amino acids; 48162 Da
Sequence caution: Sequence=AAI07758.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: A4D123 Q3B779 Q9H3F7

Explore the universe of human proteins at neXtProt for BZW2: NX_Q9Y6E2

Explore proteomics data for BZW2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y6E2

  • BZW2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BZW2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001153239.1  NP_054757.1  

    ENSEMBL proteins: 
     ENSP00000403481   ENSP00000258761   ENSP00000406402   ENSP00000406395   ENSP00000389183  
     ENSP00000385577   ENSP00000412750   ENSP00000415924   ENSP00000416531   ENSP00000384617  
     ENSP00000397249   ENSP00000411715  

    Human Recombinant Protein Products for BZW2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for BZW2
    OriGene Protein Over-expression Lysate for BZW2
    OriGene MassSpec for BZW2 
    OriGene Custom Protein Services for BZW2
    GenScript Custom Purified and Recombinant Proteins Services for BZW2
    Novus Biologicals BZW2 Protein
    Novus Biologicals BZW2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BZW2 


    BZW2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for BZW2
    OriGene Custom Antibody Services for BZW2
    GenScript Custom Superior Antibodies Services for BZW2
    Novus Biologicals BZW2 Antibodies
    Abcam antibodies for BZW2
    Cloud-Clone Corp. Antibodies for BZW2 
    ThermoFisher Antibodies for BZW2
    LSBio Antibodies in human, mouse, rat for BZW2 

    Assay Products for BZW2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BZW2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BZW2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BZW2 
    Cloud-Clone Corp. CLIAs for BZW2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR016021 MIF4-like_typ_1/2/3
     IPR003307 W2_domain
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9Y6E2

    ProtoNet protein and cluster: Q9Y6E2

    1 Blocks protein domain: IPB003307 eIF4-gamma/eIF5/eIF2-epsilon

    UniProtKB/Swiss-Prot: BZW2_HUMAN, Q9Y6E2
    Similarity: Belongs to the BZW family
    Similarity: Contains 1 W2 domain


    BZW2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BZW2_HUMAN, Q9Y6E2
    Function: May be involved in neuronal differentiation (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    BZW2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Bzw2 (no phenotypes)

    BZW2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BZW2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BZW2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BZW2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BZW2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BZW2
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate BZW2 (see all 13):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-218 hsa-let-7g hsa-let-7e hsa-miR-135b
    SwitchGear 3'UTR luciferase reporter plasmidBZW2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BZW2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BZW2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BZW2
    Sirion Biotech Customized adenovirus for overexpression of BZW2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for BZW2 (see all 13)
    OriGene ORF clones in mouse, rat for BZW2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BZW2 (NM_014038)
    Sino Biological Human cDNA Clone for BZW2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BZW2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BZW2
    Sirion Biotech Customized lentivirus for stable overexpression of BZW2 
                         Customized lentivirus expression plasmids for stable overexpression of BZW2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BZW2
    Search LifeMap BioReagents cell lines for BZW2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BZW2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BZW2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/589 Interacting proteins for BZW2 (Q9Y6E22, 3 ENSP000002587614) via UniProtKB, MINT, STRING, and/or I2D (see all 589)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BZW1Q7L1Q62, 3, ENSP000003943164MINT-7945693 I2D: score=2 STRING: ENSP00000394316
    GSK3BP498412, 3MINT-8256943 I2D: score=2 
    PSTPIP1O435863, ENSP000003689144I2D: score=2 STRING: ENSP00000368914
    ELAVL1Q157172, ENSP000003852694MINT-7945693 STRING: ENSP00000385269
    SNW1Q135732, ENSP000002615314MINT-7945693 STRING: ENSP00000261531
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development IEA--
    GO:0016070RNA metabolic process IEA--
    GO:0030154cell differentiation IEA--

    BZW2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BZW2

    Search CenterWatch for drugs/clinical trials and news about BZW2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BZW2 gene (2 alternative transcripts): 
    NM_001159767.1  NM_014038.2  

    Unigene Cluster for BZW2:

    Basic leucine zipper and W2 domains 2
    Hs.487635  [show with all ESTs]
    Unigene Representative Sequence: NM_001159767
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415365(uc011jxx.1 uc003sto.1) ENST00000258761(uc003stj.2)
    ENST00000432311 ENST00000437745 ENST00000436868 ENST00000405202 ENST00000480517(uc003stn.1)
    ENST00000446596 ENST00000438834 ENST00000430000 ENST00000407633 ENST00000433922(uc003stl.2 uc003stm.2)
    ENST00000452975
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BZW2
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate BZW2 (see all 13):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-218 hsa-let-7g hsa-let-7e hsa-miR-135b
    SwitchGear 3'UTR luciferase reporter plasmidBZW2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BZW2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BZW2
    Clone
    Products:
         
    OriGene clones in human, mouse for BZW2 (see all 13)
    OriGene ORF clones in mouse, rat for BZW2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BZW2 (NM_014038)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BZW2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BZW2
    Sirion Biotech Customized lentivirus for stable overexpression of BZW2 
                         Customized lentivirus expression plasmids for stable overexpression of BZW2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BZW2
    OriGene qSTAR qPCR primer pairs in human, mouse for BZW2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BZW2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BZW2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BZW2

    Additional mRNA sequence: 

    AF083246.1 AF110323.1 AK001218.1 AK001260.1 AK297496.1 BC001570.1 BC003056.1 BC008453.1 
    BC009597.1 BC017794.1 BC051898.1 BC107757.1 NR_027624.1 

    24/34 DOTS entries (see all 34):

    DT.97795544  DT.216172  DT.92396013  DT.100878987  DT.92328785  DT.100878978  DT.92458742  DT.100878972 
    DT.92458760  DT.92458749  DT.100878976  DT.95251126  DT.100878988  DT.100879006  DT.121051984  DT.121052020 
    DT.100878992  DT.121051997  DT.121052028  DT.121052119  DT.92396953  DT.95251196  DT.100760865  DT.100878980 

    24/578 AceView cDNA sequences (see all 578):

    CR596038 CR597590 AI784511 CA487539 BM764973 AI246414 BC017794 BE303024 
    BM828695 CR611204 BG572851 BU172987 AI479778 CR605773 CR619763 AU123865 
    BM797662 CR606506 CR618505 CR608637 BG678446 BX403810 CR622998 BF805238 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for BZW2 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
    SP1:        -     -     -     -                                   -                             -                                                               
    SP2:              -     -     -                                   -                             -                                                               
    SP3:                                                              -     -                       -                                                               
    SP4:        -     -     -     -                                   -     -                       -                                                               
    SP5:                          -                                   -                             -                                                               

    ExUns: 16
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for BZW2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BZW2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTGATTT
    BZW2 Expression
    About this image


    See BZW2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BZW2

    SOURCE GeneReport for Unigene cluster: Hs.487635
        SABiosciences Custom PCR Arrays for BZW2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BZW2
    OriGene qSTAR qPCR primer pairs in human, mouse for BZW2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BZW2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BZW2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BZW2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BZW2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BZW2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bzw21 , 5 basic leucine zipper and W2 domains 21, 5 91.73(n)1
    99.05(a)1
      12 (16.42 cM)5
    669121  NM_025840.31  NP_080116.21 
     360918465 
    chicken
    (Gallus gallus)
    Aves BZW21 basic leucine zipper and W2 domains 2 84.27(n)
    94.16(a)
      420594  NM_001006358.1  NP_001006358.1 
    lizard
    (Anolis carolinensis)
    Reptilia BZW26
    Uncharacterized protein
    91(a)
    1 ↔ 1
    6(27505693-27531544)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc555802 similar to basic leucine zipper and W2 domains 2 76.25(n)   393892  BC048052.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta exba6
    extra bases
    49(a)
    1 → many
    3R(1421086-1426858)


    ENSEMBL Gene Tree for BZW2 (if available)
    TreeFam Gene Tree for BZW2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BZW2 gene
    BZW12  
    2 SIMAP similar genes for BZW2 using alignment to 11 protein entries:     BZW2_HUMAN (see all proteins):
    Nbla10236    BZW1

    BZW2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BZW2
    PGOHUM00000237862


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1301 SNPs in BZW2 are shown (see all 1301)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs615903061,2
    C--16580201(+) AAAAA-/A/    
       AAAAA
    TACAA
    3 -- int11NA 2
    rs1888151331,2
    --16687443(+) TTACCA/GGCAGA 3 -- int10--------
    rs797618911,2
    C,F--16687458(+) TACACA/GTAATT 3 -- int12Minor allele frequency- G:0.05NA 122
    rs1455444821,2
    --16687500(+) GTGCCA/GAATCT 3 -- int10--------
    rs176201101,2
    C,F,H--16687542(+) TGTCTC/TACTGG 3 -- int128Minor allele frequency- N:0.00NA EA NS WA 2860
    rs1399279261,2
    C--16687544(+) TCTCA-/CTGG  
     GGTTGTC
    AGTTC
    3 -- int10--------
    rs2007249921,2
    --16687547(+) CACTG-/GGG   
       TTGTC
    AGTTC
    3 -- int10--------
    rs1477574901,2
    --16687570(+) GGATAC/GCAGCT 3 -- int10--------
    rs1838505011,2
    --16687624(+) TAGTGC/TTCTCT 3 -- int10--------
    rs1879779421,2
    --16687626(+) GTGCTC/GTCTGA 3 -- int10--------

    HapMap Linkage Disequilibrium report for BZW2 (16685756 - 16746148 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for BZW2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2665677CNV Deletion23128226
    esv25168CNV Loss19812545
    nsv517565CNV Loss19592680
    nsv437016CNV Loss16327808
    nsv887760CNV Gain21882294
    nsv830912CNV Gain17160897
    nsv887759CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BZW2
    DNA2.0 Custom Variant and Variant Library Synthesis for BZW2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for BZW2:    About MalaCards
    neuronitis    


    BZW2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BZW2
    Human Genome Epidemiology (HuGE) Navigator: BZW2 (4 documents)

    Export disorders for BZW2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BZW2 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with BZW2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    8. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)1 Sherva R....Green R.C. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28969 HGNC: 18808 AceView: BZW2 Ensembl:ENSG00000136261 euGenes: HUgn28969
    ECgene: BZW2 H-InvDB: BZW2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BZW2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BZW2 gene:
    Search GeneIP for patents involving BZW2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for BZW2   OriGene RNAi products in human, mouse, rat for BZW2  
     OriGene qPCR primer pairs and template standards for BZW2   OriGene Protein Over-expression Lysate for BZW2  
     OriGene MassSpec something-or-other for BZW2   OriGene clones in human, mouse for BZW2  
     OriGene qSTAR qPCR primer pairs in human, mouse for BZW2   OriGene Purified Protein for BZW2  
     OriGene ORF clones in mouse, rat for BZW2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BZW2   OriGene Custom Protein Services for BZW2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BZW2
     QIAGEN SeqTarget long-range PCR primers for resequencing BZW2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BZW2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BZW2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BZW2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BZW2
     GenScript Custom Purified and Recombinant Proteins Services for BZW2 GenScript cDNA clones with any tag delivered in your preferred vector for BZW2
     GenScript Custom Assay Services for BZW2 GenScript Custom Superior Antibodies Services for BZW2
     GenScript Custom overexpressing Cell Line Services for BZW2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in BZW2 promoter
     Search Chromatin IP Primers for BZW2
     RT2 qPCR Primer Assay in human, mouse, rat BZW2
     Search GNC Networks for BZW2
     SABiosciences Custom PCR Arrays for BZW2
     Search Tocris compounds for BZW2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for BZW2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BZW2 antibodies
     BZW2 proteins
     BZW2 lysates
     Antibodies for BZW2
     See all of Abcam's Antibodies, Kits and Proteins for BZW2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for BZW2
     Antibodies for BZW2
     ELISAs for BZW2
     CLIAs for BZW2
     Search LifeMap BioReagents cell lines for BZW2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BZW2
     SwitchGear 3'UTR luciferase reporter plasmids for BZW2
     SwitchGear Promoter luciferase reporter plasmids for BZW2
     ThermoFisher Antibodies for BZW2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BZW2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for BZW2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BZW2
    Customized:
     lentivirus for stable overexpression of BZW2
     lentivirus expression plasmids for stable overexpression of BZW2
     adenovirus for overexpression of BZW2
     LSBio Antibodies in human, mouse, rat for BZW2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BZW2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4