Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BZW2 Gene

Aliases for BZW2 Gene

  • Basic Leucine Zipper And W2 Domains 2 2 3 5
  • Basic Leucine Zipper And W2 Domain-Containing Protein 2 3
  • HSPC028 3
  • MSTP017 3
  • MST017 3

External Ids for BZW2 Gene

Previous GeneCards Identifiers for BZW2 Gene

  • GC07P016330
  • GC07P016430
  • GC07P016458
  • GC07P016652
  • GC07P016572

Summaries for BZW2 Gene

GeneCards Summary for BZW2 Gene

BZW2 (Basic Leucine Zipper And W2 Domains 2) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is BZW1.

UniProtKB/Swiss-Prot for BZW2 Gene

  • May be involved in neuronal differentiation.

Gene Wiki entry for BZW2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BZW2 Gene

Genomics for BZW2 Gene

Regulatory Elements for BZW2 Gene

Enhancers for BZW2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G016666 1.5 Ensembl ENCODE dbSUPER 17.5 +22.7 22747 4.2 ARNT SIN3A ZNF766 FOS KLF13 DEK ZHX2 ZNF592 ZNF579 MEF2D BZW2 ANKMY2 TSPAN13 ENSG00000235837
GH07G016660 1.5 Ensembl ENCODE dbSUPER 9.8 +15.4 15403 2.9 FOXA2 ATF1 DMAP1 FOS KLF13 JUNB REST ZNF592 MEF2D CREB3 BZW2 ANKMY2 ENSG00000235837
GH07G016620 1.1 ENCODE dbSUPER 11.8 -25.8 -25821 0.2 HDAC1 LEF1 PKNOX1 NFRKB ETV1 ZNF133 ZNF644 ARID3A CBX5 FOS BZW2 ANKMY2 LOC105375169
GH07G016739 1.3 Ensembl ENCODE 9.6 +94.5 94459 2.1 HDGF PKNOX1 ATF1 CREB3L1 ARNT E2F7 FEZF1 TCF12 ZNF766 CBX5 AGR2 BZW2 ANKMY2 GC07M016725 TSPAN13
GH07G016563 0.8 Ensembl ENCODE 15.1 -82.5 -82488 0.9 IRF2 RFX1 NR2F6 BMI1 IRF1 PRDM1 BZW2 ANKMY2 GC07P016564 SOSTDC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BZW2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BZW2 Gene

16,646,131 bp from pter
16,706,523 bp from pter
60,393 bases
Plus strand

Genomic View for BZW2 Gene

Genes around BZW2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BZW2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BZW2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BZW2 Gene

Proteins for BZW2 Gene

  • Protein details for BZW2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Basic leucine zipper and W2 domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A4D123
    • Q3B779
    • Q96JW5
    • Q9H3F7

    Protein attributes for BZW2 Gene

    419 amino acids
    Molecular mass:
    48162 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI07758.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for BZW2 Gene


neXtProt entry for BZW2 Gene

Post-translational modifications for BZW2 Gene

  • Ubiquitination at posLast=117117 and posLast=232232
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BZW2 Gene

Domains & Families for BZW2 Gene

Protein Domains for BZW2 Gene

Suggested Antigen Peptide Sequences for BZW2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BZW family.
  • Belongs to the BZW family.
genes like me logo Genes that share domains with BZW2: view

No data available for Gene Families for BZW2 Gene

Function for BZW2 Gene

Molecular function for BZW2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in neuronal differentiation.

Gene Ontology (GO) - Molecular Function for BZW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25147208
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with BZW2: view

Phenotypes for BZW2 Gene

MGI mutant phenotypes for BZW2:
inferred from 1 alleles
GenomeRNAi human phenotypes for BZW2:
genes like me logo Genes that share phenotypes with BZW2: view

Animal Models for BZW2 Gene

MGI Knock Outs for BZW2:
  • Bzw2 tm1b(KOMP)Mbp

Animal Model Products

CRISPR Products

miRNA for BZW2 Gene

miRTarBase miRNAs that target BZW2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BZW2 Gene

Localization for BZW2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BZW2 gene
Compartment Confidence
cytosol 3
plasma membrane 2
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BZW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 25468996
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with BZW2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BZW2 Gene

Pathways & Interactions for BZW2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BZW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with BZW2: view

No data available for Pathways by source and SIGNOR curated interactions for BZW2 Gene

Drugs & Compounds for BZW2 Gene

No Compound Related Data Available

Transcripts for BZW2 Gene

Unigene Clusters for BZW2 Gene

Basic leucine zipper and W2 domains 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for BZW2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - - - - - - - - -
SP9: - - -
SP10: -
SP11: - - - - - - - - - -
SP12: - - - - -
SP13: - - - -
SP14: - - - - - -
SP15: - - - - - -

ExUns: 16

Relevant External Links for BZW2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BZW2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BZW2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BZW2 Gene

This gene is overexpressed in Heart - Left Ventricle (x7.9) and Muscle - Skeletal (x5.4).

Protein differential expression in normal tissues from HIPED for BZW2 Gene

This gene is overexpressed in Bone (41.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BZW2 Gene

Protein tissue co-expression partners for BZW2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BZW2 Gene:


SOURCE GeneReport for Unigene cluster for BZW2 Gene:


Evidence on tissue expression from TISSUES for BZW2 Gene

  • Heart(4.5)
  • Muscle(4.4)
  • Bone marrow(4.3)
  • Blood(4.2)
  • Kidney(4.2)
  • Intestine(3.7)
  • Nervous system(3.7)
  • Lung(3.4)
genes like me logo Genes that share expression patterns with BZW2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BZW2 Gene

Orthologs for BZW2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BZW2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BZW2 34 35
  • 99.84 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 97 (a)
-- 35
  • 89 (a)
-- 35
  • 80 (a)
(Canis familiaris)
Mammalia BZW2 34 35
  • 95.07 (n)
(Bos Taurus)
Mammalia BZW2 34 35
  • 94.51 (n)
(Mus musculus)
Mammalia Bzw2 34 16 35
  • 91.73 (n)
(Rattus norvegicus)
Mammalia Bzw2 34
  • 91.57 (n)
(Monodelphis domestica)
Mammalia BZW2 35
  • 89 (a)
(Gallus gallus)
Aves BZW2 34 35
  • 84.15 (n)
(Anolis carolinensis)
Reptilia BZW2 35
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bzw2 34
  • 79 (n)
(Danio rerio)
Actinopterygii bzw2 34 35
  • 74.94 (n)
zgc55580 34
fruit fly
(Drosophila melanogaster)
Insecta exba 35
  • 50 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G65220 34
  • 46.4 (n)
(Oryza sativa)
Liliopsida Os11g0414000 34
  • 47.48 (n)
Species where no ortholog for BZW2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BZW2 Gene

Gene Tree for BZW2 (if available)
Gene Tree for BZW2 (if available)

Paralogs for BZW2 Gene

Paralogs for BZW2 Gene Pseudogenes for BZW2 Gene

genes like me logo Genes that share paralogs with BZW2: view

Variants for BZW2 Gene

Sequence variations from dbSNP and Humsavar for BZW2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000026781 -- 16,644,385(+) TCATC(A/C)GCACC intron-variant, upstream-variant-2KB
rs1000085091 -- 16,684,345(+) AAGAG(C/T)GTCTG intron-variant
rs1000116058 -- 16,704,915(+) AATAA(G/T)GAAGA intron-variant
rs1000163335 -- 16,645,614(+) GGGAG(A/T)ATTAA upstream-variant-2KB, utr-variant-5-prime
rs1000193234 -- 16,674,180(+) CAGGC(A/G)TGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BZW2 Gene

Variant ID Type Subtype PubMed ID
dgv11223n54 CNV loss 21841781
dgv11224n54 CNV loss 21841781
dgv1874e212 CNV loss 25503493
dgv6289n100 CNV gain 25217958
esv25168 CNV loss 19812545
esv2665677 CNV deletion 23128226
esv2764004 CNV loss 21179565
esv3541254 CNV deletion 23714750
esv3612403 CNV loss 21293372
nsv1028125 CNV gain 25217958
nsv437016 CNV loss 16327808
nsv475913 CNV novel sequence insertion 20440878
nsv517565 CNV loss 19592680
nsv606326 CNV loss 21841781
nsv606327 CNV loss 21841781
nsv606334 CNV loss 21841781
nsv606336 CNV loss 21841781
nsv606337 CNV loss 21841781
nsv606338 CNV gain 21841781
nsv830912 CNV gain 17160897

Variation tolerance for BZW2 Gene

Residual Variation Intolerance Score: 18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.03; 80.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BZW2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BZW2 Gene

Disorders for BZW2 Gene

Relevant External Links for BZW2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BZW2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BZW2 Gene

Publications for BZW2 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for BZW2 Gene

Sources for BZW2 Gene

Loading form....