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Aliases for BZW2 Gene

Aliases for BZW2 Gene

  • Basic Leucine Zipper And W2 Domains 2 2 3
  • Basic Leucine Zipper And W2 Domain-Containing Protein 2 3
  • HSPC028 3
  • MSTP017 3
  • MST017 3

External Ids for BZW2 Gene

Previous GeneCards Identifiers for BZW2 Gene

  • GC07P016330
  • GC07P016430
  • GC07P016458
  • GC07P016652

Summaries for BZW2 Gene

GeneCards Summary for BZW2 Gene

BZW2 (Basic Leucine Zipper And W2 Domains 2) is a Protein Coding gene. An important paralog of this gene is BZW1.

UniProtKB/Swiss-Prot for BZW2 Gene

  • May be involved in neuronal differentiation.

Gene Wiki entry for BZW2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BZW2 Gene

Genomics for BZW2 Gene

Regulatory Elements for BZW2 Gene

Genomic Location for BZW2 Gene

Start:
16,646,131 bp from pter
End:
16,706,523 bp from pter
Size:
60,393 bases
Orientation:
Plus strand

Genomic View for BZW2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BZW2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BZW2 Gene

Proteins for BZW2 Gene

  • Protein details for BZW2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6E2-BZW2_HUMAN
    Recommended name:
    Basic leucine zipper and W2 domain-containing protein 2
    Protein Accession:
    Q9Y6E2
    Secondary Accessions:
    • A4D123
    • Q3B779
    • Q96JW5
    • Q9H3F7

    Protein attributes for BZW2 Gene

    Size:
    419 amino acids
    Molecular mass:
    48162 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI07758.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for BZW2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BZW2 Gene

Proteomics data for BZW2 Gene at MOPED

Post-translational modifications for BZW2 Gene

  • Ubiquitination at Lys117 and Lys232
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BZW2 Gene

Domains for BZW2 Gene

Protein Domains for BZW2 Gene

Suggested Antigen Peptide Sequences for BZW2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6E2

UniProtKB/Swiss-Prot:

BZW2_HUMAN :
  • Q9Y6E2
Domain:
  • Contains 1 W2 domain.
Family:
  • Belongs to the BZW family.
genes like me logo Genes that share domains with BZW2: view

No data available for Gene Families for BZW2 Gene

Function for BZW2 Gene

Molecular function for BZW2 Gene

UniProtKB/Swiss-Prot Function: May be involved in neuronal differentiation.

Gene Ontology (GO) - Molecular Function for BZW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with BZW2: view

miRNA for BZW2 Gene

miRTarBase miRNAs that target BZW2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BZW2 Gene

Localization for BZW2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BZW2 Gene COMPARTMENTS Subcellular localization image for BZW2 gene
Compartment Confidence
nucleus 2
cytoskeleton 1
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BZW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with BZW2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BZW2 Gene

Pathways for BZW2 Gene

SuperPathways for BZW2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BZW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with BZW2: view

No data available for Pathways by source for BZW2 Gene

Transcripts for BZW2 Gene

Unigene Clusters for BZW2 Gene

Basic leucine zipper and W2 domains 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BZW2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - - - - - - - - -
SP8:
SP9: - - -
SP10: -
SP11: - - - - - - - - - -
SP12: - - - - -
SP13: - - - -
SP14: - - - - - -
SP15: - - - - - -

ExUns: 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for BZW2 Gene

GeneLoc Exon Structure for
BZW2
ECgene alternative splicing isoforms for
BZW2

Expression for BZW2 Gene

mRNA expression in normal human tissues for BZW2 Gene

mRNA differential expression in normal tissues according to GTEx for BZW2 Gene

This gene is overexpressed in Heart - Left Ventricle (7.9) and Muscle - Skeletal (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BZW2 Gene

SOURCE GeneReport for Unigene cluster for BZW2 Gene Hs.487635

genes like me logo Genes that share expressions with BZW2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BZW2 Gene

Orthologs for BZW2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BZW2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BZW2 35
  • 99.84 (n)
  • 100 (a)
BZW2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BZW2 35
  • 94.51 (n)
  • 99.28 (a)
BZW2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BZW2 35
  • 95.07 (n)
  • 100 (a)
BZW2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bzw2 35
  • 91.73 (n)
  • 99.05 (a)
Bzw2 16
Bzw2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BZW2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Bzw2 35
  • 91.57 (n)
  • 98.81 (a)
chicken
(Gallus gallus)
Aves BZW2 35
  • 84.15 (n)
  • 94.12 (a)
BZW2 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BZW2 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bzw2 35
  • 79 (n)
  • 89.95 (a)
zebrafish
(Danio rerio)
Actinopterygii bzw2 35
  • 74.94 (n)
  • 84.03 (a)
bzw2 36
  • 84 (a)
OneToOne
zgc55580 35
fruit fly
(Drosophila melanogaster)
Insecta exba 36
  • 50 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G65220 35
  • 46.4 (n)
  • 34 (a)
rice
(Oryza sativa)
Liliopsida Os11g0414000 35
  • 47.48 (n)
  • 33.5 (a)
Species with no ortholog for BZW2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BZW2 Gene

ENSEMBL:
Gene Tree for BZW2 (if available)
TreeFam:
Gene Tree for BZW2 (if available)

Paralogs for BZW2 Gene

Paralogs for BZW2 Gene

Pseudogenes.org Pseudogenes for BZW2 Gene

genes like me logo Genes that share paralogs with BZW2: view

Variants for BZW2 Gene

Sequence variations from dbSNP and Humsavar for BZW2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs696279 -- 16,661,173(-) GACTG(C/T)TCTGG intron-variant, upstream-variant-2KB
rs696280 -- 16,674,132(-) accag(A/G)ggtca intron-variant
rs697509 -- 16,660,870(-) gtgga(C/T)cagat intron-variant, upstream-variant-2KB
rs697510 -- 16,660,928(-) atgca(A/G)acaaa intron-variant, upstream-variant-2KB
rs697511 -- 16,661,023(-) taaaa(G/T)aaaaa intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BZW2 Gene

Variant ID Type Subtype PubMed ID
nsv830912 CNV Gain 17160897
nsv887759 CNV Gain 21882294
nsv437016 CNV Loss 16327808
esv2665677 CNV Deletion 23128226
nsv517565 CNV Loss 19592680
esv25168 CNV Loss 19812545
nsv887760 CNV Gain 21882294

Relevant External Links for BZW2 Gene

HapMap Linkage Disequilibrium report
BZW2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BZW2 Gene

Disorders for BZW2 Gene

Relevant External Links for BZW2

Genetic Association Database (GAD)
BZW2
Human Genome Epidemiology (HuGE) Navigator
BZW2
genes like me logo Genes that share disorders with BZW2: view

No data available for UniProtKB/Swiss-Prot for BZW2 Gene

Publications for BZW2 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for BZW2 Gene

Sources for BZW2 Gene

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