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Aliases for BZW1 Gene

Aliases for BZW1 Gene

  • Basic Leucine Zipper And W2 Domains 1 2 3 5
  • BZAP45 3 4
  • Putative Protein Product Of Nbla10236 3
  • Basic Leucine-Zipper Protein BZAP45 3
  • Protein Orf 4
  • Nbla10236 3
  • KIAA0005 4

External Ids for BZW1 Gene

Previous GeneCards Identifiers for BZW1 Gene

  • GC02P199893
  • GC02P200400
  • GC02P201640
  • GC02P201879
  • GC02P201501
  • GC02P201384
  • GC02P201675
  • GC02P193528

Summaries for BZW1 Gene

GeneCards Summary for BZW1 Gene

BZW1 (Basic Leucine Zipper And W2 Domains 1) is a Protein Coding gene. Diseases associated with BZW1 include phlebotomus fever. GO annotations related to this gene include poly(A) RNA binding and binding. An important paralog of this gene is BZW2.

UniProtKB/Swiss-Prot for BZW1 Gene

  • Enhances histone H4 gene transcription but does not seem to bind DNA directly.

Gene Wiki entry for BZW1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BZW1 Gene

Genomics for BZW1 Gene

Regulatory Elements for BZW1 Gene

Promoters for BZW1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BZW1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BZW1 Gene

Chromosome:
2
Start:
200,810,594 bp from pter
End:
200,827,338 bp from pter
Size:
16,745 bases
Orientation:
Plus strand

Genomic View for BZW1 Gene

Genes around BZW1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BZW1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BZW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BZW1 Gene

Proteins for BZW1 Gene

  • Protein details for BZW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L1Q6-BZW1_HUMAN
    Recommended name:
    Basic leucine zipper and W2 domain-containing protein 1
    Protein Accession:
    Q7L1Q6
    Secondary Accessions:
    • B4DLZ8
    • B4DWF7
    • Q14281
    • Q15394
    • Q9BUY0

    Protein attributes for BZW1 Gene

    Size:
    419 amino acids
    Molecular mass:
    48043 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA02795.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BZW1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BZW1 Gene

Proteomics data for BZW1 Gene at MOPED

Post-translational modifications for BZW1 Gene

  • Ubiquitination at Lys 60, Lys 140, Lys 191, Lys 197, Lys 223, Lys 231, Lys 239, Lys 272, and Lys 399
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BZW1 Gene

Domains & Families for BZW1 Gene

Protein Domains for BZW1 Gene

Suggested Antigen Peptide Sequences for BZW1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L1Q6

UniProtKB/Swiss-Prot:

BZW1_HUMAN :
  • Contains 1 W2 domain.
  • Belongs to the BZW family.
Domain:
  • Contains 1 W2 domain.
Family:
  • Belongs to the BZW family.
genes like me logo Genes that share domains with BZW1: view

No data available for Gene Families for BZW1 Gene

Function for BZW1 Gene

Molecular function for BZW1 Gene

UniProtKB/Swiss-Prot Function:
Enhances histone H4 gene transcription but does not seem to bind DNA directly.
genes like me logo Genes that share phenotypes with BZW1: view

Animal Model Products

miRNA for BZW1 Gene

miRTarBase miRNAs that target BZW1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BZW1 Gene

Localization for BZW1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BZW1 Gene COMPARTMENTS Subcellular localization image for BZW1 gene
Compartment Confidence
mitochondrion 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BZW1 Gene

Pathways & Interactions for BZW1 Gene

SuperPathways for BZW1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BZW1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BZW1 Gene

Drugs & Compounds for BZW1 Gene

No Compound Related Data Available

Transcripts for BZW1 Gene

Unigene Clusters for BZW1 Gene

Basic leucine zipper and W2 domains 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BZW1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - - - - -
SP8: - - -
SP9: -
SP10: - - -
SP11:

Relevant External Links for BZW1 Gene

GeneLoc Exon Structure for
BZW1
ECgene alternative splicing isoforms for
BZW1

Expression for BZW1 Gene

mRNA expression in normal human tissues for BZW1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BZW1 Gene

This gene is overexpressed in Bone (33.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BZW1 Gene



SOURCE GeneReport for Unigene cluster for BZW1 Gene Hs.355983

genes like me logo Genes that share expression patterns with BZW1: view

Protein tissue co-expression partners for BZW1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BZW1 Gene

Orthologs for BZW1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BZW1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BZW1 35
  • 96.18 (n)
  • 100 (a)
BZW1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BZW1 35
  • 95.86 (n)
  • 98.45 (a)
BZW1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bzw1 35
  • 92.6 (n)
  • 100 (a)
Bzw1 16
Bzw1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BZW1 35
  • 99.33 (n)
  • 99.56 (a)
BZW1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BZW1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BZW1 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bzw1 35
  • 93.08 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves BZW1 35
  • 86.49 (n)
  • 97.36 (a)
BZW1 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BZW1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bzw1 35
  • 84.49 (n)
  • 92.6 (a)
MGC76227 35
African clawed frog
(Xenopus laevis)
Amphibia bzw1-prov 35
zebrafish
(Danio rerio)
Actinopterygii bzw1a 35
  • 77.88 (n)
  • 86.16 (a)
bzw1a 36
  • 86 (a)
OneToMany
bzw1b 36
  • 79 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2730 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002413 35
  • 56.82 (n)
  • 53.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta exba 35
  • 56.11 (n)
  • 51.49 (a)
exba 36
  • 51 (a)
OneToMany
Species with no ortholog for BZW1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BZW1 Gene

ENSEMBL:
Gene Tree for BZW1 (if available)
TreeFam:
Gene Tree for BZW1 (if available)

Paralogs for BZW1 Gene

Paralogs for BZW1 Gene

(2) SIMAP similar genes for BZW1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for BZW1 Gene

genes like me logo Genes that share paralogs with BZW1: view

Variants for BZW1 Gene

Sequence variations from dbSNP and Humsavar for BZW1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2287006 -- 200,821,377(-) GAAGC(A/G)TGTGT intron-variant
rs3178825 -- 200,823,833(+) CTTAC(A/C)CTTAG utr-variant-3-prime
rs3815501 -- 200,821,399(-) ACAAA(A/G)TGGCA intron-variant
rs2881880 -- 200,818,972(+) CTATA(C/T)TTTTC intron-variant
rs6705053 -- 200,821,943(+) GGGCG(C/T)CTGTA intron-variant

Variation tolerance for BZW1 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BZW1 Gene

HapMap Linkage Disequilibrium report
BZW1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BZW1 Gene

Disorders for BZW1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BZW1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
phlebotomus fever
  • pappataci fever
- elite association - COSMIC cancer census association via MalaCards
Search BZW1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BZW1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BZW1
genes like me logo Genes that share disorders with BZW1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BZW1 Gene

Publications for BZW1 Gene

  1. Purification and functional analysis of a novel leucine- zipper/nucleotide-fold protein, BZAP45, stimulating cell cycle regulated histone H4 gene transcription. (PMID: 11524015) Mitra P. … van Wijnen A.J. (Biochemistry 2001) 2 3 4 23 67
  2. BZW1, a novel proliferation regulator that promotes growth of salivary muocepodermoid carcinoma. (PMID: 19446954) Li S. … Situ Z. (Cancer Lett. 2009) 3 23
  3. A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium. (PMID: 10964520) Machado R.D. … Nichols W.C. (Genomics 2000) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for BZW1 Gene

Sources for BZW1 Gene

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