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Aliases for BZW1 Gene

Aliases for BZW1 Gene

  • Basic Leucine Zipper And W2 Domains 1 2 3
  • BZAP45 3 4
  • Basic Leucine Zipper And W2 Domain-Containing Protein 1 3
  • Putative Protein Product Of Nbla10236 3
  • Basic Leucine-Zipper Protein BZAP45 3
  • Protein Orf 4
  • Nbla10236 3
  • KIAA0005 4

External Ids for BZW1 Gene

Previous GeneCards Identifiers for BZW1 Gene

  • GC02P199893
  • GC02P200400
  • GC02P201640
  • GC02P201879
  • GC02P201501
  • GC02P201384
  • GC02P201675
  • GC02P193528

Summaries for BZW1 Gene

GeneCards Summary for BZW1 Gene

BZW1 (Basic Leucine Zipper And W2 Domains 1) is a Protein Coding gene. Diseases associated with BZW1 include phlebotomus fever. An important paralog of this gene is BZW2.

UniProtKB/Swiss-Prot for BZW1 Gene

  • Enhances histone H4 gene transcription but does not seem to bind DNA directly.

Gene Wiki entry for BZW1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BZW1 Gene

Genomics for BZW1 Gene

Regulatory Elements for BZW1 Gene

Genomic Location for BZW1 Gene

200,810,594 bp from pter
200,823,846 bp from pter
13,253 bases
Plus strand

Genomic View for BZW1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BZW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BZW1 Gene

Proteins for BZW1 Gene

  • Protein details for BZW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Basic leucine zipper and W2 domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DLZ8
    • B4DWF7
    • Q14281
    • Q15394
    • Q9BUY0

    Protein attributes for BZW1 Gene

    419 amino acids
    Molecular mass:
    48043 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA02795.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BZW1 Gene


neXtProt entry for BZW1 Gene

Proteomics data for BZW1 Gene at MOPED

Post-translational modifications for BZW1 Gene

  • Ubiquitination at Lys5, Lys60, Lys140, Lys191, Lys197, Lys223, Lys231, Lys239, Lys259, Lys272, and Lys399
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BZW1 Gene

Domains for BZW1 Gene

Protein Domains for BZW1 Gene

Suggested Antigen Peptide Sequences for BZW1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q7L1Q6
  • Contains 1 W2 domain.
  • Belongs to the BZW family.
genes like me logo Genes that share domains with BZW1: view

No data available for Gene Families for BZW1 Gene

Function for BZW1 Gene

Molecular function for BZW1 Gene

UniProtKB/Swiss-Prot Function: Enhances histone H4 gene transcription but does not seem to bind DNA directly.

Gene Ontology (GO) - Molecular Function for BZW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with BZW1: view

Phenotypes for BZW1 Gene

GenomeRNAi human phenotypes for BZW1:
genes like me logo Genes that share phenotypes with BZW1: view

miRNA for BZW1 Gene

miRTarBase miRNAs that target BZW1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BZW1 Gene

Localization for BZW1 Gene

Subcellular locations from

Jensen Localization Image for BZW1 Gene COMPARTMENTS Subcellular localization image for BZW1 gene
Compartment Confidence
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for BZW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10942595
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with BZW1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BZW1 Gene

Pathways for BZW1 Gene

SuperPathways for BZW1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BZW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with BZW1: view

No data available for Pathways by source for BZW1 Gene

Transcripts for BZW1 Gene

Unigene Clusters for BZW1 Gene

Basic leucine zipper and W2 domains 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BZW1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - - - - -
SP8: - - -
SP9: -
SP10: - - -

Relevant External Links for BZW1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BZW1 Gene

mRNA expression in normal human tissues for BZW1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BZW1 Gene

SOURCE GeneReport for Unigene cluster for BZW1 Gene Hs.355983

genes like me logo Genes that share expressions with BZW1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BZW1 Gene

Orthologs for BZW1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BZW1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BZW1 35
  • 99.33 (n)
  • 99.56 (a)
BZW1 36
  • 100 (a)
(Bos Taurus)
Mammalia BZW1 35
  • 96.18 (n)
  • 100 (a)
BZW1 36
  • 98 (a)
(Canis familiaris)
Mammalia BZW1 35
  • 95.86 (n)
  • 98.45 (a)
BZW1 36
  • 98 (a)
(Mus musculus)
Mammalia Bzw1 35
  • 92.6 (n)
  • 100 (a)
Bzw1 16
Bzw1 36
  • 100 (a)
(Monodelphis domestica)
Mammalia BZW1 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia BZW1 36
  • 70 (a)
(Rattus norvegicus)
Mammalia Bzw1 35
  • 93.08 (n)
  • 100 (a)
(Gallus gallus)
Aves BZW1 35
  • 86.49 (n)
  • 97.36 (a)
BZW1 36
  • 97 (a)
(Anolis carolinensis)
Reptilia BZW1 36
  • 83 (a)
African clawed frog
(Xenopus laevis)
Amphibia bzw1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia bzw1 35
  • 84.49 (n)
  • 92.6 (a)
MGC76227 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2730 35
(Danio rerio)
Actinopterygii bzw1a 35
  • 77.88 (n)
  • 86.16 (a)
bzw1a 36
  • 86 (a)
bzw1b 36
  • 79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002413 35
  • 56.82 (n)
  • 53.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta exba 35
  • 56.11 (n)
  • 51.49 (a)
exba 36
  • 51 (a)
Species with no ortholog for BZW1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BZW1 Gene

Gene Tree for BZW1 (if available)
Gene Tree for BZW1 (if available)

Paralogs for BZW1 Gene

Paralogs for BZW1 Gene

Selected SIMAP similar genes for BZW1 Gene using alignment to 7 proteins: Pseudogenes for BZW1 Gene

genes like me logo Genes that share paralogs with BZW1: view

Variants for BZW1 Gene

Sequence variations from dbSNP and Humsavar for BZW1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2287006 -- 200,821,377(-) GAAGC(A/G)TGTGT intron-variant
rs2881880 -- 200,818,972(+) CTATA(C/T)TTTTC intron-variant
rs3178825 -- 200,823,833(+) CTTAC(A/C)CTTAG utr-variant-3-prime
rs3815501 -- 200,821,399(-) ACAAA(A/G)TGGCA intron-variant
rs6705053 -- 200,821,943(+) GGGCG(C/T)CTGTA intron-variant

Relevant External Links for BZW1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BZW1 Gene

Disorders for BZW1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BZW1 Gene including...

Search for BZW1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for BZW1 Gene

genes like me logo Genes that share disorders with BZW1: view

No data available for UniProtKB/Swiss-Prot for BZW1 Gene

Publications for BZW1 Gene

  1. Purification and functional analysis of a novel leucine- zipper/nucleotide-fold protein, BZAP45, stimulating cell cycle regulated histone H4 gene transcription. (PMID: 11524015) Mitra P. … van Wijnen A.J. (Biochemistry 2001) 2 3 4 23
  2. BZW1, a novel proliferation regulator that promotes growth of salivary muocepodermoid carcinoma. (PMID: 19446954) Li S. … Situ Z. (Cancer Lett. 2009) 3 23
  3. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 3 4
  4. A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium. (PMID: 10964520) Machado R.D. … Nichols W.C. (Genomics 2000) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for BZW1 Gene

Sources for BZW1 Gene

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