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Aliases for BZW1 Gene

Aliases for BZW1 Gene

  • Basic Leucine Zipper And W2 Domains 1 2 3 5
  • BZAP45 3 4
  • Basic Leucine Zipper And W2 Domain-Containing Protein 1 3
  • Putative Protein Product Of Nbla10236 3
  • Basic Leucine-Zipper Protein BZAP45 3
  • Protein Orf 4
  • Nbla10236 3
  • KIAA0005 4

External Ids for BZW1 Gene

Previous GeneCards Identifiers for BZW1 Gene

  • GC02P199893
  • GC02P200400
  • GC02P201640
  • GC02P201879
  • GC02P201501
  • GC02P201384
  • GC02P201675
  • GC02P193528

Summaries for BZW1 Gene

GeneCards Summary for BZW1 Gene

BZW1 (Basic Leucine Zipper And W2 Domains 1) is a Protein Coding gene. Diseases associated with BZW1 include Phlebotomus Fever. GO annotations related to this gene include poly(A) RNA binding and binding. An important paralog of this gene is BZW2.

UniProtKB/Swiss-Prot for BZW1 Gene

  • Enhances histone H4 gene transcription but does not seem to bind DNA directly.

Gene Wiki entry for BZW1 Gene

Additional gene information for BZW1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BZW1 Gene

Genomics for BZW1 Gene

Regulatory Elements for BZW1 Gene

Enhancers for BZW1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H200754 1.5 Ensembl ENCODE dbSUPER 15.6 -54.0 -54027 3.8 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SP5 BZW1 LOC101927795 AOX1 PPIL3 CASP8 ALS2CR12 GC02P200777 LINC01792
GH02H200785 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -23.0 -22966 4.4 PKNOX1 FOXA2 FEZF1 YY1 GLIS2 FOS TSHZ1 ZNF623 ZNF518A MAFF PPIL3 BZW1 LOC101927795 BICD1P1 AOX1 GC02P200785
GH02H200860 1.4 ENCODE dbSUPER 11.8 +52.1 52145 6 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B PPIL3 ORC2 LOC100420110 TYW5 CLK1 NIF3L1 BZW1 LOC101927795 ENSG00000252759 HNRNPA1P35
GH02H201114 1.9 FANTOM5 ENCODE dbSUPER 7.2 +313.6 313622 19 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MEF2D SSRP1 ZNF610 PPIL3 ORC2 CLK1 CDK15 CFLAR CASP10 KCTD18 FZD7 CFLAR-AS1 FAM126B
GH02H200780 1 ENCODE dbSUPER 11.2 -28.3 -28325 3.8 STAT1 JUN CEBPB EP300 BRCA1 ATF2 RFX5 GATA3 JUND POLR2A PPIL3 BZW1 LOC101927795 BICD1P1 GC02P200785 RNU1-133P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BZW1 on UCSC Golden Path with GeneCards custom track

Promoters for BZW1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000128740 1506 2201 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143

Genomic Locations for BZW1 Gene

Genomic Locations for BZW1 Gene
chr2:200,810,594-200,827,338
(GRCh38/hg38)
Size:
16,745 bases
Orientation:
Plus strand
chr2:201,675,317-201,688,569
(GRCh37/hg19)

Genomic View for BZW1 Gene

Genes around BZW1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BZW1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BZW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BZW1 Gene

Proteins for BZW1 Gene

  • Protein details for BZW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L1Q6-BZW1_HUMAN
    Recommended name:
    Basic leucine zipper and W2 domain-containing protein 1
    Protein Accession:
    Q7L1Q6
    Secondary Accessions:
    • B4DLZ8
    • B4DWF7
    • Q14281
    • Q15394
    • Q9BUY0

    Protein attributes for BZW1 Gene

    Size:
    419 amino acids
    Molecular mass:
    48043 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA02795.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BZW1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BZW1 Gene

Post-translational modifications for BZW1 Gene

  • Ubiquitination at Lys60, Lys140, posLast=191191, Lys197, Lys223, posLast=231231, Lys239, Lys272, and posLast=399399
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BZW1 Gene

Domains & Families for BZW1 Gene

Gene Families for BZW1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BZW1 Gene

Suggested Antigen Peptide Sequences for BZW1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L1Q6

UniProtKB/Swiss-Prot:

BZW1_HUMAN :
  • Belongs to the BZW family.
Family:
  • Belongs to the BZW family.
genes like me logo Genes that share domains with BZW1: view

Function for BZW1 Gene

Molecular function for BZW1 Gene

UniProtKB/Swiss-Prot Function:
Enhances histone H4 gene transcription but does not seem to bind DNA directly.

Phenotypes From GWAS Catalog for BZW1 Gene

Gene Ontology (GO) - Molecular Function for BZW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 17353931
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with BZW1: view
genes like me logo Genes that share phenotypes with BZW1: view

miRNA for BZW1 Gene

miRTarBase miRNAs that target BZW1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BZW1 Gene

Localization for BZW1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BZW1 gene
Compartment Confidence
mitochondrion 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BZW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10942595
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with BZW1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BZW1 Gene

Pathways & Interactions for BZW1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BZW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with BZW1: view

No data available for Pathways by source and SIGNOR curated interactions for BZW1 Gene

Drugs & Compounds for BZW1 Gene

No Compound Related Data Available

Transcripts for BZW1 Gene

Unigene Clusters for BZW1 Gene

Basic leucine zipper and W2 domains 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BZW1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - - - - -
SP8: - - -
SP9: -
SP10: - - -
SP11:

Relevant External Links for BZW1 Gene

GeneLoc Exon Structure for
BZW1
ECgene alternative splicing isoforms for
BZW1

Expression for BZW1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BZW1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BZW1 Gene

This gene is overexpressed in Bone (33.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BZW1 Gene



Protein tissue co-expression partners for BZW1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BZW1 Gene:

BZW1

SOURCE GeneReport for Unigene cluster for BZW1 Gene:

Hs.355983

Evidence on tissue expression from TISSUES for BZW1 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Bone marrow(4.4)
  • Eye(4.4)
  • Lung(3.6)
  • Kidney(3.4)
  • Skin(3.3)
  • Pancreas(2.7)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with BZW1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BZW1 Gene

Orthologs for BZW1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BZW1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BZW1 33 34
  • 99.33 (n)
oppossum
(Monodelphis domestica)
Mammalia BZW1 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BZW1 33 34
  • 96.18 (n)
dog
(Canis familiaris)
Mammalia BZW1 33 34
  • 95.86 (n)
rat
(Rattus norvegicus)
Mammalia Bzw1 33
  • 93.08 (n)
mouse
(Mus musculus)
Mammalia Bzw1 33 16 34
  • 92.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BZW1 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves BZW1 33 34
  • 86.49 (n)
lizard
(Anolis carolinensis)
Reptilia BZW1 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bzw1 33
  • 84.49 (n)
MGC76227 33
African clawed frog
(Xenopus laevis)
Amphibia bzw1-prov 33
zebrafish
(Danio rerio)
Actinopterygii bzw1b 34
  • 79 (a)
OneToMany
bzw1a 33 34
  • 77.88 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2730 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002413 33
  • 56.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta exba 33 34
  • 56.11 (n)
Species where no ortholog for BZW1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BZW1 Gene

ENSEMBL:
Gene Tree for BZW1 (if available)
TreeFam:
Gene Tree for BZW1 (if available)

Paralogs for BZW1 Gene

Paralogs for BZW1 Gene

(2) SIMAP similar genes for BZW1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for BZW1 Gene

genes like me logo Genes that share paralogs with BZW1: view

Variants for BZW1 Gene

Sequence variations from dbSNP and Humsavar for BZW1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000137662 -- 200,817,763(+) CACTT(C/T)AAGTA intron-variant
rs1000181290 -- 200,811,719(+) CGACG(C/T)GGAAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000418010 -- 200,821,538(+) GTTTA(C/T)AAATT intron-variant
rs1000549560 -- 200,810,516(+) AGTAG(A/G)TGATC intron-variant, upstream-variant-2KB
rs1000609594 -- 200,819,103(+) AGAAT(A/G)TGGCC intron-variant

Variation tolerance for BZW1 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BZW1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BZW1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BZW1 Gene

Disorders for BZW1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BZW1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
phlebotomus fever
  • pappataci fever
- elite association - COSMIC cancer census association via MalaCards
Search BZW1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BZW1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BZW1
genes like me logo Genes that share disorders with BZW1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BZW1 Gene

Publications for BZW1 Gene

  1. Purification and functional analysis of a novel leucine-zipper/nucleotide-fold protein, BZAP45, stimulating cell cycle regulated histone H4 gene transcription. (PMID: 11524015) Mitra P … van Wijnen AJ (Biochemistry 2001) 2 3 4 22 60
  2. BZW1, a novel proliferation regulator that promotes growth of salivary muocepodermoid carcinoma. (PMID: 19446954) Li S … Situ Z (Cancer letters 2009) 3 22 60
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 60
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60

Products for BZW1 Gene

Sources for BZW1 Gene

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