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Aliases for BZW1 Gene

Aliases for BZW1 Gene

  • Basic Leucine Zipper And W2 Domains 1 2 3 5
  • BZAP45 3 4
  • Basic Leucine Zipper And W2 Domain-Containing Protein 1 3
  • Putative Protein Product Of Nbla10236 3
  • Basic Leucine-Zipper Protein BZAP45 3
  • Protein Orf 4
  • Nbla10236 3
  • KIAA0005 4

External Ids for BZW1 Gene

Previous GeneCards Identifiers for BZW1 Gene

  • GC02P199893
  • GC02P200400
  • GC02P201640
  • GC02P201879
  • GC02P201501
  • GC02P201384
  • GC02P201675
  • GC02P193528

Summaries for BZW1 Gene

GeneCards Summary for BZW1 Gene

BZW1 (Basic Leucine Zipper And W2 Domains 1) is a Protein Coding gene. Diseases associated with BZW1 include Phlebotomus Fever. GO annotations related to this gene include poly(A) RNA binding and binding. An important paralog of this gene is BZW2.

UniProtKB/Swiss-Prot for BZW1 Gene

  • Enhances histone H4 gene transcription but does not seem to bind DNA directly.

Gene Wiki entry for BZW1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BZW1 Gene

Genomics for BZW1 Gene

Regulatory Elements for BZW1 Gene

Enhancers for BZW1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F200754 0.8 Ensembl ENCODE 15.6 -54.0 -54027 3.8 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 FOS SP5 BZW1 LOC101927795 AOX1 PPIL3 CASP8 ALS2CR12 GC02P200777 LINC01792
GH02F200732 1.2 FANTOM5 13.9 -77.6 -77583 0.2 BZW1 LOC101927795 AOX1 CFLAR CLK1 PPIL3 CASP10 LINC01792 AOX2P
GH02F200859 0.2 ENCODE 11.8 +48.9 48946 0.1 POLR2A BZW1 LOC101927795 GC02M200864 ENSG00000252759 RNA5SP115
GH02F200860 0.6 ENCODE 11.8 +52.1 52145 6.0 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 PPIL3 NIF3L1 LOC101927795 BZW1 ORC2 LOC100420110 CASP8 ENSG00000252759 GC02M200864 RNA5SP115
GH02F200785 1.1 FANTOM5 Ensembl ENCODE 11.3 -23.0 -22966 4.4 SIN3A FEZF1 FOS TSHZ1 ZNF518A ZNF623 MAFF PBX2 GLIS1 STAT3 PPIL3 BZW1 LOC101927795 BICD1P1 AOX1 GC02P200785
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BZW1 on UCSC Golden Path with GeneCards custom track

Promoters for BZW1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001046650 1806 3201 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207

Genomic Location for BZW1 Gene

Chromosome:
2
Start:
200,810,594 bp from pter
End:
200,827,338 bp from pter
Size:
16,745 bases
Orientation:
Plus strand

Genomic View for BZW1 Gene

Genes around BZW1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BZW1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BZW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BZW1 Gene

Proteins for BZW1 Gene

  • Protein details for BZW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L1Q6-BZW1_HUMAN
    Recommended name:
    Basic leucine zipper and W2 domain-containing protein 1
    Protein Accession:
    Q7L1Q6
    Secondary Accessions:
    • B4DLZ8
    • B4DWF7
    • Q14281
    • Q15394
    • Q9BUY0

    Protein attributes for BZW1 Gene

    Size:
    419 amino acids
    Molecular mass:
    48043 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA02795.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BZW1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BZW1 Gene

Post-translational modifications for BZW1 Gene

  • Ubiquitination at Lys 60, Lys 140, Lys 191, Lys 197, Lys 223, Lys 231, Lys 239, Lys 272, and Lys 399
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BZW1 Gene

Domains & Families for BZW1 Gene

Protein Domains for BZW1 Gene

Suggested Antigen Peptide Sequences for BZW1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L1Q6

UniProtKB/Swiss-Prot:

BZW1_HUMAN :
  • Contains 1 W2 domain.
  • Belongs to the BZW family.
Domain:
  • Contains 1 W2 domain.
Family:
  • Belongs to the BZW family.
genes like me logo Genes that share domains with BZW1: view

No data available for Gene Families for BZW1 Gene

Function for BZW1 Gene

Molecular function for BZW1 Gene

UniProtKB/Swiss-Prot Function:
Enhances histone H4 gene transcription but does not seem to bind DNA directly.

Gene Ontology (GO) - Molecular Function for BZW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with BZW1: view
genes like me logo Genes that share phenotypes with BZW1: view

Animal Model Products

miRNA for BZW1 Gene

miRTarBase miRNAs that target BZW1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BZW1 Gene

Localization for BZW1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BZW1 Gene COMPARTMENTS Subcellular localization image for BZW1 gene
Compartment Confidence
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for BZW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10942595
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with BZW1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BZW1 Gene

Pathways & Interactions for BZW1 Gene

SuperPathways for BZW1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BZW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with BZW1: view

No data available for Pathways by source and SIGNOR curated interactions for BZW1 Gene

Transcripts for BZW1 Gene

Unigene Clusters for BZW1 Gene

Basic leucine zipper and W2 domains 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BZW1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - - - - -
SP8: - - -
SP9: -
SP10: - - -
SP11:

Relevant External Links for BZW1 Gene

GeneLoc Exon Structure for
BZW1
ECgene alternative splicing isoforms for
BZW1

Expression for BZW1 Gene

mRNA expression in normal human tissues for BZW1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BZW1 Gene

This gene is overexpressed in Bone (33.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BZW1 Gene



Protein tissue co-expression partners for BZW1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BZW1 Gene:

BZW1

SOURCE GeneReport for Unigene cluster for BZW1 Gene:

Hs.355983
genes like me logo Genes that share expression patterns with BZW1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BZW1 Gene

Orthologs for BZW1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BZW1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BZW1 34 35
  • 99.33 (n)
oppossum
(Monodelphis domestica)
Mammalia BZW1 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BZW1 34 35
  • 96.18 (n)
dog
(Canis familiaris)
Mammalia BZW1 34 35
  • 95.86 (n)
rat
(Rattus norvegicus)
Mammalia Bzw1 34
  • 93.08 (n)
mouse
(Mus musculus)
Mammalia Bzw1 34 16 35
  • 92.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BZW1 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves BZW1 34 35
  • 86.49 (n)
lizard
(Anolis carolinensis)
Reptilia BZW1 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bzw1 34
  • 84.49 (n)
MGC76227 34
African clawed frog
(Xenopus laevis)
Amphibia bzw1-prov 34
zebrafish
(Danio rerio)
Actinopterygii bzw1b 35
  • 79 (a)
OneToMany
bzw1a 34 35
  • 77.88 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2730 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002413 34
  • 56.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta exba 34 35
  • 56.11 (n)
Species where no ortholog for BZW1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BZW1 Gene

ENSEMBL:
Gene Tree for BZW1 (if available)
TreeFam:
Gene Tree for BZW1 (if available)

Paralogs for BZW1 Gene

Paralogs for BZW1 Gene

(2) SIMAP similar genes for BZW1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for BZW1 Gene

genes like me logo Genes that share paralogs with BZW1: view

Variants for BZW1 Gene

Sequence variations from dbSNP and Humsavar for BZW1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs111306409 -- 200,813,862(+) TAAGA(C/T)GTAGT intron-variant, upstream-variant-2KB
rs112672074 -- 200,816,657(+) CAGCT(A/G)ATTTT intron-variant
rs112992571 -- 200,817,315(+) CATAG(A/G)TGTGA intron-variant
rs113241435 -- 200,817,692(+) ACCTT(A/T)CTGTA intron-variant
rs113564918 -- 200,822,344(+) TGTTG(A/G)GTTTA utr-variant-3-prime

Variation tolerance for BZW1 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BZW1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BZW1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BZW1 Gene

Disorders for BZW1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BZW1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
phlebotomus fever
  • pappataci fever
- elite association - COSMIC cancer census association via MalaCards
Search BZW1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BZW1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BZW1
genes like me logo Genes that share disorders with BZW1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BZW1 Gene

Publications for BZW1 Gene

  1. Purification and functional analysis of a novel leucine- zipper/nucleotide-fold protein, BZAP45, stimulating cell cycle regulated histone H4 gene transcription. (PMID: 11524015) Mitra P. … van Wijnen A.J. (Biochemistry 2001) 2 3 4 22 64
  2. BZW1, a novel proliferation regulator that promotes growth of salivary muocepodermoid carcinoma. (PMID: 19446954) Li S. … Situ Z. (Cancer Lett. 2009) 3 22 64
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64

Products for BZW1 Gene

Sources for BZW1 Gene

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