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BYSL Gene

protein-coding   GIFtS: 59
GCID: GC06P041888

Bystin-Like

  See BYSL-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
bystin-like1 2
BYSTIN2
By The Ribosomal Protein S6 Gene, Drosophila, Homolog-Like2
bystin2

External Ids:    HGNC: 11571   Entrez Gene: 7052   Ensembl: ENSG000001125787   OMIM: 6038715   UniProtKB: Q138953   

Export aliases for BYSL gene to outside databases

Previous GC identifers: GC06P041891 GC06P041936 GC06P041996 GC06P041607


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BYSL Gene:
Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human
trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to
trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of
HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these
molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was
determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins
were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual
cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and
then disappeared from placental villi. (provided by RefSeq, Jul 2008)

GeneCards Summary for BYSL Gene:
BYSL (bystin-like) is a protein-coding gene. Diseases associated with BYSL include teratocarcinoma.

UniProtKB/Swiss-Prot: BYST_HUMAN, Q13895
Function: Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be
required for trophinin-dependent regulation of cell adhesion during implantation of human embryos

Gene Wiki entry for BYSL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the BYSL gene promoter:
         NF-1/L   NF-1   AML1a   SRF (504 AA)   GCNF   MyoD   E47   GCNF-1   Hand1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBYSL promoter sequence
   Search Chromatin IP Primers for BYSL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BYSL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

BYSL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BYSL gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P041888:  view genomic region     (about GC identifiers)

Start:
41,888,926 bp from pter      End:
41,900,784 bp from pter
Size:
11,859 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BYST_HUMAN, Q13895 (See protein sequence)
Recommended Name: Bystin  
Size: 437 amino acids; 49601 Da
Subunit: Binds trophinin, tastin and cytokeratins
Miscellaneous: HeLa cells lacking BYSL show a delay in the processing of the 18S rRNA component of the 40S
ribosomal subunit. HT-H cells lacking BYSL show trophinin-independent signaling through ERBB4
Sequence caution: Sequence=AAC16603.2; Type=Erroneous initiation;
Secondary accessions: Q6P5W4 Q86W44 Q96IP8

Explore the universe of human proteins at neXtProt for BYSL: NX_Q13895

Explore proteomics data for BYSL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys154, Lys398
  • Modification sites at PhosphoSitePlus

  • See BYSL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004044.3  
    ENSEMBL proteins: 
     ENSP00000230340   ENSP00000417813   ENSP00000362087  

    BYSL Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for BYSL

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007955 Bystin

    Graphical View of Domain Structure for InterPro Entry Q13895

    ProtoNet protein and cluster: Q13895

    1 Blocks protein domain: IPB007955 Bystin

    UniProtKB/Swiss-Prot: BYST_HUMAN, Q13895
    Similarity: Belongs to the bystin family


    Find genes that share domains with BYSL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BYST_HUMAN, Q13895
    Function: Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be
    required for trophinin-dependent regulation of cell adhesion during implantation of human embryos

         Genatlas biochemistry entry for BYSL:
    bystin,cytoplasmic protein binding directly to trophinin and tastin which mediate the homophilic adhesion between
    trophoblast and endometrial epithelial cells,implicated in embryo implantations process

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI9560222
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with BYSL           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BYSL:
     Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Bysl):
     mortality/aging 

    Find genes that share phenotypes with BYSL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bysltm1Mfu for BYSL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BYSL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BYSL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BYSL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BYSL

    miRNA
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    miRTarBase miRNAs that target BYSL:
    hsa-mir-378a-3p (MIRT043945), hsa-mir-192-5p (MIRT026739), hsa-mir-128-3p (MIRT022085), hsa-mir-320a (MIRT044510), hsa-mir-16-5p (MIRT031885)

    Block miRNA regulation of human, mouse, rat BYSL using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate BYSL:
    hsa-miR-4323 hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidBYSL 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for BYSL 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BYSL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BYST_HUMAN, Q13895: Cytoplasm. Nucleus, nucleolus. Note=Associated with 40S ribosomal subunits
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--
    GO:0045177apical part of cell IEA--

    Find genes that share ontologies with BYSL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BYSL
    Interactions:

        GeneGlobe Interaction Network for BYSL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BYSL (Q138951, 2, 3 ENSP000002303404) via UniProtKB, MINT, STRING, and/or I2D (see all 336)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA--
    GO:0001701in utero embryonic development ----
    GO:0001825blastocyst formation ----
    GO:0001829trophectodermal cell differentiation IEA--
    GO:0007155cell adhesion TAS9560222

    Find genes that share ontologies with BYSL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BYSL (BYST)

    1 Novoseek inferred chemical compound relationship for BYSL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 11.1 2 17495530 (1), 9560222 (1)



    Find genes that share compounds with BYSL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BYSL gene: 
    NM_004053.3  

    Unigene Cluster for BYSL:

    Bystin-like
    Hs.106880  [show with all ESTs]
    Unigene Representative Sequence: AK095253
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000230340(uc003orl.3) ENST00000494032 ENST00000489290 ENST00000475702
    ENST00000372996
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate BYSL:
    hsa-miR-4323 hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidBYSL 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BYSL
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    Addgene plasmids for BYSL 
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    OriGene qPCR primer pairs and template standards for BYSL
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BYSL
      QuantiTect SYBR Green Assays in human, mouse, rat BYSL
      QuantiFast Probe-based Assays in human, mouse, rat BYSL

    Additional mRNA sequence: 

    AK095253.1 AK314147.1 BC007340.2 BC050645.1 BC062627.1 L36720.2 

    8 DOTS entries:

    DT.414559  DT.95115597  DT.100794499  DT.113635  DT.100030969  DT.100030970  DT.95115601  DT.86855253 

    Selected AceView cDNA sequences (see all 306):

    BM811352 CR604574 BU175029 CR590222 BU169238 BQ054755 BQ672556 F09196 
    BQ643240 BM714173 CR624209 BU150019 BE257545 BX462532 BQ642184 BM755868 
    BU191035 BQ642074 BM770349 BM741219 CR590918 BU158511 BC007340 BM014796 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BYSL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAAAATTG
    BYSL Expression
    About this image


    BYSL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    BYSL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BYSL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.106880

    UniProtKB/Swiss-Prot: BYST_HUMAN, Q13895
    Tissue specificity: Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the
    syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface.
    After week 10, the level decreased and then disappeared from placental villi

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BYSL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BYSL gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bysl1 , 5 bystin-like1, 5 85.63(n)1
    90.83(a)1
      17 (23.63 cM)5
    534141  NM_016859.31  NP_058555.31 
     475993315 
    chicken
    (Gallus gallus)
    Aves BYSL1 bystin-like 73.11(n)
    76.81(a)
      419927  XM_418047.4  XP_418047.3 
    lizard
    (Anolis carolinensis)
    Reptilia BYSL6
    bystin-like
    69(a)
    1 ↔ 1
    4(119264652-119277025)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480237162   -- 75.99(n)    48023716 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053134.12   -- 78.71(n)   394081  BC053134.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bys1 , 3 by S61 63(a)3
    57.6(n)1
    54.16(a)1
      1 7C23
    317011  NM_078519.21  NP_511074.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F57B9.53
    byn-11
    byn-11 59(a)3
    56.02(n)1
    52.83(a)1
      III(7003761-7007409)3
    1759681  NM_066109.31  NP_498510.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ENP1(YBR247C)4
    ENP11
    Protein associated with U3 and U14 snoRNAs, required more4
    ENP11
    48.17(n)1
    40.48(a)1
      2(714455-713004)4
    8525491, 4  NP_009806.31  NP_009806.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G316601 AT1G31660 53.85(n)
    45.66(a)
      840053  NM_102901.3  NP_174447.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g03524001 Os09g0352400 53.65(n)
    48.01(a)
      4346824  NM_001069493.1  NP_001062958.1 


    ENSEMBL Gene Tree for BYSL (if available)
    TreeFam Gene Tree for BYSL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BYSL (see all 282)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs578007341,2
    C--41890882(+) TTTTT-/TGAGAC 1 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs801927831,2
    --41890882(+) TTTTCC/TTTTTT 1 -- int10--------
    rs24797241,2
    C,F,A,H--41890982(+) tccagC/Tcgtct 1 -- int115Minor allele frequency- T:0.40NS EA NA WA CSA 778
    rs1167711731,2
    F--41891036(+) CACCAT/CGTCCA 1 -- int11Minor allele frequency- C:0.03WA 118
    rs355175921,2
    C--41891049(+) TTTTTT/-GAGCC 1 -- int11Minor allele frequency- -:0.50NA 2
    rs774914761,2
    F--41891410(+) CAAACG/CACCCT 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1419287791,2
    --41891412(+) AACGAC/TCCTCC 1 -- int10--------
    rs1838233291,2
    --41891463(+) CTACTA/GCACCC 1 -- int10--------
    rs728671831,2
    C--41891471(+) CCCTGC/TCGTGT 1 -- int10--------
    rs610275841,2
    C--41891485(+) ATACTC/GTCTAC 1 -- int13Minor allele frequency- G:0.06CSA WA EA 240

    HapMap Linkage Disequilibrium report for BYSL (41888926 - 41900784 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BYSL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830646CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BYSL
    DNA2.0 Custom Variant and Variant Library Synthesis for BYSL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603871    OMIM disorders: --

    1 disease for BYSL:    
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    teratocarcinoma


    Find genes that share disorders with BYSL           About GenesLikeMe

    2 Novoseek inferred disease relationships for BYSL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 17.2 3 18218589 (1), 17381424 (1), 17109495 (1)
    cancer 2.26 6 17381424 (2), 19687802 (1), 17917702 (1), 16245277 (1) (see all 5)

    Genetic Association Database (GAD): BYSL
    Human Genome Epidemiology (HuGE) Navigator: BYSL (3 documents)

    Export disorders for BYSL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BYSL gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with BYSL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis. (PubMed id 17381424)1, 2, 3, 9 Miyoshi M.... Nadano D. (Biochem. J. 2007)
    2. A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells. (PubMed id 9560222)1, 2, 9 Suzuki N.... Fukuda M.N. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation. (PubMed id 17360433)1, 2, 9 Sugihara K.... Fukuda M.N. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    4. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. (PubMed id 19820697)1, 4 Soranzo N....Gieger C. (Nat. Genet. 2009)
    5. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PubMed id 19862010)1, 4 Ganesh S.K....Lin J.P. (Nat. Genet. 2009)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Assignment1 of the bystin gene BYSL to human chromosome band 6p21.1 by in situ hybridization. (PubMed id 9925933)1, 3 Pack S.D....Fukuda M.N. (Cytogenet. Cell Genet. 1998)
    9. The role of bystin in embryo implantation and in ribosomal biogenesis. (PubMed id 17917702)1, 9 Fukuda M.N....Nadano D. (Cell. Mol. Life Sci. 2008)
    10. Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta. (PubMed id 10026108)1, 9 Suzuki N....Fukuda M.N. (Biol. Reprod. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 705 HGNC: 1157 AceView: BYSL Ensembl:ENSG00000112578 euGenes: HUgn705
    ECgene: BYSL H-InvDB: BYSL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BYSL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BYSL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BYSL gene:
    Search GeneIP for patents involving BYSL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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