Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BYSL Gene

Aliases for BYSL Gene

  • Bystin Like 2 3 5
  • Bystin-Like 2 3
  • By The Ribosomal Protein S6 Gene, Drosophila, Homolog-Like 3
  • BYSTIN 3

External Ids for BYSL Gene

Previous GeneCards Identifiers for BYSL Gene

  • GC06P041891
  • GC06P041936
  • GC06P041996
  • GC06P041607

Summaries for BYSL Gene

Entrez Gene Summary for BYSL Gene

  • Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008]

GeneCards Summary for BYSL Gene

BYSL (Bystin Like) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for BYSL Gene

  • Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos.

Gene Wiki entry for BYSL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BYSL Gene

Genomics for BYSL Gene

Regulatory Elements for BYSL Gene

Enhancers for BYSL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BYSL on UCSC Golden Path with GeneCards custom track

Genomic Location for BYSL Gene

Chromosome:
6
Start:
41,907,847 bp from pter
End:
41,933,046 bp from pter
Size:
25,200 bases
Orientation:
Plus strand

Genomic View for BYSL Gene

Genes around BYSL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BYSL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BYSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BYSL Gene

Proteins for BYSL Gene

  • Protein details for BYSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13895-BYST_HUMAN
    Recommended name:
    Bystin
    Protein Accession:
    Q13895
    Secondary Accessions:
    • Q6P5W4
    • Q86W44
    • Q96IP8

    Protein attributes for BYSL Gene

    Size:
    437 amino acids
    Molecular mass:
    49601 Da
    Quaternary structure:
    • Binds trophinin, tastin and cytokeratins.
    Miscellaneous:
    • HeLa cells lacking BYSL show a delay in the processing of the 18S rRNA component of the 40S ribosomal subunit. HT-H cells lacking BYSL show trophinin-independent signaling through ERBB4.
    SequenceCaution:
    • Sequence=AAC16603.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for BYSL Gene

Proteomics data for BYSL Gene at MOPED

Post-translational modifications for BYSL Gene

  • Ubiquitination at Lys 154 and Lys 398
  • Modification sites at PhosphoSitePlus

Other Protein References for BYSL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BYSL Gene

Domains & Families for BYSL Gene

Protein Domains for BYSL Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BYSL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13895

UniProtKB/Swiss-Prot:

BYST_HUMAN :
  • Belongs to the bystin family.
Family:
  • Belongs to the bystin family.
genes like me logo Genes that share domains with BYSL: view

No data available for Gene Families for BYSL Gene

Function for BYSL Gene

Molecular function for BYSL Gene

GENATLAS Biochemistry:
bystin,cytoplasmic protein binding directly to trophinin and tastin which mediate the homophilic adhesion between trophoblast and endometrial epithelial cells,implicated in embryo implantations process
UniProtKB/Swiss-Prot Function:
Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos.
genes like me logo Genes that share phenotypes with BYSL: view

Animal Models for BYSL Gene

MGI Knock Outs for BYSL:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BYSL Gene

Localization for BYSL Gene

Subcellular locations from UniProtKB/Swiss-Prot for BYSL Gene

Cytoplasm. Nucleus, nucleolus. Note=Associated with 40S ribosomal subunits.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BYSL Gene COMPARTMENTS Subcellular localization image for BYSL gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3

Gene Ontology (GO) - Cellular Components for BYSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,TAS 9560222
GO:0042995 cell projection IEA --
GO:0045177 apical part of cell IEA --
genes like me logo Genes that share ontologies with BYSL: view

Pathways & Interactions for BYSL Gene

genes like me logo Genes that share pathways with BYSL: view

Pathways by source for BYSL Gene

Gene Ontology (GO) - Biological Process for BYSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA --
GO:0001825 blastocyst formation IEA --
GO:0001829 trophectodermal cell differentiation IEA --
GO:0006364 rRNA processing TAS --
GO:0071222 cellular response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with BYSL: view

No data available for SIGNOR curated interactions for BYSL Gene

Drugs & Compounds for BYSL Gene

(1) Drugs for BYSL Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with BYSL: view

Transcripts for BYSL Gene

Unigene Clusters for BYSL Gene

Bystin-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BYSL Gene

No ASD Table

Relevant External Links for BYSL Gene

GeneLoc Exon Structure for
BYSL
ECgene alternative splicing isoforms for
BYSL

Expression for BYSL Gene

mRNA expression in normal human tissues for BYSL Gene

Protein differential expression in normal tissues from HIPED for BYSL Gene

This gene is overexpressed in Lung (41.7) and Pancreas (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BYSL Gene



SOURCE GeneReport for Unigene cluster for BYSL Gene Hs.106880

mRNA Expression by UniProt/SwissProt for BYSL Gene

Q13895-BYST_HUMAN
Tissue specificity: Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi.
genes like me logo Genes that share expression patterns with BYSL: view

Protein tissue co-expression partners for BYSL Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BYSL Gene

Orthologs for BYSL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BYSL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BYSL 35
  • 89.12 (n)
  • 93.56 (a)
BYSL 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BYSL 35
  • 90.08 (n)
  • 93.36 (a)
BYSL 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bysl 35
  • 85.63 (n)
  • 90.83 (a)
Bysl 16
Bysl 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bysl 35
  • 86.77 (n)
  • 91.06 (a)
oppossum
(Monodelphis domestica)
Mammalia BYSL 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BYSL 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves BYSL 35
  • 73.11 (n)
  • 76.81 (a)
BYSL 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BYSL 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bysl 35
  • 68.06 (n)
  • 74.77 (a)
Str.1362 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
bysl 35
  • 73.35 (n)
  • 77.05 (a)
bysl 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bys 37
  • 63 (a)
bys 35
  • 57.6 (n)
  • 54.16 (a)
bys 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002923 35
  • 58.58 (n)
  • 57.78 (a)
worm
(Caenorhabditis elegans)
Secernentea F57B9.5 37
  • 59 (a)
byn-1 35
  • 56.02 (n)
  • 52.83 (a)
byn-1 36
  • 47 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL044W 35
  • 52.71 (n)
  • 43.06 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06622g 35
  • 48.36 (n)
  • 41.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENP1 35
  • 48.17 (n)
  • 40.48 (a)
ENP1 36
  • 34 (a)
OneToOne
ENP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G31660 35
  • 53.85 (n)
  • 45.66 (a)
soybean
(Glycine max)
eudicotyledons Gma.14515 35
rice
(Oryza sativa)
Liliopsida Os09g0352400 35
  • 53.65 (n)
  • 48.01 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.29234 35
corn
(Zea mays)
Liliopsida Zm.5487 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08323 35
  • 49.69 (n)
  • 41.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC13G1.09 35
  • 50.2 (n)
  • 47.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7954 36
  • 53 (a)
OneToOne
Species with no ortholog for BYSL:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for BYSL Gene

ENSEMBL:
Gene Tree for BYSL (if available)
TreeFam:
Gene Tree for BYSL (if available)

Paralogs for BYSL Gene

No data available for Paralogs for BYSL Gene

Variants for BYSL Gene

Sequence variations from dbSNP and Humsavar for BYSL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2296916 - 41,927,412(+) AGGAC(A/G)AGGAG reference, missense
rs3828855 - 41,932,668(-) GCGGG(A/G)GACTG reference, missense
rs1053089 -- 41,931,479(+) CGTTG(C/G)TGAAT reference, missense
rs1053133 -- 41,932,887(+) TCCCT(C/T)TTCCA utr-variant-3-prime
rs1053137 -- 41,932,919(+) TAGTT(C/T)TGAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BYSL Gene

Variant ID Type Subtype PubMed ID
nsv830646 CNV Loss 17160897

Variation tolerance for BYSL Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.68; 78.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BYSL Gene

Disorders for BYSL Gene

Relevant External Links for BYSL

Genetic Association Database (GAD)
BYSL
Human Genome Epidemiology (HuGE) Navigator
BYSL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BYSL

No disorders were found for BYSL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BYSL Gene

Publications for BYSL Gene

  1. Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis. (PMID: 17381424) Miyoshi M. … Nadano D. (Biochem. J. 2007) 2 3 4 23 67
  2. The role of bystin in embryo implantation and in ribosomal biogenesis. (PMID: 17917702) Fukuda M.N. … Nadano D. (Cell. Mol. Life Sci. 2008) 3 23
  3. Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation. (PMID: 17360433) Sugihara K. … Fukuda M.N. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 23
  4. Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnancies: possible role of human chorionic gonadotrophin on ectopic pregnancy. (PMID: 14633596) Nakayama J. … Fukuda M.N. (Am. J. Pathol. 2003) 3 23
  5. Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta. (PMID: 10026108) Suzuki N. … Fukuda M.N. (Biol. Reprod. 1999) 3 23

Products for BYSL Gene

Sources for BYSL Gene

Content