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Aliases for BYSL Gene

Aliases for BYSL Gene

  • Bystin-Like 2 3
  • By The Ribosomal Protein S6 Gene, Drosophila, Homolog-Like 3
  • BYSTIN 3

External Ids for BYSL Gene

Previous GeneCards Identifiers for BYSL Gene

  • GC06P041891
  • GC06P041936
  • GC06P041996
  • GC06P041607

Summaries for BYSL Gene

Entrez Gene Summary for BYSL Gene

  • Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008]

GeneCards Summary for BYSL Gene

BYSL (Bystin-Like) is a Protein Coding gene. Diseases associated with BYSL include teratocarcinoma.

UniProtKB/Swiss-Prot for BYSL Gene

  • Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos.

Gene Wiki entry for BYSL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BYSL Gene

Genomics for BYSL Gene

Regulatory Elements for BYSL Gene

Genomic Location for BYSL Gene

Start:
41,921,188 bp from pter
End:
41,933,046 bp from pter
Size:
11,859 bases
Orientation:
Plus strand

Genomic View for BYSL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BYSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BYSL Gene

Proteins for BYSL Gene

  • Protein details for BYSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13895-BYST_HUMAN
    Recommended name:
    Bystin
    Protein Accession:
    Q13895
    Secondary Accessions:
    • Q6P5W4
    • Q86W44
    • Q96IP8

    Protein attributes for BYSL Gene

    Size:
    437 amino acids
    Molecular mass:
    49601 Da
    Quaternary structure:
    • Binds trophinin, tastin and cytokeratins
    Miscellaneous:
    • HeLa cells lacking BYSL show a delay in the processing of the 18S rRNA component of the 40S ribosomal subunit. HT-H cells lacking BYSL show trophinin-independent signaling through ERBB4
    SequenceCaution:
    • Sequence=AAC16603.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for BYSL Gene

Proteomics data for BYSL Gene at MOPED

Post-translational modifications for BYSL Gene

  • Ubiquitination at Lys154 and Lys398
  • Modification sites at PhosphoSitePlus

Other Protein References for BYSL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BYSL Gene

Domains for BYSL Gene

Protein Domains for BYSL Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BYSL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13895

UniProtKB/Swiss-Prot:

BYST_HUMAN :
  • Q13895
Family:
  • Belongs to the bystin family.
genes like me logo Genes that share domains with BYSL: view

No data available for Gene Families for BYSL Gene

Function for BYSL Gene

Molecular function for BYSL Gene

GENATLAS Biochemistry: bystin,cytoplasmic protein binding directly to trophinin and tastin which mediate the homophilic adhesion between trophoblast and endometrial epithelial cells,implicated in embryo implantations process
UniProtKB/Swiss-Prot Function: Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos.

Gene Ontology (GO) - Molecular Function for BYSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with BYSL: view

Phenotypes for BYSL Gene

MGI mutant phenotypes for BYSL:
inferred from 1 alleles
GenomeRNAi human phenotypes for BYSL:
genes like me logo Genes that share phenotypes with BYSL: view

Animal Models for BYSL Gene

MGI Knock Outs for BYSL:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BYSL Gene

Localization for BYSL Gene

Subcellular locations from UniProtKB/Swiss-Prot for BYSL Gene

Cytoplasm. Nucleus, nucleolus. Note=Associated with 40S ribosomal subunits.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BYSL Gene COMPARTMENTS Subcellular localization image for BYSL gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for BYSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with BYSL: view

Pathways for BYSL Gene

SuperPathways for BYSL Gene

No Data Available

Gene Ontology (GO) - Biological Process for BYSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA --
GO:0001701 in utero embryonic development --
GO:0001825 blastocyst formation --
GO:0001829 trophectodermal cell differentiation IEA --
GO:0007155 cell adhesion TAS 9560222
genes like me logo Genes that share ontologies with BYSL: view

No data available for Pathways by source for BYSL Gene

Compounds for BYSL Gene

(1) Novoseek inferred chemical compound relationships for BYSL Gene

Compound -log(P) Hits PubMed IDs
tyrosine 11.1 2
genes like me logo Genes that share compounds with BYSL: view

Transcripts for BYSL Gene

Unigene Clusters for BYSL Gene

Bystin-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BYSL Gene

No ASD Table

Relevant External Links for BYSL Gene

GeneLoc Exon Structure for
BYSL
ECgene alternative splicing isoforms for
BYSL

Expression for BYSL Gene

mRNA expression in normal human tissues for BYSL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BYSL Gene

SOURCE GeneReport for Unigene cluster for BYSL Gene Hs.106880

mRNA Expression by UniProt/SwissProt for BYSL Gene

Q13895-BYST_HUMAN
Tissue specificity: Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi
genes like me logo Genes that share expressions with BYSL: view

No data available for mRNA differential expression in normal tissues for BYSL Gene

Orthologs for BYSL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BYSL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BYSL 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BYSL 35
  • 89.12 (n)
  • 93.56 (a)
BYSL 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BYSL 35
  • 90.08 (n)
  • 93.36 (a)
BYSL 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bysl 35
  • 85.63 (n)
  • 90.83 (a)
Bysl 16
Bysl 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BYSL 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bysl 35
  • 86.77 (n)
  • 91.06 (a)
chicken
(Gallus gallus)
Aves BYSL 35
  • 73.11 (n)
  • 76.81 (a)
BYSL 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BYSL 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bysl 35
  • 68.06 (n)
  • 74.77 (a)
Str.1362 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
bysl 35
  • 73.35 (n)
  • 77.05 (a)
bysl 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002923 35
  • 58.58 (n)
  • 57.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta bys 35
  • 57.6 (n)
  • 54.16 (a)
bys 36
  • 50 (a)
OneToOne
bys 37
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea byn-1 35
  • 56.02 (n)
  • 52.83 (a)
byn-1 36
  • 47 (a)
OneToOne
F57B9.5 37
  • 59 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL044W 35
  • 52.71 (n)
  • 43.06 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENP1 35
  • 48.17 (n)
  • 40.48 (a)
ENP1 36
  • 34 (a)
OneToOne
ENP1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06622g 35
  • 48.36 (n)
  • 41.08 (a)
soybean
(Glycine max)
eudicotyledons Gma.14515 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G31660 35
  • 53.85 (n)
  • 45.66 (a)
corn
(Zea mays)
Liliopsida Zm.5487 35
rice
(Oryza sativa)
Liliopsida Os09g0352400 35
  • 53.65 (n)
  • 48.01 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.29234 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08323 35
  • 49.69 (n)
  • 41.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC13G1.09 35
  • 50.2 (n)
  • 47.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7954 36
  • 53 (a)
OneToOne
Species with no ortholog for BYSL:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for BYSL Gene

ENSEMBL:
Gene Tree for BYSL (if available)
TreeFam:
Gene Tree for BYSL (if available)

Paralogs for BYSL Gene

No data available for Paralogs for BYSL Gene

Variants for BYSL Gene

Sequence variations from dbSNP and Humsavar for BYSL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1053089 -- 41,931,479(+) CGTTG(C/G)TGAAT reference, missense
rs1053133 -- 41,932,887(+) TCCCT(C/T)TTCCA utr-variant-3-prime
rs1053137 -- 41,932,919(+) TAGTT(C/T)TGAGA utr-variant-3-prime
rs1053156 -- 41,932,991(+) TTTTT(C/T)TATGG utr-variant-3-prime
rs2296916 - 41,927,412(+) AGGAC(A/G)AGGAG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for BYSL Gene

Variant ID Type Subtype PubMed ID
nsv830646 CNV Loss 17160897

Relevant External Links for BYSL Gene

HapMap Linkage Disequilibrium report
BYSL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BYSL Gene

Disorders for BYSL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BYSL Gene including...

Search for BYSL Gene in MalaCards »

(2) Novoseek inferred disease relationships for BYSL Gene

Disease -log(P) Hits PubMed IDs
shock 17.2 3
cancer 2.26 6

Relevant External Links for BYSL

Genetic Association Database (GAD)
BYSL
Human Genome Epidemiology (HuGE) Navigator
BYSL
genes like me logo Genes that share disorders with BYSL: view

No data available for UniProtKB/Swiss-Prot for BYSL Gene

Publications for BYSL Gene

  1. Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis. (PMID: 17381424) Miyoshi M. … Nadano D. (Biochem. J. 2007) 2 3 4 23
  2. A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells. (PMID: 9560222) Suzuki N. … Fukuda M.N. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  3. Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation. (PMID: 17360433) Sugihara K. … Fukuda M.N. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for BYSL Gene

Sources for BYSL Gene

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