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Aliases for BUD31 Gene

Aliases for BUD31 Gene

  • BUD31 Homolog 2 3 5
  • Functional Spliceosome-Associated Protein 17 2 3
  • Protein G10 Homolog 3 4
  • Protein EDG-2 3 4
  • EDG2 3 4
  • G10 Maternal Transcript Homolog (Xenopus Laevis) 2
  • G10 Maternal Transcript Homolog 3
  • BUD31 Homolog (S. Cerevisiae) 2
  • Maternal G10 Transcript 3
  • BUD31 Homolog (Yeast) 2
  • Protein BUD31 Homolog 3
  • YCR063W 3
  • FSAP17 3
  • Cwc14 3
  • EDG-2 3
  • G10 3

External Ids for BUD31 Gene

Previous HGNC Symbols for BUD31 Gene

  • G10

Previous GeneCards Identifiers for BUD31 Gene

  • GC07P098844
  • GC07P099006
  • GC07P093642

Summaries for BUD31 Gene

GeneCards Summary for BUD31 Gene

BUD31 (BUD31 Homolog) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity.

Additional gene information for BUD31 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BUD31 Gene

Genomics for BUD31 Gene

GeneHancer (GH) Regulatory Elements for BUD31 Gene

Promoters and enhancers for BUD31 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I099406 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 0.0 -23 4.7 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 BUD31 PDAP1 ZSCAN25 TRIM4 SMURF1 ZNF394 ZNF3 ZNF655 ARPC1B ATP5MF
GH07I099557 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 15.6 +152.3 152345 7.9 ZFP64 DMAP1 YY1 E2F8 ZNF143 SP3 MEF2D SSRP1 GLIS1 NBN ZNF655 FAM200A ZSCAN25 ZNF3 TRIM4 PTCD1 LOC101927550 ZNF394 LOC100419643 TRRAP
GH07I099373 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12 -30.3 -30333 9 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 ARPC1B ZSCAN25 TRRAP ZNF655 ZNF394 TRIM4 PTCD1 LOC101927550 ZNF3 STAG3L5P
GH07I099471 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.9 +64.0 63963 3 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF789 ZSCAN25 PPP1R35 PTCD1 MEPCE TRRAP STAG3L5P TRIM4 LOC101927550 AP4M1
GH07I099324 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 -80.0 -80003 7.3 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 NFYC MEF2D ARPC1A TRRAP ZSCAN25 ENSG00000242798 ZNF655 ZNF3 ARPC1B CPSF4 PTCD1 TRIM4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BUD31 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BUD31 gene promoter:

Genomic Locations for BUD31 Gene

Genomic Locations for BUD31 Gene
chr7:99,408,641-99,419,616
(GRCh38/hg38)
Size:
10,976 bases
Orientation:
Plus strand
chr7:99,006,264-99,017,239
(GRCh37/hg19)

Genomic View for BUD31 Gene

Genes around BUD31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BUD31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BUD31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BUD31 Gene

Proteins for BUD31 Gene

  • Protein details for BUD31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41223-BUD31_HUMAN
    Recommended name:
    Protein BUD31 homolog
    Protein Accession:
    P41223
    Secondary Accessions:
    • A4D274
    • B7Z4S9
    • D6W5S6
    • Q6IB53
    • Q9UDV1

    Protein attributes for BUD31 Gene

    Size:
    144 amino acids
    Molecular mass:
    17000 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for BUD31 Gene

    Alternative splice isoforms for BUD31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BUD31 Gene

Post-translational modifications for BUD31 Gene

No data available for DME Specific Peptides for BUD31 Gene

Domains & Families for BUD31 Gene

Protein Domains for BUD31 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BUD31 Gene

Graphical View of Domain Structure for InterPro Entry

P41223

UniProtKB/Swiss-Prot:

BUD31_HUMAN :
  • Belongs to the BUD31 (G10) family.
Family:
  • Belongs to the BUD31 (G10) family.
genes like me logo Genes that share domains with BUD31: view

Function for BUD31 Gene

Phenotypes From GWAS Catalog for BUD31 Gene

Gene Ontology (GO) - Molecular Function for BUD31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity TAS 7841202
GO:0005515 protein binding IPI 25091737
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 25091737
GO:0035257 nuclear hormone receptor binding IDA 25091737
genes like me logo Genes that share ontologies with BUD31: view
genes like me logo Genes that share phenotypes with BUD31: view

Animal Model Products

miRNA for BUD31 Gene

miRTarBase miRNAs that target BUD31

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BUD31 Gene

Localization for BUD31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BUD31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BUD31 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 2
plasma membrane 1
peroxisome 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Microtubules (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BUD31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 colocalizes_with nuclear chromatin IDA 25091737
GO:0005634 nucleus IEA,TAS 7841202
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IBA --
genes like me logo Genes that share ontologies with BUD31: view

Pathways & Interactions for BUD31 Gene

genes like me logo Genes that share pathways with BUD31: view

Pathways by source for BUD31 Gene

Gene Ontology (GO) - Biological Process for BUD31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006357 regulation of transcription by RNA polymerase II TAS 7841202
GO:2000825 positive regulation of androgen receptor activity IDA 25091737
genes like me logo Genes that share ontologies with BUD31: view

No data available for SIGNOR curated interactions for BUD31 Gene

Drugs & Compounds for BUD31 Gene

No Compound Related Data Available

Transcripts for BUD31 Gene

Unigene Clusters for BUD31 Gene

BUD31 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BUD31 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for BUD31 Gene

GeneLoc Exon Structure for
BUD31
ECgene alternative splicing isoforms for
BUD31

Expression for BUD31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BUD31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BUD31 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BUD31 Gene



Protein tissue co-expression partners for BUD31 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BUD31 Gene:

BUD31

SOURCE GeneReport for Unigene cluster for BUD31 Gene:

Hs.380233

Evidence on tissue expression from TISSUES for BUD31 Gene

  • Nervous system(3)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with BUD31: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BUD31 Gene

Orthologs for BUD31 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BUD31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BUD31 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
OneToMany
BUD31 33
  • 93.29 (n)
-- 34
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Bud31 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BUD31 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BUD31 34 33
  • 93.52 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bud31 33
  • 89.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BUD31 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves BUD31 34 33
  • 81.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BUD31 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bud31 33
  • 79.17 (n)
Str.6577 33
African clawed frog
(Xenopus laevis)
Amphibia g10-prov 33
zebrafish
(Danio rerio)
Actinopterygii bud31 33 34
  • 78.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(1)10Bb 33 34
  • 75.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002301 33
  • 74.54 (n)
worm
(Caenorhabditis elegans)
Secernentea C07A9.2 33 34
  • 65.73 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08800g 33
  • 58.33 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUD31 33 34 36
  • 56.25 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G21110 33
  • 64.8 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.371 33
rice
(Oryza sativa)
Liliopsida Os05g0446300 33
  • 64.57 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.6375 33
corn
(Zea mays)
Liliopsida Zm.7011 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 84 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00417 33
  • 59.21 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cwf14 33
  • 55.71 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3886 33
Species where no ortholog for BUD31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BUD31 Gene

ENSEMBL:
Gene Tree for BUD31 (if available)
TreeFam:
Gene Tree for BUD31 (if available)

Paralogs for BUD31 Gene

Pseudogenes.org Pseudogenes for BUD31 Gene

genes like me logo Genes that share paralogs with BUD31: view

No data available for Paralogs for BUD31 Gene

Variants for BUD31 Gene

Sequence variations from dbSNP and Humsavar for BUD31 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs886043246 uncertain-significance, not specified 99,420,092(+) G/A downstream_transcript_variant
rs1000026358 -- 99,416,421(+) T/G intron_variant
rs1000087151 -- 99,410,930(+) A/G intron_variant
rs1000375588 -- 99,410,460(+) G/A intron_variant
rs1000698508 -- 99,409,159(+) C/T 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BUD31 Gene

Variant ID Type Subtype PubMed ID
nsv5864 CNV insertion 18451855
nsv831069 CNV loss 17160897
nsv951382 CNV deletion 24416366

Variation tolerance for BUD31 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BUD31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BUD31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BUD31 Gene

Disorders for BUD31 Gene

Additional Disease Information for BUD31

No disorders were found for BUD31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BUD31 Gene

Publications for BUD31 Gene

  1. Characterization of edg-2, a human homologue of the Xenopus maternal transcript G10 from endothelial cells. (PMID: 7841202) Hla T … Maciag T (Biochimica et biophysica acta 1995) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for BUD31 Gene

Sources for BUD31 Gene

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