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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BUB3 Gene

protein-coding   GIFtS: 67
GCID: GC10P124903

BUB3 Mitotic Checkpoint Protein

(Previous names: BUB3 (budding uninhibited by benzimidazoles 3, yeast) homolog,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BUB3 Mitotic Checkpoint Protein1 2     Budding Uninhibited By Benomyl2
BUB3 (Budding Uninhibited By Benzimidazoles 3, Yeast) Homolog1     Budding Uninhibited By Benzimidazoles 3 Homolog2
Budding Uninhibited By Benzimidazoles 3 Homolog (Yeast)1     hBUB32
BUB3L2     Mitotic Checkpoint Component2
BUB3 Budding Uninhibited By Benzimidazoles 3 Homolog2     Mitotic Checkpoint Protein BUB32

External Ids:    HGNC: 11511   Entrez Gene: 91842   Ensembl: ENSG000001544737   OMIM: 6037195   UniProtKB: O436843   

Export aliases for BUB3 gene to outside databases

Previous GC identifers: GC10P123930 GC10P124163 GC10P124920 GC10P124454 GC10P118531


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BUB3 Gene:
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat
domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants,
encoding different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for BUB3 Gene: 
BUB3 (BUB3 mitotic checkpoint protein) is a protein-coding gene. Diseases associated with BUB3 include polyploidy, and familial breast cancer, and among its related super-pathways are Cell cycle and Regulation of APC/C activators between G1/S and early anaphase. GO annotations related to this gene include protein binding. An important paralog of this gene is RAE1.

UniProtKB/Swiss-Prot: BUB3_HUMAN, O43684
Function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of
correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments.
Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The
BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when
spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating
its activator CDC20. This complex can also phosphorylate MAD1L1

Gene Wiki entry for BUB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BUB3 gene promoter:
         p53   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBUB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for BUB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BUB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q24

BUB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BUB3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P124903:  view genomic region     (about GC identifiers)

Start:
124,913,760 bp from pter      End:
124,924,886 bp from pter
Size:
11,127 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BUB3_HUMAN, O43684 (See protein sequence)
Recommended Name: Mitotic checkpoint protein BUB3  
Size: 328 amino acids; 37155 Da
Subunit: Interacts with BUB1 and BUBR1. The BUB1/BUB3 complex interacts with MAD1L1
Subcellular location: Nucleus. Chromosome, centromere, kinetochore (By similarity). Note=Starts to localize at
kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I
(MI-AI) transition (By similarity)
Secondary accessions: A6NJ42 B2R6E7 D3DRE9 O43685
Alternative splicing: 2 isoforms:  O43684-1   O43684-2   

Explore the universe of human proteins at neXtProt for BUB3: NX_O43684

Explore proteomics data for BUB3 at MOPED 

Post-translational modifications:

  • UniProtKB: Poly-ADP-ribosylated by PARP1 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43684

  • BUB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BUB3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001007794.1  NP_004716.1  

    ENSEMBL proteins: 
     ENSP00000357858   ENSP00000357852   ENSP00000357851   ENSP00000383941   ENSP00000444354  
    Reactome Protein details: O43684
    Human Recombinant Protein Products for BUB3: 
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    ProSpec Recombinant Protein for BUB3
    Cloud-Clone Corp. Proteins for BUB3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA9660858
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--

    BUB3 for ontologies           About GeneDecksing



    BUB3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry O43684

    ProtoNet protein and cluster: O43684

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: BUB3_HUMAN, O43684
    Similarity: Belongs to the WD repeat BUB3 family
    Similarity: Contains 5 WD repeats


    BUB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BUB3_HUMAN, O43684
    Function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of
    correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments.
    Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The
    BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when
    spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating
    its activator CDC20. This complex can also phosphorylate MAD1L1

         Genatlas biochemistry entry for BUB3:
    budding inhibited by benzidimidazoles,mitotic spindle assembly checkpoint gene 1,homolog of yeast Bub1p,expressed
    in testis and thymus,colon and small intestine,modulating the timing of anaphase initiation in mitotic cells with
    improperly aligned chromosomes

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10198256
         
    BUB3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for BUB3:
     Decreased number of cells in m  Increased gamma-H2AX phosphory  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bub3):
     adipose tissue  cellular  embryogenesis  growth/size  homeostasis/metabolism 
     integument  mortality/aging  muscle  skeleton  tumorigenesis 
     vision/eye 

    BUB3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bub3tm1Jvd for BUB3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BUB3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BUB3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BUB3 
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    SwitchGear 3'UTR luciferase reporter plasmidBUB3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BUB3 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2CDK-mediated phosphorylation and removal of Cdc6
    APC/C:Cdc20 mediated degradation of mitotic proteins0.94
    Regulation of mitotic cell cycle0.94
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins0.93
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cell Cycle Checkpoints0.58
    APC/C-mediated degradation of cell cycle proteins0.94
    3M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    4Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    Mitotic Spindle Checkpoint0.95
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.95
    Inactivation of APC/C via direct inhibition of the APC/C complex0.95
    APC-Cdc20 mediated degradation of Nek2A0.78
    5Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for BUB3
        Cell cycle Role of APC in cell cycle regulation


    1 Cell Signaling Technology (CST) Pathway for BUB3
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for BUB3
        Cell cycle Role of APC in cell cycle regulation

    1 BioSystems Pathway for BUB3
        Cell cycle


    5/20        Reactome Pathways for BUB3 (see all 20)
        Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    APC/C:Cdc20 mediated degradation of mitotic proteins
    Cell Cycle
    M Phase


    2         Kegg Pathways  (Kegg details for BUB3):
        Cell cycle
    HTLV-I infection


    BUB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BUB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/917 Interacting proteins for BUB3 (O436841, 2, 3 ENSP000003578584) via UniProtKB, MINT, STRING, and/or I2D (see all 917)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BUB1O436832, 3, ENSP000003025304MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000302530
    HDAC1Q135472, 3, ENSP000003626494MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000362649
    ANAPC1Q9H1A42, 3, ENSP000003391094MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000339109
    CDC16Q130422, 3, ENSP000003485544MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000348554
    CDC23Q9UJX22, 3, ENSP000003783504MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000378350
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000070mitotic sister chromatid segregation IEA--
    GO:0000278mitotic cell cycle TAS--
    GO:0007059chromosome segregation ----
    GO:0007094mitotic spindle assembly checkpoint TAS--
    GO:0007126meiosis IEA--

    BUB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BUB3

    Search CenterWatch for drugs/clinical trials and news about BUB3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BUB3 gene (2 alternative transcripts): 
    NM_001007793.2  NM_004725.3  

    Unigene Cluster for BUB3:

    BUB3 mitotic checkpoint protein
    Hs.418533  [show with all ESTs]
    Unigene Representative Sequence: AK226060
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368865(uc009yah.2 uc001lhf.4 uc001lhd.2 uc001lhe.2 uc010qud.1)
    ENST00000368859 ENST00000368858 ENST00000407911 ENST00000481952 ENST00000538238

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    Additional mRNA sequence: 

    AF047472.1 AF047473.1 AF053304.1 AF081496.1 AK226060.1 AK293255.1 AK307958.1 AK312546.1 
    BC005138.2 BC022438.1 

    21 DOTS entries:

    DT.456137  DT.101965243  DT.100826408  DT.433658  DT.92454912  DT.95299996  DT.100826404  DT.121220643 
    DT.100826405  DT.121220629  DT.95369488  DT.92454916  DT.95369487  DT.121220594  DT.100826411  DT.121065891 
    DT.121220583  DT.121220589  DT.121220604  DT.87016702  DT.121220641 

    24/536 AceView cDNA sequences (see all 536):

    BG530417 BM667672 BQ773418 BQ026821 N29806 BU734965 BP350769 BM679664 
    BQ723773 BQ212308 AA814414 AI382646 BG776751 CB129513 AA809500 BM705763 
    AI254220 CB134834 AA251758 BG504215 BU506853 CA421181 BG260092 BU173487 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for BUB3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                -                       -                                                               
    SP2:                                -                       -                                               -     -         
    SP3:                                -                       -                                                               
    SP4:                                -                                                                                       
    SP5:                                                        -                                                               


    ECgene alternative splicing isoforms for BUB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BUB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTATTCCTT
    BUB3 Expression
    About this image


    See BUB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BUB3

    SOURCE GeneReport for Unigene cluster: Hs.418533
        SABiosciences Custom PCR Arrays for BUB3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BUB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BUB3 gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bub31 , 5 budding uninhibited by benzimidazoles 3 homolog (S. more1, 5 90.36(n)1
    100(a)1
      7 (74.36 cM)5
    122371  NM_009774.31  NP_033904.21 
     1315603915 
    chicken
    (Gallus gallus)
    Aves BUB31 budding uninhibited by benzimidazoles 3 homolog (yeast) 84(n)
    96.92(a)
      423949  NM_001006506.1  NP_001006506.1 
    lizard
    (Anolis carolinensis)
    Reptilia BUB36
    BUB3 mitotic checkpoint protein
    98(a)
    1 ↔ 1
    3(60225524-60252878)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76442 Xenopus laevis mRNA for mitotic checkpoint, complete more 79.15(n)    AB018419.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.44312 Danio rerio BUB3 budding uninhibited by benzimidazoles more 73.49(n)    AY391411.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bub31 , 3 mitotic checkpoint3
    Bub31
    56(a)3
    59.87(n)1
    61.13(a)1
      99B73
    434901  NM_058033.31  NP_477381.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54G9A.63 WD domain, G-beta repeat (2 domains) 43(a)   II(13725974-13729356)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BUB3(YOR026W)4 Kinetochore checkpoint WD40 repeat protein that localizes more   --   15(379781-380806) 854191  NP_014669.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons BUB3.21 cell cycle arrest protein BUB3 55.8(n)
    56.33(a)
      841414  NM_103878.1  NP_175413.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g04486001 hypothetical protein 57.38(n)
    56.33(a)
      4333230  NM_001057006.1  NP_001050471.1 


    ENSEMBL Gene Tree for BUB3 (if available)
    TreeFam Gene Tree for BUB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BUB3 gene
    RAE12  
    2 SIMAP similar genes for BUB3 using alignment to 4 protein entries:     BUB3_HUMAN (see all proteins):
    RAE1    WDR38

    BUB3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BUB3
    PGOHUM00000232959


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/273 SNPs in BUB3 are shown (see all 273)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910828021,2
    --124911797(+) ATAGAC/TTACAG 2 -- us2k10--------
    rs1825644111,2
    --124911979(+) TTCTTC/TTTACT 2 -- us2k10--------
    rs24211761,2
    H--124912035(+) TCTTAG/CGAATT 2 -- us2k14Minor allele frequency- C:0.00NS EA 404
    rs30410651,2
    C--124912066(+) GTTTT-/ACACACA 2 -- us2k10--------
    rs61441371,2
    C--124912066(+) GTTTT-/ACAC  
            
    acaca
    2 -- us2k10--------
    rs569291361,2
    C--124912107(+) CACAC-/AC/CA 
     
    /CACACA
    AACTT
    4 -- us2k1 cds11NA 2
    rs18984581,2
    C,F,A,H--124912115(+) CTTTGC/TATTTG 2 -- us2k1 tfbs320Minor allele frequency- T:0.06NS EA NA CSA 2356
    rs1482442321,2
    --124912313(+) CACTGA/GATAAT 2 -- us2k10--------
    rs1402451831,2
    --124912347(+) TGGGTA/GATTCA 2 -- us2k10--------
    rs1503180571,2
    --124912441(+) CTAAAG/TTTAGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for BUB3 (124913760 - 124924886 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BUB3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BUB3
    DNA2.0 Custom Variant and Variant Library Synthesis for BUB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603719    OMIM disorders: --

    10 diseases for BUB3:    About MalaCards
    polyploidy    familial breast cancer    gastric cancer    osteosarcoma
    cervical cancer    glioblastoma    cervicitis    breast cancer
    hepatocellular carcinoma    lung cancer


    BUB3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for BUB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 18.5 2 17991869 (1), 15796961 (1)
    gastric cancer 6.87 2 12692836 (2)

    Genetic Association Database (GAD): BUB3
    Human Genome Epidemiology (HuGE) Navigator: BUB3 (2 documents)

    Export disorders for BUB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BUB3 gene, integrated from 9 sources (see all 103):
    (articles sorted by number of sources associating them with BUB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. (PubMed id 9660858)1, 2, 3, 9 Taylor S.S.... McKeon F. (1998)
    2. Phosphorylation of human MAD1 by the BUB1 kinase in vitro. (PubMed id 10198256)1, 2, 9 Seeley T.W.... Zhen J.Y. (1999)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    4. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1, 2 Meierhofer D.... Kaiser P. (2008)
    5. The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments. (PubMed id 18199686)1, 2 Logarinho E.... Bousbaa H. (2008)
    6. Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk. (PubMed id 17268814)1, 4 Vaclavicek A....Forsti A. (2007)
    7. Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. (PubMed id 15525512)1, 2 Tang Z....Yu H. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes. (PubMed id 15796961)1, 9 Mendoza S....Miller C.W. (2005)
    10. The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3. (PubMed id 17289665)1, 9 Lo K.W....Pfister K.K. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9184 HGNC: 1151 AceView: BUB3 Ensembl:ENSG00000154473 euGenes: HUgn9184
    ECgene: BUB3 Kegg: 9184 H-InvDB: BUB3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BUB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BUB3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BUB3 gene:
    Search GeneIP for patents involving BUB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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