BUB3 Gene
protein-coding GIFtS: 66
GCID: GC10P124903
|
|
BUB3 mitotic checkpoint protein(Previous names: BUB3 (budding uninhibited by benzimidazoles 3, yeast) homolog,...)
| |
Aliases
for BUB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BUB3 Mitotic Checkpoint Protein1 2 | | Budding Uninhibited By Benomyl2 | | BUB3L1 2 | | Budding Uninhibited By Benzimidazoles 3 Homolog2 | | BUB3 (Budding Uninhibited By Benzimidazoles 3, Yeast) Homolog1 | | HBUB31 | | Budding Uninhibited By Benzimidazoles 3 Homolog (Yeast)1 | | Mitotic Checkpoint Component2 | | BUB3 Budding Uninhibited By Benzimidazoles 3 Homolog2 | | Mitotic Checkpoint Protein BUB32 |
Export aliases for BUB3 gene to outside databasesPrevious GC identifers: GC10P123930 GC10P124163 GC10P124920 GC10P124454 GC10P118531 |
Summaries
for BUB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BUB3:
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeatdomains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encodingdifferent isoforms, have been characterized. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: BUB3_HUMAN, O43684Function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correctkinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary forkinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex playsa role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint isactivated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex canalso phosphorylate MAD1L1
Gene Wiki entry for BUB3
|
Genomic Views
for BUB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BUB3 gene promoter:
p53 NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for BUB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BUB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26 Ensembl cytogenetic band: 10q26.13 HGNC cytogenetic band: 10q24BUB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P124903: view genomic region
(about GC identifiers)
Start:
|
124,913,760 bp from pter |
End:
|
124,924,886 bp from pter |
Size:
|
11,127 bases |
Orientation:
|
plus strand |
|
Proteins
for BUB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BUB3_HUMAN, O43684 (See
protein sequence)Recommended Name: Mitotic checkpoint protein BUB3 Size: 328 amino acids; 37155 Da
Subunit: Interacts with BUB1 and BUBR1. The BUB1/BUB3 complex interacts with MAD1L1
Subcellular location: Nucleus. Chromosome, centromere, kinetochore (By similarity). Note=Starts to localize atkinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI)transition (By similarity)
Secondary accessions: A6NJ42 B2R6E7 D3DRE9 O43685Alternative splicing: 2 isoforms: O43684-1 O43684-2 Explore the universe of human proteins at neXtProt for BUB3: NX_O43684
Post-translational modifications:
Poly-ADP-ribosylated by PARP1 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43684
BUB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001007794.1 NP_004716.1
ENSEMBL proteins: ENSP00000357858 ENSP00000357852 ENSP00000357851 ENSP00000383941 ENSP00000444354 Reactome Protein details: O43684
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
BUB3 for ontologies About GeneDecksing
BUB3 Antibody Products:
Assay Products for BUB3: |
Protein
Domains /
Families
for BUB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BUB3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43684ProtoNet protein and cluster: O43684 1 Blocks protein family: IPB001680 G-protein beta WD-40 repeat signature
UniProtKB/Swiss-Prot: BUB3_HUMAN, O43684Similarity: Belongs to the WD repeat BUB3 familySimilarity: Contains 5 WD repeats |
Function
for BUB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BUB3_HUMAN, O43684Function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correctkinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary forkinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex playsa role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint isactivated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex canalso phosphorylate MAD1L1 Genatlas biochemistry entry for BUB3:budding inhibited by benzidimidazoles,mitotic spindle assembly checkpoint gene 1,homolog of yeast Bub1p,expressed intestis and thymus,colon and small intestine,modulating the timing of anaphase initiation in mitotic cells withimproperly aligned chromosomes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BUB3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BUB3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): BUB3 (NM_004725) | |  | Sino Biological Human cDNA Clone for BUB3 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BUB3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BUB3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BUB3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
BUB3 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for BUB3:
Animal Models:
Mouse knock-out Bub3tm1Jvd for BUB3
11 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Bub3):
BUB3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for BUB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitinated Orc1 is degraded by the proteasome | | | 2 | M Phase | | | 3 | APC-Cdc20 mediated degradation of Nek2A | | | 4 | Resolution of Sister Chromatid Cohesion | | | 5 | Cell Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for BUB3
1 
Cell Signaling Technology (CST) Pathway for BUB3
1  GeneGo (Thomson Reuters) Pathway for BUB3
1  BioSystems Pathway for BUB3
5/23 
Reactome Pathways for BUB3 (see all 23)
1 
Kegg Pathway (Kegg details for BUB3):
BUB3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BUB3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/880 Interacting proteins for BUB3 (O436841, 2, 3 ENSP000003578584) via UniProtKB, MINT, STRING, and/or I2D (see all 880)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| BUB1 | O436832, 3, ENSP000003025304 | MINT-7945693 MINT-7947479 I2D:
score=3 STRING: ENSP00000302530 | | HDAC1 | Q135472, 3, ENSP000003626494 | MINT-7945693 MINT-7947479 I2D:
score=2 STRING: ENSP00000362649 | | ANAPC1 | Q9H1A42, 3, ENSP000003391094 | MINT-7945693 MINT-7947479 I2D:
score=1 STRING: ENSP00000339109 | | CDC16 | Q130422, 3, ENSP000003485544 | MINT-7945693 MINT-7947479 I2D:
score=1 STRING: ENSP00000348554 | | CDC23 | Q9UJX22, 3, ENSP000003783504 | MINT-7945693 MINT-7947479 I2D:
score=1 STRING: ENSP00000378350 |
About this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table
BUB3 for ontologies About GeneDecksing
|
Drugs & Compounds
for BUB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BUB3
Search CenterWatch for drugs/clinical trials and news about BUB3
|
Transcripts
for BUB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BUB3 gene (2 alternative transcripts): NM_001007793.2 NM_004725.3 Unigene Cluster for BUB3: Budding uninhibited by benzimidazoles 3 homolog (yeast) Hs.418533 [show with all ESTs]Unigene Representative Sequence: AK2260607 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368865(uc009yah.2 uc001lhf.4 uc001lhd.2 uc001lhe.2 uc010qud.1)
ENST00000368859 ENST00000368858 ENST00000490143 ENST00000407911 ENST00000481952
ENST00000538238
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BUB3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BUB3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): BUB3 (NM_004725) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BUB3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BUB3 |
Additional cDNA sequence: AF047472.1 AF047473.1 AF053304.1 AF081496.1 AK226060.1 AK293255.1 AK307958.1 AK312546.1 BC005138.2 BC022438.1 20 DOTS entries: DT.456137 DT.100826408 DT.101965243 DT.433658 DT.92454912 DT.95299996 DT.100826404 DT.121220643 DT.100826405 DT.121220629 DT.95369488 DT.92454916 DT.95369487 DT.121220594 DT.100826411 DT.121065891 DT.121220583 DT.121220589 DT.121220604 DT.87016702 24/536 AceView cDNA sequences (see all 536): AA236129 BQ439181 AA290942 AA405955 AA280260 BU147541 BG776751 AA809500 AA811838 AA251758 BQ054086 AI254220 BM667672 CB134834 BF691649 BE890197 CA503070 AA322426 AA282569 BX116075 CR615326 AF047473 CB112673 BE219336
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for BUB3 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | - | | - | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for BUB3
|
Expression
for BUB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BUB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTATTCCTT
About this image
See BUB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BUB3
SOURCE GeneReport for Unigene cluster: Hs.418533
SABiosciences Custom PCR Arrays for BUB3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BUB3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BUB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BUB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BUB3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BUB3 |
Orthologs
for BUB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for BUB3 gene from 9/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Bub31 , 5 |
budding uninhibited by benzimidazoles 3 homolog (S. more1, 5 |
90.36(n)1
100(a)1 |
|
7 (74.36 cM)5
122371 NM_009774.31 NP_033904.21
1315603915 |
chicken
(Gallus gallus) |
Aves |
BUB31 |
budding uninhibited by benzimidazoles 3 homolog (yeast) |
84(n)
96.92(a) |
|
423949 NM_001006506.1 NP_001006506.1 |
lizard
(Anolis carolinensis) |
Reptilia |
BUB36 |
-- |
97(a) |
1 ↔ 1 |
3(60230969-60240739) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.76442 |
Xenopus laevis mRNA for mitotic checkpoint, complete more |
79.15(n) |
|
AB018419.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.44312 |
Danio rerio BUB3 budding uninhibited by benzimidazoles more |
73.49(n) |
|
AY391411.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Bub31 , 3 |
mitotic checkpoint3
Bub31 |
56(a)3
59.87(n)1
61.13(a)1 |
|
99B73
434901 NM_058033.31 NP_477381.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y54G9A.63 |
WD domain, G-beta repeat (2 domains) |
43(a) |
|
II(13725974-13729356) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
BUB3.21 |
cell cycle arrest protein BUB3 |
55.8(n)
56.33(a) |
|
841414 NM_103878.1 NP_175413.1 |
rice
(Oryza sativa) |
Liliopsida |
Os03g04486001 |
hypothetical protein |
57.38(n)
56.33(a) |
|
4333230 NM_001057006.1 NP_001050471.1 |
ENSEMBL Gene Tree for BUB3 (if available)
TreeFam Gene Tree for BUB3 (if available) |
Paralogs
for BUB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BUB3 gene
- RAE12
2 SIMAP similar genes for BUB3 using alignment to 4 protein entries: BUB3_HUMAN (see all proteins):RAE1 WDR38
BUB3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for BUB3
PGOHUM00000232959
|
Genomic Variants
for BUB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BUB3 (124913760 - 124924886 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BUB3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BUB3 |
|
Disorders
/ Diseases
for BUB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BUB3 for disorders About GeneDecksing
OMIM gene information: 603719
OMIM disorders: --
12  diseases for BUB3: About MalaCardsadenomatous polyposis coli familial breast cancer polyposis gastric cancer
breast cancer hepatocellular carcinoma cervical cancer cervicitis
osteosarcoma lung cancer glioblastoma carcinoma
2 Novoseek disease relationships for BUB3 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
18.5 |
2 |
17991869 (1), 15796961 (1) |
| gastric cancer |
6.87 |
2 |
12692836 (2) |
Human Genome Epidemiology (HuGE) Navigator: BUB3 (2 documents)
Export disorders for BUB3 gene to outside databases
|
Publications
for BUB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BUB3 gene, integrated from 9 sources (see all 95):
(articles sorted by number of sources associating them with BUB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. (PubMed id 9660858)1, 2, 3, 9 Taylor S.S.... McKeon F. (1998)
- Phosphorylation of human MAD1 by the BUB1 kinase in vitro. (PubMed id 10198256)1, 2, 9 Seeley T.W.... Zhen J.Y. (1999)
- Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1, 2 Meierhofer D.... Kaiser P. (2008)
- The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments. (PubMed id 18199686)1, 2 Logarinho E.... Bousbaa H. (2008)
- Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. (PubMed id 15525512)1, 2 Tang Z....Yu H. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes. (PubMed id 15796961)1, 9 Mendoza S....Miller C.W. (2005)
- The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3. (PubMed id 17289665)1, 9 Lo K.W....Pfister K.K. (2007)
- TAp73alpha binds the kinetochore proteins Bub1 and Bub3 resulting in polyploidy. (PubMed id 19182530)1, 9 Vernole P....De Laurenzi V. (2009)
- WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase. (PubMed id 15388328)1, 9 Yoon Y.M....Lee C.W. (2004)
|
External Searches for BUB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing BUB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing BUB3 gene
(According to HUGE)
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Specialized Databases showing BUB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for BUB3 gene:
Search GeneIP for patents involving BUB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for BUB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for BUB3 | | OriGene shRNA RFP for BUB3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BUB3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BUB3 | | | OriGene Protein Over-expression Lysate for BUB3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BUB3 | | OriGene 3'-UTR Clone for BUB3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BUB3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BUB3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for BUB3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BUB3 | | OriGene Custom Protein Services for BUB3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BUB3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BUB3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BUB3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BUB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BUB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BUB3 |
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| | Antibodies & Assays for BUB3 |
| | | | Search Tocris compounds for BUB3 |
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 | | | BUB3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BUB3 |
|  |  |  | | | | ThermoFisher Antibodies for BUB3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BUB3 |
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