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Aliases for BUB1B-PAK6 Gene

Aliases for BUB1B-PAK6 Gene

  • BUB1B-PAK6 Readthrough 2 3 5

External Ids for BUB1B-PAK6 Gene

Summaries for BUB1B-PAK6 Gene

Entrez Gene Summary for BUB1B-PAK6 Gene

  • This gene represents readthrough transcription between the genes BUB1B (mitotic checkpoint serine/threonine-protein kinase BUB1 beta) and PAK6 (serine/threonine-protein kinase PAK 6). The protein encoded by the readthrough transcripts is the same as the product of the downstream gene (PAK6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for BUB1B-PAK6 Gene

BUB1B-PAK6 (BUB1B-PAK6 Readthrough) is a Protein Coding gene. Among its related pathways are Focal Adhesion and Ras signaling pathway. An important paralog of this gene is PAK6.

Additional gene information for BUB1B-PAK6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BUB1B-PAK6 Gene

Genomics for BUB1B-PAK6 Gene

Regulatory Elements for BUB1B-PAK6 Gene

Enhancers for BUB1B-PAK6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H040217 0.7 ENCODE 0.7 +0.1 57 0 CTCF ZNF654 ZNF362 RB1 TEAD1 TRIM22 ZNF384 REST ELF1 ZNF2 BUB1B-PAK6 PAK6 ENSG00000273786
GH15H040218 0.7 ENCODE 0.7 -0.1 -64 0 CTCF PKNOX1 ZNF654 ZNF362 RB1 TEAD1 TRIM22 ZNF384 REST ELF1 BUB1B BUB1B-PAK6 PAK6
GH15H040182 0.8 Ensembl ENCODE 0.3 -34.5 -34530 0 IKZF1 MLLT1 DPF2 RUNX3 IKZF2 BUB1B PAK6 ANKRD63 SRP14 SRP14-AS1 C15orf56 BMF PLCB2 RPLP0P10 BUB1B-PAK6
GH15H040160 1.1 ENCODE 0.2 -55.6 -55638 2 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 INO80 BMF SRP14 SRP14-AS1 RAD51-AS1 EIF2AK4 DNAJC17 ENSG00000259211 BUB1B PAK6
GH15H040183 0.5 Ensembl 0.3 -33.6 -33628 0 PAF1 RUNX3 IKZF2 BUB1B PAK6 ANKRD63 C15orf56 SRP14 SRP14-AS1 BMF RPLP0P10 PLCB2 BUB1B-PAK6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BUB1B-PAK6 on UCSC Golden Path with GeneCards custom track

Genomic Location for BUB1B-PAK6 Gene

Chromosome:
15
Start:
40,217,428 bp from pter
End:
40,276,396 bp from pter
Size:
58,969 bases
Orientation:
Plus strand

Genomic View for BUB1B-PAK6 Gene

Genes around BUB1B-PAK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BUB1B-PAK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BUB1B-PAK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BUB1B-PAK6 Gene

Proteins for BUB1B-PAK6 Gene

  • Protein details for BUB1B-PAK6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0U1RQB7
    Recommended name:
    BUB1B-PAK6 readthrough
    Protein Accession:
    A0A0U1RQB7

    Protein attributes for BUB1B-PAK6 Gene

    Size:
    133 amino acids
    Molecular mass:
    14939 Da
    Quaternary structure:
    No Data Available
  • Protein details for BUB1B-PAK6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BSN5
    Recommended name:
    BUB1B-PAK6 readthrough
    Protein Accession:
    H3BSN5

    Protein attributes for BUB1B-PAK6 Gene

    Size:
    160 amino acids
    Molecular mass:
    17672 Da
    Quaternary structure:
    No Data Available
  • Protein details for BUB1B-PAK6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BTB9
    Recommended name:
    BUB1B-PAK6 readthrough
    Protein Accession:
    H3BTB9

    Protein attributes for BUB1B-PAK6 Gene

    Size:
    141 amino acids
    Molecular mass:
    15993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BUB1B-PAK6 Gene

Post-translational modifications for BUB1B-PAK6 Gene

No Post-translational modifications

Other Protein References for BUB1B-PAK6 Gene

No data available for DME Specific Peptides for BUB1B-PAK6 Gene

Domains & Families for BUB1B-PAK6 Gene

Protein Domains for BUB1B-PAK6 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BUB1B-PAK6: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for BUB1B-PAK6 Gene

Function for BUB1B-PAK6 Gene

Gene Ontology (GO) - Molecular Function for BUB1B-PAK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with BUB1B-PAK6: view
genes like me logo Genes that share phenotypes with BUB1B-PAK6: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BUB1B-PAK6 Gene

Localization for BUB1B-PAK6 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BUB1B-PAK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with BUB1B-PAK6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for BUB1B-PAK6 Gene

Pathways & Interactions for BUB1B-PAK6 Gene

genes like me logo Genes that share pathways with BUB1B-PAK6: view

Interacting Proteins for BUB1B-PAK6 Gene

Gene Ontology (GO) - Biological Process for BUB1B-PAK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with BUB1B-PAK6: view

No data available for SIGNOR curated interactions for BUB1B-PAK6 Gene

Drugs & Compounds for BUB1B-PAK6 Gene

No Compound Related Data Available

Transcripts for BUB1B-PAK6 Gene

mRNA/cDNA for BUB1B-PAK6 Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BUB1B-PAK6 Gene

No ASD Table

Relevant External Links for BUB1B-PAK6 Gene

GeneLoc Exon Structure for
BUB1B-PAK6
ECgene alternative splicing isoforms for
BUB1B-PAK6

Expression for BUB1B-PAK6 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BUB1B-PAK6 Gene

Orthologs for BUB1B-PAK6 Gene

Evolution for BUB1B-PAK6 Gene

ENSEMBL:
Gene Tree for BUB1B-PAK6 (if available)
TreeFam:
Gene Tree for BUB1B-PAK6 (if available)

No data available for Orthologs for BUB1B-PAK6 Gene

Paralogs for BUB1B-PAK6 Gene

Paralogs for BUB1B-PAK6 Gene

genes like me logo Genes that share paralogs with BUB1B-PAK6: view

Variants for BUB1B-PAK6 Gene

Sequence variations from dbSNP and Humsavar for BUB1B-PAK6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs28989183 Pathogenic 40,217,580(+) GTGCA(C/G)CTGGA intron-variant, reference, missense, utr-variant-5-prime
rs28989185 Pathogenic 40,220,641(+) TGTTC(C/T)TGGGG intron-variant, reference, missense
rs747000103 Uncertain significance 40,217,546(+) GATAG(A/T)GGACT intron-variant, reference, missense, utr-variant-5-prime
rs1802286 Benign 40,218,461(+) GTAGA(C/T)CTGTT intron-variant, reference, synonymous-codon
rs35611758 Benign 40,220,705(+) AACAA(A/G)GCCTT intron-variant, reference, synonymous-codon

Relevant External Links for BUB1B-PAK6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BUB1B-PAK6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for BUB1B-PAK6 Gene

Disorders for BUB1B-PAK6 Gene

Relevant External Links for BUB1B-PAK6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BUB1B-PAK6

No disorders were found for BUB1B-PAK6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BUB1B-PAK6 Gene

Publications for BUB1B-PAK6 Gene

  1. p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2). (PMID: 23132866) Liu T … Li F (The Journal of biological chemistry 2013) 3 60
  2. Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV. (PMID: 22339630) Shepelev MV … Korobko IV (Biochemistry. Biokhimiia 2012) 3 60
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 60
  4. The emerging importance of group II PAKs. (PMID: 20070256) Wells CM … Jones GE (The Biochemical journal 2010) 3 60
  5. Group I p21-activated kinases regulate thyroid cancer cell migration and are overexpressed and activated in thyroid cancer invasion. (PMID: 20817787) McCarty SK … Ringel MD (Endocrine-related cancer 2010) 3 60

Products for BUB1B-PAK6 Gene

Sources for BUB1B-PAK6 Gene

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