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Aliases for BUB1 Gene

Aliases for BUB1 Gene

  • BUB1 Mitotic Checkpoint Serine/Threonine Kinase 2 3 5
  • BUB1L 3 4
  • BUB1A 3 4
  • HBUB1 3 4
  • Budding Uninhibited By Benzimidazoles 1 (Yeast Homolog) 2
  • Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) 2
  • Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB1 3
  • BUB1 Budding Uninhibited By Benzimidazoles 1 Homolog 3
  • Budding Uninhibited By Benzimidazoles 1 Homolog 3
  • Putative Serine/Threonine-Protein Kinase 3
  • Mitotic Spindle Checkpoint Kinase 3
  • EC 2.7.11.1 4

External Ids for BUB1 Gene

Previous HGNC Symbols for BUB1 Gene

  • BUB1L

Previous GeneCards Identifiers for BUB1 Gene

  • GC02M108625
  • GC02M109316
  • GC02M111302
  • GC02M111490
  • GC02M111111
  • GC02M111395
  • GC02M104274

Summaries for BUB1 Gene

Entrez Gene Summary for BUB1 Gene

  • This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for BUB1 Gene

BUB1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with BUB1 include Mosaic Variegated Aneuploidy Syndrome and Colorectal Cancer. Among its related pathways are PLK1 signaling events and Cell cycle. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is BUB1B.

UniProtKB/Swiss-Prot for BUB1 Gene

  • Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.

Gene Wiki entry for BUB1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BUB1 Gene

Genomics for BUB1 Gene

Regulatory Elements for BUB1 Gene

Enhancers for BUB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G110673 1.6 Ensembl ENCODE dbSUPER 0.7 +1.1 1122 6.5 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF207 FOS ACOXL LINC00116 LINC01123 ENSG00000186148 BUB1 RPL22P12
GH02G110656 0.8 ENCODE 0.3 +20.4 20384 2.2 PKNOX1 FEZF1 ZNF335 EGR1 PAF1 USF2 ZEB2 ZNF843 TBX21 ZNF592 ENSG00000184115 BUB1 RPL22P12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BUB1 on UCSC Golden Path with GeneCards custom track

Promoters for BUB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000121672 114 2401 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 FOS KLF13 SP3 SP5

Genomic Location for BUB1 Gene

Chromosome:
2
Start:
110,637,527 bp from pter
End:
110,678,114 bp from pter
Size:
40,588 bases
Orientation:
Minus strand

Genomic View for BUB1 Gene

Genes around BUB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BUB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BUB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BUB1 Gene

Proteins for BUB1 Gene

  • Protein details for BUB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43683-BUB1_HUMAN
    Recommended name:
    Mitotic checkpoint serine/threonine-protein kinase BUB1
    Protein Accession:
    O43683
    Secondary Accessions:
    • E9PC26
    • F5GXI5
    • O43430
    • O43643
    • O60626
    • Q53QE4

    Protein attributes for BUB1 Gene

    Size:
    1085 amino acids
    Molecular mass:
    122375 Da
    Quaternary structure:
    • Interacts with BUB3 and KNL1. Interacts (when phosphorylated) with PLK1. The BUB1-BUB3 complex interacts with MAD1L1. Interacts with SV40 Large T antigen; this interaction induces activation of a DNA damage response and promotes p53/TP53 stabilization and phosphorylation (Probable).

    Three dimensional structures from OCA and Proteopedia for BUB1 Gene

    Alternative splice isoforms for BUB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BUB1 Gene

Post-translational modifications for BUB1 Gene

  • Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1.
  • Upon spindle-assembly checkpoint activation it is hyperphosphorylated and its kinase activity toward CDC20 is stimulated. Phosphorylation at Thr-609 is required for interaction with PLK1, phosphorylation at this site probably creates a binding site for the POLO-box domain of PLK1, thus enhancing the PLK1-BUB1 interaction.
  • Ubiquitination at Lys175 and posLast=299299
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for BUB1 Gene

Domains & Families for BUB1 Gene

Gene Families for BUB1 Gene

Suggested Antigen Peptide Sequences for BUB1 Gene

Graphical View of Domain Structure for InterPro Entry

O43683

UniProtKB/Swiss-Prot:

BUB1_HUMAN :
  • The KEN box is required for its ubiquitination and degradation.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.
Domain:
  • The KEN box is required for its ubiquitination and degradation.
  • BUB1 N-terminal domain directs kinetochore localization and binding to BUB3.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.
genes like me logo Genes that share domains with BUB1: view

Function for BUB1 Gene

Molecular function for BUB1 Gene

GENATLAS Biochemistry:
budding inhibited by benzidimidazoles,mitotic spindle assembly checkpoint gene 1,homolog of yeast Bub1p,expressed in testis and thymus,colon and small intestine,modulating the timing of anaphase initiation in mitotic cells with improperly aligned chromosomes,rarely mutated in colorectal and other cancers
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Autophosphorylated when the cells enters mitosis.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
UniProtKB/Swiss-Prot Induction:
Inhibited by phorbol 12-myristate 13-acetate (PMA).

Enzyme Numbers (IUBMB) for BUB1 Gene

Gene Ontology (GO) - Molecular Function for BUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10198256
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 10198256
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with BUB1: view
genes like me logo Genes that share phenotypes with BUB1: view

Human Phenotype Ontology for BUB1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for BUB1 Gene

MGI Knock Outs for BUB1:

Animal Model Products

  • Taconic Biosciences Mouse Models for BUB1

CRISPR Products

miRNA for BUB1 Gene

miRTarBase miRNAs that target BUB1

No data available for Transcription Factor Targets and HOMER Transcription for BUB1 Gene

Localization for BUB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BUB1 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Nuclear in interphase cells. Accumulates gradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. Localizes to the outer kinetochore. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage and occurs very early in prophase. AURKB, KNL1 and INCENP are required for kinetochore localization (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BUB1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for BUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA,IDA 15020684
GO:0000777 condensed chromosome kinetochore IEA,IDA 19465021
GO:0000942 condensed nuclear chromosome outer kinetochore IDA 24055156
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with BUB1: view

Pathways & Interactions for BUB1 Gene

genes like me logo Genes that share pathways with BUB1: view

Pathways by source for BUB1 Gene

1 GeneGo (Thomson Reuters) pathway for BUB1 Gene

SIGNOR curated interactions for BUB1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for BUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IEA --
GO:0007062 sister chromatid cohesion TAS --
genes like me logo Genes that share ontologies with BUB1: view

Drugs & Compounds for BUB1 Gene

(3) Drugs for BUB1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for BUB1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with BUB1: view

Transcripts for BUB1 Gene

Unigene Clusters for BUB1 Gene

BUB1 mitotic checkpoint serine/threonine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BUB1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^
SP1: - - - -
SP2: - - -
SP3: - -
SP4:
SP5: - - - -
SP6: -
SP7: - - -
SP8:
SP9:
SP10:

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for BUB1 Gene

GeneLoc Exon Structure for
BUB1
ECgene alternative splicing isoforms for
BUB1

Expression for BUB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BUB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BUB1 Gene

This gene is overexpressed in Testis (x10.4).

Protein differential expression in normal tissues from HIPED for BUB1 Gene

This gene is overexpressed in Testis (55.1) and Ovary (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BUB1 Gene



Protein tissue co-expression partners for BUB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BUB1 Gene:

BUB1

SOURCE GeneReport for Unigene cluster for BUB1 Gene:

Hs.469649

mRNA Expression by UniProt/SwissProt for BUB1 Gene:

O43683-BUB1_HUMAN
Tissue specificity: High expression in testis and thymus, less in colon, spleen, lung and small intestine. Expressed in fetal thymus, bone marrow, heart, liver, spleen and thymus. Expression is associated with cells/tissues with a high mitotic index.

Evidence on tissue expression from TISSUES for BUB1 Gene

  • Lung(4.3)
  • Intestine(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for BUB1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • hypothalamus
  • jaw
  • lip
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • nose
  • outer ear
  • pituitary gland
  • skull
  • thyroid
Thorax:
  • aorta
  • chest wall
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • sternum
Abdomen:
  • abdominal wall
  • intestine
  • kidney
  • large intestine
  • small intestine
Pelvis:
  • penis
  • placenta
  • testicle
  • urethra
  • uterus
  • vagina
  • vulva
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • lymph vessel
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with BUB1: view

Primer Products

Orthologs for BUB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BUB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BUB1 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia BUB1 34 35
  • 88.03 (n)
cow
(Bos Taurus)
Mammalia BUB1 34 35
  • 84.31 (n)
mouse
(Mus musculus)
Mammalia Bub1 34 16 35
  • 82.23 (n)
rat
(Rattus norvegicus)
Mammalia Bub1 34
  • 81.99 (n)
oppossum
(Monodelphis domestica)
Mammalia BUB1 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BUB1 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves BUB1 34 35
  • 57.44 (n)
lizard
(Anolis carolinensis)
Reptilia BUB1 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bub1 34
  • 58.08 (n)
Str.351 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398234 34
zebrafish
(Danio rerio)
Actinopterygii bub1 34 35
  • 51.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14030 36
  • 35 (a)
Bub1 36 35
  • 32 (a)
BubR1 35
  • 13 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea bub-1 36 35
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUB1 35 37
  • 20 (a)
ManyToMany
MAD3 35
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5042 35
  • 35 (a)
ManyToMany
-- 35
  • 16 (a)
ManyToMany
Species where no ortholog for BUB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BUB1 Gene

ENSEMBL:
Gene Tree for BUB1 (if available)
TreeFam:
Gene Tree for BUB1 (if available)

Paralogs for BUB1 Gene

Paralogs for BUB1 Gene

Pseudogenes.org Pseudogenes for BUB1 Gene

genes like me logo Genes that share paralogs with BUB1: view

Variants for BUB1 Gene

Sequence variations from dbSNP and Humsavar for BUB1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs121909055 Pathogenic, Colorectal cancer 110,658,451(-) GCAAT(A/C)TCTAG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1801328 Colorectal cancer 110,674,203(-) GAAGA(G/T)AATTT nc-transcript-variant, reference, missense
rs376649190 Colorectal cancer 110,653,457(+) TTGAA(C/G)GCACC nc-transcript-variant, reference, missense
VAR_015687 Pancreatic cancer
VAR_015688 Pancreatic cancer

Structural Variations from Database of Genomic Variants (DGV) for BUB1 Gene

Variant ID Type Subtype PubMed ID
dgv4047n100 CNV loss 25217958
dgv7007n54 CNV loss 21841781
dgv730e214 CNV gain 21293372
esv3591965 CNV gain 21293372
esv3591966 CNV loss 21293372
nsv1109281 CNV deletion 24896259
nsv1149522 OTHER inversion 26484159
nsv521956 CNV loss 19592680
nsv582696 CNV gain 21841781

Variation tolerance for BUB1 Gene

Residual Variation Intolerance Score: 8.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BUB1 Gene

Human Gene Mutation Database (HGMD)
BUB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BUB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BUB1 Gene

Disorders for BUB1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for BUB1 Gene - From: ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mosaic variegated aneuploidy syndrome
  • mva syndrome
colorectal cancer
  • colorectal cancer, somatic
giant cell glioblastoma
  • monstrocellular sarcoma [obs]
- elite association - COSMIC cancer census association via MalaCards
Search BUB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BUB1

Genetic Association Database (GAD)
BUB1
Human Genome Epidemiology (HuGE) Navigator
BUB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BUB1
genes like me logo Genes that share disorders with BUB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BUB1 Gene

Publications for BUB1 Gene

  1. Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. (PMID: 18922873) Hein J. … Gjoerup O.V. (J. Virol. 2009) 3 4 22 64
  2. Bub1 regulates chromosome segregation in a kinetochore-independent manner. (PMID: 19487456) Klebig C. … Meraldi P. (J. Cell Biol. 2009) 3 4 22 64
  3. Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. (PMID: 17981135) Kiyomitsu T. … Yanagida M. (Dev. Cell 2007) 3 4 22 64
  4. KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome. (PMID: 17158872) Qi W. … Yu H. (J. Biol. Chem. 2007) 3 4 22 64
  5. Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. (PMID: 16760428) Qi W. … Yu H. (Mol. Biol. Cell 2006) 3 4 22 64

Products for BUB1 Gene

Sources for BUB1 Gene

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