BUB1 Gene
protein-coding GIFtS : 65 GCID: GC02 M111395
BUB1 mitotic checkpoint serine/threonine kinase budding uninhibited by benzimidazoles 1 (yeast homolog),... BUB1L )
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Aliasesfor BUB1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases BUB1 Mitotic Checkpoint Serine/Threonine Kinase 1 2 BUB1 Budding Uninhibited By Benzimidazoles 1 Homolog2 BUB1A1 2 3 Budding Uninhibited By Benzimidazoles 1 Homolog2 BUB1L1 2 3 Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB12 HBUB11 Mitotic Spindle Checkpoint Kinase2 Budding Uninhibited By Benzimidazoles 1 (Yeast Homolog)1 Putative Serine/Threonine-Protein Kinase2 Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast)1 EC 2.7.11.13
Export aliases for BUB1 gene to outside databases Previous GC identifers: GC02M108625 GC02M109316 GC02M111302 GC02M111490 GC02M111111 GC02M104274
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Summariesfor BUB1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for BUB1 : This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: BUB1_HUMAN, O43683 Function : Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential forspindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis Gene Wiki entry for BUB1
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Genomic Viewsfor BUB1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_022135.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the BUB1 gene promoter:POU2F1 AML1a POU2F1a c-Myb Tal-1beta ITF-2 Gfi-1 Other transcription factors Search SABiosciences Chromatin IP Primers for BUB1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q14 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q13 BUB1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M111395: view genomic region
(about GC identifiers )
Start: 111,395,275 bp from pter End:
111,435,691 bp from pter
Size: 40,417 bases Orientation:
minus strand
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Proteinsfor BUB1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: BUB1_HUMAN, O43683 See
protein sequence )Recommended Name: Size : 1085 amino acids; 122375 DaSubunit : Interacts with BUB3 and CASC5. Interacts (when phosphorylated) with PLK1. The BUB1-BUB3 complex interacts withMAD1L1. Interacts with SV40 Large T antigen; this interaction induces activation of a DNA damage response and promotes p53/TP53 stabilization and phosphorylation (Probable)
Subcellular location : Nucleus. Chromosome, centromere, kinetochore. Note=Nuclear in interphase cells. Accumulatesgradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. Localizes to the outer kinetochore. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage and occurs very early in prophase. AURKB, CASC5 and INCENP are required for kinetochore localization (By similarity)
3 PDB 3D structures from :2LAH (3D) 3E7E (3D) 4A1G (3D) Secondary accessions : O43430 O43643 O60626 Q53QE4Explore the universe of human proteins at neXtProt for BUB1: NX_O43683 Post-translational modifications:
Upon spindle-assembly checkpoint activation it is hyperphosphorylated and its kinase activity toward CDC20 is stimulated. Phosphorylation at Thr-609 is required for interaction with PLK1, phosphorylation at this site probably creates a binding site for the POLO-box domain of PLK1, thus enhancing the PLK1-BUB1 interaction1
Ubiquitinated and degraded during mitotic exit by APC/C-Cdh11 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O43683 BUB1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_004327.1 ENSEMBL proteins: ENSP00000386701 ENSP00000302530 ENSP00000402883 ENSP00000409713 ENSP00000392219 ENSP00000441013 Reactome Protein details: O43683 Human Recombinant Protein Products: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing BUB1 Antibody Products: Assay Products for BUB1:
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Protein
Domains /for BUB1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry O43683 ProtoNet protein and cluster: O43683
UniProtKB/Swiss-Prot: BUB1_HUMAN, O43683 Domain : The KEN box is required for its ubiquitination and degradationDomain : BUB1 N-terminal domain directs kinetochore localization and binding to BUB3Similarity : Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamilySimilarity : Contains 1 BUB1 N-terminal domainSimilarity : Contains 1 protein kinase domain
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Functionfor BUB1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: BUB1_HUMAN, O43683 Function : Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential forspindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis Catalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme regulation : Autophosphorylated when the cells enters mitosisInduction : Inhibited by phorbol 12-myristate 13-acetate (PMA)
Genatlas biochemistry entry for BUB1 budding inhibited by benzidimidazoles,mitotic spindle assembly checkpoint gene 1,homolog of yeast Bub1p,expressed in testis and thymus,colon and small intestine,modulating the timing of anaphase initiation in mitotic cells with improperly aligned chromosomes,rarely mutated in colorectal and other cancers Enzyme Number (IUBMB): EC 2.7.11.1 1 Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: BUB1 (NM_004336 ) Sino Biological Human cDNA Clone for BUB1 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BUB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat BUB1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BUB1
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing 9 GenomeRNAi human phenotypes for BUB1 :Animal Models: Bub1 tm1.1Tvd Bub1 tm1.1Ssta Bub1 tm1.1Jvd 13 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Bub1) :About GeneDecksing
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Pathways & Interactionsfor BUB1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/8 super-pathways (see all 8 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 M Phase 2 Resolution of Sister Chromatid Cohesion 3 Cell cycle Role of APC in cell cycle regulation 4 Oocyte meiosis 5 Cell cycle
Pathway sources See GeneCards unified pathways Show all pathways 1 1 3 5/10 (see all 10 )3 (Kegg details for BUB1) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BUB1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/890 Interacting proteins for BUB1 (O43683 2 , 3 ENSP00000302530 4 via UniProtKB, MINT, STRING , and/or I2D (see all 890 )About this table Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15 ): About this table
About GeneDecksing
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Drugs & Compoundsfor BUB1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for BUB1 2 HMDB Compounds for BUB1 About this table 3 Novoseek chemical compound relationships for BUB1 gene About this table BUB1
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Transcriptsfor BUB1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for BUB1 gene: NM_004336.3 Unigene Cluster for BUB1:
Budding uninhibited by benzimidazoles 1 homolog (yeast) Hs.469649 [show with all ESTs ] Unigene Representative Sequence: AK302418 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000409311 ENST00000302759 (uc002tgc.3 uc010yxh.2 uc010fkb.3 )ENST00000478175 ENST00000466333 ENST00000490632 ENST00000465029 (uc002tgd.2 )ENST00000477481 ENST00000468927 ENST00000447014 ENST00000420328 ENST00000436916 ENST00000535254 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: BUB1 (NM_004336 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BUB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat BUB1
Additional cDNA sequence: AF011387.1 AF043294.2 AF046078.1 AF047471.1 AF053305.1 AK023540.1 AK225317.1 AK291221.1 AK302418.1 BC017038.1 BC028201.1
12 DOTS entries : DT.100646001 DT.112990
DT.121000041 DT.97844027 DT.70104702 DT.444542 DT.95263322 DT.95263343 DT.102831704 DT.40131760 DT.95263320 DT.100808212 24/134 AceView cDNA sequences (see all 134 ):
AA449311 BQ232794 CB149547 AF043294 AU123572 BC017038 BM457569 AW576327 NM_004336 AU156551 BE889636 BM802016 AF047471 BU186646 CB159765 BX101106 BM828025 AA383290 AA315653 BC028201 AW661857 AU130932 BG576874 AU121568 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for BUB1 (see all 10 ) About this scheme ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ SP1 : - - - - SP2 : - - - SP3 : - - SP4 : SP5 : - - - -
ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 SP1 : - - SP2 : SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for BUB1
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Expression for BUB1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section BUB1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTATGTTGAA
About this image BUB1 expression in embryonic tissues and stem cells About this table See BUB1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for BUB1 SOURCE GeneReport for Unigene cluster: Hs.469649 UniProtKB/Swiss-Prot: BUB1_HUMAN, O43683 Tissue specificity : High expression in testis and thymus, less in colon, spleen, lung and small intestine. Expressed infetal thymus, bone marrow, heart, liver, spleen and thymus. Expression is associated with cells/tissues with a high mitotic index SABiosciences Custom PCR Arrays for BUB1 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BUB1
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Orthologsfor BUB1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for BUB1 gene from 7/23 species (see all 23 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves BUB11
budding uninhibited by benzimidazoles 1 homolog (yeast)
57.02(n) 46.06(a)
421226 NM_001012870.1 NP_001012888.1
lizard Reptilia BUB16
--
41(a)
1 ↔ 1
GL343727.1(6063-45201)
African clawed frog Amphibia LOC3982342
spindle checkpoint protein Bub1
71.96(n)
AF348328.1
zebrafish Actinopterygii si:ch1073-192f24.11
si:ch1073-192f24.1
53.39(n) 50.22(a)
100307076 XM_002665639.2 XP_002665685.2
worm Secernentea bub-13
Eukaryotic protein kinase domain
25(a)
I(7260012-7263196) --
thale cress eudicotyledons AT2G206351
catalytic domain of protein kinase and Mad3-BUB1-I more
45.99(n) 33.73(a)
816591 NM_127628.4 NP_179656.4
rice Liliopsida Os07g05085001
hypothetical protein
49.56(n) 37.64(a)
4343342 NM_001066280.1 NP_001059745.1
ENSEMBL Gene Tree for BUB1 (if available)TreeFam Gene Tree for BUB1 (if available)
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Paralogsfor BUB1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for BUB1 gene BUB1B 2 About GeneDecksing 1 Pseudogenes.org Pseudogene for BUB1 PGOHUM00000238967
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Genomic Variantsfor BUB1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 2 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for BUB1 (111395275 - 111435691 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for BUB1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor BUB1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 602452
OMIM disorders : --20/31 (see all 31 ): About MalaCards adenomatous polyposis coli colorectal cancer with chromosomal instability leukemia/lymphoma leukemia/lymphoma, t-cell adult t-cell leukemia conduct disorder acute myeloid leukemia myeloid leukemia kaposi's sarcoma colorectal cancer polyposis stomach cancer hepatocellular carcinoma t-cell leukemia leukemia embryonal carcinoma gastric cancer pancreatic cancer carcinoma breast cancer 10/21 Novoseek disease relationships for BUB1 gene (see all 21 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
microsatellite instability
39.3
3
10960763 (2), 9521327 (1)
colorectal tumors
38.6
2
10395177 (1), 10960763 (1)
cancer
38.5
22
10543255 (3), 16525682 (2), 10773412 (1), 14732683 (1) (see all 16 )
gastric carcinoma
30.6
12
11410785 (4), 11641614 (4), 12692836 (1)
colorectal cancer
30.2
10
10969775 (2), 10773412 (1), 11115566 (1), 15162061 (1) (see all 8 )
tumors
22.2
28
16525682 (3), 10992296 (2), 10543255 (2), 10969775 (2) (see all 14 )
solid tumor
17.4
1
14517964 (1)
carcinoma
15.4
17
11115566 (4), 11782350 (2), 16525682 (1), 18383837 (1)
somatic mutations
14.3
2
14517964 (1), 10992296 (1)
colon cancer
14.2
2
10773412 (1), 10835495 (1)
Human Genome Epidemiology (HuGE) Navigator: BUB1 (3 documents) Export disorders for BUB1 gene to outside databases
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Publicationsfor BUB1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for BUB1 gene, integrated from 9 sources (see all 166 ):(articles sorted by number of sources associating them with BUB1) Utopia : connect your pdf to the dynamic
KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome. (PubMed id 17158872) 1 , 2 , 9(2007) Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation. (PubMed id 9790499) 1 , 2 , 9(1998) Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. (PubMed id 16760428) 1 , 2 , 9(2006) The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. (PubMed id 9660858) 1 , 2 , 9(1998) Bub1 regulates chromosome segregation in a kinetochore-independent manner. (PubMed id 19487456) 1 , 2 , 9(2009) A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T. (PubMed id 12655561) 1 , 2 , 9(2003) Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. (PubMed id 15525512) 1 , 2 , 9(2004) Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. (PubMed id 18922873) 1 , 2 , 9(2009) Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. (PubMed id 17981135) 1 , 2 , 9(2007) Phosphorylation of human MAD1 by the BUB1 kinase in vitro. (PubMed id 10198256) 1 , 2 , 9(1999)
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Specialized Databases showing BUB1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for BUB1 gene: BUB1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor BUB1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for BUB1 OriGene shRNA RFP for BUB1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for BUB1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for BUB1 OriGene 3'-UTR Clone for BUB1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for BUB1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for BUB1 OriGene Custom Protein Services for BUB1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BUB1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat BUB1
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