BTRC Gene
protein-coding GIFtS: 64
GCID: GC10P103103
|
|
beta-transducin repeat containing E3 ubiquitin protein ligase(Previous name: beta-transducin repeat containing )
| |
Aliases
for BTRC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase1 2 | | PIkappaBalpha-E3 Receptor Subunit2 3 | | FBXW1A1 2 3 | | BTRCP3 5 | | BTrCP1 | | Fwd11 | | BTrCP11 | | Beta-Transducin Repeat Containing1 | | Beta-TrCP11 | | BETA-TRCP2 | | BetaTrCP1 | | FBXW12 | | Epididymis Tissue Protein Li 2a2 3 | | FWD12 | | E3RSIkappaB2 3 | | F-Box And WD-Repeat Protein 1B2 | | FBW1A2 3 | | F-Box/WD Repeat-Containing Protein 1A2 | | F-Box And WD Repeats Protein Beta-TrCP2 3 | | |
Export aliases for BTRC gene to outside databasesPrevious GC identifers: GC10P102007 GC10P102347 GC10P103245 GC10P102778 GC10P096744 |
Summaries
for BTRC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BTRC:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either differentprotein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbwsclass; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradationof CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclearfactor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thusactivating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogeneexists in chromosome 6. (provided by RefSeq, Mar 2012)
UniProtKB/Swiss-Prot: FBW1A_HUMAN, Q9Y297Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex whichmediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds tophosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling.SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 totranslocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'.SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3,SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May beinvolved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase.Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required forproteolytic processing of GLI3
Gene Wiki entry for BTRC
|
Genomic Views
for BTRC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BTRC gene promoter:
AML1a MIF-1 STAT5A Cdc5 Evi-1 HNF-1A HNF-1 Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for BTRC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTRC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.32 Ensembl cytogenetic band: 10q24.32 HGNC cytogenetic band: 10q24.32BTRC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P103103: view genomic region
(about GC identifiers)
Start:
|
103,113,820 bp from pter |
End:
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103,317,078 bp from pter |
Size:
|
203,259 bases |
Orientation:
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plus strand |
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Proteins
for BTRC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBW1A_HUMAN, Q9Y297 (See
protein sequence)Recommended Name: F-box/WD repeat-containing protein 1A Size: 605 amino acids; 68867 Da
Subunit: Homodimer. Self-associates. Component of the SCF(BTRC) complex formed of CUL1, SKP1, RBX1 and a BTRC dimer.Direct interaction with SKP1 occurs via the F-box domain. Interacts with phosphorylated ubiquitination substratesSMAD3 and SMAD4. Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, NFKBIB, NFKBIE, NFKB1/nuclearfactor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5 and SNAI1; the interaction requires the phosphorylation ofthe 2 serine residues in the substrate destruction motif D-S-G-X(2,3,4)-S. Binds UBQLN1. Interacts with CDC34 andUBE2R2. Interacts with FBXW11. Interacts with CUL4A and DDB1. Part of a SCF(BTRC)-like complex lacking CUL1, which isassociated with phosphorylated NKBIA and RELA; RELA interacts directly with NFKBIA. Interacts with HIV-1 Vpu.Interacts with the phosphorylated form of GLI3. Interacts with CLU
Subcellular location: Cytoplasm. Nucleus (By similarity)
2 PDB 3D structures from  and Proteopedia  for BTRC:1P22 (3D)
2P64 (3D)
Secondary accessions: B5MD49 Q5W141 Q5W142 Q9Y213Alternative splicing: 2 isoforms: Q9Y297-1 Q9Y297-2 Explore the universe of human proteins at neXtProt for BTRC: NX_Q9Y297
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y297
BTRC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001243785.1 NP_003930.1 NP_378663.1
ENSEMBL proteins: ENSP00000359206 ENSP00000385339 ENSP00000359202 ENSP00000377088 Reactome Protein details: Q9Y297
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
BTRC for ontologies About GeneDecksing
BTRC Antibody Products:
Assay Products for BTRC: |
Protein
Domains /
Families
for BTRC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BTRC for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9Y297ProtoNet protein and cluster: Q9Y297 UniProtKB/Swiss-Prot: FBW1A_HUMAN, Q9Y297Domain: The N-terminal D domain mediates homodimerizationSimilarity: Contains 1 F-box domainSimilarity: Contains 7 WD repeats |
Function
for BTRC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FBW1A_HUMAN, Q9Y297Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex whichmediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds tophosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling.SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 totranslocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'.SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3,SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May beinvolved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase.Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required forproteolytic processing of GLI3 Genatlas biochemistry entry for BTRC:beta transducin repeat containing protein,interacting with HIV Vpu to trigger the destruction of CD4 in the endoplasmicreticulum
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTRC (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTRC (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): BTRC (NM_033637) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BTRC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTRC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTRC |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
BTRC for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for BTRC: Btrctm1Paga Btrctm1Kin
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Btrc):
BTRC for phenotypes About GeneDecksing
|
Pathways & Interactions
for BTRC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/42 super-pathways (see all 42) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitinated Orc1 is degraded by the proteasome | | | 2 | Antigen processing: Ubiquitination & Proteasome degradation | | | 3 | Wnt Signaling Pathway | | | 4 | FBXW7 WD mutants do not bind NICD1 | | | 5 | Cell cycle_Role of SCF complex in cell cycle regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for BTRC
1  R&D Systems Pathway for BTRC
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BTRC
1 
Cell Signaling Technology (CST) Pathway for BTRC
5  GeneGo (Thomson Reuters) Pathways for BTRC
5/14  BioSystems Pathways for BTRC (see all 14)
5/34 
Reactome Pathways for BTRC (see all 34)
5/6 
Kegg Pathways (Kegg details for BTRC) (see all 6):
UniProtKB/Swiss-Prot: FBW1A_HUMAN, Q9Y297Pathway: Protein modification; protein ubiquitination
BTRC for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BTRC
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/231 Interacting proteins for BTRC (Q9Y2971, 2, 3 ENSP000003592064) via UniProtKB, MINT, STRING, and/or I2D (see all 231)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CTNNB1 | P352222, 3, ENSP000003444564 | MINT-8012296 MINT-1773933 MINT-8012282 I2D:
score=7 STRING: ENSP00000344456 | | CDC25A | P303042, 3, ENSP000003037064 | MINT-49914 MINT-49900 MINT-49902 I2D:
score=5 STRING: ENSP00000303706 | | CDC34 | P494272, 3, ENSP000002155744 | MINT-16770 MINT-16769 I2D:
score=5 STRING: ENSP00000215574 | | NFKB2 | Q006532, 3, ENSP000001894444 | MINT-48617 MINT-6804748 I2D:
score=5 STRING: ENSP00000189444 | | TRIM9 | Q9C0262, 3, ENSP000002983554 | MINT-68269 I2D:
score=4 STRING: ENSP00000298355 |
About this table
Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table
BTRC for ontologies About GeneDecksing
|
Drugs & Compounds
for BTRC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
BTRC for compounds About GeneDecksing
 Browse Tocris compounds for BTRC
3 Novoseek chemical compound relationships for BTRC gene About this table
Search CenterWatch for drugs/clinical trials and news about BTRC / FBW1A
|
Transcripts
for BTRC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BTRC gene (3 alternative transcripts): NM_001256856.1 NM_003939.4 NM_033637.3 Unigene Cluster for BTRC: Beta-transducin repeat containing E3 ubiquitin protein ligase Hs.643802 [show with all ESTs]Unigene Representative Sequence: NM_0336377 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370187(uc001ksz.1 uc001kta.3 uc001ktb.3 uc001ktc.3)
ENST00000475200 ENST00000408038 ENST00000465182 ENST00000370183 ENST00000493877
ENST00000393441
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTRC (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTRC (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): BTRC (NM_033637) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BTRC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTRC |
Additional cDNA sequence: AF101784.1 AF129530.1 AK295870.1 AK313353.1 AK313417.1 AK314880.1 AY207475.1 AY207476.1 BC006204.2 BC027994.1 BC063673.1 CR749295.1 GU727631.1 Y14153.1 16 DOTS entries: DT.100778133 DT.97869214 DT.91752087 DT.100762657 DT.101980092 DT.100778134 DT.443990 DT.95196257 DT.121293360 DT.121293383 DT.91752083 DT.91752089 DT.95357657 DT.97772137 DT.91749951 DT.97839582 24/209 AceView cDNA sequences (see all 209): CN483452 BM830599 BQ948186 AI126995 BF001281 AI191826 BC027994 AA356877 BM997883 BU621667 AI241413 BE550634 BM930063 NM_033637 N58485 AL833133 BM664414 BX508858 AI802912 AA854373 BF056474 AI817740 AW593173 AA009496
GeneLoc Exon Structure
|
Expression
for BTRC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BTRC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAATGGAGT
About this image
See BTRC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BTRC
SOURCE GeneReport for Unigene cluster: Hs.643802
UniProtKB/Swiss-Prot: FBW1A_HUMAN, Q9Y297Tissue specificity: Expressed in epididymis (at protein level)
SABiosciences Expression via Pathway-Focused PCR Arrays including BTRC (see all 8):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BTRC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BTRC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTRC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTRC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTRC |
Orthologs
for BTRC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BTRC gene from 5/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
BTRC1 |
beta-transducin repeat containing |
86.83(n)
98.64(a) |
|
423854 XM_421723.3 XP_421723.3 |
lizard
(Anolis carolinensis) |
Reptilia |
BTRC6 |
-- |
97(a) |
1 ↔ 1 |
GL343239.1(919177-958212) |
African clawed frog
(Xenopus laevis) |
Amphibia |
btrc-A-prov2 |
beta-transducin repeat containing |
82.72(n) |
|
M98268.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
slmb1 , 3 |
circadian rhythm ubiquitin-protein ligase3
supernumerary limbs1 |
80(a)3
66.87(n)1
80.91(a)1 |
|
425041 NM_079706.21 NP_524430.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
lin-236 |
F-box/WD repeat-containing protein lin-23 |
48(a) |
1 → many |
II(6371273-6374502) |
ENSEMBL Gene Tree for BTRC (if available)
TreeFam Gene Tree for BTRC (if available) |
Paralogs
for BTRC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BTRC gene
- FBXW72 TRAF72 FBXW22 ZNF1062 FBXW112 WDR862
8 SIMAP similar genes for BTRC using alignment to 5 protein entries: FBW1A_HUMAN (see all proteins):DKFZp781N011 FBXW11 PF20 WSB1 FBXW7 POC1B
WDR83 FBXW2
BTRC for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for BTRC
PGOHUM00000243384
|
Genomic Variants
for BTRC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BTRC (103113820 - 103317078 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BTRC
1 CNV: 8666
Human Gene Mutation Database (HGMD): BTRC
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTRC |
|
Disorders
/ Diseases
for BTRC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BTRC for disorders About GeneDecksing
OMIM gene information: 603482
OMIM disorders: --
20/33  diseases for BTRC (see all 33): About MalaCardsfamilial adenomatous polyposis adenomatous polyposis coli esophagus squamous cell carcinoma cerebellar medulloblastoma
squamous cell carcinoma polyposis basal cell carcinoma wilms tumor
medulloblastoma shigellosis gastric cancer epididymitis
colorectal cancer hepatoblastoma breast cancer hepatocellular carcinoma
alzheimer's disease colon cancer carcinoma immunodeficiency
10/11 Novoseek disease relationships for BTRC gene (see all 11) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| familial adenomatous polyposis |
48.2 |
5 |
11212302 (1), 14970870 (1), 19582507 (1) |
| cancer |
25.2 |
16 |
18500245 (2), 19931512 (1), 15753389 (1), 16778892 (1) (see all 8) |
| tumors |
25 |
28 |
15292388 (5), 12898158 (3), 19931512 (2), 17387146 (2) (see all 13) |
| somatic mutations |
14.6 |
3 |
17295679 (3) |
| colorectal cancer |
11.7 |
7 |
15292388 (4), 16778892 (1), 16510874 (1) |
| necrosis |
8.78 |
4 |
10644755 (1), 19966869 (1), 14592850 (1) |
| immunodeficiency |
7.4 |
2 |
14561767 (1) |
| leukemia |
0 |
1 |
14526201 (1) |
| primary tumor |
0 |
1 |
15292388 (1) |
| breast cancer |
0 |
6 |
15753389 (2), 16278670 (1) |
Genetic Association Database (GAD): BTRC
Human Genome Epidemiology (HuGE) Navigator: BTRC (5 documents)
Export disorders for BTRC gene to outside databases
|
Publications
for BTRC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for BTRC gene, integrated from 9 sources (see all 288):
(articles sorted by number of sources associating them with BTRC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. (PubMed id 9660940)1, 2, 3 Margottin F.... Benarous R. (1998)
- Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination. (PubMed id 10644755)1, 2, 9 Suzuki H.... Tanaka K. (2000)
- Regulation of the discs large tumor suppressor by a phosphorylation- dependent interaction with the beta-TrCP ubiquitin ligase receptor. (PubMed id 12902344)1, 2, 9 Mantovani F. and Banks L. (2003)
- SCFbeta-TRCP controls oncogenic transformation and ne ural differentiation through REST degradation. (PubMed id 18354483)1, 3, 9 Westbrook T.F....Elledge S.J. (2008)
- ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase. (PubMed id 11238952)1, 2, 9 Lassot I....Margottin-Goguet F. (2001)
- IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2. (PubMed id 10066435)1, 2, 9 Suzuki H.... Tanaka K. (1999)
- Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. (PubMed id 16705181)1, 2, 9 Tempe D....Concordet J.P. (2006)
- Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. (PubMed id 11359933)1, 2, 9 Fukuchi M....Miyazono K. (2001)
- Identification of the receptor component of the IkappaBalpha- ubiquitin ligase. (PubMed id 9859996)1, 2, 9 Yaron A.... Ben-Neriah Y. (1998)
- Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. (PubMed id 12820959)1, 2, 9 Wu G....Pavletich N.P. (2003)
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External Searches for BTRC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing BTRC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing BTRC gene
(According to HUGE)
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Specialized Databases showing BTRC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for BTRC gene:
Search GeneIP for patents involving BTRC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for BTRC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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