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Aliases for BTNL9 Gene

Aliases for BTNL9 Gene

  • Butyrophilin Like 9 2 3 5
  • Butyrophilin-Like Protein 9 3
  • Butyrophilin-Like 9 2
  • Butyrophilin 3 3
  • VDLS1900 3
  • BTN3 3
  • BTN8 3

External Ids for BTNL9 Gene

Previous GeneCards Identifiers for BTNL9 Gene

  • GC05P180577
  • GC05P180399
  • GC05P180467
  • GC05P175192

Summaries for BTNL9 Gene

GeneCards Summary for BTNL9 Gene

BTNL9 (Butyrophilin Like 9) is a Protein Coding gene. An important paralog of this gene is BTN3A3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTNL9 Gene

Genomics for BTNL9 Gene

Regulatory Elements for BTNL9 Gene

Enhancers for BTNL9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around BTNL9 on UCSC Golden Path with GeneCards custom track

Genomic Location for BTNL9 Gene

Chromosome:
5
Start:
181,040,225 bp from pter
End:
181,061,523 bp from pter
Size:
21,299 bases
Orientation:
Plus strand

Genomic View for BTNL9 Gene

Genes around BTNL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTNL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTNL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTNL9 Gene

Proteins for BTNL9 Gene

  • Protein details for BTNL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXG8-BTNL9_HUMAN
    Recommended name:
    Butyrophilin-like protein 9
    Protein Accession:
    Q6UXG8
    Secondary Accessions:
    • A6NL42
    • Q6P660
    • Q96DM5

    Protein attributes for BTNL9 Gene

    Size:
    535 amino acids
    Molecular mass:
    59716 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTNL9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTNL9 Gene

Post-translational modifications for BTNL9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTNL9 Gene

No data available for DME Specific Peptides for BTNL9 Gene

Domains & Families for BTNL9 Gene

Gene Families for BTNL9 Gene

Suggested Antigen Peptide Sequences for BTNL9 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UXG8

UniProtKB/Swiss-Prot:

BTNL9_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
Domain:
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTNL9: view

Function for BTNL9 Gene

genes like me logo Genes that share phenotypes with BTNL9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BTNL9

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTNL9 Gene

Localization for BTNL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTNL9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTNL9 Gene COMPARTMENTS Subcellular localization image for BTNL9 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BTNL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BTNL9: view

Pathways & Interactions for BTNL9 Gene

SuperPathways for BTNL9 Gene

No Data Available

Interacting Proteins for BTNL9 Gene

Gene Ontology (GO) - Biological Process for BTNL9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BTNL9 Gene

Drugs & Compounds for BTNL9 Gene

No Compound Related Data Available

Transcripts for BTNL9 Gene

Unigene Clusters for BTNL9 Gene

Butyrophilin-like 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTNL9 Gene

No ASD Table

Relevant External Links for BTNL9 Gene

GeneLoc Exon Structure for
BTNL9
ECgene alternative splicing isoforms for
BTNL9

Expression for BTNL9 Gene

mRNA expression in normal human tissues for BTNL9 Gene

mRNA differential expression in normal tissues according to GTEx for BTNL9 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x10.2), Breast - Mammary Tissue (x6.7), Adipose - Subcutaneous (x6.6), and Lung (x4.0).

Protein differential expression in normal tissues from HIPED for BTNL9 Gene

This gene is overexpressed in Lung (42.5), Placenta (16.8), and Gallbladder (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTNL9 Gene



Protein tissue co-expression partners for BTNL9 Gene

NURSA nuclear receptor signaling pathways regulating expression of BTNL9 Gene:

BTNL9

SOURCE GeneReport for Unigene cluster for BTNL9 Gene:

Hs.546502
genes like me logo Genes that share expression patterns with BTNL9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BTNL9 Gene

Orthologs for BTNL9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTNL9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BTNL9 34
  • 78.43 (n)
  • 71.77 (a)
BTNL9 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTNL9 34
  • 77.98 (n)
  • 74.25 (a)
BTNL9 35
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btnl9 34
  • 75.64 (n)
  • 70.85 (a)
Btnl9 16
Btnl9 35
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BTNL9 34
  • 97.94 (n)
  • 96.29 (a)
BTNL9 35
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC684480 34
  • 73.75 (n)
  • 70.24 (a)
oppossum
(Monodelphis domestica)
Mammalia BTNL9 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 39 (a)
ManyToMany
Species where no ortholog for BTNL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTNL9 Gene

ENSEMBL:
Gene Tree for BTNL9 (if available)
TreeFam:
Gene Tree for BTNL9 (if available)

Paralogs for BTNL9 Gene

Paralogs for BTNL9 Gene

genes like me logo Genes that share paralogs with BTNL9: view

Variants for BTNL9 Gene

Sequence variations from dbSNP and Humsavar for BTNL9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10068763 - 181,059,785(+) GGACG(C/G/T)GCGTC reference, missense
rs4132833 -- 181,049,425(-) TACTA(G/T)AAATC intron-variant
rs4385169 -- 181,050,473(+) TCTGC(A/G)TATAG intron-variant
rs6891631 -- 181,060,863(+) ACATT(C/G)Tctct utr-variant-3-prime
rs10054109 -- 181,059,841(+) GCGGA(C/T)CCCGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for BTNL9 Gene

Variant ID Type Subtype PubMed ID
dgv10250n54 CNV gain 21841781
dgv10251n54 CNV gain 21841781
dgv5855n100 CNV gain 25217958
dgv5856n100 CNV gain 25217958
dgv5857n100 CNV gain 25217958
dgv5858n100 CNV gain 25217958
dgv5859n100 CNV gain 25217958
dgv5860n100 CNV gain 25217958
dgv735n27 CNV gain 19166990
esv1001577 CNV insertion 20482838
esv1265655 CNV insertion 17803354
esv1267126 CNV insertion 17803354
esv2759400 CNV gain 17122850
esv2763931 CNV gain+loss 21179565
esv3335910 CNV duplication 20981092
esv3447138 CNV insertion 20981092
esv3607801 CNV gain 21293372
esv3607803 CNV loss 21293372
esv3607804 CNV loss 21293372
esv3607805 CNV gain 21293372
esv3890777 CNV gain 25118596
esv3890778 CNV gain 25118596
nsv1015341 CNV gain 25217958
nsv1021633 CNV gain 25217958
nsv10792 CNV gain 18304495
nsv1125865 CNV tandem duplication 24896259
nsv1161326 CNV duplication 26073780
nsv428133 CNV gain 18775914
nsv462588 CNV gain 19166990
nsv471062 CNV gain 18288195
nsv509112 CNV insertion 20534489
nsv5162 CNV insertion 18451855
nsv818395 CNV gain 17921354
nsv950743 CNV deletion 24416366

Variation tolerance for BTNL9 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTNL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BTNL9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTNL9 Gene

Disorders for BTNL9 Gene

Relevant External Links for BTNL9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BTNL9

No disorders were found for BTNL9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTNL9 Gene

Publications for BTNL9 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 65
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for BTNL9 Gene

Sources for BTNL9 Gene

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