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Aliases for BTNL9 Gene

Aliases for BTNL9 Gene

  • Butyrophilin Like 9 2 3
  • Butyrophilin-Like 9 2 3 5
  • Butyrophilin 3 3
  • VDLS1900 3
  • BTN3 3
  • BTN8 3

External Ids for BTNL9 Gene

Previous GeneCards Identifiers for BTNL9 Gene

  • GC05P180577
  • GC05P180399
  • GC05P180467
  • GC05P175192

Summaries for BTNL9 Gene

GeneCards Summary for BTNL9 Gene

BTNL9 (Butyrophilin Like 9) is a Protein Coding gene. An important paralog of this gene is BTNL8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTNL9 Gene

Genomics for BTNL9 Gene

Regulatory Elements for BTNL9 Gene

Enhancers for BTNL9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BTNL9 on UCSC Golden Path with GeneCards custom track

Genomic Location for BTNL9 Gene

181,040,225 bp from pter
181,061,523 bp from pter
21,299 bases
Plus strand

Genomic View for BTNL9 Gene

Genes around BTNL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTNL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTNL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTNL9 Gene

Proteins for BTNL9 Gene

  • Protein details for BTNL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin-like protein 9
    Protein Accession:
    Secondary Accessions:
    • A6NL42
    • Q6P660
    • Q96DM5

    Protein attributes for BTNL9 Gene

    535 amino acids
    Molecular mass:
    59716 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTNL9 Gene


neXtProt entry for BTNL9 Gene

Proteomics data for BTNL9 Gene at MOPED

Post-translational modifications for BTNL9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTNL9 Gene

No data available for DME Specific Peptides for BTNL9 Gene

Domains & Families for BTNL9 Gene

Gene Families for BTNL9 Gene

Suggested Antigen Peptide Sequences for BTNL9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTNL9: view

Function for BTNL9 Gene

Phenotypes for BTNL9 Gene

genes like me logo Genes that share phenotypes with BTNL9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BTNL9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTNL9 Gene

Localization for BTNL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTNL9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for BTNL9 Gene COMPARTMENTS Subcellular localization image for BTNL9 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for BTNL9 Gene

Pathways & Interactions for BTNL9 Gene

SuperPathways for BTNL9 Gene

No Data Available

Interacting Proteins for BTNL9 Gene

Gene Ontology (GO) - Biological Process for BTNL9 Gene


No data available for Pathways by source and SIGNOR curated interactions for BTNL9 Gene

Drugs & Compounds for BTNL9 Gene

No Compound Related Data Available

Transcripts for BTNL9 Gene

Unigene Clusters for BTNL9 Gene

Butyrophilin-like 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTNL9 Gene

No ASD Table

Relevant External Links for BTNL9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTNL9 Gene

mRNA expression in normal human tissues for BTNL9 Gene

mRNA differential expression in normal tissues according to GTEx for BTNL9 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x10.2), Breast - Mammary Tissue (x6.7), Adipose - Subcutaneous (x6.6), and Lung (x4.0).

Protein differential expression in normal tissues from HIPED for BTNL9 Gene

This gene is overexpressed in Lung (42.5), Placenta (16.8), and Gallbladder (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTNL9 Gene

SOURCE GeneReport for Unigene cluster for BTNL9 Gene Hs.546502

genes like me logo Genes that share expression patterns with BTNL9: view

Protein tissue co-expression partners for BTNL9 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BTNL9 Gene

Orthologs for BTNL9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTNL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BTNL9 35
  • 78.43 (n)
  • 71.77 (a)
BTNL9 36
  • 73 (a)
(Canis familiaris)
Mammalia BTNL9 35
  • 77.98 (n)
  • 74.25 (a)
BTNL9 36
  • 72 (a)
(Mus musculus)
Mammalia Btnl9 35
  • 75.64 (n)
  • 70.85 (a)
Btnl9 16
Btnl9 36
  • 69 (a)
(Pan troglodytes)
Mammalia BTNL9 35
  • 97.94 (n)
  • 96.29 (a)
BTNL9 36
  • 96 (a)
(Rattus norvegicus)
Mammalia LOC684480 35
  • 73.75 (n)
  • 70.24 (a)
(Monodelphis domestica)
Mammalia BTNL9 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
Species with no ortholog for BTNL9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTNL9 Gene

Gene Tree for BTNL9 (if available)
Gene Tree for BTNL9 (if available)

Paralogs for BTNL9 Gene

Paralogs for BTNL9 Gene

genes like me logo Genes that share paralogs with BTNL9: view

Variants for BTNL9 Gene

Sequence variations from dbSNP and Humsavar for BTNL9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10068763 - 181,059,785(+) GGACG(C/G/T)GCGTC reference, missense
rs1467 -- 181,058,720(-) GCCAT(C/T)TGACA intron-variant
rs1053110 -- 181,061,260(+) TGTAG(C/T)AAAAT utr-variant-3-prime
rs6601165 -- 181,054,998(+) AATTA(G/T)TTGGG intron-variant
rs6601166 -- 181,059,247(+) GTGAC(G/T)CTGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for BTNL9 Gene

Variant ID Type Subtype PubMed ID
nsv428133 CNV Gain 18775914
dgv1883e1 CNV Complex 17122850
nsv509112 CNV Insertion 20534489
nsv818395 CNV Gain 17921354
nsv462588 CNV Gain 19166990
nsv471062 CNV Gain 18288195
dgv735n27 CNV Gain 19166990
nsv5162 CNV Insertion 18451855
dgv6406n71 CNV Gain 21882294
nsv883302 CNV Gain 21882294
esv1001577 CNV Insertion 20482838
esv1267126 CNV Insertion 17803354
dgv6407n71 CNV Loss 21882294
esv1265655 CNV Insertion 17803354
nsv10792 CNV Gain 18304495

Variation tolerance for BTNL9 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BTNL9 Gene

Disorders for BTNL9 Gene

Relevant External Links for BTNL9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BTNL9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTNL9 Gene

Publications for BTNL9 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The cluster of BTN genes in the extended major histocompatibility complex. (PMID: 11170752) Rhodes D.A. … Trowsdale J. (Genomics 2001) 23

Products for BTNL9 Gene

Sources for BTNL9 Gene