BTNL8 Gene
protein-coding GIFtS: 44
GCID: GC05P180326
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|
butyrophilin-like 8
| |
Aliases
for BTNL8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Butyrophilin-Like 81 2 | | FLJ214581 | | B7-H5 Costimulatory Molecule2 | | Butyrophilin-Like Protein 82 |
Export aliases for BTNL8 gene to outside databasesPrevious GC identifers: GC05P180436 GC05P180258 GC05P175051 |
Summaries
for BTNL8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for BTNL8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for BTNL8
Other transcription factors
Search SABiosciences Chromatin IP Primers for BTNL8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTNL8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3BTNL8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P180326: view genomic region
(about GC identifiers)
Start:
|
180,326,077 bp from pter |
End:
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180,377,906 bp from pter |
Size:
|
51,830 bases |
Orientation:
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plus strand |
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Proteins
for BTNL8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BTNL8_HUMAN, Q6UX41 (See
protein sequence)Recommended Name: Butyrophilin-like protein 8 precursor Size: 500 amino acids; 56748 Da
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: A4QMZ8 A6NEX6 B7Z409 B7Z5B1 E9PEF6 E9PG07 F2Z2B2 F8W712 Q9H730Alternative splicing: 7 isoforms: Q6UX41-1 Q6UX41-2 Q6UX41-3 Q6UX41-4 Q6UX41-5 Q6UX41-6 Q6UX41-7 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for BTNL8: NX_Q6UX41
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UX41
BTNL8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001035552.1 NP_001153179.1 NP_001153180.1 NP_001153181.1 NP_001153182.1 NP_079126.1
ENSEMBL proteins: ENSP00000231229 ENSP00000342197 ENSP00000383543 ENSP00000424585 ENSP00000425207 ENSP00000427441 ENSP00000422069 ENSP00000435098
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
BTNL8 for ontologies About GeneDecksing
BTNL8 Antibody Products:
Assay Products for BTNL8: |
Protein
Domains /
Families
for BTNL8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BTNL8 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q6UX41ProtoNet protein and cluster: Q6UX41 2 Blocks protein families: IPB003599 Immunoglobulin subtype IPB006574 SPRY-associated domain
UniProtKB/Swiss-Prot: BTNL8_HUMAN, Q6UX41Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG familySimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains |
Function
for BTNL8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTNL8 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTNL8 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for BTNL8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTNL8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTNL8 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
BTNL8 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for BTNL8:
|
Pathways & Interactions
for BTNL8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BTNL8
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for BTNL8 (Q6UX411 ENSP000003421974) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for BTNL8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BTNL8
Search CenterWatch for drugs/clinical trials and news about BTNL8
|
Transcripts
for BTNL8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BTNL8 gene (6 alternative transcripts): NM_001040462.2 NM_001159707.1 NM_001159708.1 NM_001159709.1 NM_001159710.1 NM_024850.2 Unigene Cluster for BTNL8: Butyrophilin-like 8 Hs.189109 [show with all ESTs]Unigene Representative Sequence: NM_02485010 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000231229(uc003mmp.3 uc003mmq.3 uc010jll.3 uc011dhg.2 uc010jlm.3)
ENST00000340184 ENST00000400707 ENST00000508408 ENST00000511704 ENST00000505126
ENST00000514448 ENST00000513442 ENST00000503543 ENST00000533815(uc011dhh.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTNL8 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTNL8 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): BTNL8 (NM_024850) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BTNL8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTNL8 |
Additional cDNA sequence: AK025111.1 AK225213.1 AK296597.1 AK298687.1 AK308012.1 AK309639.1 AY358523.1 BC119696.1 BC119697.1 3 DOTS entries: DT.101977979 DT.40303187 DT.100745634 24 AceView cDNA sequences: AK025111 AK025267 BM792815 NM_197975 NM_006707 NM_024850 BX109154 AY358523 AI339669 BQ027683 BM922175 AB020625 AY358385 BI831158 AI991125 BX481901 CB852920 AW000848 CB852944 AU098650 AW629106 BQ027973 AA884903 BF333492
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for BTNL8 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c |
|---|
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| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for BTNL8
|
Expression
for BTNL8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BTNL8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See BTNL8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BTNL8
SOURCE GeneReport for Unigene cluster: Hs.189109
SABiosciences Custom PCR Arrays for BTNL8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BTNL8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat BTNL8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTNL8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTNL8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTNL8 |
Orthologs
for BTNL8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for BTNL8 gene from 1/4 species (see all 4) About this table
ENSEMBL Gene Tree for BTNL8 (if available)
TreeFam Gene Tree for BTNL8 (if available) |
Paralogs
for BTNL8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BTNL8 gene
- BTN3A22 BTN2A12 ERMAP2 BTN3A32 BTN2A22 HHLA22 CD2762 BTNL102
- MOG2 BTNL22 BTN3A12 VTCN12 BTN1A12 BTNL92 BTNL32
15 SIMAP similar genes for BTNL8 using alignment to 3 protein entries: BTNL8_HUMAN (see all proteins):BTNL3 MOG TRIM27 MEFV BTNL2 BTN3A2
BTN1A1 BTNL9 BTN2A3P BT3.3 BTN2A1 BTN2A2
BTN3A1 TRIM69 BTN3A3
BTNL8 for paralogs About GeneDecksing
|
Genomic Variants
for BTNL8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BTNL8 (180326077 - 180377906 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for BTNL8
14 CNVs: 64400 2094 93403 2093 59614 32765 31262 93408 93406 64398 99383 32763 32764 59254
3 Indels: 99382 33415 69266 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTNL8 |
|
Disorders
/ Diseases
for BTNL8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for BTNL8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BTNL8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with BTNL8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for BTNL8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BTNL8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BTNL8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BTNL8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BTNL8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BTNL8 gene:
Search GeneIP for patents involving BTNL8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BTNL8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | BTNL8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTNL8 |
|  |  |  | | | | ThermoFisher Antibodies for BTNL8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTNL8 |
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