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Aliases for BTNL8 Gene

Aliases for BTNL8 Gene

  • Butyrophilin-Like 8 2 3
  • BTN9.2 3 6
  • B7-H5 Costimulatory Molecule 3
  • Butyrophilin-Like Protein 8 3

External Ids for BTNL8 Gene

Previous GeneCards Identifiers for BTNL8 Gene

  • GC05P180436
  • GC05P180258
  • GC05P180326
  • GC05P175051

Summaries for BTNL8 Gene

GeneCards Summary for BTNL8 Gene

BTNL8 (Butyrophilin-Like 8) is a Protein Coding gene. An important paralog of this gene is BTNL9.

UniProtKB/Swiss-Prot for BTNL8 Gene

  • May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTNL8 Gene

Genomics for BTNL8 Gene

Genomic Location for BTNL8 Gene

180,899,077 bp from pter
180,950,906 bp from pter
51,830 bases
Plus strand

Genomic View for BTNL8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTNL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTNL8 Gene

No data available for Regulatory Elements for BTNL8 Gene

Proteins for BTNL8 Gene

  • Protein details for BTNL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin-like protein 8
    Protein Accession:
    Secondary Accessions:
    • A4QMZ8
    • A6NEX6
    • B7Z409
    • B7Z5B1
    • E9PEF6
    • E9PG07
    • F2Z2B2
    • F8W712
    • Q9H730

    Protein attributes for BTNL8 Gene

    500 amino acids
    Molecular mass:
    56748 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTNL8 Gene

neXtProt entry for BTNL8 Gene

Proteomics data for BTNL8 Gene at MOPED

Post-translational modifications for BTNL8 Gene

  • Glycosylation at Asn103
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BTNL8 Gene

Domains for BTNL8 Gene

Gene Families for BTNL8 Gene

  • BTN :Butyrophilins
  • VSET :Immunoglobulin superfamily / V-set domain containing

Suggested Antigen Peptide Sequences for BTNL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6UX41
  • Contains 1 B30.2/SPRY domain.
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTNL8: view

Function for BTNL8 Gene

Molecular function for BTNL8 Gene

UniProtKB/Swiss-Prot Function: May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.
UniProtKB/Swiss-Prot Induction: Down-regulated in neutrophils after treatment with LPS and TNF.

Gene Ontology (GO) - Molecular Function for BTNL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with BTNL8: view

Phenotypes for BTNL8 Gene

genes like me logo Genes that share phenotypes with BTNL8: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BTNL8 Gene

Localization for BTNL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTNL8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for BTNL8 Gene COMPARTMENTS Subcellular localization image for BTNL8 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BTNL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BTNL8: view

Pathways for BTNL8 Gene

SuperPathways for BTNL8 Gene

No Data Available

Interacting Proteins for BTNL8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000342197 Q6UX41-BTNL8_HUMAN for BTNL8 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for BTNL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with BTNL8: view

No data available for Pathways by source for BTNL8 Gene

Transcripts for BTNL8 Gene

Unigene Clusters for BTNL8 Gene

Butyrophilin-like 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BTNL8

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for BTNL8
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTNL8 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP2: -

Relevant External Links for BTNL8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTNL8 Gene

mRNA expression in normal human tissues for BTNL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTNL8 Gene

This gene is overexpressed in Whole Blood (17.9), Small Intestine - Terminal Ileum (14.5), and Colon - Transverse (10.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for BTNL8 Gene

SOURCE GeneReport for Unigene cluster for BTNL8 Gene Hs.189109

mRNA Expression by UniProt/SwissProt for BTNL8 Gene

Tissue specificity: Expressed in neutrophils. Isoforms 1 and 5 are expressed at high levels in the colon, lung,testis, lymph nodes and thyroid tissue. Isoform 5, but not isoform 1, is detected in spleen.
genes like me logo Genes that share expressions with BTNL8: view

In Situ Assay Products

Orthologs for BTNL8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTNL8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTNL8 35
  • 98.76 (n)
  • 97.11 (a)
BTNL8 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
-- 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
-- 36
  • 44 (a)
Species with no ortholog for BTNL8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTNL8 Gene

Gene Tree for BTNL8 (if available)
Gene Tree for BTNL8 (if available)

Paralogs for BTNL8 Gene

Paralogs for BTNL8 Gene

Selected SIMAP similar genes for BTNL8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BTNL8: view

Variants for BTNL8 Gene

Sequence variations from dbSNP and Humsavar for BTNL8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs187488 -- 180,917,311(+) ACTAT(G/T)AAAAA intron-variant
rs190348 -- 180,915,620(+) agact(A/G)gagga intron-variant
rs249355 -- 180,908,671(+) CCTAA(A/G)ACCAA synonymous-codon, reference, intron-variant, upstream-variant-2KB
rs249356 -- 180,914,895(+) tcttc(C/T)gaggt intron-variant
rs249357 -- 180,916,749(+) acgta(C/T)agtac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTNL8 Gene

Variant ID Type Subtype PubMed ID
dgv6n29 CNV Loss 16826518
nsv428133 CNV Gain 18775914
nsv820020 CNV Loss 19587683
nsv830566 CNV Loss 17160897
nsv883299 CNV Gain 21882294
nsv10790 CNV Gain+Loss 18304495
esv2427567 CNV Insertion 19546169
esv25559 CNV Gain+Loss 19812545
esv992764 CNV Loss 20482838
esv2601471 CNV Insertion 19546169
esv267826 CNV Insertion 20981092
nsv10791 CNV Gain+Loss 18304495
dgv1066e199 CNV Deletion 23128226
nsv821169 CNV Deletion 20802225
nsv823367 CNV Loss 20364138
nsv513283 CNV Loss 21212237
esv29779 CNV Gain+Loss 19812545
nsv514338 CNV Complex 21397061
nsv819450 CNV Loss 19587683
esv2421695 CNV Deletion 20811451

Relevant External Links for BTNL8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTNL8 Gene

Disorders for BTNL8 Gene

No disorders were found for BTNL8 Gene.

No data available for UniProtKB/Swiss-Prot for BTNL8 Gene

Publications for BTNL8 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  4. BTNL8, a butyrophilin-like molecule that costimulates the primary immune response. (PMID: 24036152) Chapoval A.I. … Mezes P.S. (Mol. Immunol. 2013) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4

Products for BTNL8 Gene

Sources for BTNL8 Gene

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