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Aliases for BTNL8 Gene

Aliases for BTNL8 Gene

  • Butyrophilin Like 8 2 3
  • Butyrophilin-Like 8 2 3 5
  • B7-H5 Costimulatory Molecule 3
  • BTN9.2 3

External Ids for BTNL8 Gene

Previous GeneCards Identifiers for BTNL8 Gene

  • GC05P180436
  • GC05P180258
  • GC05P180326
  • GC05P175051

Summaries for BTNL8 Gene

GeneCards Summary for BTNL8 Gene

BTNL8 (Butyrophilin Like 8) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. An important paralog of this gene is BTN1A1.

UniProtKB/Swiss-Prot for BTNL8 Gene

  • May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTNL8 Gene

Genomics for BTNL8 Gene

Regulatory Elements for BTNL8 Gene

Enhancers for BTNL8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BTNL8 on UCSC Golden Path with GeneCards custom track

Genomic Location for BTNL8 Gene

180,899,077 bp from pter
180,952,166 bp from pter
53,090 bases
Plus strand

Genomic View for BTNL8 Gene

Genes around BTNL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTNL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTNL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTNL8 Gene

Proteins for BTNL8 Gene

  • Protein details for BTNL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin-like protein 8
    Protein Accession:
    Secondary Accessions:
    • A4QMZ8
    • A6NEX6
    • B7Z409
    • B7Z5B1
    • E9PEF6
    • E9PG07
    • F2Z2B2
    • F8W712
    • Q9H730

    Protein attributes for BTNL8 Gene

    500 amino acids
    Molecular mass:
    56748 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTNL8 Gene

neXtProt entry for BTNL8 Gene

Proteomics data for BTNL8 Gene at MOPED

Post-translational modifications for BTNL8 Gene

  • Glycosylation at Asn 103
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BTNL8 Gene

Domains & Families for BTNL8 Gene

Gene Families for BTNL8 Gene

Suggested Antigen Peptide Sequences for BTNL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
  • Contains 1 B30.2/SPRY domain.
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTNL8: view

Function for BTNL8 Gene

Molecular function for BTNL8 Gene

UniProtKB/Swiss-Prot Function:
May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.
UniProtKB/Swiss-Prot Induction:
Down-regulated in neutrophils after treatment with LPS and TNF.
genes like me logo Genes that share phenotypes with BTNL8: view

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BTNL8 Gene

Localization for BTNL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTNL8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for BTNL8 Gene COMPARTMENTS Subcellular localization image for BTNL8 gene
Compartment Confidence
nucleus 3
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for BTNL8 Gene

Pathways & Interactions for BTNL8 Gene

genes like me logo Genes that share pathways with BTNL8: view

Pathways by source for BTNL8 Gene

1 R&D Systems pathway for BTNL8 Gene

Interacting Proteins for BTNL8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000342197 Q6UX41-BTNL8_HUMAN for BTNL8 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for BTNL8 Gene


No data available for SIGNOR curated interactions for BTNL8 Gene

Drugs & Compounds for BTNL8 Gene

No Compound Related Data Available

Transcripts for BTNL8 Gene

Unigene Clusters for BTNL8 Gene

Butyrophilin-like 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTNL8 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP2: -

Relevant External Links for BTNL8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTNL8 Gene

mRNA expression in normal human tissues for BTNL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTNL8 Gene

This gene is overexpressed in Whole Blood (x17.9), Small Intestine - Terminal Ileum (x14.5), and Colon - Transverse (x10.5).

Protein differential expression in normal tissues from HIPED for BTNL8 Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTNL8 Gene

SOURCE GeneReport for Unigene cluster for BTNL8 Gene Hs.189109

mRNA Expression by UniProt/SwissProt for BTNL8 Gene

Tissue specificity: Expressed in neutrophils. Isoforms 1 and 5 are expressed at high levels in the colon, lung,testis, lymph nodes and thyroid tissue. Isoform 5, but not isoform 1, is detected in spleen.
genes like me logo Genes that share expression patterns with BTNL8: view

Protein tissue co-expression partners for BTNL8 Gene

Primer Products

Orthologs for BTNL8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTNL8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTNL8 35
  • 98.76 (n)
  • 97.11 (a)
BTNL8 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
-- 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
-- 36
  • 44 (a)
Species with no ortholog for BTNL8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTNL8 Gene

Gene Tree for BTNL8 (if available)
Gene Tree for BTNL8 (if available)

Paralogs for BTNL8 Gene

Paralogs for BTNL8 Gene

(13) SIMAP similar genes for BTNL8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BTNL8: view

Variants for BTNL8 Gene

Sequence variations from dbSNP and Humsavar for BTNL8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2276995 - 180,911,368(+) CCATC(A/G)CGGGA intron-variant, reference, missense, utr-variant-5-prime
rs7724813 - 180,947,523(+) TTTTC(A/G)AGCCT intron-variant, reference, missense
rs146303629 - 180,949,974(+) ACCCA(C/G/T)AGAAA reference, synonymous-codon, missense, utr-variant-3-prime
rs7703365 - 180,950,018(+) ATTTA(A/C)AAGGA reference, missense, utr-variant-3-prime
rs113820381 - 180,950,470(+) CCTCT(A/G)CAATC reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BTNL8 Gene

Variant ID Type Subtype PubMed ID
dgv6n29 CNV Loss 16826518
nsv428133 CNV Gain 18775914
nsv820020 CNV Loss 19587683
nsv830566 CNV Loss 17160897
nsv883299 CNV Gain 21882294
nsv10790 CNV Gain+Loss 18304495
esv2427567 CNV Insertion 19546169
esv25559 CNV Gain+Loss 19812545
esv992764 CNV Loss 20482838
esv2601471 CNV Insertion 19546169
esv267826 CNV Insertion 20981092
nsv10791 CNV Gain+Loss 18304495
dgv1066e199 CNV Deletion 23128226
nsv821169 CNV Deletion 20802225
nsv823367 CNV Loss 20364138
nsv513283 CNV Loss 21212237
esv29779 CNV Gain+Loss 19812545
nsv514338 CNV Complex 21397061
nsv819450 CNV Loss 19587683
esv2421695 CNV Deletion 20811451

Variation tolerance for BTNL8 Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.35; 63.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTNL8 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTNL8 Gene

Disorders for BTNL8 Gene

Relevant External Links for BTNL8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BTNL8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTNL8 Gene

Publications for BTNL8 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. BTNL8, a butyrophilin-like molecule that costimulates the primary immune response. (PMID: 24036152) Chapoval A.I. … Mezes P.S. (Mol. Immunol. 2013) 3
  4. A secreted protein microarray platform for extracellular protein interaction discovery. (PMID: 21982860) Ramani S.R. … Gonzalez L.C. (Anal. Biochem. 2012) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for BTNL8 Gene

Sources for BTNL8 Gene