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Aliases for BTNL3 Gene

Aliases for BTNL3 Gene

  • Butyrophilin Like 3 2 3
  • Butyrophilin-Like Receptor 2 3 4
  • Butyrophilin-Like 3 2 3 5
  • BTNLR 3 4
  • COLF4100 4
  • BTN9.1 3

External Ids for BTNL3 Gene

Previous GeneCards Identifiers for BTNL3 Gene

  • GC05P180545
  • GC05P181402
  • GC05P180480
  • GC05P180525
  • GC05P180348
  • GC05P180415
  • GC05P175140

Summaries for BTNL3 Gene

GeneCards Summary for BTNL3 Gene

BTNL3 (Butyrophilin Like 3) is a Protein Coding gene. An important paralog of this gene is BTNL8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTNL3 Gene

Genomics for BTNL3 Gene

Regulatory Elements for BTNL3 Gene

Genomic Location for BTNL3 Gene

180,988,845 bp from pter
181,006,727 bp from pter
17,883 bases
Plus strand

Genomic View for BTNL3 Gene

Genes around BTNL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTNL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTNL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTNL3 Gene

Proteins for BTNL3 Gene

  • Protein details for BTNL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q496L7
    • Q9Y2C7

    Protein attributes for BTNL3 Gene

    466 amino acids
    Molecular mass:
    52251 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTNL3 Gene


neXtProt entry for BTNL3 Gene

Proteomics data for BTNL3 Gene at MOPED

Post-translational modifications for BTNL3 Gene

No Post-translational modifications

Other Protein References for BTNL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BTNL3 Gene

Domains & Families for BTNL3 Gene

Gene Families for BTNL3 Gene

Suggested Antigen Peptide Sequences for BTNL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTNL3: view

Function for BTNL3 Gene

Molecular function for BTNL3 Gene

GENATLAS Biochemistry:
butyrophilin-like 8A,B box family of proteins,involved in cell proliferation and development
genes like me logo Genes that share phenotypes with BTNL3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTNL3 Gene

Localization for BTNL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTNL3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for BTNL3 Gene COMPARTMENTS Subcellular localization image for BTNL3 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for BTNL3 Gene

Pathways & Interactions for BTNL3 Gene

SuperPathways for BTNL3 Gene

No Data Available

Interacting Proteins for BTNL3 Gene

Gene Ontology (GO) - Biological Process for BTNL3 Gene


No data available for Pathways by source and SIGNOR curated interactions for BTNL3 Gene

Drugs & Compounds for BTNL3 Gene

No Compound Related Data Available

Transcripts for BTNL3 Gene

mRNA/cDNA for BTNL3 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTNL3 Gene

Butyrophilin-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTNL3 Gene

No ASD Table

Relevant External Links for BTNL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTNL3 Gene

mRNA expression in normal human tissues for BTNL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTNL3 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x24.2), Colon - Transverse (x20.3), and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for BTNL3 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTNL3 Gene

SOURCE GeneReport for Unigene cluster for BTNL3 Gene Hs.225949

mRNA Expression by UniProt/SwissProt for BTNL3 Gene

Tissue specificity: Expressed in small intestine, colon, testis, spleen, and leukocyte.
genes like me logo Genes that share expression patterns with BTNL3: view

Protein tissue co-expression partners for BTNL3 Gene

Primer Products

In Situ Assay Products

Orthologs for BTNL3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTNL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTNL3 35
  • 97.93 (n)
  • 96.78 (a)
BTNL3 36
  • 95 (a)
(Canis familiaris)
Mammalia -- 36
  • 27 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
-- 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
-- 36
  • 44 (a)
Species with no ortholog for BTNL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTNL3 Gene

Gene Tree for BTNL3 (if available)
Gene Tree for BTNL3 (if available)

Paralogs for BTNL3 Gene

Paralogs for BTNL3 Gene

(12) SIMAP similar genes for BTNL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BTNL3: view

Variants for BTNL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for BTNL3 Gene

Variant ID Type Subtype PubMed ID
nsv428133 CNV Gain 18775914
nsv820020 CNV Loss 19587683
nsv830566 CNV Loss 17160897
nsv883299 CNV Gain 21882294
nsv10791 CNV Gain+Loss 18304495
dgv1066e199 CNV Deletion 23128226
nsv821169 CNV Deletion 20802225
nsv823367 CNV Loss 20364138
nsv513283 CNV Loss 21212237
esv29779 CNV Gain+Loss 19812545
nsv514338 CNV Complex 21397061
nsv819450 CNV Loss 19587683
esv2421695 CNV Deletion 20811451
nsv442972 CNV CNV 18776908
dgv1883e1 CNV Complex 17122850
nsv508390 CNV Loss 20534489
dgv988n67 CNV Loss 20364138
esv988906 CNV Gain 20482838
esv33360 CNV Gain 17666407
nsv471441 CNV Deletion 19718026
esv29991 CNV Gain 17803354
nsv509112 CNV Insertion 20534489

Variation tolerance for BTNL3 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTNL3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for BTNL3 Gene

Disorders for BTNL3 Gene

Relevant External Links for BTNL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BTNL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTNL3 Gene

Publications for BTNL3 Gene

  1. Cloning, expression analysis, and chromosomal localization of a novel butyrophilin-like receptor. (PMID: 10429365) Shibui A. … Sugane K. (J. Hum. Genet. 1999) 2 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for BTNL3 Gene

Sources for BTNL3 Gene

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