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Aliases for BTNL3 Gene

Aliases for BTNL3 Gene

  • Butyrophilin Like 3 2 3 5
  • Butyrophilin-Like Receptor 2 3 4
  • BTNLR 3 4
  • Butyrophilin-Like Protein 3 3
  • Butyrophilin-Like 3 2
  • COLF4100 4
  • BTN9.1 3

External Ids for BTNL3 Gene

Previous GeneCards Identifiers for BTNL3 Gene

  • GC05P180545
  • GC05P181402
  • GC05P180480
  • GC05P180525
  • GC05P180348
  • GC05P180415
  • GC05P175140

Summaries for BTNL3 Gene

GeneCards Summary for BTNL3 Gene

BTNL3 (Butyrophilin Like 3) is a Protein Coding gene. An important paralog of this gene is BTNL8.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTNL3 Gene

Genomics for BTNL3 Gene

Regulatory Elements for BTNL3 Gene

Enhancers for BTNL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G181027 1.2 Ensembl ENCODE 72.1 +39.3 39321 0.9 HDGF PKNOX1 ATF1 CREB3L1 SIN3A ETS1 ELK1 KLF13 KDM4B GTF2B BTNL3 ENSG00000233937 MGAT1 BTNL8 BTNL9 RNU6-1036P
GH05G180885 1.2 Ensembl ENCODE 57.8 -102.8 -102787 0.9 ELF3 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 RAD21 ZNF48 RARA YY1 BTNL3 BTNL8 ZFP62
GH05G180897 0.5 ENCODE 55.7 -89.8 -89830 3.1 ZNF600 ZIC2 TRIM28 BTNL3 BTNL8 ZFP62
GH05G180944 0.5 FANTOM5 49.2 -44.3 -44279 0.2 CTCF RAD21 BTNL3 BTNL8 OR2Y1 OR2V2 RPS29P12 ENSG00000222852
GH05G181051 0.7 ENCODE 22.3 +62.4 62371 0.2 ZNF263 MTA2 BHLHE40 NR2F1 TBX21 ARID1B ZFHX2 ARID3A EGR1 IKZF1 BTNL3 PIR56545 MIR8089
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BTNL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for BTNL3 Gene

180,988,845 bp from pter
181,006,727 bp from pter
17,883 bases
Plus strand

Genomic View for BTNL3 Gene

Genes around BTNL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTNL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTNL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTNL3 Gene

Proteins for BTNL3 Gene

  • Protein details for BTNL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q496L7
    • Q9Y2C7

    Protein attributes for BTNL3 Gene

    466 amino acids
    Molecular mass:
    52251 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTNL3 Gene


neXtProt entry for BTNL3 Gene

Post-translational modifications for BTNL3 Gene

No Post-translational modifications

Other Protein References for BTNL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BTNL3 Gene

Domains & Families for BTNL3 Gene

Gene Families for BTNL3 Gene

Suggested Antigen Peptide Sequences for BTNL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTNL3: view

Function for BTNL3 Gene

Molecular function for BTNL3 Gene

GENATLAS Biochemistry:
butyrophilin-like 8A,B box family of proteins,involved in cell proliferation and development

Gene Ontology (GO) - Molecular Function for BTNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with BTNL3: view
genes like me logo Genes that share phenotypes with BTNL3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTNL3 Gene

Localization for BTNL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTNL3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTNL3 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for BTNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BTNL3: view

Pathways & Interactions for BTNL3 Gene

SuperPathways for BTNL3 Gene

No Data Available

Interacting Proteins for BTNL3 Gene

Gene Ontology (GO) - Biological Process for BTNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with BTNL3: view

No data available for Pathways by source and SIGNOR curated interactions for BTNL3 Gene

Drugs & Compounds for BTNL3 Gene

No Compound Related Data Available

Transcripts for BTNL3 Gene

mRNA/cDNA for BTNL3 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTNL3 Gene

Butyrophilin-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTNL3 Gene

No ASD Table

Relevant External Links for BTNL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTNL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BTNL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTNL3 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x24.2), Colon - Transverse (x20.3), and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for BTNL3 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTNL3 Gene

Protein tissue co-expression partners for BTNL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of BTNL3 Gene:


SOURCE GeneReport for Unigene cluster for BTNL3 Gene:


mRNA Expression by UniProt/SwissProt for BTNL3 Gene:

Tissue specificity: Expressed in small intestine, colon, testis, spleen, and leukocyte.

Evidence on tissue expression from TISSUES for BTNL3 Gene

  • Intestine(4.3)
genes like me logo Genes that share expression patterns with BTNL3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BTNL3 Gene

Orthologs for BTNL3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTNL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTNL3 34 35
  • 97.93 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 44 (a)
-- 35
  • 35 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 40 (a)
-- 35
  • 39 (a)
(Canis familiaris)
Mammalia -- 35
  • 27 (a)
Species where no ortholog for BTNL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTNL3 Gene

Gene Tree for BTNL3 (if available)
Gene Tree for BTNL3 (if available)

Paralogs for BTNL3 Gene

Paralogs for BTNL3 Gene

(12) SIMAP similar genes for BTNL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BTNL3: view

Variants for BTNL3 Gene

Sequence variations from dbSNP and Humsavar for BTNL3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000208551 -- 180,987,725(+) AAGAA(C/G)TGCCT upstream-variant-2KB
rs1000254824 -- 181,003,098(+) TGTCT(A/G)TAATC intron-variant
rs1000360653 -- 180,995,847(+) CTCCT(A/G)GGGTC intron-variant
rs1000861700 -- 181,001,372(+) AATCA(C/T)GGCTC intron-variant
rs1000964057 -- 181,007,112(+) TGTGA(A/C)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTNL3 Gene

Variant ID Type Subtype PubMed ID
dgv10246n54 CNV loss 21841781
dgv10248n54 CNV gain 21841781
dgv10249n54 CNV gain 21841781
dgv10250n54 CNV gain 21841781
dgv1066e199 CNV deletion 23128226
dgv1687e212 CNV loss 25503493
dgv1688e212 CNV gain 25503493
dgv1689e212 CNV gain 25503493
dgv1690e212 CNV gain 25503493
dgv1691e212 CNV loss 25503493
dgv215n111 OTHER complex 26073780
dgv5851n100 CNV gain 25217958
dgv5852n100 CNV gain+loss 25217958
dgv5853n100 CNV gain+loss 25217958
dgv5854n100 CNV loss 25217958
dgv5855n100 CNV gain 25217958
dgv5856n100 CNV gain 25217958
dgv5857n100 CNV gain 25217958
dgv5858n100 CNV gain 25217958
dgv988n67 CNV loss 20364138
esv2421695 CNV deletion 20811451
esv2759400 CNV gain 17122850
esv2760983 CNV loss 21179565
esv2763931 CNV gain+loss 21179565
esv29779 CNV gain+loss 19812545
esv29991 CNV gain 17803354
esv33360 CNV gain 17666407
esv3584834 CNV loss 24956385
esv3584835 CNV loss 24956385
esv3607798 CNV loss 21293372
esv3607799 CNV gain 21293372
esv3607801 CNV gain 21293372
esv988906 CNV gain 20482838
nsv1021633 CNV gain 25217958
nsv1026751 CNV gain 25217958
nsv1029408 CNV gain+loss 25217958
nsv1074358 CNV deletion 25765185
nsv10791 CNV gain+loss 18304495
nsv1137540 CNV deletion 24896259
nsv1161325 CNV deletion 26073780
nsv428133 CNV gain 18775914
nsv442972 CNV loss 18776908
nsv471441 CNV loss 19718026
nsv508390 CNV deletion 20534489
nsv509112 CNV insertion 20534489
nsv513283 CNV loss 21212237
nsv514338 CNV gain+loss 21397061
nsv600684 CNV loss 21841781
nsv600697 CNV loss 21841781
nsv600698 CNV gain 21841781
nsv600700 CNV gain 21841781
nsv819450 CNV loss 19587683
nsv820020 CNV loss 19587683
nsv821169 CNV deletion 20802225
nsv823367 CNV loss 20364138
nsv830566 CNV loss 17160897
nsv950742 CNV deletion 24416366

Variation tolerance for BTNL3 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTNL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTNL3 Gene

Disorders for BTNL3 Gene

Relevant External Links for BTNL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BTNL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTNL3 Gene

Publications for BTNL3 Gene

  1. Cloning, expression analysis, and chromosomal localization of a novel butyrophilin-like receptor. (PMID: 10429365) Shibui A. … Sugane K. (J. Hum. Genet. 1999) 2 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for BTNL3 Gene

Sources for BTNL3 Gene

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