Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BTNL2 Gene

protein-coding   GIFtS: 52
GCID: GC06M032359

Butyrophilin-Like 2 (MHC Class II Associated)

  See BTNL2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Butyrophilin-Like 2 (MHC Class II Associated)1 2
BTL-II2 3
SS22 5
BTN72
HSBLMHC12
Butyrophilin-Like Protein 22

External Ids:    HGNC: 11421   Entrez Gene: 562442   Ensembl: ENSG000002042907   OMIM: 6060005   UniProtKB: Q9UIR03   

Export aliases for BTNL2 gene to outside databases

Previous GC identifers: GC06M032389 GC06M032133 GC06M032433 GC06M032470


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for BTNL2 Gene:
BTNL2 (butyrophilin-like 2 (MHC class II associated)) is a protein-coding gene. Diseases associated with BTNL2 include sarcoidosis 2, and human immunodeficiency virus infectious disease. An important paralog of this gene is BTN3A2.

UniProtKB/Swiss-Prot: BTNL2_HUMAN, Q9UIR0
Function: Negative regulator of T-cell proliferation (By similarity)

Gene Wiki entry for BTNL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NT_187692.1  NC_000006.12  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167246.2  
NT_167247.2  NT_167248.2  NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BTNL2 gene promoter:
         HOXA9B   HOXA9   Meis-1b   YY1   E47   AREB6   ATF6   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBTNL2 promoter sequence
   Search Chromatin IP Primers for BTNL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BTNL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

BTNL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTNL2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032359:  view genomic region     (about GC identifiers)

Start:
32,361,740 bp from pter      End:
32,374,905 bp from pter
Size:
13,166 bases      Orientation:
minus strand

Selected alternative locations (see all 7):
Chr6-,NT_113891.2 3,832,934-3,845,307      Chr6-,NT_167244 3,676,883-3,689,268      Chr6-,NT_167249 3,709,956-3,722,348     
Chr6-,NT_167247 3,742,071-3,754,463      Chr6-,NT_167245 3,641,412-3,653,786      Chr6-,NT_167248 3,623,371-3,635,765     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BTNL2_HUMAN, Q9UIR0 (See protein sequence)
Recommended Name: Butyrophilin-like protein 2  
Size: 455 amino acids; 50436 Da
Secondary accessions: A0PJV5 B0UYW9 B0V0N6 O98261 Q08E96 Q58R22 Q58R23 Q5JYF9 Q5MP42 Q5MP43
Q5RIF8 Q5SP08 Q5SP09 Q5SRW3 Q5SRW4 Q5SU36 Q95HK0
Alternative splicing: 6 isoforms:  Q9UIR0-1   Q9UIR0-2   Q9UIR0-3   Q9UIR0-4   Q9UIR0-5   Q9UIR0-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BTNL2: NX_Q9UIR0

Explore proteomics data for BTNL2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn210, Asn427
  • Modification sites at PhosphoSitePlus

  • See BTNL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_062548.1  
    ENSEMBL proteins: 
     ENSP00000390613   ENSP00000420063   ENSP00000388434   ENSP00000364134   ENSP00000364132  
     ENSP00000390512   ENSP00000444714   ENSP00000443364   ENSP00000411166  

    BTNL2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for BTNL2
    GenScript Custom Purified and Recombinant Proteins Services for BTNL2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BTNL2

     
    Search eBioscience for Proteins for BTNL2 

    BTNL2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for BTNL2 (BTNL2/Butyrophilin-like 2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for BTNL2
    Novus Biologicals BTNL2 Antibody
    Abcam antibodies for BTNL2
    Cloud-Clone Corp. Antibodies for BTNL2
    ThermoFisher Antibodies for BTNL2
    Search LSBio for Antibodies for BTNL2

    BTNL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BTNL2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BTNL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BTNL2
    Cloud-Clone Corp. CLIAs for BTNL2
    Search eBioscience for ELISAs for BTNL2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    BTN: Butyrophilins
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9UIR0

    ProtoNet protein and cluster: Q9UIR0

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: BTNL2_HUMAN, Q9UIR0
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 3 Ig-like V-type (immunoglobulin-like) domains


    Find genes that share domains with BTNL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BTNL2_HUMAN, Q9UIR0
    Function: Negative regulator of T-cell proliferation (By similarity)
    Induction: By proinflammatory cytokines such as TNF and IL1B/interleukin-1 beta

         Genatlas biochemistry entry for BTNL2:
    butyrophilin-like 7,B box family of proteins,involved in cell proliferation and development

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with BTNL2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BTNL2:
     Increased circadian rhythm amp 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BTNL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BTNL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BTNL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BTNL2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat BTNL2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate BTNL2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BTNL2
    Predesigned siRNA for gene silencing in human, mouse, rat BTNL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BTNL2

    Clone
    Products:
         
    OriGene clones in human, mouse for BTNL2 (see all 5)
    OriGene ORF clones in mouse, rat for BTNL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BTNL2 (NM_019602)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTNL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTNL2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BTNL2
    Browse ESI BIO Cell Lines and PureStem Progenitors for BTNL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTNL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    BTNL2_HUMAN, Q9UIR0: Membrane; Single-pass type II membrane protein. Note=Isoform 2 is present in the nuclear,
    vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with BTNL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BTNL2
    Interactions:

        GeneGlobe Interaction Network for BTNL2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BTNL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BTNL2 gene: 
    NM_019602.1  

    Unigene Cluster for BTNL2:

    Butyrophilin-like 2 (MHC class II associated)
    Hs.534471
    Unigene Representative Sequence: NM_019602
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454136 ENST00000465865(uc010jtz.1) ENST00000446536 ENST00000374995
    ENST00000374993(uc003obg.1) ENST00000414363(uc010jua.1) ENST00000540315
    ENST00000544175(uc010jty.1) ENST00000429232
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BTNL2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate BTNL2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BTNL2
    Predesigned siRNA for gene silencing in human, mouse, rat BTNL2
    Clone
    Products:
         
    OriGene clones in human, mouse for BTNL2 (see all 5)
    OriGene ORF clones in mouse, rat for BTNL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BTNL2 (NM_019602)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTNL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTNL2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for BTNL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BTNL2
      QuantiTect SYBR Green Assays in human, mouse, rat BTNL2
      QuantiFast Probe-based Assays in human, mouse, rat BTNL2

    Additional mRNA sequence: 

    AY684332.1 AY684333.1 BC119668.1 BC127641.1 BC127642.1 

    2 DOTS entries:

    DT.91958098  DT.121380822 

    1 AceView cDNA sequence:

    NM_019602 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BTNL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGAAAGA
    BTNL2 Expression
    About this image

    BTNL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BTNL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534471

    UniProtKB/Swiss-Prot: BTNL2_HUMAN, Q9UIR0
    Tissue specificity: Expressed in brain, heart, kidney, liver, pancreas, ovary, leukocyte, small intestine, testis
    and thymus

        Custom PCR Arrays for BTNL2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for BTNL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BTNL2
    QuantiTect SYBR Green Assays in human, mouse, rat BTNL2
    QuantiFast Probe-based Assays in human, mouse, rat BTNL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTNL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for BTNL2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Btnl21 , 5 butyrophilin-like 21, 5 74.93(n)1
    63.94(a)1
      17 (17.98 cM)5
    5474311  NM_079835.21  NP_524574.11 
     343548225 


    ENSEMBL Gene Tree for BTNL2 (if available)
    TreeFam Gene Tree for BTNL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for BTNL2 gene
    BTN3A22  BTN2A12  BTNL82  ERMAP2  BTN2A22  BTN3A32  MOG2  BTN3A12  
    BTN1A12  BTNL32  BTNL92  
    11 SIMAP similar genes for BTNL2 using alignment to 9 protein entries:     BTNL2_HUMAN (see all proteins):
    BTNL3    BTN1A1    BTN2A2    BTN2A1    SKINTL    BTNL9
    MOG    BTN3A2    BTN3A3    BTN3A1    BTNL10

    Find genes that share paralogs with BTNL2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for BTNL2
    PGOHUM00000244014


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BTNL2 (see all 764)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1837290311,2
    C--32130625(+) TGCTAC/TAGACC 1 -- us2k10--------
    rs92685021,2
    C,F,A,H--32130645(+) GCTTGT/CGTTCC 1 -- us2k111Minor allele frequency- C:0.41NS NA WA CSA EA 491
    rs728479311,2
    C,F--32362020(+) TTGCTC/TGTCTC 1 -- ds50015Minor allele frequency- T:0.18WA NA EA 362
    rs1860568771,2
    --32362021(+) TGCTCA/GTCTCA 1 -- ds50010--------
    rs1425923081,2
    C--32362049(+) GACAA-/GTTGTTTT 1 -- cds10--------
    rs775422711,2
    --32362062(+) CTTCTC/GTCTTC 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs681905451,2
    C,F--32362075(+) ACTATA/GTCACA 1 -- ds50015Minor allele frequency- G:0.18WA NA EA 362
    rs728479321,2
    C,F--32362085(+) ACAATC/TACTGG 1 -- ds50015Minor allele frequency- T:0.17WA NA EA 362
    rs1908152951,2
    --32362086(+) CAATCA/GCTGGA 1 -- ds50010--------
    rs2020504131,2
    C--32362122(+) TTACTA/CAAGCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for BTNL2 (32361740 - 32374905 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BTNL2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731830CNV Deletion23290073
    dgv1011n67CNV Loss20364138
    nsv884741CNV Loss21882294
    nsv7882CNV Loss18304495
    nsv884740CNV Loss21882294
    nsv830630CNV Loss17160897
    esv33644CNV Loss17666407
    dgv1012n67CNV Loss20364138
    nsv428142CNV Gain+Loss18775914
    dgv1931e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): BTNL2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BTNL2
    DNA2.0 Custom Variant and Variant Library Synthesis for BTNL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606000   
    OMIM disorders: 612387  
    UniProtKB/Swiss-Prot: BTNL2_HUMAN, Q9UIR0
  • Sarcoidosis 2 (SS2) [MIM:612387]: An idiopathic, systemic, inflammatory disease characterized by the
    formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic
    system, but also skin, liver, spleen, eyes and other organs may be involved. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry. A nucleotide transition affecting a
    splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals
    expressing isoform 3 have a higher risk for sarcoidosis

  • 6 diseases for BTNL2:    
    About MalaCards
    sarcoidosis 2    human immunodeficiency virus infectious disease    sarcoidosis    sarcoidosis 1
    pulmonary sarcoidosis    wegener's granulomatosis

    1 disease from the University of Copenhagen DISEASES database for BTNL2:
    Sarcoidosis

    Find genes that share disorders with BTNL2           About GenesLikeMe

    1 Novoseek inferred disease relationship for BTNL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcoidosis 69.4 13 17661910 (4), 15735647 (2), 17927685 (2), 17610417 (1)

    Genetic Association Database (GAD): BTNL2
    Human Genome Epidemiology (HuGE) Navigator: BTNL2 (37 documents)

    Export disorders for BTNL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BTNL2 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with BTNL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sarcoidosis is associated with a truncating splice site mutation in BTNL2. (PubMed id 15735647)1, 2, 3, 4, 9 Valentonyte R....Schreiber S. (Nat. Genet. 2005)
    2. BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse. (PubMed id 10803852)1, 2, 3, 9 Stammers M.... Beck S. (Immunogenetics 2000)
    3. BTNL2 gene polymorphisms may be associated with susceptibility to Kawasaki disease and formation of coronary artery lesions in Taiwanese children. (PubMed id 19882345)1, 4, 9 Hsueh K.C....Tsai F.J. (Eur. J. Pediatr. 2010)
    4. Analysis of BTNL2 genetic polymorphisms in British and Dutch patients with sarcoidosis. (PubMed id 17661910)1, 4, 9 Spagnolo P....Welsh K.I. (Tissue Antigens 2007)
    5. BTNL2 allele associations with chronic beryllium disease in HLA-DPB1*Glu69-negative individuals. (PubMed id 17927685)1, 4, 9 Sato H....Maier L.A. (Tissue Antigens 2007)
    6. Butyrophilin-like 2 gene is associated with ulcerative colitis in the Japanese under strong linkage disequilibrium with HLA-DRB1*1502. (PubMed id 17610417)1, 4, 9 Mochida A....Shimosegawa T. (Tissue Antigens 2007)
    7. Confirmation of the novel association at the BTNL2 locus with ulcerative colitis. (PubMed id 19659809)1, 4, 9 Pathan S....Jewell D.P. (Tissue Antigens 2009)
    8. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    9. New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study. (PubMed id 20305777)1, 4 Nakajima M....Ikegawa S. (PLoS ONE 2010)
    10. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PubMed id 19861958)1, 4 Festen E.A....Weersma R.K. (Am. J. Gastroenterol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 56244 HGNC: 1142 AceView: BTNL2 Ensembl:ENSG00000204290 euGenes: HUgn56244
    ECgene: BTNL2 H-InvDB: BTNL2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BTNL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BTNL2 gene:
    Search GeneIP for patents involving BTNL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for BTNL2 (BTNL2/Butyrophilin-like 2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for BTNL2 (BTNL2/Butyrophilin-like 2)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for BTNL2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for BTNL2  
     OriGene qSTAR qPCR primer pairs in human, mouse for BTNL2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for BTNL2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BTNL2   OriGene Custom Protein Services for BTNL2  

     
     
     Block miRNA regulation of human, mouse, rat BTNL2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BTNL2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BTNL2 Predesigned siRNA for gene silencing in human, mouse, rat BTNL2
     QuantiFast Probe-based Assays in human, mouse, rat BTNL2 QuantiTect SYBR Green Assays in human, mouse, rat BTNL2
     Custom PCR Arrays for BTNL2 Search Chromatin IP Primers for BTNL2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BTNL2  GeneGlobe Interaction Network for BTNL2
     Regulatory tfbs in BTNL2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for BTNL2 GenScript cDNA clones with any tag delivered in your preferred vector for BTNL2
     GenScript Custom Assay Services for BTNL2 GenScript Custom overexpressing Cell Line Services for BTNL2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for BTNL2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BTNL2 antibodies
     Antibodies for BTNL2
     See all of Abcam's Antibodies, Kits and Proteins for BTNL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for BTNL2
     Antibodies for BTNL2
     ELISAs for BTNL2
     CLIAs for BTNL2



     Browse ESI BIO Cell Lines and PureStem Progenitors for BTNL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTNL2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for BTNL2
     SwitchGear Promoter luciferase reporter plasmids for BTNL2
     ThermoFisher Antibodies for BTNL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTNL2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BTNL2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BTNL2
     Search LSBio for Antibodies for BTNL2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for BTNL2
      Search eBioscience for proteins for BTNL2
      Search eBioscience for elisas for BTNL2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BTNL2 gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4