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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BTNL10 Gene

protein-coding   GIFtS: 21
GCID: GC01M228697          (predicted)

butyrophilin-like 10

  Search for BTNL10
in our new
 Human Malady Compendium 
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Butyrophilin-Like 101 2
BUTR12
Butyrophilin Related 12
Butyrophilin-Like Protein 102

External Ids:    HGNC: 425401   Entrez Gene: 1001290942   Ensembl: ENSG000002158117   UniProtKB: A8MVZ53   

Export aliases for BTNL10 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for BTNL10
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for BTNL10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTNL10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.13

BTNL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTNL10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M228697:  view genomic region     (about GC identifiers)

Start:
228,696,347 bp from pter      End:
228,700,004 bp from pter
Size:
3,658 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BTNLA_HUMAN, A8MVZ5 (See protein sequence)
Recommended Name: Butyrophilin-like protein 10 precursor  
Size: 291 amino acids; 32612 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Caution: Product of a dubious gene prediction

Explore the universe of human proteins at neXtProt for BTNL10: NX_A8MVZ5

BTNL10 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000383732   ENSP00000403905  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--


BTNL10 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BTNL10 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR007110 Ig-like_dom
 IPR003599 Ig_sub
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry A8MVZ5

ProtoNet protein and cluster: A8MVZ5

UniProtKB/Swiss-Prot: BTNLA_HUMAN, A8MVZ5
Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA
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Inhib. RNA
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BTNL10

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for BTNL10 (ENSP000003837324) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SYNCENSP000003864394STRING: ENSP00000386439
ZFYVE9ENSP000002877274STRING: ENSP00000287727
C1orf100ENSP000003112184STRING: ENSP00000311218
NCKIPSDENSP000002941294STRING: ENSP00000294129
PIGQENSP000000262184STRING: ENSP00000026218
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BTNL10
Search CenterWatch for drugs/clinical trials and news about BTNL10 / BTNLA 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000400948 ENST00000413130

miRNA
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Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTNL10
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTNL10

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

See BTNL10 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for BTNL10
Primer
Products:
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In Situ
Assay Products:
 

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for BTNL10

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for BTNL10 gene from 1/2 species (see all 2)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Btnl101 , 5 butyrophilin-like 101, 5 66.84(n)1
53.48(a)1
  11 (36.37 cM)5
1921941  NM_138678.21  NP_619619.21 
 589179085 


ENSEMBL Gene Tree for BTNL10 (if available)
TreeFam Gene Tree for BTNL10 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for BTNL10 gene
BTN3A22  BTN2A12  BTNL82  ERMAP2  BTN3A32  BTN2A22  HHLA22  CD2762  
MOG2  BTNL22  BTN3A12  VTCN12  BTN1A12  BTNL92  BTNL32  
8 SIMAP similar genes for BTNL10 using alignment to 1 protein entry:     BTNLA_HUMAN:
BTN2A1    BTN3A1    BTN2A2    BTN3A3    BTN3A2    MOG
BTNL9    BTNL2

BTNL10 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/110 NCBI SNPs in BTNL10 are shown (see all 110    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs782871771,2
C,F,--199210683(+) AGCCCA/CACCAG 1 -- ds50011Minor allele frequency- C:0.08WA 118
rs1117105861,2
--199210970(+) TTTCTC/G/TTTCAC 1 -- ds50011CSA 2
rs782756931,2
F,--199211994(+) CTAAAT/CGCGTA 1 -- int11Minor allele frequency- C:0.09WA 118
rs1136670451,2
--199212219(+) TAGAAC/TCATGG 1 -- int11Minor allele frequency- T:0.50CSA 2
rs763871181,2
F,--199212311(+) GTGGAC/TGTTCC 1 -- int11Minor allele frequency- T:0.03WA 118
rs741445081,2
C,--199212706(+) CAGAAC/TTGAAT 1 -- int11Minor allele frequency- T:0.50WA 2
rs617461751,2
C,F,--199212845(+) NNNNGG/ATGGTG 2 /T /I mis14Minor allele frequency- A:0.03NS CSA WA 187
rs121335811,2
H--199212931(+) AAACAG/ACCTGC 2 /G syn14Minor allele frequency- A:0.00NS EA 420
rs1154767821,2
C,F,--199212936(+) NNNNGC/ATGATG 2 /A /S mis12Minor allele frequency- A:0.05NA EU 690
rs1181330331,2
C,F,--199213003(+) CCCAGC/TCCTGA 2 G syn11Minor allele frequency- T:0.03EA 120

HapMap Linkage Disequilibrium report for BTNL10 (228696347 - 228700004 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for BTNL10: --

SABiosciences Cancer Mutation PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for BTNL10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed article for BTNL10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with BTNL10)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 100129094 HGNC: 42540 Ensembl:ENSG00000215811 euGenes: HUgn100129094 ECgene: BTNL10
H-InvDB: BTNL10

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for BTNL10 gene:
Search GeneIP for patents involving BTNL10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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