BTN3A3 Gene
protein-coding GIFtS: 46
GCID: GC06P026448
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butyrophilin, subfamily 3, member A3
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Aliases
for BTN3A3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Butyrophilin, Subfamily 3, Member A31 2 | | BTF31 2 3 5 | | Butyrophilin 32 | | Butyrophilin Subfamily 3 Member A32 |
Export aliases for BTN3A3 gene to outside databasesPrevious GC identifers: GC06P026498 GC06P026427 GC06P026548 GC06P026441 GC06P026384 GC06P026442 GC06P026443 GC06P026446 GC06P026447 |
Summaries
for BTN3A3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BTN3A3:
The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type Imembrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Threesubfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and theBTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3copies of each (summary by Smith et al., 2010 (PubMed 20208008)).(supplied by OMIM, Nov 2010)
UniProtKB/Swiss-Prot: BT3A3_HUMAN, O00478Function: Plays a role in T-cell responses in the adaptive immune response
Gene Wiki entry for BTN3A3
|
Genomic Views
for BTN3A3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BTN3A3 gene promoter:
p53 NF-kappaB YY1 MEF-2A POU2F1 POU2F1a NF-kappaB2 STAT3 NF-kappaB1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for BTN3A3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTN3A3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p22.2 HGNC cytogenetic band: 6p22.1BTN3A3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P026448: view genomic region
(about GC identifiers)
Start:
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26,440,700 bp from pter |
End:
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26,453,643 bp from pter |
Size:
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12,944 bases |
Orientation:
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plus strand |
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Proteins
for BTN3A3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BT3A3_HUMAN, O00478 (See
protein sequence)Recommended Name: Butyrophilin subfamily 3 member A3 precursor Size: 584 amino acids; 65002 Da
Subunit: Homodimer
Subcellular location: Cell membrane; Single-pass type I membrane protein
1 PDB 3D structure from  and Proteopedia  for BTN3A3:4F8T (3D)
Secondary accessions: B4DWI7 E9PCP5Alternative splicing: 2 isoforms: O00478-1 O00478-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for BTN3A3: NX_O00478
Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00478
BTN3A3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001229732.1 NP_008925.1 NP_932078.2
ENSEMBL proteins: ENSP00000417234 ENSP00000419312 ENSP00000244519 ENSP00000417717 ENSP00000355238 ENSP00000420339 ENSP00000420147 ENSP00000419736 ENSP00000420290 ENSP00000419445 ENSP00000344968
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IDA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
BTN3A3 for ontologies About GeneDecksing
BTN3A3 Antibody Products:
Assay Products for BTN3A3: |
Protein
Domains /
Families
for BTN3A3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BTN3A3 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry O00478ProtoNet protein and cluster: O00478 4 Blocks protein families: IPB003599 Immunoglobulin subtype IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: BT3A3_HUMAN, O00478Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG familySimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains |
Function
for BTN3A3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BT3A3_HUMAN, O00478Function: Plays a role in T-cell responses in the adaptive immune response Genatlas biochemistry entry for BTN3A3:butyrophilin subfamily 3,member A3,B box family of proteins,involved in cell proliferation and development
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTN3A3 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTN3A3 |
|
Pathways & Interactions
for BTN3A3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BTN3A3
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for BTN3A3 (ENSP000002445194) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002456 | T cell mediated immunity |
IMP | -- |
BTN3A3 for ontologies About GeneDecksing
|
Drugs & Compounds
for BTN3A3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BTN3A3
Search CenterWatch for drugs/clinical trials and news about BTN3A3 / BT3A3
|
Transcripts
for BTN3A3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BTN3A3 gene (3 alternative transcripts): NM_001242803.1 NM_006994.4 NM_197974.2 Unigene Cluster for BTN3A3: Butyrophilin, subfamily 3, member A3 Hs.167741 [show with all ESTs]Unigene Representative Sequence: NM_00699417 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000494393 ENST00000482451 ENST00000244519(uc003nhz.3 uc011dkn.2 uc021ynh.1)
ENST00000471353 ENST00000361232 ENST00000474790 ENST00000487627 ENST00000496719
ENST00000480110 ENST00000467524 ENST00000490254 ENST00000476281 ENST00000487272
ENST00000483179 ENST00000477388 ENST00000497681 ENST00000339789
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTN3A3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTN3A3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): BTN3A3 (NM_006994) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AK223279.1 AK223301.1 AK291722.1 AK301553.1 BC015815.2 BT007251.1 U90548.1 18 DOTS entries: DT.91838414 DT.100800862 DT.100799407 DT.91719140 DT.91845984 DT.121381011 DT.121381034 DT.121381117 DT.65285590 DT.92381252 DT.95375284 DT.121381024 DT.121381057 DT.422538 DT.87017064 DT.87017066 DT.91765456 DT.95160541 24/107 AceView cDNA sequences (see all 107): CB157746 BX362684 BQ082601 NM_197974 BM820421 AA234051 AA731296 CO392914 AA402951 CR618410 AA479322 CB268571 AW779191 BC015815 AA344281 BQ646764 AA478585 AI571622 BP345297 AI335723 AA825832 AA505847 AW273488 AW338105
GeneLoc Exon Structure
|
Expression
for BTN3A3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BTN3A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCACAGAT
About this image
See BTN3A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BTN3A3
SOURCE GeneReport for Unigene cluster: Hs.167741
UniProtKB/Swiss-Prot: BT3A3_HUMAN, O00478Tissue specificity: Detected in peripheral blood mononuclear cells and in T-cells (at protein level). Detected inspleen and lymphocytes
SABiosciences Custom PCR Arrays for BTN3A3
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTN3A3 |
Orthologs
for BTN3A3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for BTN3A3 gene from 1/3 species (see all 3) About this table
ENSEMBL Gene Tree for BTN3A3 (if available)
TreeFam Gene Tree for BTN3A3 (if available) |
Paralogs
for BTN3A3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BTN3A3 gene
- BTN3A22 BTN2A12 BTNL82 ERMAP2 BTN2A22 HHLA22 CD2762 BTNL102
- MOG2 BTNL22 BTN3A12 VTCN12 BTN1A12 BTNL92 BTNL32
18/22 SIMAP similar genes for BTN3A3 using alignment to 10 protein entries: BT3A3_HUMAN (see all proteins)
(see all similar genes):BTN3A2 BTN3A1 BT3.3 BTN2A1 MOG BTN1A1
BTNL9 SKINT1 TRIM27 BTN2A2 ERMAP BTNL10
BTNL2 TRIM69 BTN2A3P RFPL3 BTNL3 RFPL1
BTN3A3 for paralogs About GeneDecksing
|
Genomic Variants
for BTN3A3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BTN3A3 (26440700 - 26453643 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BTN3A3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTN3A3 |
|
Disorders
/ Diseases
for BTN3A3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BTN3A3 for disorders About GeneDecksing
OMIM gene information: 613595
OMIM disorders: --
1  disease for BTN3A3: About MalaCardshemochromatosis
Export disorders for BTN3A3 gene to outside databases
|
Publications
for BTN3A3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BTN3A3 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with BTN3A3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PubMed id 9149941)1, 2, 3 Ruddy D.A.... Feder J.N. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Structure and evolution of the extended B7 family. (PubMed id 10354554)1, 3 Henry J....Pontarotti P. (1999)
- The molecular basis for modulation of human Vgamma9Vdelta2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. (PubMed id 22846996)2 Palakodeti A.... Adams E.J. (2012)
- Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset. (PubMed id 22767497)2 Harly C.... Scotet E. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Differential role for CD277 as a co-regulator of the i mmune signal in T and NK cells. (PubMed id 21918970)2 Messal N....Olive D. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
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External Searches for BTN3A3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BTN3A3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BTN3A3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BTN3A3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BTN3A3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BTN3A3 gene:
Search GeneIP for patents involving BTN3A3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BTN3A3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTN3A3 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTN3A3 |
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