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Aliases for BTN3A3 Gene

Aliases for BTN3A3 Gene

  • Butyrophilin Subfamily 3 Member A3 2 3 5
  • Butyrophilin, Subfamily 3, Member A3 2 3
  • BTF3 3 4
  • Butyrophilin Subfamily 3 Member A3 Secreted Isoform 3
  • Butyrophilin 3 3
  • BTN3.3 3

External Ids for BTN3A3 Gene

Previous GeneCards Identifiers for BTN3A3 Gene

  • GC06P026498
  • GC06P026427
  • GC06P026548
  • GC06P026441
  • GC06P026384
  • GC06P026442
  • GC06P026443
  • GC06P026446
  • GC06P026447
  • GC06P026448
  • GC06P026449
  • GC06P026450

Summaries for BTN3A3 Gene

Entrez Gene Summary for BTN3A3 Gene

  • The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]

GeneCards Summary for BTN3A3 Gene

BTN3A3 (Butyrophilin Subfamily 3 Member A3) is a Protein Coding gene. An important paralog of this gene is BTNL8.

UniProtKB/Swiss-Prot for BTN3A3 Gene

  • Plays a role in T-cell responses in the adaptive immune response.

Gene Wiki entry for BTN3A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTN3A3 Gene

Genomics for BTN3A3 Gene

Regulatory Elements for BTN3A3 Gene

Enhancers for BTN3A3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BTN3A3 on UCSC Golden Path with GeneCards custom track

Promoters for BTN3A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BTN3A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for BTN3A3 Gene

26,440,472 bp from pter
26,453,415 bp from pter
12,944 bases
Plus strand

Genomic View for BTN3A3 Gene

Genes around BTN3A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTN3A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTN3A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTN3A3 Gene

Proteins for BTN3A3 Gene

  • Protein details for BTN3A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin subfamily 3 member A3
    Protein Accession:
    Secondary Accessions:
    • B4DWI7
    • E9PCP5

    Protein attributes for BTN3A3 Gene

    584 amino acids
    Molecular mass:
    65002 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for BTN3A3 Gene

    Alternative splice isoforms for BTN3A3 Gene


neXtProt entry for BTN3A3 Gene

Proteomics data for BTN3A3 Gene at MOPED

Post-translational modifications for BTN3A3 Gene

No data available for DME Specific Peptides for BTN3A3 Gene

Domains & Families for BTN3A3 Gene

Gene Families for BTN3A3 Gene

Suggested Antigen Peptide Sequences for BTN3A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
  • Contains 1 B30.2/SPRY domain.
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTN3A3: view

Function for BTN3A3 Gene

Molecular function for BTN3A3 Gene

GENATLAS Biochemistry:
butyrophilin subfamily 3,member A3,B box family of proteins,involved in cell proliferation and development
UniProtKB/Swiss-Prot Function:
Plays a role in T-cell responses in the adaptive immune response.

Phenotypes for BTN3A3 Gene

GenomeRNAi human phenotypes for BTN3A3:
genes like me logo Genes that share phenotypes with BTN3A3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTN3A3 Gene

Localization for BTN3A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTN3A3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for BTN3A3 Gene COMPARTMENTS Subcellular localization image for BTN3A3 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 2
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for BTN3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005886 plasma membrane IDA 22767497
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BTN3A3: view

Pathways & Interactions for BTN3A3 Gene

SuperPathways for BTN3A3 Gene

No Data Available

Interacting Proteins for BTN3A3 Gene

Gene Ontology (GO) - Biological Process for BTN3A3 Gene


No data available for Pathways by source and SIGNOR curated interactions for BTN3A3 Gene

Drugs & Compounds for BTN3A3 Gene

No Compound Related Data Available

Transcripts for BTN3A3 Gene

Unigene Clusters for BTN3A3 Gene

Butyrophilin, subfamily 3, member A3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTN3A3 Gene

No ASD Table

Relevant External Links for BTN3A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTN3A3 Gene

mRNA expression in normal human tissues for BTN3A3 Gene

Protein differential expression in normal tissues from HIPED for BTN3A3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.1), CD4 Tcells (10.0), CD8 Tcells (8.5), Frontal cortex (7.7), and Spleen (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BTN3A3 Gene

SOURCE GeneReport for Unigene cluster for BTN3A3 Gene Hs.167741

mRNA Expression by UniProt/SwissProt for BTN3A3 Gene

Tissue specificity: Detected in peripheral blood mononuclear cells and in T-cells (at protein level). Detected in spleen and lymphocytes.
genes like me logo Genes that share expression patterns with BTN3A3: view

Protein tissue co-expression partners for BTN3A3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BTN3A3 Gene

Orthologs for BTN3A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BTN3A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BTN3A3 35
  • 78.35 (n)
  • 68.33 (a)
-- 36
  • 36 (a)
(Pan troglodytes)
Mammalia BTN3A3 35
  • 99.03 (n)
  • 99.32 (a)
BTN3A1 36
  • 99 (a)
(Canis familiaris)
Mammalia -- 36
  • 37 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
(Mus musculus)
Mammalia Btnl4 36
  • 35 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
(Danio rerio)
Actinopterygii zgc:175177 35
  • 45.57 (n)
  • 34.3 (a)
Species with no ortholog for BTN3A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTN3A3 Gene

Gene Tree for BTN3A3 (if available)
Gene Tree for BTN3A3 (if available)

Paralogs for BTN3A3 Gene

Paralogs for BTN3A3 Gene

genes like me logo Genes that share paralogs with BTN3A3: view

Variants for BTN3A3 Gene

Sequence variations from dbSNP and Humsavar for BTN3A3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10484440 -- 26,453,514(+) GCAGC(A/G)TTTTC downstream-variant-500B
rs9770 -- 26,453,363(+) ctact(G/T)ggcaa utr-variant-3-prime
rs11459966 -- 26,453,595(+) TTTTT(-/T)GAGAT downstream-variant-500B
rs113625452 -- 26,453,307(+) TAGGG(-/A)AAAAC utr-variant-3-prime
rs144256388 -- 26,452,392(+) GGCAC(A/C/G)CACTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for BTN3A3 Gene

Variant ID Type Subtype PubMed ID
dgv6440n71 CNV Loss 21882294
nsv883499 CNV Gain 21882294
esv2731730 CNV Deletion 23290073
nsv528172 CNV Loss 19592680

Variation tolerance for BTN3A3 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BTN3A3 Gene

Disorders for BTN3A3 Gene

Relevant External Links for BTN3A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BTN3A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTN3A3 Gene

Publications for BTN3A3 Gene

  1. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy D.A. … Feder J.N. (Genome Res. 1997) 2 3 4 67
  2. Structure and evolution of the extended B7 family. (PMID: 10354554) Henry J. … Pontarotti P. (Immunol. Today 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia. (PMID: 25243493) Chen C. … Liu C. (Bipolar Disord 2014) 3
  5. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset. (PMID: 22767497) Harly C. … Scotet E. (Blood 2012) 3

Products for BTN3A3 Gene

Sources for BTN3A3 Gene