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Aliases for BTN3A2 Gene

Aliases for BTN3A2 Gene

  • Butyrophilin, Subfamily 3, Member A2 2 3
  • BTF4 3 4 6
  • BT3.2 3 4
  • Butyrophilin Subfamily 3 Member A2 3
  • Butyrophilin Protein 3
  • BTN3.2 3
  • CD277 3
  • BTF3 4

External Ids for BTN3A2 Gene

Previous GeneCards Identifiers for BTN3A2 Gene

  • GC06P026423
  • GC06P026473
  • GC06P026308

Summaries for BTN3A2 Gene

Entrez Gene Summary for BTN3A2 Gene

  • This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for BTN3A2 Gene

BTN3A2 (Butyrophilin, Subfamily 3, Member A2) is a Protein Coding gene. An important paralog of this gene is BTNL9.

UniProtKB/Swiss-Prot for BTN3A2 Gene

  • Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTN3A2 Gene

Genomics for BTN3A2 Gene

Regulatory Elements for BTN3A2 Gene

Transcription factor binding sites by QIAGEN in the BTN3A2 gene promoter:

Genomic Location for BTN3A2 Gene

26,365,159 bp from pter
26,378,320 bp from pter
13,162 bases
Plus strand

Genomic View for BTN3A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTN3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTN3A2 Gene

Proteins for BTN3A2 Gene

  • Protein details for BTN3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin subfamily 3 member A2
    Protein Accession:
    Secondary Accessions:
    • B4DRT7
    • B4E103
    • F5H791
    • F8W6E0
    • O00477
    • O15338
    • O75658
    • Q76PA0
    • Q9BU81
    • Q9NR44

    Protein attributes for BTN3A2 Gene

    334 amino acids
    Molecular mass:
    36428 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=AAB53424.1; Type=Frameshift; Positions=317; Evidence={ECO:0000305}; Sequence=AAC02652.1; Type=Frameshift; Positions=334; Evidence={ECO:0000305}; Sequence=AAC02655.1; Type=Frameshift; Positions=334; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BTN3A2 Gene

    Alternative splice isoforms for BTN3A2 Gene


neXtProt entry for BTN3A2 Gene

Proteomics data for BTN3A2 Gene at MOPED

Post-translational modifications for BTN3A2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for BTN3A2

No data available for DME Specific Peptides for BTN3A2 Gene

Domains for BTN3A2 Gene

Gene Families for BTN3A2 Gene

  • BTN :Butyrophilins
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for BTN3A2 Gene

Suggested Antigen Peptide Sequences for BTN3A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P78410
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTN3A2: view

Function for BTN3A2 Gene

Molecular function for BTN3A2 Gene

GENATLAS Biochemistry: butyrophilin subfamily 3,member A2,B box family of proteins,involved in cell proliferation and development
UniProtKB/Swiss-Prot Function: Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.

Gene Ontology (GO) - Molecular Function for BTN3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with BTN3A2: view

Animal Model Products

CRISPR Products

miRNA for BTN3A2 Gene

miRTarBase miRNAs that target BTN3A2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BTN3A2 Gene

Localization for BTN3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTN3A2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for BTN3A2 Gene COMPARTMENTS Subcellular localization image for BTN3A2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BTN3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 22767497
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BTN3A2: view

Pathways for BTN3A2 Gene

SuperPathways for BTN3A2 Gene

No Data Available

Interacting Proteins for BTN3A2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000348751 for BTN3A2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for BTN3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002456 T cell mediated immunity IMP 22767497
GO:0072643 interferon-gamma secretion IMP 21918970
genes like me logo Genes that share ontologies with BTN3A2: view

No data available for Pathways by source for BTN3A2 Gene

Transcripts for BTN3A2 Gene

Unigene Clusters for BTN3A2 Gene

Butyrophilin, subfamily 3, member A2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BTN3A2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTN3A2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP2: -

Relevant External Links for BTN3A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTN3A2 Gene

mRNA expression in normal human tissues for BTN3A2 Gene

mRNA differential expression in normal tissues according to GTEx for BTN3A2 Gene

This gene is overexpressed in Whole Blood (5.4) and Spleen (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BTN3A2 Gene

SOURCE GeneReport for Unigene cluster for BTN3A2 Gene Hs.376046

mRNA Expression by UniProt/SwissProt for BTN3A2 Gene

Tissue specificity: Detected in T-cells and natural killer cells.
genes like me logo Genes that share expressions with BTN3A2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BTN3A2 Gene

Orthologs for BTN3A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTN3A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTN3A2 35
  • 97.06 (n)
  • 93.85 (a)
(Bos Taurus)
Mammalia -- 36
  • 25 (a)
(Canis familiaris)
Mammalia -- 36
  • 19 (a)
(Mus musculus)
Mammalia Btnl10 36
  • 33 (a)
Btnl4 16
(Monodelphis domestica)
Mammalia -- 36
  • 17 (a)
-- 36
  • 20 (a)
-- 36
  • 18 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 3 (a)
Species with no ortholog for BTN3A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTN3A2 Gene

Gene Tree for BTN3A2 (if available)
Gene Tree for BTN3A2 (if available)

Paralogs for BTN3A2 Gene

Paralogs for BTN3A2 Gene

genes like me logo Genes that share paralogs with BTN3A2: view

Variants for BTN3A2 Gene

Sequence variations from dbSNP and Humsavar for BTN3A2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1977 -- 26,377,318(+) CATTC(A/G)ATTAT utr-variant-3-prime
rs1978 -- 26,377,345(+) TTGAG(A/T)TTGGT utr-variant-3-prime
rs1979 -- 26,377,363(+) TATTG(G/T)CCCCT utr-variant-3-prime
rs9104 -- 26,377,921(+) GACTA(A/G)AGGCC utr-variant-3-prime
rs14232 -- 26,377,713(+) AGAGC(C/G)CACAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BTN3A2 Gene

Variant ID Type Subtype PubMed ID
nsv883491 CNV Loss 21882294
dgv6440n71 CNV Loss 21882294
nsv883496 CNV Gain 21882294
nsv527328 CNV Loss 19592680
esv2673332 CNV Deletion 23128226
nsv883499 CNV Gain 21882294
esv2731728 CNV Deletion 23290073
esv2731730 CNV Deletion 23290073

Relevant External Links for BTN3A2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTN3A2 Gene

Disorders for BTN3A2 Gene

Relevant External Links for BTN3A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BTN3A2: view

No data available for UniProtKB/Swiss-Prot for BTN3A2 Gene

Publications for BTN3A2 Gene

  1. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy D.A. … Feder J.N. (Genome Res. 1997) 2 3 4
  2. Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex. (PMID: 9382921) Tazi-Ahnini R. … Pontarotti P. (Immunogenetics 1997) 3 4 23
  3. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset. (PMID: 22767497) Harly C. … Scotet E. (Blood 2012) 3 4
  4. The molecular basis for modulation of human Vgamma9Vdelta2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. (PMID: 22846996) Palakodeti A. … Adams E.J. (J. Biol. Chem. 2012) 3 4
  5. The cluster of BTN genes in the extended major histocompatibility complex. (PMID: 11170752) Rhodes D.A. … Trowsdale J. (Genomics 2001) 3 4

Products for BTN3A2 Gene

Sources for BTN3A2 Gene

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