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Aliases for BTN3A2 Gene

Aliases for BTN3A2 Gene

  • Butyrophilin Subfamily 3 Member A2 2 3 5
  • Butyrophilin, Subfamily 3, Member A2 2 3
  • BT3.2 3 4
  • BTF4 3 4
  • Butyrophilin Protein 3
  • BTN3.2 3
  • CD277 3
  • BTF3 4

External Ids for BTN3A2 Gene

Previous GeneCards Identifiers for BTN3A2 Gene

  • GC06P026423
  • GC06P026473
  • GC06P026308

Summaries for BTN3A2 Gene

Entrez Gene Summary for BTN3A2 Gene

  • This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for BTN3A2 Gene

BTN3A2 (Butyrophilin Subfamily 3 Member A2) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. An important paralog of this gene is BTNL8.

UniProtKB/Swiss-Prot for BTN3A2 Gene

  • Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTN3A2 Gene

Genomics for BTN3A2 Gene

Regulatory Elements for BTN3A2 Gene

Enhancers for BTN3A2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BTN3A2 on UCSC Golden Path with GeneCards custom track

Promoters for BTN3A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BTN3A2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the BTN3A2 gene promoter:

Genomic Location for BTN3A2 Gene

26,365,159 bp from pter
26,451,653 bp from pter
86,495 bases
Plus strand

Genomic View for BTN3A2 Gene

Genes around BTN3A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTN3A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTN3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTN3A2 Gene

Proteins for BTN3A2 Gene

  • Protein details for BTN3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin subfamily 3 member A2
    Protein Accession:
    Secondary Accessions:
    • B4DRT7
    • B4E103
    • F5H791
    • F8W6E0
    • O00477
    • O15338
    • O75658
    • Q76PA0
    • Q9BU81
    • Q9NR44

    Protein attributes for BTN3A2 Gene

    334 amino acids
    Molecular mass:
    36428 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=AAB53424.1; Type=Frameshift; Positions=317; Evidence={ECO:0000305}; Sequence=AAC02652.1; Type=Frameshift; Positions=334; Evidence={ECO:0000305}; Sequence=AAC02655.1; Type=Frameshift; Positions=334; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BTN3A2 Gene

    Alternative splice isoforms for BTN3A2 Gene


neXtProt entry for BTN3A2 Gene

Proteomics data for BTN3A2 Gene at MOPED

Post-translational modifications for BTN3A2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for BTN3A2

No data available for DME Specific Peptides for BTN3A2 Gene

Domains & Families for BTN3A2 Gene

Gene Families for BTN3A2 Gene

Protein Domains for BTN3A2 Gene

Suggested Antigen Peptide Sequences for BTN3A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTN3A2: view

Function for BTN3A2 Gene

Molecular function for BTN3A2 Gene

GENATLAS Biochemistry:
butyrophilin subfamily 3,member A2,B box family of proteins,involved in cell proliferation and development
UniProtKB/Swiss-Prot Function:
Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.
genes like me logo Genes that share phenotypes with BTN3A2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTN3A2 Gene

Localization for BTN3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTN3A2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for BTN3A2 Gene COMPARTMENTS Subcellular localization image for BTN3A2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for BTN3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 22767497
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BTN3A2: view

Pathways & Interactions for BTN3A2 Gene

genes like me logo Genes that share pathways with BTN3A2: view

Pathways by source for BTN3A2 Gene

1 R&D Systems pathway for BTN3A2 Gene

Interacting Proteins for BTN3A2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000348751 for BTN3A2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for BTN3A2 Gene


No data available for SIGNOR curated interactions for BTN3A2 Gene

Drugs & Compounds for BTN3A2 Gene

No Compound Related Data Available

Transcripts for BTN3A2 Gene

Unigene Clusters for BTN3A2 Gene

Butyrophilin, subfamily 3, member A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTN3A2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP2: -

Relevant External Links for BTN3A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTN3A2 Gene

mRNA expression in normal human tissues for BTN3A2 Gene

mRNA differential expression in normal tissues according to GTEx for BTN3A2 Gene

This gene is overexpressed in Whole Blood (x5.4) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for BTN3A2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.9), Ovary (26.2), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTN3A2 Gene

SOURCE GeneReport for Unigene cluster for BTN3A2 Gene Hs.376046

mRNA Expression by UniProt/SwissProt for BTN3A2 Gene

Tissue specificity: Detected in T-cells and natural killer cells.
genes like me logo Genes that share expression patterns with BTN3A2: view

Protein tissue co-expression partners for BTN3A2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BTN3A2 Gene

Orthologs for BTN3A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTN3A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTN3A2 35
  • 97.06 (n)
  • 93.85 (a)
(Bos Taurus)
Mammalia -- 36
  • 25 (a)
(Canis familiaris)
Mammalia -- 36
  • 19 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 17 (a)
-- 36
  • 20 (a)
-- 36
  • 18 (a)
(Mus musculus)
Mammalia Btnl10 36
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 3 (a)
Species with no ortholog for BTN3A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTN3A2 Gene

Gene Tree for BTN3A2 (if available)
Gene Tree for BTN3A2 (if available)

Paralogs for BTN3A2 Gene

Paralogs for BTN3A2 Gene

genes like me logo Genes that share paralogs with BTN3A2: view

Variants for BTN3A2 Gene

Sequence variations from dbSNP and Humsavar for BTN3A2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9358936 - 26,370,429(+) GGAGC(A/G)ACGCC intron-variant, reference, missense
rs9379861 - 26,370,388(+) GTGCA(A/C/G)GTCCA intron-variant, reference, missense
rs12205731 - 26,370,432(+) GCAAC(A/G)CCAAG intron-variant, reference, missense
rs35183513 - 26,370,520(+) CATGA(A/G)AGGCG intron-variant, reference, missense
rs13216828 - 26,373,279(+) AGAGA(A/G)CCTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for BTN3A2 Gene

Variant ID Type Subtype PubMed ID
nsv883491 CNV Loss 21882294
dgv6440n71 CNV Loss 21882294
nsv883496 CNV Gain 21882294
nsv527328 CNV Loss 19592680
esv2673332 CNV Deletion 23128226
nsv883499 CNV Gain 21882294
esv2731728 CNV Deletion 23290073
esv2731730 CNV Deletion 23290073

Variation tolerance for BTN3A2 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.70; 83.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BTN3A2 Gene

Disorders for BTN3A2 Gene

Relevant External Links for BTN3A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BTN3A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTN3A2 Gene

Publications for BTN3A2 Gene

  1. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy D.A. … Feder J.N. (Genome Res. 1997) 2 3 4 67
  2. Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex. (PMID: 9382921) Tazi-Ahnini R. … Pontarotti P. (Immunogenetics 1997) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. BTN3A2 expression in epithelial ovarian cancer is associated with higher tumor infiltrating T cells and a better prognosis. (PMID: 22685580) Le Page C. … Cailhier J.F. (PLoS ONE 2012) 3
  5. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset. (PMID: 22767497) Harly C. … Scotet E. (Blood 2012) 3

Products for BTN3A2 Gene

Sources for BTN3A2 Gene