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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BTN2A3P Gene

pseudogene   GIFtS: 41
GCID: GC06P026430

Butyrophilin, Subfamily 2, Member A3, Pseudogene

(Previous names: butyrophilin, subfamily 2, member A3)
(Previous symbol: BTN2A3)
  Search for BTN2A3P
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Butyrophilin, Subfamily 2, Member A3, Pseudogene1 2
BTN2A31 2 3 5
Butyrophilin, Subfamily 2, Member A31

External Ids:    HGNC: 132291   Entrez Gene: 547182   Ensembl: ENSG000001245497   OMIM: 6135925   UniProtKB: Q96KV63   
ORGUL members:         
NONCODE14:n408032      

Export aliases for BTN2A3P gene to outside databases

Previous GC identifers: GC06P026425 GC06P026426 GC06P026428


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BTN2A3P Gene:
The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode
type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY)
domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene
(MIM 601610) and the BTN2 (e.g., BTN2A3) and BTN3 (e.g., BNT3A1; MIM 613593) genes, which have undergone tandem
duplication, resulting in 3 copies of each (summary by Smith et al., 2010 (PubMed 20208008)).(supplied by OMIM,
Nov 2010)

GeneCards Summary for BTN2A3P Gene: 
BTN2A3P (butyrophilin, subfamily 2, member A3, pseudogene) is a pseudogene, and is affiliated with the lncRNA class.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for BTN2A3P
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBTN2A3P promoter sequence
   Search SABiosciences Chromatin IP Primers for BTN2A3P

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTN2A3P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

BTN2A3P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTN2A3P gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026430:  view genomic region     (about GC identifiers)

Start:
26,421,619 bp from pter      End:
26,432,611 bp from pter
Size:
10,993 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BT2A3_HUMAN, Q96KV6 (See protein sequence)
Recommended Name: Putative butyrophilin subfamily 2 member A3 precursor  
Size: 586 amino acids; 65713 Da
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
Caution: Could be the product of a pseudogene
Sequence caution: Sequence=CAC69644.2; Type=Erroneous gene model prediction;
Secondary accessions: A6NEF4

Explore the universe of human proteins at neXtProt for BTN2A3P: NX_Q96KV6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96KV6

  • BTN2A3P Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    BTN2A3P for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/10 InterPro protein domains (see all 10):
     IPR007110 Ig-like_dom
     IPR006574 PRY
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt
     IPR003596 Ig_V-set_subgr

    Graphical View of Domain Structure for InterPro Entry Q96KV6

    ProtoNet protein and cluster: Q96KV6

    3 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: BT2A3_HUMAN, Q96KV6
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    BTN2A3P for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for BTN2A3P:
     Increased S DNA content  Increased number of mitotic ce 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BTN2A3P

    1 Interacting protein for BTN2A3P (Q96KV62) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --P310162MINT-8108420
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BTN2A3P (BT2A3)

    Search CenterWatch for drugs/clinical trials and news about BTN2A3P

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BTN2A3P gene: 
    NM_024018.1  

    Unigene Cluster for BTN2A3P:

    Butyrophilin, subfamily 2, member A3, pseudogene
    Hs.729655  [show with all ESTs]
    Unigene Representative Sequence: NR_027795
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465856 ENST00000377662 ENST00000466808(uc011dkm.2) ENST00000475151
    ENST00000463944 ENST00000297020(uc011dkl.1)
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK056871.1 AK292658.1 BC143636.1 NR_027795.1 

    3 DOTS entries:

    DT.95259255  DT.121381036  DT.101975063 

    14 AceView cDNA sequences:

    BX114430 NM_024018 AK056871 AW300475 AI129022 AW934803 AA588005 BF435600 
    CA427717 CK000336 AV704235 AI202379 AW044260 BF887738 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for BTN2A3P    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for BTN2A3P

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BTN2A3P expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAAAAGA
    BTN2A3P Expression
    About this image


    Genevestigator expression for BTN2A3P

    SOURCE GeneReport for Unigene cluster: Hs.729655
        SABiosciences Custom PCR Arrays for BTN2A3P
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTN2A3P

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for BTN2A3P (if available)
    TreeFam Gene Tree for BTN2A3P (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BTN2A3P gene
    8 SIMAP similar genes for BTN2A3P using alignment to 1 protein entry:     BT2A3_HUMAN:
    BTN2A1    BTN2A2    BTN1A1    BTN3A1    BTNL3    BTNL8
    BTN3A3    BTNL9

    BTN2A3P for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/279 SNPs in BTN2A3P are shown (see all 279)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs758253291,2
    C--26419694(+) TATAAA/GATCAT 1 -- us2k10--------
    rs767470121,2
    C--26419696(+) TAAAAG/TCATCA 1 -- us2k10--------
    rs790072611,2
    C--26419697(+) AAAATA/CATCAG 1 -- us2k10--------
    rs748674191,2
    C--26419700(+) ATCATA/CAGATA 1 -- us2k10--------
    rs797363641,2
    C,F--26419861(+) CAGGTC/GAACTT 1 -- us2k11Minor allele frequency- G:0.14WA 118
    rs1807761381,2
    --26419935(+) ACATTA/TTATCT 1 -- us2k10--------
    rs104473901,2
    C,F,A,H--26420052(+) TACTTC/GCTATG 1 -- us2k119Minor allele frequency- G:0.12NA NS EA WA CSA 1350
    rs1861396641,2
    --26420137(+) GCTGCC/TGTTTC 1 -- us2k10--------
    rs1918650761,2
    --26420197(+) ACTTGC/GTTTAG 1 -- us2k10--------
    rs1149734401,2
    C,F--26420239(+) AGGAAC/GCTACT 1 -- us2k11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for BTN2A3P (26421619 - 26432611 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BTN2A3P:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2731730CNV Deletion23290073
    dgv6440n71CNV Loss21882294
    nsv883499CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    BTN2A3P for disorders           About MalaCards
    OMIM gene information: 613592    OMIM disorders: --


    BTN2A3P for disorders           About GeneDecksing


    Export disorders for BTN2A3P gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BTN2A3P gene integrated from 9 sources:
    (articles sorted by number of sources associating them with BTN2A3P)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    2. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    3. BTN1A1, the mammary gland butyrophilin, and BTN2A2 ar e both inhibitors of T cell activation. (PubMed id 20208008)1 Smith I.A....Trowsdale J. (2010)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. The cluster of BTN genes in the extended major histocompatibility complex. (PubMed id 11170752)1 Rhodes D.A.... Trowsdale J. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54718 HGNC: 13229 AceView: BTN2A3 Ensembl:ENSG00000124549 euGenes: HUgn54718
    ECgene: BTN2A3P H-InvDB: BTN2A3P

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BTN2A3P Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BTN2A3P gene:
    Search GeneIP for patents involving BTN2A3P

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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