BTN2A3P Gene
pseudogene GIFtS: 40
GCID: GC06P026428
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butyrophilin, subfamily 2, member A3, pseudogene(Previous names: butyrophilin, subfamily 2, member A3 )
(Previous symbol: BTN2A3)
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Aliases
for BTN2A3P gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| Butyrophilin, Subfamily 2, Member A3, Pseudogene1 2 | | BTN2A31 2 3 5 | | Butyrophilin, Subfamily 2, Member A31 |
| External Ids: | HGNC: 132291 | Entrez Gene: 547182 | Ensembl: ENSG000001245497 | OMIM: 6135925 | UniProtKB: Q96KV63 |
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| | ORGUL members: | |
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| NONCODE:n408032 | |
Export aliases for BTN2A3P gene to outside databasesPrevious GC identifers: GC06P026425 GC06P026426
Summaries
for BTN2A3P gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BTN2A3P:
The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type Imembrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Threesubfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and theBTN2 (e.g., BTN2A3) and BTN3 (e.g., BNT3A1; MIM 613593) genes, which have undergone tandem duplication, resulting in 3copies of each (summary by Smith et al., 2010 (PubMed 20208008)).(supplied by OMIM, Nov 2010)
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Genomic Views
for BTN2A3P gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for BTN2A3P
Other transcription factors
Search SABiosciences Chromatin IP Primers for BTN2A3P
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTN2A3P |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.2 HGNC cytogenetic band: 6p22.1BTN2A3P Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P026428: view genomic region
(about GC identifiers)
Start:
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26,421,619 bp from pter |
End:
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26,431,928 bp from pter |
Size:
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10,310 bases |
Orientation:
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plus strand |
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Proteins
for BTN2A3P gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: BT2A3_HUMAN, Q96KV6 (See
protein sequence)Recommended Name: Putative butyrophilin subfamily 2 member A3 precursor Size: 586 amino acids; 65713 Da
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
Caution: Could be the product of a pseudogene
Sequence caution: Sequence=CAC69644.2; Type=Erroneous gene model prediction;
Secondary accessions: A6NEF4Explore the universe of human proteins at neXtProt for BTN2A3P: NX_Q96KV6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96KV6
BTN2A3P Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral to membrane |
IEA | -- |
BTN2A3P for ontologies About GeneDecksing
BTN2A3P Antibody Products:
Assay Products for BTN2A3P: |
Protein
Domains /
Families
for BTN2A3P gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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BTN2A3P for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q96KV6ProtoNet protein and cluster: Q96KV6 3 Blocks protein families: IPB003596 Immunoglobulin V-type IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain
UniProtKB/Swiss-Prot: BT2A3_HUMAN, Q96KV6Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG familySimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for BTN2A3P gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTN2A3P |
2 GenomeRNAi human phenotypes for BTN2A3P:
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Pathways & Interactions
for BTN2A3P gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BTN2A3P
1 Interacting protein for BTN2A3P (Q96KV62) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for BTN2A3P gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BTN2A3P
Search CenterWatch for drugs/clinical trials and news about BTN2A3P 
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Transcripts
for BTN2A3P gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for BTN2A3P gene: NM_024018.1 Unigene Cluster for BTN2A3P: Butyrophilin, subfamily 2, member A3, pseudogene Hs.729655 [show with all ESTs]Unigene Representative Sequence: NR_0277956 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000465856 ENST00000377662 ENST00000466808(uc011dkm.2) ENST00000475151
ENST00000463944 ENST00000297020(uc011dkl.1)
Additional cDNA sequence: AK056871.1 AK292658.1 BC143636.1 NR_027795.1 3 DOTS entries: DT.95259255 DT.121381036 DT.101975063 14 AceView cDNA sequences: NM_024018 AK056871 BX114430 CA427717 AW300475 BF435600 AA588005 AW934803 AI129022 CK000336 AV704235 AI202379 AW044260 BF887738
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for BTN2A3P About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c |
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| SP1: | | | | | - | | | | | | |
| SP2: | | | | | | | | | | |
ECgene alternative splicing isoforms for BTN2A3P
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Expression
for BTN2A3P gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BTN2A3P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAAAAAGA
About this image
Genevestigator expression for BTN2A3P
SOURCE GeneReport for Unigene cluster: Hs.729655
SABiosciences Custom PCR Arrays for BTN2A3P
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BTN2A3P
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat BTN2A3P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTN2A3P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTN2A3P | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTN2A3P |
Orthologs
for BTN2A3P gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for BTN2A3P (if available)
TreeFam Gene Tree for BTN2A3P (if available) |
Paralogs
for BTN2A3P gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for BTN2A3P gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for BTN2A3P (26421619 - 26431928 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BTN2A3P: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTN2A3P |
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Disorders
/ Diseases
for BTN2A3P gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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 BTN2A3P for disorders About MalaCards
BTN2A3P for disorders About GeneDecksing
OMIM gene information: 613592
OMIM disorders: --
Export disorders for BTN2A3P gene to outside databases
|
Publications
for BTN2A3P gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for BTN2A3P gene integrated from 9 sources:
(articles sorted by number of sources associating them with BTN2A3P) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- BTN1A1, the mammary gland butyrophilin, and BTN2A2 ar e both inhibitors of T cell activation. (PubMed id 20208008)1 Smith I.A....Trowsdale J. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The cluster of BTN genes in the extended major histocompatibility complex. (PubMed id 11170752)1 Rhodes D.A.... Trowsdale J. (2001)
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External Searches for BTN2A3P gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing BTN2A3P gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing BTN2A3P gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BTN2A3P gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BTN2A3P | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for BTN2A3P gene:
Search GeneIP for patents involving BTN2A3P
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BTN2A3P gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BTN2A3P | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTN2A3P | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTN2A3P | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BTN2A3P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTN2A3P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTN2A3P |
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 |  |  |  | |
| | | | Search Tocris compounds for BTN2A3P |
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 | | | BTN2A3P Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTN2A3P |
|  |  |  | | | | Search ThermoFisher Antibodies for BTN2A3P |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTN2A3P |
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