BTN2A2 Gene
protein-coding GIFtS: 50
GCID: GC06P026383
|
|
butyrophilin, subfamily 2, member A2
| |
Aliases
for BTN2A2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Butyrophilin, Subfamily 2, Member A21 2 | | BTF21 2 3 5 | | BT2.21 2 3 | | Butyrophilin 22 | | Butyrophilin Subfamily 2 Member A22 |
Export aliases for BTN2A2 gene to outside databasesPrevious GC identifers: GC06P026440 GC06P026445 GC06P026491 GC06P026332 |
Summaries
for BTN2A2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BTN2A2:
Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamilyof genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster onchromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of theimmunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acidand sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been foundfor this gene. (provided by RefSeq, Oct 2010)
UniProtKB/Swiss-Prot: BT2A2_HUMAN, Q8WVV5Function: Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2and IFNG secretion (By similarity)
Gene Wiki entry for BTN2A2 (Butyrophilin, subfamily 2, member A2)
|
Genomic Views
for BTN2A2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BTN2A2 gene promoter:
Elk-1 p53 MyoD NF-kappaB POU2F1 NF-kappaB2 POU2F1a STAT3 NF-kappaB1 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for BTN2A2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTN2A2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.2 HGNC cytogenetic band: 6p22.1BTN2A2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P026383: view genomic region
(about GC identifiers)
Start:
|
26,383,324 bp from pter |
End:
|
26,395,102 bp from pter |
Size:
|
11,779 bases |
Orientation:
|
plus strand |
|
Proteins
for BTN2A2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BT2A2_HUMAN, Q8WVV5 (See
protein sequence)Recommended Name: Butyrophilin subfamily 2 member A2 precursor Size: 523 amino acids; 59070 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: A6NM84 B4DE97 B4DQ01 E9PH07 O00480Alternative splicing: 5 isoforms: Q8WVV5-1 Q8WVV5-2 Q8WVV5-3 Q8WVV5-4 Q8WVV5-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for BTN2A2: NX_Q8WVV5
Post-translational modifications:
N-glycosylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WVV5
BTN2A2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001184166.1 NP_001184167.1 NP_001184168.1 NP_001184169.1 NP_008926.2 NP_853509.1
ENSEMBL proteins: ENSP00000417472 ENSP00000418965 ENSP00000349143 ENSP00000337117 ENSP00000418857 ENSP00000419226 ENSP00000419451 ENSP00000394241 ENSP00000417676 ENSP00000418657 ENSP00000399308 ENSP00000417511 ENSP00000418176 ENSP00000417129
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
BTN2A2 for ontologies About GeneDecksing
BTN2A2 Antibody Products:
Assay Products for BTN2A2: |
Protein
Domains /
Families
for BTN2A2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BTN2A2 for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry Q8WVV5ProtoNet protein and cluster: Q8WVV5 4 Blocks protein families: IPB003599 Immunoglobulin subtype IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: BT2A2_HUMAN, Q8WVV5Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG familySimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for BTN2A2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BT2A2_HUMAN, Q8WVV5Function: Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2and IFNG secretion (By similarity) Genatlas biochemistry entry for BTN2A2:butyrophilin subfamily 2,member A2,B box family of proteins,involved in cell proliferation and development
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTN2A2 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTN2A2 |
3 GenomeRNAi human phenotypes for BTN2A2:
|
Pathways & Interactions
for BTN2A2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BTN2A2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for BTN2A2 (Q8WVV53 ENSP000003491434) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031324 | negative regulation of cellular metabolic process |
ISS | -- | | GO:0046007 | negative regulation of activated T cell proliferation |
ISS | -- | | GO:0050710 | negative regulation of cytokine secretion |
ISS | -- |
BTN2A2 for ontologies About GeneDecksing
|
Drugs & Compounds
for BTN2A2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BTN2A2
Search CenterWatch for drugs/clinical trials and news about BTN2A2 / BT2A2
|
Transcripts
for BTN2A2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BTN2A2 gene (6 alternative transcripts): NM_001197237.1 NM_001197238.1 NM_001197239.1 NM_001197240.1 NM_006995.4 NM_181531.2 Unigene Cluster for BTN2A2: Butyrophilin, subfamily 2, member A2 Hs.373938 [show with all ESTs]Unigene Representative Sequence: NM_00119723716 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000469230(uc003nhs.3) ENST00000490025 ENST00000356709(uc003nhq.3 uc003nhr.3 uc011dkh.2 uc011dkg.2 uc003nht.3)
ENST00000467485(uc011dkf.2) ENST00000352867 ENST00000493275 ENST00000472507
ENST00000482536 ENST00000432533 ENST00000482842 ENST00000482636 ENST00000471116
ENST00000416795 ENST00000494184 ENST00000483410 ENST00000495632(uc011dki.1)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTN2A2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): BTN2A2 (NM_006995) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BTN2A2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTN2A2 |
Additional cDNA sequence: AK289883.1 AK293526.1 AK298570.1 BC013258.2 BC014021.2 BC017497.1 U90550.1 12 DOTS entries: DT.213193 DT.95375284 DT.40303942 DT.91765455 DT.100814077 DT.97845505 DT.121380997 DT.75101454 DT.91710456 DT.92009716 DT.101975063 DT.91765456 24/60 AceView cDNA sequences (see all 60): AI885174 BF870685 NM_006995 BE503839 BC017497 CB305707 CF125260 BE551924 BC013258 AL832800 BX399136 BC014021 BP344944 NM_181531 BX106145 BU620822 BE328278 AW772688 R54384 BM549369 BP357861 AL710876 AA700399 AI817490
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for BTN2A2 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for BTN2A2
|
Expression
for BTN2A2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BTN2A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGATGTGGT
About this image
See BTN2A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BTN2A2
SOURCE GeneReport for Unigene cluster: Hs.373938
UniProtKB/Swiss-Prot: BT2A2_HUMAN, Q8WVV5Tissue specificity: Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderateexpression was seen in lung, liver and kidney
SABiosciences Custom PCR Arrays for BTN2A2
Primer
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Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTN2A2 |
Orthologs
for BTN2A2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for BTN2A2 gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1003320771 |
butyrophilin subfamily 1 member A1-like |
45.56(n)
34.72(a) |
|
100332077 XM_002667289.2 XP_002667335.2 |
ENSEMBL Gene Tree for BTN2A2 (if available)
TreeFam Gene Tree for BTN2A2 (if available) |
Paralogs
for BTN2A2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BTN2A2 gene
- BTN3A22 BTN2A12 BTNL82 ERMAP2 BTN3A32 HHLA22 CD2762 BTNL102
- MOG2 BTNL22 BTN3A12 VTCN12 BTN1A12 BTNL92 BTNL32
18 SIMAP similar genes for BTN2A2 using alignment to 9 protein entries: BT2A2_HUMAN (see all proteins):BTN2A1 BTN2A3P TRIM69 TRIM27 MEFV BTN1A1
MOG BTNL2 BTN3A2 BTN3A3 BTNL10 BTN3A1
SKINT1 BTNL3 BTNL9 BTNL8 ERMAP BT3.3
BTN2A2 for paralogs About GeneDecksing
|
Genomic Variants
for BTN2A2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BTN2A2 (26383324 - 26395102 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BTN2A2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTN2A2 |
|
Disorders
/ Diseases
for BTN2A2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BTN2A2 for disorders About GeneDecksing
OMIM gene information: 613591
OMIM disorders: --
2  diseases for BTN2A2: About MalaCardshemochromatosis schizophrenia
Export disorders for BTN2A2 gene to outside databases
|
Publications
for BTN2A2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BTN2A2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with BTN2A2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PubMed id 9149941)1, 2, 3 Ruddy D.A.... Feder J.N. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Structure and evolution of the extended B7 family. (PubMed id 10354554)1, 3 Henry J....Pontarotti P. (1999)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Common variants on chromosome 6p22.1 are associated w ith schizophrenia. (PubMed id 19571809)1 Shi J....Gejman P.V. (2009)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- A proteomic approach to evaluate the butyrophilin gene family expression in human milk fat globule membrane. (PubMed id 12124930)1 Cavaletto M....Conti A. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for BTN2A2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BTN2A2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BTN2A2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BTN2A2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BTN2A2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BTN2A2 gene:
Search GeneIP for patents involving BTN2A2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BTN2A2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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