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Aliases for BTN2A2 Gene

Aliases for BTN2A2 Gene

  • Butyrophilin Subfamily 2 Member A2 2 3 5
  • BT2.2 3 4
  • BTF2 3 4
  • Butyrophilin, Subfamily 2, Member A2 2
  • Butyrophilin 2 3
  • BTN2.2 3

External Ids for BTN2A2 Gene

Previous GeneCards Identifiers for BTN2A2 Gene

  • GC06P026440
  • GC06P026445
  • GC06P026491
  • GC06P026383
  • GC06P026332

Summaries for BTN2A2 Gene

Entrez Gene Summary for BTN2A2 Gene

  • Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for BTN2A2 Gene

BTN2A2 (Butyrophilin Subfamily 2 Member A2) is a Protein Coding gene. Among its related pathways are Immune System and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. An important paralog of this gene is BTN2A1.

UniProtKB/Swiss-Prot for BTN2A2 Gene

  • Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.

Gene Wiki entry for BTN2A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTN2A2 Gene

Genomics for BTN2A2 Gene

Regulatory Elements for BTN2A2 Gene

Enhancers for BTN2A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F026471 1.4 Ensembl ENCODE 22.6 +92.9 92895 7.6 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 BTN3A2 HMGN4 BTN2A2 HCG11 BTN2A3P BTN2A1 RNU6-502P BTN1A1 ABT1 LOC102724851
GH06F026445 0.8 ENCODE 27.6 +63.2 63192 1.3 HDGF PKNOX1 TBL1XR1 EBF1 ZBTB40 RELA EED ETV6 CREM CHD2 BTN2A2 BTN2A1 BTN3A1 BTN1A1 HIST1H2APS4 HIST1H3G LOC102724851 GC06M026555 BTN3A3
GH06F027176 1.8 FANTOM5 Ensembl ENCODE 8.7 +794.8 794827 3.4 CREB3L1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 ZNF610 ZNF391 BTN3A2 ZNF204P ZKSCAN8 ZNF192P1 ABT1 ZNF322 HIST1H2BK ENSG00000271755 ENSG00000261353
GH06F026349 1.3 Ensembl ENCODE 11.3 -31.7 -31680 3.4 PKNOX1 ARNT ARID4B SIN3A SLC30A9 ZNF766 FOS SP5 NFYC JUNB BTN3A2 HMGN4 ABT1 BTN2A1 BTN2A2 BTN2A3P BTN3A1 BTN3A3 ENSG00000272312 LOC101928743
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BTN2A2 on UCSC Golden Path with GeneCards custom track

Promoters for BTN2A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001214085 714 1201 HDGF PKNOX1 ATF1 SIN3A FEZF1 GLI4 BRCA1 ZNF2 ZNF121 GLIS2

Genomic Location for BTN2A2 Gene

26,382,886 bp from pter
26,394,874 bp from pter
11,989 bases
Plus strand

Genomic View for BTN2A2 Gene

Genes around BTN2A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTN2A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTN2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTN2A2 Gene

Proteins for BTN2A2 Gene

  • Protein details for BTN2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin subfamily 2 member A2
    Protein Accession:
    Secondary Accessions:
    • A6NM84
    • B4DE97
    • B4DQ01
    • E9PH07
    • O00480

    Protein attributes for BTN2A2 Gene

    523 amino acids
    Molecular mass:
    59070 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTN2A2 Gene


neXtProt entry for BTN2A2 Gene

Post-translational modifications for BTN2A2 Gene

No data available for DME Specific Peptides for BTN2A2 Gene

Domains & Families for BTN2A2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTN2A2: view

Function for BTN2A2 Gene

Molecular function for BTN2A2 Gene

GENATLAS Biochemistry:
butyrophilin subfamily 2,member A2,B box family of proteins,involved in cell proliferation and development
UniProtKB/Swiss-Prot Function:
Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.

Gene Ontology (GO) - Molecular Function for BTN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BTN2A2: view
genes like me logo Genes that share phenotypes with BTN2A2: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTN2A2 Gene

Localization for BTN2A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTN2A2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTN2A2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for BTN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with BTN2A2: view

Pathways & Interactions for BTN2A2 Gene

genes like me logo Genes that share pathways with BTN2A2: view

Pathways by source for BTN2A2 Gene

2 Reactome pathways for BTN2A2 Gene
1 R&D Systems pathway for BTN2A2 Gene

Gene Ontology (GO) - Biological Process for BTN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031324 negative regulation of cellular metabolic process ISS --
GO:0046007 negative regulation of activated T cell proliferation ISS --
GO:0050710 negative regulation of cytokine secretion ISS --
genes like me logo Genes that share ontologies with BTN2A2: view

No data available for SIGNOR curated interactions for BTN2A2 Gene

Transcripts for BTN2A2 Gene

Unigene Clusters for BTN2A2 Gene

Butyrophilin, subfamily 2, member A2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTN2A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - - - -
SP5: -
SP6: - - -
SP7: - -

Relevant External Links for BTN2A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTN2A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BTN2A2 Gene

Protein differential expression in normal tissues from HIPED for BTN2A2 Gene

This gene is overexpressed in Urine (57.2) and Heart (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTN2A2 Gene

Protein tissue co-expression partners for BTN2A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of BTN2A2 Gene:


SOURCE GeneReport for Unigene cluster for BTN2A2 Gene:


mRNA Expression by UniProt/SwissProt for BTN2A2 Gene:

Tissue specificity: Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.
genes like me logo Genes that share expression patterns with BTN2A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BTN2A2 Gene

Orthologs for BTN2A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTN2A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTN2A2 34 35
  • 99.36 (n)
(Canis familiaris)
Mammalia BTN2A2 34
  • 80.37 (n)
-- 35
  • 72 (a)
(Mus musculus)
Mammalia Btn2a2 34 16 35
  • 77.36 (n)
(Rattus norvegicus)
Mammalia Btn2a2 34
  • 76.08 (n)
(Bos Taurus)
Mammalia BTN2A1 34
  • 73.69 (n)
-- 35
  • 58 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 40 (a)
Species where no ortholog for BTN2A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTN2A2 Gene

Gene Tree for BTN2A2 (if available)
Gene Tree for BTN2A2 (if available)

Paralogs for BTN2A2 Gene

Variants for BTN2A2 Gene

Sequence variations from dbSNP and Humsavar for BTN2A2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs111318670 -- 26,392,193(+) GGAGA(C/G)ATAGA intron-variant, reference, missense
rs111432027 -- 26,393,087(+) ATCTT(C/T)CAGCT intron-variant, utr-variant-3-prime
rs111574843 -- 26,384,518(+) TAAAT(A/G)ATCAC intron-variant
rs111615265 -- 26,392,774(+) CTTCT(A/G)CAACA intron-variant, reference, missense, utr-variant-3-prime
rs111793144 -- 26,387,211(+) ATCCA(C/G)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTN2A2 Gene

Variant ID Type Subtype PubMed ID
nsv970087 CNV duplication 23825009
nsv601184 CNV gain 21841781
nsv1030863 CNV gain+loss 25217958
nsv1023453 CNV gain 25217958
esv3890802 CNV loss 25118596
esv3608404 CNV gain 21293372
esv3608403 CNV loss 21293372
esv3608402 CNV loss 21293372
esv2731730 CNV deletion 23290073
esv2731728 CNV deletion 23290073

Variation tolerance for BTN2A2 Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTN2A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTN2A2 Gene

Disorders for BTN2A2 Gene

Relevant External Links for BTN2A2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BTN2A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTN2A2 Gene

Publications for BTN2A2 Gene

  1. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy D.A. … Feder J.N. (Genome Res. 1997) 2 3 4 64
  2. Common variants on chromosome 6p22.1 are associated with schizophrenia. (PMID: 19571809) Shi J. … Gejman P.V. (Nature 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for BTN2A2 Gene

Sources for BTN2A2 Gene

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