Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BTN1A1 Gene

Aliases for BTN1A1 Gene

  • Butyrophilin Subfamily 1 Member A1 2 3 5
  • Butyrophilin, Subfamily 1, Member A1 2 3
  • BTN 3 4
  • BT 3 4
  • BK14H9.2 (Butyrophilin, Subfamily 1, Member A1) 3
  • BTN1 3

External Ids for BTN1A1 Gene

Previous HGNC Symbols for BTN1A1 Gene

  • BTN

Previous GeneCards Identifiers for BTN1A1 Gene

  • GC06P026558
  • GC06P026608
  • GC06P026501
  • GC06P026444
  • GC06P026500

Summaries for BTN1A1 Gene

Entrez Gene Summary for BTN1A1 Gene

  • Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families [provided by RefSeq, Jul 2008]

GeneCards Summary for BTN1A1 Gene

BTN1A1 (Butyrophilin Subfamily 1 Member A1) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. GO annotations related to this gene include receptor activity. An important paralog of this gene is BTNL8.

UniProtKB/Swiss-Prot for BTN1A1 Gene

  • May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity).

Gene Wiki entry for BTN1A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTN1A1 Gene

Genomics for BTN1A1 Gene

Regulatory Elements for BTN1A1 Gene

Genomic Location for BTN1A1 Gene

Chromosome:
6
Start:
26,499,306 bp from pter
End:
26,510,425 bp from pter
Size:
11,120 bases
Orientation:
Plus strand

Genomic View for BTN1A1 Gene

Genes around BTN1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTN1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTN1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTN1A1 Gene

Proteins for BTN1A1 Gene

  • Protein details for BTN1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13410-BT1A1_HUMAN
    Recommended name:
    Butyrophilin subfamily 1 member A1
    Protein Accession:
    Q13410
    Secondary Accessions:
    • Q4VAN3
    • Q4VAN4
    • Q9H458

    Protein attributes for BTN1A1 Gene

    Size:
    526 amino acids
    Molecular mass:
    58960 Da
    Quaternary structure:
    • Seems to associate with xanthine dehydrogenase/oxidase.

neXtProt entry for BTN1A1 Gene

Proteomics data for BTN1A1 Gene at MOPED

Post-translational modifications for BTN1A1 Gene

Other Protein References for BTN1A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for BTN1A1 (BTN1A1/Butyrophilin)

No data available for DME Specific Peptides for BTN1A1 Gene

Domains & Families for BTN1A1 Gene

Suggested Antigen Peptide Sequences for BTN1A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13410

UniProtKB/Swiss-Prot:

BT1A1_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
Domain:
  • Contains 1 B30.2/SPRY domain.
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTN1A1: view

Function for BTN1A1 Gene

Molecular function for BTN1A1 Gene

GENATLAS Biochemistry:
butyrophilin,subfamily 1,member A1,B box family of proteins,involved in cell proliferation and development
UniProtKB/Swiss-Prot Function:
May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity).
genes like me logo Genes that share phenotypes with BTN1A1: view

Animal Models for BTN1A1 Gene

MGI Knock Outs for BTN1A1:

Animal Model Products

miRNA for BTN1A1 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BTN1A1 Gene

Localization for BTN1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTN1A1 Gene

Membrane; Single-pass type I membrane protein. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTN1A1 Gene COMPARTMENTS Subcellular localization image for BTN1A1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for BTN1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8611614
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BTN1A1: view

Pathways & Interactions for BTN1A1 Gene

genes like me logo Genes that share pathways with BTN1A1: view

Pathways by source for BTN1A1 Gene

1 R&D Systems pathway for BTN1A1 Gene

Gene Ontology (GO) - Biological Process for BTN1A1 Gene

None

No data available for SIGNOR curated interactions for BTN1A1 Gene

Drugs & Compounds for BTN1A1 Gene

No Compound Related Data Available

Transcripts for BTN1A1 Gene

mRNA/cDNA for BTN1A1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTN1A1 Gene

Butyrophilin, subfamily 1, member A1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTN1A1 Gene

No ASD Table

Relevant External Links for BTN1A1 Gene

GeneLoc Exon Structure for
BTN1A1
ECgene alternative splicing isoforms for
BTN1A1

Expression for BTN1A1 Gene

mRNA expression in normal human tissues for BTN1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTN1A1 Gene

This gene is overexpressed in Breast - Mammary Tissue (x16.7) and Testis (x4.3).

Protein differential expression in normal tissues from HIPED for BTN1A1 Gene

This gene is overexpressed in Milk (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BTN1A1 Gene



SOURCE GeneReport for Unigene cluster for BTN1A1 Gene Hs.153058

genes like me logo Genes that share expression patterns with BTN1A1: view

Protein tissue co-expression partners for BTN1A1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for BTN1A1 Gene

Orthologs for BTN1A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BTN1A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BTN1A1 35
  • 86.06 (n)
  • 84.03 (a)
BTN1A1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTN1A1 35
  • 84.64 (n)
  • 80.42 (a)
BTN1A1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btn1a1 35
  • 80.18 (n)
  • 74.38 (a)
Btn1a1 16
Btn1a1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BTN1A1 35
  • 99.62 (n)
  • 99.05 (a)
BTN1A1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btn1a1 35
  • 79.5 (n)
  • 74.71 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
chicken
(Gallus gallus)
Aves BTN1A1 35
  • 54.63 (n)
  • 42.13 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100144947 35
  • 46.81 (n)
  • 35.51 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101885077 35
  • 50.27 (n)
  • 39.34 (a)
Species with no ortholog for BTN1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTN1A1 Gene

ENSEMBL:
Gene Tree for BTN1A1 (if available)
TreeFam:
Gene Tree for BTN1A1 (if available)

Paralogs for BTN1A1 Gene

Paralogs for BTN1A1 Gene

(14) SIMAP similar genes for BTN1A1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for BTN1A1 Gene

genes like me logo Genes that share paralogs with BTN1A1: view

Variants for BTN1A1 Gene

Sequence variations from dbSNP and Humsavar for BTN1A1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3736781 - 26,505,134(+) CTTCT(A/G)CGAAA reference, missense
rs9393728 - 26,509,102(+) GAGGA(C/G)TCTGC reference, missense
rs1980600 - 26,508,501(+) TCCAG(C/T)TGATG reference, missense
rs35555795 - 26,509,154(+) CCCAA(C/T)CCAGC reference, missense
rs1056667 -- 26,510,336(+) GCTTA(C/T)ACCTT utr-variant-3-prime

Variation tolerance for BTN1A1 Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTN1A1 Gene

HapMap Linkage Disequilibrium report
BTN1A1
Human Gene Mutation Database (HGMD)
BTN1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BTN1A1 Gene

Disorders for BTN1A1 Gene

Relevant External Links for BTN1A1

Genetic Association Database (GAD)
BTN1A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BTN1A1

No disorders were found for BTN1A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTN1A1 Gene

Publications for BTN1A1 Gene

  1. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PMID: 19084217) Benyamin B. … Visscher P.M. (Am. J. Hum. Genet. 2009) 3 48 67
  2. The PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1) binds to xanthine oxidoreductase: implications for the function of BTN1A1 in the mammary gland and other tissues. (PMID: 19531472) Jeong J. … Mather I.H. (J. Biol. Chem. 2009) 3 23
  3. The cluster of BTN genes in the extended major histocompatibility complex. (PMID: 11170752) Rhodes D.A. … Trowsdale J. (Genomics 2001) 3 23
  4. Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex. (PMID: 9382921) Tazi-Ahnini R. … Pontarotti P. (Immunogenetics 1997) 2 3
  5. Evolutionary study of multigenic families mapping close to the human MHC class I region. (PMID: 8114113) Vernet C. … Pontarotti P. (J. Mol. Evol. 1993) 2 3

Products for BTN1A1 Gene

Sources for BTN1A1 Gene

Back to Top

Content