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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BTN1A1 Gene

protein-coding   GIFtS: 54
GCID: GC06P026501

Butyrophilin, Subfamily 1, Member A1


(Previous symbol: BTN)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Butyrophilin, Subfamily 1, Member A11 2
BTN1 2 3 5
BT2 3
BK14H9.2 (Butyrophilin, Subfamily 1, Member A1)2
Butyrophilin Subfamily 1 Member A12

External Ids:    HGNC: 11351   Entrez Gene: 6962   Ensembl: ENSG000001245577   OMIM: 6016105   UniProtKB: Q134103   

Export aliases for BTN1A1 gene to outside databases

Previous GC identifers: GC06P026558 GC06P026608 GC06P026444


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BTN1A1 Gene:
Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin
superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major
histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the
shuffling of exons between 2 ancestral gene families (provided by RefSeq, Jul 2008)

GeneCards Summary for BTN1A1 Gene: 
BTN1A1 (butyrophilin, subfamily 1, member A1) is a protein-coding gene. Diseases associated with BTN1A1 include encephalomyelitis, and pneumonia. GO annotations related to this gene include receptor activity. An important paralog of this gene is BTN3A2.

UniProtKB/Swiss-Prot: BT1A1_HUMAN, Q13410
Function: May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor
for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the
proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG
secretion (By similarity)

Gene Wiki entry for BTN1A1 (Butyrophilin, subfamily 1, member A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BTN1A1 gene promoter:
         LHX3b/Lhx3b   Pbx1a   Pax-5   p53   Brachyury   FOXD1   Nkx6-1   FOXO1a   LHX3a/Lhx3a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBTN1A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for BTN1A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTN1A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

BTN1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTN1A1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026501:  view genomic region     (about GC identifiers)

Start:
26,501,449 bp from pter      End:
26,510,653 bp from pter
Size:
9,205 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BT1A1_HUMAN, Q13410 (See protein sequence)
Recommended Name: Butyrophilin subfamily 1 member A1 precursor  
Size: 526 amino acids; 58960 Da
Subunit: Seems to associate with xanthine dehydrogenase/oxidase (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein. Secreted
Secondary accessions: Q4VAN3 Q4VAN4 Q9H458

Explore the universe of human proteins at neXtProt for BTN1A1: NX_Q13410

Explore proteomics data for BTN1A1 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13410

  • BTN1A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BTN1A1 Protein Expression
    REFSEQ proteins: NP_001723.2  
    ENSEMBL proteins: 
     ENSP00000244513  

    Human Recombinant Protein Products for BTN1A1: 
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    Novus Biologicals BTN1A1 Proteins
    Novus Biologicals BTN1A1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BTN1A1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005887integral to plasma membrane TAS8611614

    BTN1A1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5/11 InterPro protein domains (see all 11):
     IPR007110 Ig-like_dom
     IPR006574 PRY
     IPR013162 CD80_C2-set
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q13410

    ProtoNet protein and cluster: Q13410

    3 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: BT1A1_HUMAN, Q13410
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    BTN1A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BT1A1_HUMAN, Q13410
    Function: May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor
    for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the
    proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG
    secretion (By similarity)

         Genatlas biochemistry entry for BTN1A1:
    butyrophilin,subfamily 1,member A1,B box family of proteins,involved in cell proliferation and development

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS8611614
    GO:0005515protein binding ----
         
    BTN1A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BTN1A1:
     Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Btn1a1):
     endocrine/exocrine gland  integument 

    BTN1A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BTN1A1: Btn1a1tm1Ihm Btn1a1tm2Ihm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BTN1A1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BTN1A1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BTN1A1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BTN1A1 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate BTN1A1:
    hsa-miR-4291
    SwitchGear 3'UTR luciferase reporter plasmidBTN1A1 3' UTR sequence
    Inhib. RNA
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTN1A1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BTN1A1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for BTN1A1 (Q134103 ENSP000002445134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XDHP479893, ENSP000003687274I2D: score=1 STRING: ENSP00000368727
    PLK1P533503, ENSP000003000934I2D: score=2 STRING: ENSP00000300093
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BTN1A1 (BT1A1)

    Search CenterWatch for drugs/clinical trials and news about BTN1A1 / BT1A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BTN1A1 gene: 
    NM_001732.2  

    Unigene Cluster for BTN1A1:

    Butyrophilin, subfamily 1, member A1
    Hs.153058  [show with all ESTs]
    Unigene Representative Sequence: U39576
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000244513(uc003nif.4)
    miRNA
    Products:
         
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate BTN1A1:
    hsa-miR-4291
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    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BTN1A1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    Sirion Biotech Customized lentivirus for stable overexpression of BTN1A1 
                         Customized lentivirus expression plasmids for stable overexpression of BTN1A1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTN1A1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTN1A1

    Additional mRNA sequence: 

    BC096312.3 BC096313.1 BC096314.1 BC096315.1 U39576.1 

    2 DOTS entries:

    DT.453220  DT.121407003 

    10 AceView cDNA sequences:

    AA280049 BX106561 AA805147 AA279987 U39576 AA768577 NM_001732 AA731332 
    BU430550 AW977526 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BTN1A1 expression in normal human tissues (normalized intensities)      BTN1A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTTGTCT
    BTN1A1 Expression
    About this image


    BTN1A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
             salivary gland ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Breast (Uncategorized)    fully expand to see all 2 entries
             breast ; myoepithelial cells   
     
     Brain (Nervous System)
             Cerebral Cortex

    See BTN1A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BTN1A1

    SOURCE GeneReport for Unigene cluster: Hs.153058
        SABiosciences Custom PCR Arrays for BTN1A1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTN1A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BTN1A1 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Btn1a11 , 5 butyrophilin, subfamily 1, member A11, 5 80.18(n)1
    74.38(a)1
      13 (9.72 cM)5
    122311  NM_013483.31  NP_038511.11 
     234569925 
    chicken
    (Gallus gallus)
    Aves BTN1A11 butyrophilin, subfamily 1, member A1 54.54(n)
    41.65(a)
      420061  NM_001034817.1  NP_001029989.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005356451 butyrophilin subfamily 1 member A1-like 45.71(n)
    34.07(a)
      100535645  XM_003198053.1  XP_003198101.1 


    ENSEMBL Gene Tree for BTN1A1 (if available)
    TreeFam Gene Tree for BTN1A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BTN1A1 gene
    BTN3A22  BTN2A12  BTNL82  ERMAP2  BTN2A22  BTN3A32  MOG2  BTN3A12  
    BTNL22  BTNL32  BTNL92  
    15 SIMAP similar genes for BTN1A1 using alignment to 3 protein entries:     BT1A1_HUMAN (see all proteins):
    TRIM27    MOG    TRIM11    BTN2A2    BTN2A3P    BTNL2
    BTN3A3    BTN2A1    BTN3A2    BTN3A1    BTNL8    BTNL9
    BTNL3    RFPL3    RFPL1

    BTN1A1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for BTN1A1
    PGOHUM00000244693 PGOHUM00000243523


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/228 SNPs in BTN1A1 are shown (see all 228)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1498867411,2
    C,Funtested126505268(+) TCCAAG/AGGAGA 2 /K syn11Minor allele frequency- A:0.00NA 4550
    rs1893642491,2
    --26499576(+) ATAAAA/GACTTA 1 -- us2k10--------
    rs1819400701,2
    --26499578(+) AAAGAC/TTTATA 1 -- us2k10--------
    rs1850233291,2
    --26499593(+) AAGTGC/TATTAT 1 -- us2k10--------
    rs1902040451,2
    --26499660(+) AACAAC/TATTTT 1 -- us2k10--------
    rs1819028181,2
    --26499753(+) GAATTA/GAGGCT 1 -- us2k10--------
    rs745038241,2
    C--26499882(+) ATGATA/GAGTTG 1 -- us2k10--------
    rs69266291,2
    C,F,A,H--26499903(+) AATAAC/TTGTCA 1 -- us2k124Minor allele frequency- T:0.46NS EA NA WA CSA 2486
    rs69039731,2
    C,F,A,H--26499942(+) GAATTA/CACAGC 1 -- us2k121Minor allele frequency- C:0.46NS EA NA WA CSA 2330
    rs93937271,2
    C,F,A--26500011(+) ACGGAC/GGCTCC 1 -- us2k110Minor allele frequency- G:0.18NA WA EA 508

    HapMap Linkage Disequilibrium report for BTN1A1 (26501449 - 26510653 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BTN1A1: --

    Human Gene Mutation Database (HGMD): BTN1A1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BTN1A1
    DNA2.0 Custom Variant and Variant Library Synthesis for BTN1A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601610    OMIM disorders: --

    4 diseases for BTN1A1:    About MalaCards
    encephalomyelitis    pneumonia    multiple sclerosis    neuronitis


    BTN1A1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for BTN1A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mimicry 53 2 14978022 (1), 14688379 (1)

    Genetic Association Database (GAD): BTN1A1

    Export disorders for BTN1A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BTN1A1 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with BTN1A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PubMed id 19084217)1, 4 Benyamin B....Visscher P.M. (2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex. (PubMed id 9382921)1, 3 Tazi-Ahnini R....Pontarotti P. (1997)
    5. Cloning and sequence analysis of human butyrophilin reveals a potential receptor function. (PubMed id 8611614)1, 2 Taylor M.R.... Couto J.R. (1996)
    6. Evolutionary study of multigenic families mapping close to the human MHC class I region. (PubMed id 8114113)1, 3 Vernet C....Pontarotti P. (1993)
    7. The PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1 ) binds to xanthine oxidoreductase: implications for the function of BTN1A1 in the mammary gland and other tissues. (PubMed id 19531472)1, 9 Jeong J....Mather I.H. (2009)
    8. The cluster of BTN genes in the extended major histocompatibility complex. (PubMed id 11170752)1, 9 Rhodes D.A.... Trowsdale J. (2001)
    9. Akt1 is essential for postnatal mammary gland develop ment, function, and the expression of Btn1a1. (PubMed id 21915327)1 LaRocca J....Hixon M. (2011)
    10. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. (PubMed id 19596235)1 Svendsen J.M.... Harper J.W. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 696 HGNC: 1135 AceView: BTN1A1 Ensembl:ENSG00000124557 euGenes: HUgn696
    ECgene: BTN1A1 H-InvDB: BTN1A1

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for BTN1A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for BTN1A1 gene:
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