BTLA Gene

Aliases
for BTLA gene

Previous GC identifers: GC03M113466 GC03M113505 GC03M113667 GC03M109566

Summaries
for BTLA gene

Genomic Views
for BTLA gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_005612.16  

SwitchGear Promoter luciferase reporter plasmid: BTLA promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTLA

BTLA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M112182:  view genomic region     (about GC identifiers)

Proteins
for BTLA gene

1 PDB 3D structure from and Proteopedia for BTLA:

2AW2 (3D)    

Explore the universe of human proteins at neXtProt for BTLA: NX_Q7Z6A9

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: BTLA OriGene Protein Over-expression Lysate (see all 3): BTLA OriGene Custom Protein Services for BTLA
	GenScript Custom Purified and Recombinant Proteins Services for BTLA
	Novus Biologicals BTLA Proteins Novus Biologicals BTLA Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for BTLA

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for BTLA
	OriGene Antibodies (see all 9): BTLA OriGene Custom Antibody Services for BTLA
	GenScript Custom Superior Antibodies Services for BTLA
	Novus Biologicals BTLA Antibodies
	Abcam antibodies for BTLA
	Uscn Antibodies for BTLA
	ThermoFisher Antibodies for BTLA

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for BTLA
	GenScript Custom Assay Services for BTLA
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for BTLA

Protein Domains /
Families
for BTLA gene

ProtoNet protein and cluster: Q7Z6A9

Function
for BTLA gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BTLA
		8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate BTLA (see all 25):
		hsa-miR-4291 hsa-miR-4251 hsa-miR-539 hsa-miR-15a hsa-miR-555 hsa-miR-138-2* hsa-miR-103a hsa-miR-3161
		SwitchGear 3'UTR luciferase reporter plasmid: BTLA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BTLA (see all 7) OriGene shRNA RFP: BTLA OriGene siRNA: BTLA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BTLA

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for BTLA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTLA (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTLA (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): BTLA (NM_181780)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTLA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTLA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BTLA
		Search LifeMap BioReagents cell lines for BTLA

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTLA

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Btla)

Pathways & Interactions
for BTLA gene

	Super-pathway	contained gene-specific pathways
1	Immune System	Immune System 1.00 Adaptive Immune System 0.59
2	CD28 co-stimulation	Costimulation by the CD28 family 0.41

3        Reactome Pathways for BTLA

	Costimulation by the CD28 family
	Adaptive Immune System
	Immune System

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

Drugs & Compounds
for BTLA gene

Transcripts
for BTLA gene

Expression
for BTLA gene

BTLA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	AdiposeBody Subcutaneous White Adipose			Adipose
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BTLA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BTLA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTLA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTLA

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTLA

Orthologs
for BTLA gene

Paralogs
for BTLA gene

Genomic Variants
for BTLA gene

10/625 NCBI SNPs in BTLA are shown (see all 625)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs800215081,2	F,	--	112182462(+)	AAGTTT/CATATA	2	--	ds5001		1		EA	120
rs1497487931,2		--	112182490(+)	GATCGC/TGCCAG	2	--	ds5001		0	--	--	--	--
rs1454387961,2		--	112182491(+)	ATCGCA/GCCAGA	2	--	ds5001		0	--	--	--	--
rs1834760611,2		--	112182543(+)	AACTGA/GTCAAA	2	--	ds5001		0	--	--	--	--
rs1402353131,2		--	112182629(+)	TGGCAG/TGTCTT	2	--	ds5001		0	--	--	--	--
rs19828091,2	C,F,A,H,	--	112182740(-)	ACACAT/CAAAAG	2	--	ds5001		17		NS EA NA WA	2342
rs117176571,2	C,F,H,	--	112182855(+)	TTGAGC/TACAAT	2	--	ut31		6		NS EA NA	528
rs26335701,2	C,A,H,	--	112182929(-)	CATTAA/GTTTAT	2	--	ut31		11		NA WA CSA EA	374
rs558091961,2	C,F,	--	112182995(+)	TCTCTG/AACACC	2	--	ut31		6		WA NA CSA	246
rs1149229951,2	F,	--	112183077(+)	AGAGAT/AGAAAT	2	--	ut31		1		WA	118

HapMap Linkage Disequilibrium report for BTLA (112182813 - 112218408 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for BTLA: --
Human Gene Mutation Database (HGMD): BTLA

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTLA

DNA2.0 Custom Variant and Variant Library Synthesis for BTLA

Disorders / Diseases
for BTLA gene

Publications
for BTLA gene

PubMed articles for BTLA gene, integrated from 9 sources (see all 38): (articles sorted by number of sources associating them with BTLA)

Utopia: connect your pdf to the dynamic world of online information

1. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. (PubMed id 12796776)^{1, 2, 3} Watanabe N.... Murphy K.M. (2003)
2. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. (PubMed id 15568026)^{1, 2} Sedy J.R.... Murphy K.M. (2005)
3. Attenuating lymphocyte activity: the crystal structure of the BTLA- HVEM complex. (PubMed id 16169851)^{1, 2} Compaan D.M....Hymowitz S.G. (2005)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2. (PubMed id 14652006)^{1, 2} Gavrieli M.... Murphy K.M. (2003)
7. BTLA expression contributes to septic morbidity and mo rtality by inducing innate inflammatory cell dysfunction. (PubMed id 22459947)¹ Shubin N.J....Ayala A. (2012)
8. CD8(+) T cells specific for tumor antigens can be rend ered dysfunctional by the tumor microenvironment through upregulation of the inh ibitory receptors BTLA and PD-1. (PubMed id 22205715)¹ Fourcade J....Zarour H.M. (2012)
9. The expression and anatomical distribution of BTLA and its ligand HVEM in rheumatoid synovium. (PubMed id 22179929)¹ Shang Y....Chen Y. (2012)
10. [Expression of the costimulatory molecule BTLA in syno vial tissues from rheumatoid arthritis patients]. (PubMed id 22691359)¹ Shang Y.J....Zhu W.Y. (2012)

External Searches for BTLA gene

Genome Databases showing BTLA gene

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Specialized Databases showing BTLA gene

Products
for BTLA gene