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Aliases for BTLA Gene

Aliases for BTLA Gene

  • B And T Lymphocyte Associated 2 3
  • B- And T-Lymphocyte-Associated Protein 3 4
  • B- And T-Lymphocyte Attenuator 3
  • B And T Lymphocyte Attenuator 3
  • CD272 Antigen 4
  • BTLA1 3
  • CD272 3

External Ids for BTLA Gene

Previous GeneCards Identifiers for BTLA Gene

  • GC03M113466
  • GC03M113505
  • GC03M113667
  • GC03M112182
  • GC03M109566

Summaries for BTLA Gene

Entrez Gene Summary for BTLA Gene

  • This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]

GeneCards Summary for BTLA Gene

BTLA (B And T Lymphocyte Associated) is a Protein Coding gene. Diseases associated with BTLA include subacute sclerosing panencephalitis and rheumatoid arthritis. Among its related pathways are Class I MHC mediated antigen processing and presentation and CD28 co-stimulation. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for BTLA Gene

  • Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.

Gene Wiki entry for BTLA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTLA Gene

Genomics for BTLA Gene

Regulatory Elements for BTLA Gene

Genomic Location for BTLA Gene

112,463,966 bp from pter
112,499,590 bp from pter
35,625 bases
Minus strand

Genomic View for BTLA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTLA Gene

Proteins for BTLA Gene

  • Protein details for BTLA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    B- and T-lymphocyte attenuator
    Protein Accession:
    Secondary Accessions:
    • Q3B831
    • Q3HS85
    • Q6ZNH9

    Protein attributes for BTLA Gene

    289 amino acids
    Molecular mass:
    32834 Da
    Quaternary structure:
    • Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM.
    • Sequence=BAD18396.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BTLA Gene

    Alternative splice isoforms for BTLA Gene


neXtProt entry for BTLA Gene

Proteomics data for BTLA Gene at MOPED

Post-translational modifications for BTLA Gene

  • N-glycosylated.
  • Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.
  • Glycosylation at Asn75, Asn94, and Asn110
  • Modification sites at PhosphoSitePlus

Other Protein References for BTLA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BTLA Gene

Domains for BTLA Gene

Gene Families for BTLA Gene

  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for BTLA Gene


Graphical View of Domain Structure for InterPro Entry



  • Q7Z6A9
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with BTLA: view

Function for BTLA Gene

Molecular function for BTLA Gene

UniProtKB/Swiss-Prot Function: Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.

Gene Ontology (GO) - Molecular Function for BTLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with BTLA: view

Phenotypes for BTLA Gene

genes like me logo Genes that share phenotypes with BTLA: view

Animal Models for BTLA Gene

MGI Knock Outs for BTLA:

Animal Model Products

CRISPR Products

miRNA for BTLA Gene

miRTarBase miRNAs that target BTLA

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BTLA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BTLA Gene

Localization for BTLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTLA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for BTLA Gene COMPARTMENTS Subcellular localization image for BTLA gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BTLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with BTLA: view

Pathways for BTLA Gene

genes like me logo Genes that share pathways with BTLA: view

Pathways by source for BTLA Gene

2 Reactome pathways for BTLA Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • T-Cell Anergy & Immune Tolerance in human,mouse,rat

Gene Ontology (GO) - Biological Process for BTLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002768 immune response-regulating cell surface receptor signaling pathway IEA --
GO:0007166 cell surface receptor signaling pathway --
GO:0030889 negative regulation of B cell proliferation IEA --
GO:0031295 T cell costimulation TAS --
GO:0042130 negative regulation of T cell proliferation --
genes like me logo Genes that share ontologies with BTLA: view

Transcripts for BTLA Gene

mRNA/cDNA for BTLA Gene

Unigene Clusters for BTLA Gene

B and T lymphocyte associated:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BTLA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTLA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP2: -

Relevant External Links for BTLA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTLA Gene

mRNA expression in normal human tissues for BTLA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for BTLA Gene

SOURCE GeneReport for Unigene cluster for BTLA Gene Hs.445162

genes like me logo Genes that share expressions with BTLA: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BTLA Gene

Orthologs for BTLA Gene

This gene was present in the common ancestor of chordates.

Orthologs for BTLA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTLA 35
  • 99.77 (n)
  • 99.65 (a)
  • 99 (a)
(Bos Taurus)
Mammalia BTLA 35
  • 75.41 (n)
  • 62.59 (a)
  • 62 (a)
(Canis familiaris)
Mammalia BTLA 35
  • 78.13 (n)
  • 66.67 (a)
  • 65 (a)
(Mus musculus)
Mammalia Btla 35
  • 70.74 (n)
  • 56.47 (a)
Btla 16
Btla 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia BTLA 36
  • 32 (a)
(Rattus norvegicus)
Mammalia Btla 35
  • 69.66 (n)
  • 56.47 (a)
(Anolis carolinensis)
Reptilia BTLA 36
  • 33 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732729 35
  • 51.25 (n)
  • 35.48 (a)
(Danio rerio)
Actinopterygii BTLA 36
  • 17 (a)
Species with no ortholog for BTLA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTLA Gene

Gene Tree for BTLA (if available)
Gene Tree for BTLA (if available)

Paralogs for BTLA Gene

No data available for Paralogs for BTLA Gene

Variants for BTLA Gene

Sequence variations from dbSNP and Humsavar for BTLA Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1386895 -- 112,482,528(-) AAGGT(A/G)TATTA intron-variant
rs1386896 -- 112,495,000(-) AGTCC(C/T)GTTAA intron-variant
rs1844089 -- 112,498,887(-) GAGTG(C/T)TGCAG intron-variant
rs1982809 -- 112,463,893(-) acaca(C/T)aaaag downstream-variant-500B
rs2171513 -- 112,466,080(-) GACCA(C/T)TGAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BTLA Gene

Variant ID Type Subtype PubMed ID
nsv3950 CNV Insertion 18451855
nsv877342 CNV Gain 21882294

Relevant External Links for BTLA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTLA Gene

Disorders for BTLA Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for BTLA Gene including...

Search for BTLA Gene in MalaCards »

Relevant External Links for BTLA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BTLA: view

No data available for UniProtKB/Swiss-Prot for BTLA Gene

Publications for BTLA Gene

  1. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. (PMID: 12796776) Watanabe N. … Murphy K.M. (Nat. Immunol. 2003) 2 3 4
  2. Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2. (PMID: 14652006) Gavrieli M. … Murphy K.M. (Biochem. Biophys. Res. Commun. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. (PMID: 15568026) Sedy J.R. … Murphy K.M. (Nat. Immunol. 2005) 3 4

Products for BTLA Gene

Sources for BTLA Gene

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