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BTLA Gene

protein-coding   GIFtS: 57
GCID: GC03M112182

B And T Lymphocyte Associated

  See BTLA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
B And T Lymphocyte Associated1 2     B And T Lymphocyte Attenuator2
B- And T-Lymphocyte-Associated Protein2 3     B- And T-Lymphocyte Attenuator2
BTLA12     CD272 Antigen3
CD2722     

External Ids:    HGNC: 210871   Entrez Gene: 1518882   Ensembl: ENSG000001862657   OMIM: 6079255   UniProtKB: Q7Z6A93   

Export aliases for BTLA gene to outside databases

Previous GC identifers: GC03M113466 GC03M113505 GC03M113667 GC03M109566


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BTLA Gene:
This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin
(Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative
splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an
increased risk of rheumatoid arthritis. (provided by RefSeq, Aug 2011)

GeneCards Summary for BTLA Gene:
BTLA (B and T lymphocyte associated) is a protein-coding gene. Diseases associated with BTLA include subacute sclerosing panencephalitis, and rheumatoid arthritis. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot: BTLA_HUMAN, Q7Z6A9
Function: Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response

Gene Wiki entry for BTLA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BTLA gene promoter:
         p53   RelA   Nkx2-5   RORalpha2   Evi-1   Meis-1b   POU2F1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBTLA promoter sequence
   Search Chromatin IP Primers for BTLA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BTLA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.2

BTLA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTLA gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M112182:  view genomic region     (about GC identifiers)

Start:
112,182,813 bp from pter      End:
112,218,408 bp from pter
Size:
35,596 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BTLA_HUMAN, Q7Z6A9 (See protein sequence)
Recommended Name: B- and T-lymphocyte attenuator precursor  
Size: 289 amino acids; 32834 Da
Subunit: Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM
Sequence caution: Sequence=BAD18396.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for BTLA:
2AW2 (3D)    
Secondary accessions: Q3B831 Q3HS85 Q6ZNH9
Alternative splicing: 2 isoforms:  Q7Z6A9-1   Q7Z6A9-2   

Explore the universe of human proteins at neXtProt for BTLA: NX_Q7Z6A9

Explore proteomics data for BTLA at MOPED

Post-translational modifications: 

  • Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with
    PTPN6 and PTPN111
  • N-glycosylated1
  • Glycosylation2 at Asn75, Asn94, Asn110
  • Modification sites at PhosphoSitePlus

  • See BTLA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001078826.1  NP_861445.3  

    ENSEMBL proteins: 
     ENSP00000333919   ENSP00000373178  
    Reactome Protein details: Q7Z6A9

    BTLA Human Recombinant Protein Products:

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    Novus Biologicals BTLA Proteins
    Novus Biologicals BTLA Lysates
    Sino Biological Recombinant Protein for BTLA
    Sino Biological Cell Lysate for BTLA
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BTLA

     
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    antibodies-online proteins for BTLA (11 products) 

     
    antibodies-online peptides for BTLA

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    antibodies-online antibodies for BTLA (85 products) 

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    antibodies-online kits for BTLA (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q7Z6A9

    ProtoNet protein and cluster: Q7Z6A9

    UniProtKB/Swiss-Prot: BTLA_HUMAN, Q7Z6A9
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with BTLA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BTLA_HUMAN, Q7Z6A9
    Function: Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with BTLA           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Btla):
     hematopoietic system  immune system 

    Find genes that share phenotypes with BTLA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BTLA: Btlatm1Dgra Btlatm1Kay Btlatm1Kmm

       genOway: Develop your customized and physiologically relevant rodent model for BTLA

    miRNA
    Products:
        
    miRTarBase miRNAs that target BTLA:
    hsa-mir-335-5p (MIRT017901)

    Block miRNA regulation of human, mouse, rat BTLA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BTLA (see all 25):
    hsa-miR-4291 hsa-miR-4251 hsa-miR-539 hsa-miR-15a hsa-miR-555 hsa-miR-138-2* hsa-miR-103a hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidBTLA 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat BTLA

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    Sino Biological Human cDNA Clone for BTLA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTLA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTLA

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTLA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BTLA_HUMAN, Q7Z6A9: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with BTLA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BTLA About    
    See pathways by source

    SuperPathContained pathways About
    1CD28 co-stimulation
    Costimulation by the CD28 family0.44
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41


    Find genes that share SuperPaths with BTLA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for BTLA
        Costimulation by the CD28 family


        Pathway & Disease-focused RT2 Profiler PCR Arrays including BTLA: 
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BTLA

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for BTLA (Q7Z6A92, 3 ENSP000003339194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061242, 3, ENSP000003409444MINT-8034569 MINT-8031411 I2D: score=7 STRING: ENSP00000340944
    PTPN6P293502, 3, ENSP000003915924MINT-8034558 MINT-8031400 I2D: score=2 STRING: ENSP00000391592
    TNFRSF14Q929563, ENSP000003479484I2D: score=2 STRING: ENSP00000347948
    SIRPAP783243, ENSP000003483074I2D: score=1 STRING: ENSP00000348307
    VTCN1Q7Z7D33, ENSP000003584704I2D: score=1 STRING: ENSP00000358470
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002768immune response-regulating cell surface receptor signaling pathway IEA--
    GO:0007166cell surface receptor signaling pathway ----
    GO:0030889negative regulation of B cell proliferation IEA--
    GO:0031295T cell costimulation TAS--
    GO:0042130negative regulation of T cell proliferation ----

    Find genes that share ontologies with BTLA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BTLA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BTLA gene (2 alternative transcripts): 
    NM_001085357.1  NM_181780.3  

    Unigene Cluster for BTLA:

    B and T lymphocyte associated
    Hs.445162  [show with all ESTs]
    Unigene Representative Sequence: NM_181780
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334529(uc003dza.4 uc003dzb.4) ENST00000474965 ENST00000383680
    ENST00000496584
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BTLA (see all 25):
    hsa-miR-4291 hsa-miR-4251 hsa-miR-539 hsa-miR-15a hsa-miR-555 hsa-miR-138-2* hsa-miR-103a hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidBTLA 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat BTLA
      QuantiFast Probe-based Assays in human, mouse, rat BTLA

    Additional mRNA sequence: 

    AJ717664.1 AK131204.1 AK292692.1 AY293286.1 AY599411.1 AY606805.1 BC107091.1 BC107092.1 
    DQ198368.1 

    3 DOTS entries:

    DT.99977691  DT.120847864  DT.40126643 

    16 AceView cDNA sequences:

    AI792952 AW241471 BX111230 AK131204 AW241411 AA931122 AW294080 AI651719 
    AW188302 CF143307 AA828425 CD702861 BF940033 NM_181780 AY293286 CB963019 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for BTLA    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for BTLA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BTLA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BTLA Expression
    About this image


    BTLA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
    BTLA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BTLA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445162
        Pathway & Disease-focused RT2 Profiler PCR Arrays including BTLA: 
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BTLA gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Btla1 , 5 B and T lymphocyte associated1, 5 70.74(n)1
    56.47(a)1
      16 (29.52 cM)5
    2081541  NM_001037719.21  NP_001032808.21 
     452243155 
    lizard
    (Anolis carolinensis)
    Reptilia BTLA6
    B and T lymphocyte associated
    33(a)
    1 ↔ 1
    3(167508259-167519462)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017327291 uncharacterized LOC101732729 51.25(n)
    35.48(a)
      101732729  XM_004912256.1  XP_004912313.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BTLA6
    B and T lymphocyte associated
    17(a)
    1 ↔ 1
    9(9517634-9522601) ENSDARG00000092106


    ENSEMBL Gene Tree for BTLA (if available)
    TreeFam Gene Tree for BTLA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BTLA (see all 709)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs800215081,2
    F--112182462(+) AAGTTT/CATATA 2 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1497487931,2
    C--112182490(+) GATCGC/TGCCAG 2 -- ds50010--------
    rs1454387961,2
    --112182491(+) ATCGCA/GCCAGA 2 -- ds50010--------
    rs1834760611,2
    --112182543(+) AACTGA/GTCAAA 2 -- ds50010--------
    rs1402353131,2
    --112182629(+) TGGCAG/TGTCTT 2 -- ds50010--------
    rs19828091,2
    C,F,A,H--112182740(-) acacaT/Caaaag 2 -- ds500117Minor allele frequency- C:0.46NS EA NA WA 2342
    rs117176571,2
    C,F,H--112182855(+) TTGAGC/TACAAT 2 -- ut316Minor allele frequency- T:0.02NS EA NA 528
    rs26335701,2
    C,A,H--112182929(-) CATTAA/GTTTAT 2 -- ut3111Minor allele frequency- G:0.02NA WA CSA EA 374
    rs558091961,2
    C,F--112182995(+) TCTCTG/AACACC 2 -- ut316Minor allele frequency- A:0.09WA NA CSA 246
    rs1149229951,2
    C,F--112183077(+) AGAGAT/AGAAAT 2 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for BTLA (112182813 - 112218408 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BTLA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3950CNV Insertion18451855
    nsv877342CNV Gain21882294

    Human Gene Mutation Database (HGMD): BTLA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BTLA
    DNA2.0 Custom Variant and Variant Library Synthesis for BTLA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607925    OMIM disorders: --

    3 diseases for BTLA:    
    About MalaCards
    subacute sclerosing panencephalitis    rheumatoid arthritis    type 1 diabetes mellitus


    Find genes that share disorders with BTLA           About GenesLikeMe

    Genetic Association Database (GAD): BTLA
    Human Genome Epidemiology (HuGE) Navigator: BTLA (8 documents)

    Export disorders for BTLA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BTLA gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with BTLA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. (PubMed id 12796776)1, 2, 3 Watanabe N.... Murphy K.M. (Nat. Immunol. 2003)
    2. Association of BTLA gene polymorphisms with the risk of malignant breast cancer in Chinese women of Heilongjiang Province. (PubMed id 19585237)1, 4 Fu Z....Li D. (Breast Cancer Res. Treat. 2010)
    3. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    4. PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis. (PubMed id 20066438)1, 4 Ishizaki Y....Hara T. (Hum. Genet. 2010)
    5. Association study between B- and T-lymphocyte attenuator gene and type 1 diabetes mellitus or systemic lupus erythematosus in the Japanese population. (PubMed id 19207938)1, 4 Inuo M....Hara T. (Int. J. Immunogenet. 2009)
    6. Association of a BTLA gene polymorphism with the risk of rheumatoid arthritis. (PubMed id 17024343)1, 4 Lin S.C....Chan C.H. (J. Biomed. Sci. 2006)
    7. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. (PubMed id 15568026)1, 2 Sedy J.R.... Murphy K.M. (Nat. Immunol. 2005)
    8. Attenuating lymphocyte activity: the crystal structure of the BTLA- HVEM complex. (PubMed id 16169851)1, 2 Compaan D.M....Hymowitz S.G. (J. Biol. Chem. 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 151888 HGNC: 21087 AceView: BTLA Ensembl:ENSG00000186265 euGenes: HUgn151888
    ECgene: BTLA H-InvDB: BTLA

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BTLA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
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    Patent Information for BTLA gene:
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    GeneCards and IP:
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