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BTK Gene

protein-coding   GIFtS: 79
GCID: GC0XM100604

Bruton Agammaglobulinemia Tyrosine Kinase


(Previous symbols: AGMX1, IMD1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Bruton Agammaglobulinemia Tyrosine Kinase1 2     PSCTK12
AGMX11 2 3 5     Agammaglobulinaemia Tyrosine Kinase2
IMD11 2 5     Dominant-Negative Kinase-Deficient Brutons Tyrosine Kinase2
ATK2 3     Truncated Bruton Agammaglobulinemia Tyrosine Kinase2
BPK2 3     Tyrosine-Protein Kinase BTK2
B-Cell Progenitor Kinase2 3     Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 14)2
EC 2.7.10.23 8     Agammaglobulinemia Tyrosine Kinase3
AT2 5     Bruton Tyrosine Kinase3
XLA2 5     EC 2.7.108

External Ids:    HGNC: 11331   Entrez Gene: 6952   Ensembl: ENSG000000106717   OMIM: 3003005   UniProtKB: Q061873   
ORGUL members:         

Export aliases for BTK gene to outside databases

Previous GC identifers: GC0XM095896 GC0XM097575 GC0XM098640 GC0XM099376 GC0XM100410 GC0XM100491 GC0XM090410


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BTK Gene:
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked
agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B
lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in
multiple transcript variants encoding different isoforms. (provided by RefSeq, Dec 2013)

GeneCards Summary for BTK Gene:
BTK (Bruton agammaglobulinemia tyrosine kinase) is a protein-coding gene. Diseases associated with BTK include agammaglobulinemia, and agammaglobulinemia and isolated hormone deficiency. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity and identical protein binding. An important paralog of this gene is TEC.

UniProtKB/Swiss-Prot: BTK_HUMAN, Q06187
Function: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling.
Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell
activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites,
igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein
kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein
B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is
implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of
innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway
acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host
defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR
pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical
role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the
expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B.
Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then
translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are
other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding
complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the
regulation of apoptosis

summary for BTK Gene:
Bruton's Tyrosine Kinase (BTK) is member of the Tec family that is critically important for the growth,
differentiation and activation of myeloid-, mast- and B-cells. BTK is activated firstly by membrane
localization stimulated by PIP3 generation, and subsequently, by transphosphorylation of Tyr-551 by Src
family kinases. Activated BTK is involved in the phosphorylation of a number of signaling molecules involved
in the PLCgamma, JNK and p38 MAPK pathways, leading to Ca2+ mobilization, mRNA stabilization and the
induction of NF-kappaB and AP-1 transcription factors. BTK activity is negatively regulated by a number of
proteins including inhibitor of BTK (IBTK), Sab and c-Cbl. Mutations in this enzyme are known in humans and
result in the immunological disorder X-linked agammaglobulemia.

Gene Wiki entry for BTK (Bruton's tyrosine kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the BTK gene promoter:
         HOXA9B   HOXA9   C/EBPbeta   Meis-1b   AREB6   CREB   deltaCREB   STAT3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BTK promoter sequence
   Search Chromatin IP Primers for BTK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BTK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.33-q22   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq21.33-q22

BTK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTK gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM100604:  view genomic region     (about GC identifiers)

Start:
100,604,435 bp from pter      End:
100,641,212 bp from pter
Size:
36,778 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BTK_HUMAN, Q06187 (See protein sequence)
Recommended Name: Tyrosine-protein kinase BTK  
Size: 659 amino acids; 76281 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Binds GTF2I through the PH domain. Interacts with SH3BP5 via the SH3 domain. Interacts with IBTK via its
PH domain. Interacts with ARID3A, CAV1, FASLG, PIN1, TLR8 and TLR9
Selected PDB 3D structures from and Proteopedia for BTK (see all 20):
1AWW (3D)        1AWX (3D)        1B55 (3D)        1BTK (3D)        1BWN (3D)        1K2P (3D)    
Secondary accessions: B2RAW1 Q32ML5
Alternative promoter usage: 2 isoforms:  Q06187-1   Q06187-2   (Produced by alternative promoter usage. Predominant form in many tumor cells where it may function as an anti-apoptotic cell survival factor)

Explore the universe of human proteins at neXtProt for BTK: NX_Q06187

Explore proteomics data for BTK at MOPED

Post-translational modifications: 

  • Following B-cell receptor (BCR) engagement, translocates to the plasma membrane where it gets phosphorylated at
    Tyr-551 by LYN and SYK. Phosphorylation at Tyr-551 is followed by autophosphorylation of Tyr-223 which may create
    a docking site for a SH2 containing protein. Phosphorylation at Ser-180 by PRKCB, leads in translocation of BTK
    back to the cytoplasmic fraction. Phosphorylation at Ser-21 and Ser-115 creates a binding site for PIN1 at these
    Ser-Pro motifs, and promotes it's recruitment1
  • Ubiquitination2 at Lys322, Lys406
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for BTK (Q06187) (see all 10)
     EAMEYLE  YYLAEKH  RDLAARN  LSYYEYD 


    See BTK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000052.1  NP_001274273.1  NP_001274274.1  

    ENSEMBL proteins: 
     ENSP00000308176   ENSP00000361971  
    Reactome Protein details: Q06187

    BTK Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for BTK
    Novus Biologicals BTK Proteins
    Novus Biologicals BTK Lysate
    Sino Biological Recombinant Protein for BTK
    Sino Biological Cell Lysate for BTK
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    BTK Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BTK
    R&D Systems Antibodies for BTK
    Cell Signaling Technology (CST) Antibodies for BTK 
    OriGene Antibodies for BTK
    OriGene Custom Antibody Services for BTK
    Novus Biologicals BTK Antibodies
    Abcam antibodies for BTK
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for BTK
    LSBio Antibodies in human, mouse, rat for BTK

    BTK Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BTK
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BTK
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: Bruton agammaglobulinemia tyrosine kinase
    Tec family

    Selected InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q06187

    ProtoNet protein and cluster: Q06187

    5 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001562 Tec/Btk domain signature
    IPB001849 Pleckstrin-like
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: BTK_HUMAN, Q06187
    Domain: The PH domain mediates the binding to inositol polyphosphate and phosphoinositides, leading to its
    targeting to the plasma membrane. It is extended in the BTK kinase family by a region designated the TH (Tec
    homology) domain, which consists of about 80 residues preceding the SH3 domain
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily
    Similarity: Contains 1 Btk-type zinc finger
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    BTK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BTK_HUMAN, Q06187
    Function: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling.
    Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell
    activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites,
    igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein
    kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein
    B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is
    implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of
    innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway
    acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host
    defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR
    pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical
    role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the
    expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B.
    Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then
    translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are
    other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding
    complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the
    regulation of apoptosis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated by phosphorylation. In primary B lymphocytes, is almost always non-phosphorylated and
    is thus catalytically inactive. Stimulation of TLR8 and TLR9 causes BTK activation. As a negative feedback
    mechanism to fine-tune BCR signaling, activated PRKCB down-modulates BTK function via direct phosphorylation of
    BTK at Ser-180, resulting in translocation of BTK back to the cytoplasmic fraction. PIN1, SH3BP5, and IBTK were
    also identified as BTK activity inhibitors. Interaction with CAV1 leads to dramatic down-regulation of the kinase
    activity of BTK. LFM-13A is a specific inhibitor of BTK. Dasatinib, a cancer drug acting as a tyrosine kinase
    inhibitor, also blocks BTK activity

         Genatlas biochemistry entry for BTK:
    B cell progenitor tyrosine kinase

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS11913944
    GO:0004715non-membrane spanning protein tyrosine kinase activity TAS19290921
    GO:0005515protein binding IPI11788586
    GO:0005524ATP binding TAS11913944
         
    BTK for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for BTK:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  Increased gamma-H2AX phosphory 
     Increased mitotic index  Upregulation of Wnt/beta-caten 

         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Btk):
     cellular  digestive/alimentary  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  tumorigenesis 

    BTK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Btktm1Wk for BTK

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BTK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BTK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BTK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BTK

    miRNA
    Products:
        
    miRTarBase miRNAs that target BTK:
    hsa-mir-346 (MIRT001128)

    Block miRNA regulation of human, mouse, rat BTK using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate BTK:
    hsa-miR-374a* hsa-miR-590-5p hsa-miR-2116* hsa-miR-622 hsa-miR-513a-3p hsa-miR-205* hsa-miR-590-3p hsa-miR-21
    SwitchGear 3'UTR luciferase reporter plasmidBTK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BTK
    Predesigned siRNA for gene silencing in human, mouse, rat BTK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BTK

    Clone
    Products:
         
    OriGene clones in human, mouse for BTK (see all 7)
    OriGene ORF clones in mouse, rat for BTK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BTK (NM_000061)
    Sino Biological Human cDNA Clone for BTK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTK

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BTK
    Browse ESI BIO Cell Lines and PureStem Progenitors for BTK 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BTK_HUMAN, Q06187: Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=In steady state, BTK is
    predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma
    membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A
    fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the
    nuclear export receptor CRM1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    plasma membrane5
    mitochondrion2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS19290921
    GO:0005737cytoplasm TAS15046600
    GO:0005829cytosol TAS19290921
    GO:0005886plasma membrane TAS19290921
    GO:0031410cytoplasmic vesicle IEA--

    BTK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BTK About   (see all 44)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Fc epsilon RI signaling pathway0.41
    Immune response BCR pathway0.43
    Fc-epsilon receptor I signaling in mast cells0.34
    2B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    BCR signaling pathway0.42
    3PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for BTK
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BTK (see all 38)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    G12-G13 in Cellular Signaling

    2 Cell Signaling Technology (CST) Pathways for BTK
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    Selected GeneGo (Thomson Reuters) Pathways for BTK (see all 8)
        Development EPO-induced MAPK pathway
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Immune response BCR pathway
    G-protein signaling G-Protein alpha-12 signaling pathway
    Immune response NFAT in immune response

    Selected BioSystems Pathways for BTK (see all 9)
        IL-5 Signaling Pathway
    Kit Receptor Signaling Pathway
    IL-6 Signaling Pathway
    B Cell Receptor Signaling Pathway
    Class I PI3K signaling events

    1 Sino Biological Pathway for BTK
        NF-kB (NFkB) Pathway

    5 Reactome Pathways for BTK
        DAP12 signaling
    Regulation of actin dynamics for phagocytic cup formation
    Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
    MyD88:Mal cascade initiated on plasma membrane
    FCERI mediated Ca+2 mobilization


    5 Kegg Pathways  (Kegg details for BTK):
        NF-kappa B signaling pathway
    Osteoclast differentiation
    B cell receptor signaling pathway
    Fc epsilon RI signaling pathway
    Primary immunodeficiency


    BTK for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BTK: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BTK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BTK (Q061871, 2, 3 ENSP000003081764) via UniProtKB, MINT, STRING, and/or I2D (see all 188)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BLNKQ8WV281, 2, 3, ENSP000002243374EBI-624835,EBI-2623522 MINT-59470 MINT-59465 MINT-3374560 MINT-3374585 I2D: score=5 STRING: ENSP00000224337
    ARID3AQ998561, 2, 3, ENSP000002636204EBI-624835,EBI-5458244 MINT-7230949 MINT-7230913 MINT-7230932 MINT-7230971 I2D: score=4 STRING: ENSP00000263620
    GTF2IP783471, 2, 3, ENSP000003225424EBI-624835,EBI-359622 MINT-7230971 I2D: score=3 STRING: ENSP00000322542
    IBTKQ9P2D02, 3, ENSP000003057214MINT-49849 MINT-49797 MINT-49799 MINT-49793 I2D: score=5 STRING: ENSP00000305721
    DAAM1Q9Y4D12, 3, ENSP000002471704MINT-7146361 I2D: score=1 STRING: ENSP00000247170
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302response to reactive oxygen species IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002250adaptive immune response TAS19290921
    GO:0002553histamine secretion by mast cell IEA--
    GO:0002721regulation of B cell cytokine production TAS19290921

    BTK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for BTK
    4 ApexBio Compounds for BTK     About this table
    CompoundAction CAS #
    AVL-292covalent, highly selective, orally active small molecule inhibitor of Btk[1202757-89-8]
    CGI-1746small-molecule Bruton's tyrosine kinase (Btk) inhibitor[910232-84-7]
    PCI-32765 (Ibrutinib)inhibitor of Bruton's tyrosine kinase (BTK) [936563-96-1]
    QL47inhibits BTK kinase activity[1469988-75-7]

    Compounds for BTK available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (-)-Terreic acidSelective inhibitor of BTK[121-40-4]
    LFM-A13 Potent, selective BTK inhibitor [62004-35-7]

    2 HMDB Compounds for BTK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for BTK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Inositol 1,3,4,5-Tetrakisphosphate-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for BTK gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 89 1216 11413148 (5), 12437073 (5), 7565679 (5), 10051622 (4) (see all 99)
    phosphatidylinositol-3,4,5-trisphosphate 75.7 10 11279148 (2), 10201980 (2), 11698416 (1), 12734372 (1) (see all 5)
    phosphoinositide 62 19 9928954 (3), 16619289 (3), 11756681 (2), 11329620 (1) (see all 12)
    piceatannol 57.9 1 15180535 (1)
    phosphatidylinositol 57 21 12215216 (2), 10201980 (2), 14610042 (1), 18657320 (1) (see all 14)
    leflunomide 48.4 9 12188892 (1), 17469650 (1), 10092645 (1), 9880544 (1) (see all 6)
    inositol 1,4,5 trisphosphate 43.8 6 9830001 (1), 10327049 (1), 16547971 (1), 17237388 (1) (see all 5)
    phosphotyrosine 42.1 5 10754312 (2), 10051622 (1), 9391111 (1), 7657668 (1)
    inositol 1,3,4,5-tetrakisphosphate 41.8 3 8939985 (2), 10196129 (1)
    wortmannin 34.8 11 10840066 (2), 11329620 (1), 16619289 (1), 10590061 (1) (see all 6)



    BTK for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for BTK gene (3 alternative transcripts): 
    NM_000061.2  NM_001287344.1  NM_001287345.1  

    Unigene Cluster for BTK:

    Bruton agammaglobulinemia tyrosine kinase
    Hs.159494  [show with all ESTs]
    Unigene Representative Sequence: NM_000061
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308731(uc004ehf.2 uc010nnh.2 uc010nni.2 uc004ehe.2 uc010nnj.2 uc010nnk.2 uc010nnl.2 uc010nnm.2 uc004ehh.1 uc004ehg.2 uc004ehi.3 uc010nno.2)
    ENST00000470069 ENST00000488970 ENST00000478995 ENST00000470329 ENST00000464006
    ENST00000464567 ENST00000372880(uc010nnn.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat BTK using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate BTK:
    hsa-miR-374a* hsa-miR-590-5p hsa-miR-2116* hsa-miR-622 hsa-miR-513a-3p hsa-miR-205* hsa-miR-590-3p hsa-miR-21
    SwitchGear 3'UTR luciferase reporter plasmidBTK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BTK
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      QuantiFast Probe-based Assays in human, mouse, rat BTK

    Additional mRNA sequence: 

    AF153364.1 AF153755.1 AF153756.1 AF153757.1 AF153758.1 AF153759.1 AF153760.1 AF153761.1 
    AF153762.1 AF153763.1 AF153764.1 AJ888376.1 AJ888377.1 AJ888378.1 AJ888379.1 AJ888380.1 
    AJ888381.1 AK057105.1 AK225577.1 AK309851.1 AK314382.1 AM051275.1 AM051276.1 AM051277.1 
    AM051278.1 AM051279.1 AM051280.1 AM051281.1 AM051282.1 AM051283.1 AM051284.1 AM051285.1 
    AM051286.1 BC109079.1 BC109080.1 X58957.1 

    9 DOTS entries:

    DT.444365  DT.95165288  DT.121325060  DT.432796  DT.86849846  DT.91687758  DT.121325046  DT.112417 
    DT.446289 

    Selected AceView cDNA sequences (see all 98):

    BM478046 BP345102 BI489714 BF795127 BI766828 AI361486 BQ059300 CA435879 
    BM458740 AA346572 BU619204 BQ642017 CD365313 BG106420 AW402365 BQ439666 
    BM925197 AA767797 BE561034 AF153757 BX325261 BE267612 BG611983 BM997994 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BTK (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^
    SP1:                    -     -                             -                 -                                                                                 
    SP2:                          -                             -                 -                                                                 -     -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                    -     -                             -                 -                                                                                 

    ExUns: 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21a · 21b · 21c · 21d · 21e
    SP1:              -                                                         
    SP2:  -           -                                                         
    SP3:              -                       -                                 
    SP4:        -     -                                                         
    SP5:                                                                        


    ECgene alternative splicing isoforms for BTK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BTK expression in normal human tissues (normalized intensities)      BTK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGAAGAAT
    BTK Expression
    About this image


    BTK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Lymph (Hematopoietic System)
     
     Spleen (Hematopoietic System)
    BTK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BTK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159494

    UniProtKB/Swiss-Prot: BTK_HUMAN, Q06187
    Tissue specificity: Predominantly expressed in B-lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BTK: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BTK gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Btk1 , 5 Bruton agammaglobulinemia tyrosine kinase1, 5 91.5(n)1
    98.33(a)1
      X (56.18 cM)5
    122291  NM_013482.21  NP_038510.21 
     1345423365 
    chicken
    (Gallus gallus)
    Aves BTK1 Bruton agammaglobulinemia tyrosine kinase 79.13(n)
    86.11(a)
      374075  NM_204233.2  NP_989564.2 
    lizard
    (Anolis carolinensis)
    Reptilia BTK6
    Bruton agammaglobulinemia tyrosine kinase
    78(a)
    1 ↔ 1
    GL343451.1(234133-246433)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia btk1 Bruton agammaglobulinemia tyrosine kinase 69.76(n)
    73.68(a)
      100170477  NM_001130260.1  NP_001123732.1 
    zebrafish
    (Danio rerio)
    Actinopterygii btk1 Bruton agammaglobulinemia tyrosine kinase 65.51(n)
    65.35(a)
      568653  XM_691995.5  XP_697087.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Btk29A3 male genital morphogenesis (sensu
    Holometabola) more
    52(a)   29A1   --


    ENSEMBL Gene Tree for BTK (if available)
    TreeFam Gene Tree for BTK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BTK gene
    TEC2  CSK2  FER2  ITK2  TXK2  FES2  DSTYK2  MATK2  
    BMX2  
    Selected SIMAP similar genes for BTK using alignment to 9 protein entries:     BTK_HUMAN (see all proteins) (see all similar genes):
    BTK kinase deficient isoform 7    BTK kinase deficient isoform 9    BTK kinase deficient isoform 5    BTK kinase deficient isoform 4    BTK kinase deficient isoform 3    BTK kinase deficient isoform 1
    BTK kinase deficient isoform 8    BTK kinase deficient isoform 2    BTK kinase deficient isoform 6    tec    DKFZp686M05208    TXK
    ABL1    NTRK1    NCK2    c-fgr    A20    ALK

    BTK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BTK (see all 806)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289354781,2,,4
    CX-linked agammaglobulinemia (XLA)4 pathogenic1100580316(-) TAACTA/GCCATC 2 Y C mis1 ese30--------
    VAR_0062514
    X-linked agammaglobulinemia (XLA)4--see VAR_0062512 R Q mis40--------
    VAR_0062444
    X-linked agammaglobulinemia (XLA)4--see VAR_0062442 M R mis40--------
    VAR_0062354
    X-linked agammaglobulinemia (XLA)4--see VAR_0062352 H Q mis40--------
    VAR_0083004
    X-linked agammaglobulinemia (XLA)4--see VAR_0083002 Q H mis40--------
    VAR_0083354
    X-linked agammaglobulinemia (XLA)4--see VAR_0083352 F L mis40--------
    VAR_0062814
    X-linked agammaglobulinemia (XLA)4--see VAR_0062812 L P mis40--------
    VAR_0062624
    X-linked agammaglobulinemia (XLA)4--see VAR_0062622 W R mis40--------
    VAR_0089624
    X-linked agammaglobulinemia (XLA)4--see VAR_0089622 L Q mis40--------
    VAR_0083334
    X-linked agammaglobulinemia (XLA)4--see VAR_0083332 V G mis40--------

    HapMap Linkage Disequilibrium report for BTK (100604435 - 100641212 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BTK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524411CNV Loss19592680

    Human Gene Mutation Database (HGMD): BTK
    Locus Specific Mutation Databases (LSDB): BTK

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BTK
    DNA2.0 Custom Variant and Variant Library Synthesis for BTK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 300300   
    OMIM disorders: 300755  307200  
    UniProtKB/Swiss-Prot: BTK_HUMAN, Q06187
  • X-linked agammaglobulinemia (XLA) [MIM:300755]: Humoral immunodeficiency disease which results in
    developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in
    their bone marrow but virtually no circulating mature B-lymphocytes. This results in a lack of immunoglobulins of
    all classes and leads to recurrent bacterial infections like otitis, conjunctivitis, dermatitis, sinusitis in the
    first few years of life, or even some patients present overwhelming sepsis or meningitis, resulting in death in a
    few hours. Treatment in most cases is by infusion of intravenous immunoglobulin. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • X-linked hypogammaglobulinemia and isolated growth hormone deficiency (XLA-IGHD) [MIM:307200]: In rare
    cases XLA is inherited together with isolated growth hormone deficiency (IGHD). Note=The disease may be caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for BTK (see all 49):    About MalaCards
    agammaglobulinemia    agammaglobulinemia and isolated hormone deficiency    isolated growth hormone deficiency type 3    bruton-type agammaglobulinemia
    agammaglobulinemia, x-linked 1    paralytic poliomyelitis    poliomyelitis    congenital hypogammaglobulinemia
    b cell deficiency    gamma chain deficiency    isolated growth hormone deficiency    wiskott-aldrich syndrome
    growth hormone deficiency    fabry disease    splenic marginal zone lymphoma    t cell deficiency
    pyoderma    common variable immunodeficiency    plasmacytoma    neutropenia

    2 diseases from the University of Copenhagen DISEASES database for BTK:
    Agammaglobulinemia     Tropical spastic paraparesis

    BTK for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for BTK gene (see all 37)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    x-linked agammaglobulinemia 98.8 328 9445504 (2), 17301411 (2), 8162056 (2), 18726917 (2) (see all 99)
    agammaglobulinemia 94.2 70 11577078 (3), 8090769 (2), 11698416 (2), 8934542 (2) (see all 33)
    hypogammaglobulinemia 78.6 14 11668622 (1), 16862044 (1), 16053733 (1), 19067895 (1) (see all 9)
    hypogammaglobulinemia x-linked 75.1 3 16264330 (1), 8364206 (1)
    immunodeficiency 74.7 167 7946052 (3), 10844531 (2), 8939985 (2), 10068673 (2) (see all 96)
    common variable immunodeficiency 70.7 6 10844531 (1), 11472409 (1), 17024564 (1), 18051214 (1) (see all 5)
    mohr-tranebjaerg syndrome 69.3 1 17851739 (1)
    wiskott-aldrich syndrome 56.2 6 11557038 (1), 16460447 (1), 10068673 (1), 9191173 (1)
    leukemia mast cell 55.7 1 8283037 (1)
    hyper-igm syndrome 54.5 2 11987983 (1)

    GeneTests: BTK
    GeneReviews: BTK
    Genetic Association Database (GAD): BTK
    Human Genome Epidemiology (HuGE) Navigator: BTK (8 documents)

    Export disorders for BTK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BTK gene, integrated from 10 sources (see all 567):
    (articles sorted by number of sources associating them with BTK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. (PubMed id 8380905)1, 2, 3 Vetrie D.... Bentley D.R. (Nature 1993)
    2. Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia. (PubMed id 9218782)1, 2, 9 Hyvoenen M. and Saraste M. (EMBO J. 1997)
    3. Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan. (PubMed id 8695804)1, 2, 9 Hashimoto S....Kishimoto T. (Blood 1996)
    4. Mutations in btk in patients with presumed X-linked agammaglobulinemia. (PubMed id 9545398)1, 2, 9 Conley M.E.... Rohrer J. (Am. J. Hum. Genet. 1998)
    5. BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement. (PubMed id 9012831)1, 2, 9 Yang W. and Desiderio S. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    6. Genotype-phenotype correlation in Bruton's tyrosine kinase deficiency. (PubMed id 18776760)1, 4, 9 Teimourian S....Aghamohammadi A. (J. Pediatr. Hematol. Oncol. 2008)
    7. Molecular and structural characterization of five novel mutations in the Bruton's tyrosine kinase gene from patients with X-linked agammaglobulinemia. (PubMed id 9260159)1, 2, 9 Saha B.K.... Vihinen M. (Mol. Med. 1997)
    8. Regulation of Btk function by a major autophosphorylation site within the SH3 domain. (PubMed id 8630736)1, 2, 9 Park H.... Witte O.N. (Immunity 1996)
    9. Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci. (PubMed id 7626884)1, 2, 9 Oeltjen J.C....Gibbs R.A. (Mamm. Genome 1995)
    10. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. (PubMed id 17932028)1, 2, 9 Doyle S.L.... O'Neill L.A. (J. Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 695 HGNC: 1133 AceView: BTK Ensembl:ENSG00000010671 euGenes: HUgn695
    ECgene: BTK Kegg: 695 H-InvDB: BTK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BTK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BTK Genetics and Cytogenetics in Oncology and Haematology
    BTKbasehttp://bioinf.uta.fi/BTKbase/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=BTK[genesymbol]

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BTK gene:
    Search GeneIP for patents involving BTK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     OriGene Custom Antibody Services for BTK   OriGene Custom Protein Services for BTK  

     
     
     Block miRNA regulation of human, mouse, rat BTK using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BTK
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     QuantiFast Probe-based Assays in human, mouse, rat BTK QuantiTect SYBR Green Assays in human, mouse, rat BTK
     PCR Arrays including human, mouse, rat BTK Search Chromatin IP Primers for BTK
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BTK  GeneGlobe Interaction Network for BTK
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     Antibodies & Assays for BTK 

     Tocris compounds for BTK
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     Search Sino Biological for antibodies, proteins & pathways
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for BTK
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     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
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     Browse ESI BIO Cell Lines and PureStem Progenitors for BTK
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTK
     SwitchGear 3'UTR luciferase reporter plasmids for BTK
     SwitchGear Promoter luciferase reporter plasmids for BTK
     ThermoFisher Antibody for BTK
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTK
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BTK
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BTK
     LSBio Antibodies in human, mouse, rat for BTK
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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