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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BTG4 Gene

protein-coding   GIFtS: 54
GCID: GC11M111372

B-Cell Translocation Gene 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
B-Cell Translocation Gene 41 2
PC3B2 3 5
Protein PC3b2 3
BTG Family Member 42 3
Protein BTG42

External Ids:    HGNC: 138621   Entrez Gene: 547662   Ensembl: ENSG000001377077   OMIM: 6056735   UniProtKB: Q9NY303   

Export aliases for BTG4 gene to outside databases

Previous GC identifers: GC11M113691 GC11M112850 GC11M110875 GC11M110843 GC11M107262


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BTG4 Gene:
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins
that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle.
(provided by RefSeq, Jul 2008)

GeneCards Summary for BTG4 Gene: 
BTG4 (B-cell translocation gene 4) is a protein-coding gene. Diseases associated with BTG4 include chronic lymphocytic leukemia, and gastric cancer, and among its related super-pathways are Deadenylation-dependent mRNA decay. An important paralog of this gene is TOB1.

UniProtKB/Swiss-Prot: BTG4_HUMAN, Q9NY30
Function: Shows marked antiproliferative activity, being able to induce G(1) arrest

Gene Wiki entry for BTG4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BTG4 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   C/EBPalpha   POU2F1   Nkx6-1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBTG4 promoter sequence
   Search SABiosciences Chromatin IP Primers for BTG4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23

BTG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTG4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M111372:  view genomic region     (about GC identifiers)

Start:
111,338,251 bp from pter      End:
111,383,079 bp from pter
Size:
44,829 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BTG4_HUMAN, Q9NY30 (See protein sequence)
Recommended Name: Protein BTG4  
Size: 223 amino acids; 25970 Da

Explore the universe of human proteins at neXtProt for BTG4: NX_Q9NY30

Explore proteomics data for BTG4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NY30

  • BTG4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BTG4 Protein Expression
    REFSEQ proteins: NP_060059.1  
    ENSEMBL proteins: 
     ENSP00000348300   ENSP00000432018   ENSP00000392358  

    Human Recombinant Protein Products for BTG4: 
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    Novus Biologicals BTG4 Lysate
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    Cloud-Clone Corp. Proteins for BTG4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    BTG4 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for BTG4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002087 Anti_prolifrtn

    Graphical View of Domain Structure for InterPro Entry Q9NY30

    ProtoNet protein and cluster: Q9NY30

    1 Blocks protein domain: IPB002087 Anti-proliferative protein

    UniProtKB/Swiss-Prot: BTG4_HUMAN, Q9NY30
    Similarity: Belongs to the BTG family


    BTG4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BTG4_HUMAN, Q9NY30
    Function: Shows marked antiproliferative activity, being able to induce G(1) arrest

    Animal Models:

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    SwitchGear 3'UTR luciferase reporter plasmidBTG4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BTG4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for BTG4):
        RNA degradation


    BTG4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BTG4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for BTG4 (Q9NY303 ENSP000003483004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF19BQ6ZMZ03, ENSP000003625554I2D: score=1 STRING: ENSP00000362555
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007050cell cycle arrest TAS10995567
    GO:0008285negative regulation of cell proliferation TAS10995567
    GO:0030182neuron differentiation TAS10995567
    GO:0045930negative regulation of mitotic cell cycle IEA--

    BTG4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BTG4

    Search CenterWatch for drugs/clinical trials and news about BTG4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BTG4 gene: 
    NM_017589.3  

    Unigene Clusters for BTG4:

    B-cell translocation gene 4
    Hs.128180  [show with all ESTs], Hs.734027  [show with all ESTs]
    Unigene Representative Sequences: NM_017589, BC031045
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356018(uc001plj.3) ENST00000525791(uc001plk.3) ENST00000456861

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate BTG4:
    hsa-miR-4297 hsa-miR-3155 hsa-miR-3155b hsa-miR-484 hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmidBTG4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BTG4
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTG4
    Sirion Biotech Customized lentivirus for stable overexpression of BTG4 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTG4

    Additional mRNA sequence: BC031045.1 

    2 DOTS entries:

    DT.40127299  DT.99997052 

    9 AceView cDNA sequences:

    AI028546 BX099301 BC031045 AJ271351 NM_017589 AI798233 AA972143 AI827608 
    BI462306 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for BTG4    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:                                            -               
    SP2:                                                            
    SP3:        -                                                   


    ECgene alternative splicing isoforms for BTG4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BTG4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACAGTGCT
    BTG4 Expression
    About this image


    See BTG4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BTG4

    SOURCE GeneReport for Unigene clusters: Hs.128180 Hs.734027

    UniProtKB/Swiss-Prot: BTG4_HUMAN, Q9NY30
    Tissue specificity: Highly expressed in testis and in olfactory epithelium

        SABiosciences Custom PCR Arrays for BTG4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BTG4 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Btg41 , 5 B cell translocation gene 41, 5 77.98(n)1
    73.3(a)1
      9 (27.84 cM)5
    560571  NM_019493.31  NP_062366.21 
     511160015 
    chicken
    (Gallus gallus)
    Aves BTG41 B-cell translocation gene 4 64.9(n)
    61.54(a)
      419781  XM_417919.3  XP_417919.1 
    lizard
    (Anolis carolinensis)
    Reptilia BTG46
    --
    --
    52(a)
    43(a)
    1 ↔ 1
    possible ortholog
    GL343521.1(206487-209977)
    GL343604.1(329430-351485)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979132 p30 B9.15 74.63(n)    X73316.1 
    zebrafish
    (Danio rerio)
    Actinopterygii btg41 B-cell translocation gene 4 58.16(n)
    54.26(a)
      378946  NM_198121.1  NP_937754.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tob6
    Tob
    9(a)
    1 → many
    X(15969396-15985528)


    ENSEMBL Gene Tree for BTG4 (if available)
    TreeFam Gene Tree for BTG4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BTG4 gene
    TOB12  TOB22  BTG12  BTG32  BTG22  
    4 SIMAP similar genes for BTG4 using alignment to 3 protein entries:     BTG4_HUMAN (see all proteins):
    BTG3    BTG1    TOB2    BTG2

    BTG4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BTG4
    PGOHUM00000235166


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/832 SNPs in BTG4 are shown (see all 832)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486962461,2
    --111337806(+) TCGAAC/TGATAT 1 -- int10--------
    rs1135891861,2
    C--111337807(+) CGAATA/GATATT 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs1422074371,2
    --111337814(+) TATTAA/GTCACA 1 -- int10--------
    rs730113711,2
    C--111337853(+) GCCAGA/GAAATA 1 -- int10--------
    rs1830681741,2
    --111337943(+) AAATTC/GAGCAG 1 -- int10--------
    rs5482431,2
    C,H--111337951(-) TGTCTC/GTTCTG 1 -- int113Minor allele frequency- G:0.08NA WA CSA 259
    rs1866868901,2
    --111338118(+) AGTTAC/TTCTTT 1 -- int10--------
    rs1507270871,2
    --111338215(+) GCCACA/GTAGCT 1 -- int10--------
    rs1390245661,2
    --111338319(+) TCTTCC/GTGCCA 1 -- ut310--------
    rs128034061,2
    C,F--111338328(+) CATGGA/GAGCCC 1 -- ut31 ese35Minor allele frequency- G:0.10NA 128

    HapMap Linkage Disequilibrium report for BTG4 (111338251 - 111383079 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BTG4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832268CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605673    OMIM disorders: --

    4 diseases for BTG4:    About MalaCards
    chronic lymphocytic leukemia    gastric cancer    colorectal cancer    leukemia


    BTG4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BTG4
    Human Genome Epidemiology (HuGE) Navigator: BTG4 (1 document)

    Export disorders for BTG4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BTG4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with BTG4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium. (PubMed id 10995567)1, 2, 3 Buanne P....Tirone F. (2000)
    2. A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocel lular carcinoma. (PubMed id 20309940)1, 4 Xu Y....Hu Z. (2010)
    3. Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. (PubMed id 15672409)1, 9 Auer R.L....Cotter F.E. (2005)
    4. Frequent promoter hypermethylation and transcriptiona l downregulation of BTG4 gene in gastric cancer. (PubMed id 19576178)1 Dong W....Wang L. (2009)
    5. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. (PubMed id 18519671)1 Toyota M....Tokino T. (2008)
    6. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PubMed id 16709802)1 Fortier J.M. and Kornbluth J. (2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PubMed id 11429045)1 Yoshida Y....Yamamoto T. (2001)
    9. The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair? (PubMed id 11267995)1 Tirone F. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54766 HGNC: 13862 AceView: BTG4 Ensembl:ENSG00000137707 euGenes: HUgn54766
    ECgene: BTG4 Kegg: 54766 H-InvDB: BTG4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BTG4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BTG4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BTG4 gene:
    Search GeneIP for patents involving BTG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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