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BTG4 Gene

protein-coding   GIFtS: 52
GCID: GC11M111372

B-Cell Translocation Gene 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
B-Cell Translocation Gene 41 2
PC3B2 3 5
Protein PC3b2 3
BTG Family Member 42 3
Protein BTG42

External Ids:    HGNC: 138621   Entrez Gene: 547662   Ensembl: ENSG000001377077   OMIM: 6056735   UniProtKB: Q9NY303   

Export aliases for BTG4 gene to outside databases

Previous GC identifers: GC11M113691 GC11M112850 GC11M110875 GC11M110843 GC11M107262


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BTG4 Gene:
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins
that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle.
(provided by RefSeq, Jul 2008)

GeneCards Summary for BTG4 Gene:
BTG4 (B-cell translocation gene 4) is a protein-coding gene. Diseases associated with BTG4 include chronic lymphocytic leukemia, and colorectal cancer. An important paralog of this gene is TOB1.

UniProtKB/Swiss-Prot: BTG4_HUMAN, Q9NY30
Function: Shows marked antiproliferative activity, being able to induce G(1) arrest

Gene Wiki entry for BTG4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BTG4 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   C/EBPalpha   POU2F1   Nkx6-1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBTG4 promoter sequence
   Search Chromatin IP Primers for BTG4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BTG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23

BTG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTG4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M111372:  view genomic region     (about GC identifiers)

Start:
111,338,251 bp from pter      End:
111,383,079 bp from pter
Size:
44,829 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BTG4_HUMAN, Q9NY30 (See protein sequence)
Recommended Name: Protein BTG4  
Size: 223 amino acids; 25970 Da
Secondary accessions: Q8NEH7
Alternative splicing: 2 isoforms:  Q9NY30-1   Q9NY30-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BTG4: NX_Q9NY30

Explore proteomics data for BTG4 at MOPED


See BTG4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_060059.1  
ENSEMBL proteins: 
 ENSP00000348300   ENSP00000432018   ENSP00000392358  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR002087 Anti_prolifrtn

Graphical View of Domain Structure for InterPro Entry Q9NY30

ProtoNet protein and cluster: Q9NY30

1 Blocks protein domain: IPB002087 Anti-proliferative protein

UniProtKB/Swiss-Prot: BTG4_HUMAN, Q9NY30
Similarity: Belongs to the BTG family


BTG4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: BTG4_HUMAN, Q9NY30
Function: Shows marked antiproliferative activity, being able to induce G(1) arrest

Animal Models:

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SwitchGear 3'UTR luciferase reporter plasmidBTG4 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
extracellular2
mitochondrion1
nucleus1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--

BTG4 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for BTG4 About    
See pathways by source

SuperPathContained pathways About
1Deadenylation-dependent mRNA decay
RNA degradation0.48

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways




1 Kegg Pathway  (Kegg details for BTG4):
    RNA degradation


BTG4 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BTG4
Interactions:

    Search GeneGlobe Interaction Network for BTG4

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for BTG4 (Q9NY303 ENSP000003483004) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
RNF19BQ6ZMZ03, ENSP000003625554I2D: score=1 STRING: ENSP00000362555
UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007050cell cycle arrest TAS10995567
GO:0008285negative regulation of cell proliferation TAS10995567
GO:0030182neuron differentiation TAS10995567
GO:0045930negative regulation of mitotic cell cycle IEA--

BTG4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for BTG4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for BTG4 gene: 
NM_017589.3  

Unigene Cluster for BTG4:

B-cell translocation gene 4
Hs.128180  [show with all ESTs]
Unigene Representative Sequence: NM_017589
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000356018(uc001plj.3) ENST00000525791(uc001plk.3) ENST00000456861

miRNA
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5 qRT-PCR Assays for microRNAs that regulate BTG4:
hsa-miR-4297 hsa-miR-3155 hsa-miR-3155b hsa-miR-484 hsa-miR-1248
SwitchGear 3'UTR luciferase reporter plasmidBTG4 3' UTR sequence
Inhib. RNA
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  QuantiFast Probe-based Assays in human, mouse, rat BTG4

Additional mRNA sequence: AJ271351.1 

1 DOTS entry:

DT.40127299 

9 AceView cDNA sequences:

BX099301 AI028546 NM_017589 BC031045 AJ271351 AI827608 AA972143 AI798233 
BI462306 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for BTG4    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1:                                            -               
SP2:                                                            
SP3:        -                                                   


ECgene alternative splicing isoforms for BTG4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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BTG4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAACAGTGCT
BTG4 Expression
About this image

BTG4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

BTG4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.128180

UniProtKB/Swiss-Prot: BTG4_HUMAN, Q9NY30
Tissue specificity: Highly expressed in testis and in olfactory epithelium

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for BTG4 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Btg41 , 5 B cell translocation gene 41, 5 77.98(n)1
73.3(a)1
  9 (27.84 cM)5
560571  NM_019493.31  NP_062366.21 
 511160015 
chicken
(Gallus gallus)
Aves BTG41 B-cell translocation gene 4 64.63(n)
61.5(a)
  419781  NM_001278123.1  NP_001265052.1 
lizard
(Anolis carolinensis)
Reptilia BTG46
B-cell translocation gene 4
54(a)
1 ↔ 1
GL343521.1(206487-209977)
African clawed frog
(Xenopus laevis)
Amphibia LOC3979132 p30 B9.15 74.63(n)    X73316.1 
zebrafish
(Danio rerio)
Actinopterygii btg41 B-cell translocation gene 4 58.33(n)
54.26(a)
  378946  NM_198121.1  NP_937754.1 
fruit fly
(Drosophila melanogaster)
Insecta Tob6
Tob
9(a)
1 → many
X(15969396-15985528)


ENSEMBL Gene Tree for BTG4 (if available)
TreeFam Gene Tree for BTG4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for BTG4 gene
TOB12  TOB22  BTG12  BTG32  BTG22  
4 SIMAP similar genes for BTG4 using alignment to 2 protein entries:     BTG4_HUMAN (see all proteins):
BTG3    BTG1    TOB2    BTG2

BTG4 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for BTG4
PGOHUM00000235166


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for BTG4 (see all 832)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1486962461,2
--111337806(+) TCGAAC/TGATAT 1 -- int10--------
rs1135891861,2
C--111337807(+) CGAATA/GATATT 1 -- int11Minor allele frequency- G:0.00CSA 1
rs1422074371,2
--111337814(+) TATTAA/GTCACA 1 -- int10--------
rs730113711,2
C--111337853(+) GCCAGA/GAAATA 1 -- int10--------
rs1830681741,2
--111337943(+) AAATTC/GAGCAG 1 -- int10--------
rs5482431,2
C,H--111337951(-) TGTCTC/GTTCTG 1 -- int113Minor allele frequency- G:0.08NA WA CSA 259
rs1866868901,2
--111338118(+) AGTTAC/TTCTTT 1 -- int10--------
rs1507270871,2
--111338215(+) GCCACA/GTAGCT 1 -- int10--------
rs1390245661,2
--111338319(+) TCTTCC/GTGCCA 1 -- ut310--------
rs128034061,2
C,F--111338328(+) CATGGA/GAGCCC 1 -- ut31 ese35Minor allele frequency- G:0.10NA 128

HapMap Linkage Disequilibrium report for BTG4 (111338251 - 111383079 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for BTG4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv832268CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing BTG4
DNA2.0 Custom Variant and Variant Library Synthesis for BTG4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605673    OMIM disorders: --

5 diseases for BTG4:    
About MalaCards
chronic lymphocytic leukemia    colorectal cancer    hepatocellular carcinoma    leukemia
neuronitis


BTG4 for disorders           About GeneDecksing

Genetic Association Database (GAD): BTG4
Human Genome Epidemiology (HuGE) Navigator: BTG4 (1 document)

Export disorders for BTG4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for BTG4 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with BTG4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium. (PubMed id 10995567)1, 2, 3 Buanne P....Tirone F. (Genomics 2000)
  2. A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. (PubMed id 20309940)1, 4 Xu Y....Hu Z. (Int. J. Cancer 2011)
  3. Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. (PubMed id 15672409)1, 9 Auer R.L....Cotter F.E. (amp 2005)
  4. Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer. (PubMed id 19576178)1 Dong W....Wang L. (Biochem. Biophys. Res. Commun. 2009)
  5. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. (PubMed id 18519671)1 Toyota M....Tokino T. (Cancer Res. 2008)
  6. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PubMed id 16709802)1 Fortier J.M. and Kornbluth J. (J. Immunol. 2006)
  7. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PubMed id 11429045)1 Yoshida Y....Yamamoto T. (Jpn. J. Cancer Res. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 54766 HGNC: 13862 AceView: BTG4 Ensembl:ENSG00000137707 euGenes: HUgn54766
ECgene: BTG4 Kegg: 54766 H-InvDB: BTG4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for BTG4 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BTG4 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for BTG4 gene:
Search GeneIP for patents involving BTG4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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