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Aliases for BTG4 Gene

Aliases for BTG4 Gene

  • BTG Anti-Proliferation Factor 4 2 3 5
  • BTG Family Member 4 2 3 4
  • B-Cell Translocation Gene 4 2 3
  • Protein PC3b 3 4
  • PC3B 3 4
  • Protein BTG4 3
  • APRO3 3

External Ids for BTG4 Gene

Previous GeneCards Identifiers for BTG4 Gene

  • GC11M113691
  • GC11M112850
  • GC11M111372
  • GC11M110875
  • GC11M110843
  • GC11M107262
  • GC11M111467

Summaries for BTG4 Gene

Entrez Gene Summary for BTG4 Gene

  • The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for BTG4 Gene

BTG4 (BTG Anti-Proliferation Factor 4) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. An important paralog of this gene is BTG3.

UniProtKB/Swiss-Prot for BTG4 Gene

  • Shows marked antiproliferative activity, being able to induce G(1) arrest.

Gene Wiki entry for BTG4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTG4 Gene

Genomics for BTG4 Gene

Regulatory Elements for BTG4 Gene

Enhancers for BTG4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F111548 0.6 ENCODE 11 -34.8 -34798 1.6 ZNF316 JUND STAT1 MAFG SIN3A RAD21 MAFK ENSG00000254980 BTG4 C11orf88 MIR34B MIR34C LAYN SIK2
GH11F111559 0.5 Ensembl ENCODE 10.7 -46.8 -46820 3.9 SOX13 SAP130 RARA TEAD3 NR2F6 SOX5 GATAD2A TEAD1 NR2F1 HLF SIK2 LAYN ENSG00000254980 BTG4 C11orf88 MIR34B MIR34C POU2AF1 LOC644277 PPP2R1B
GH11F111565 0.2 ENCODE 10.6 -50.6 -50598 0.2 CTCF TFAP4 PKNOX1 NFRKB SIN3A CEBPG RAD21 ZNF316 ZNF366 ZNF143 LAYN SIK2 MIR34B MIR34C BTG4 C11orf88 ENSG00000254980 PPP2R1B
GH11F111429 0.6 ENCODE 10.6 +85.5 85483 0.1 CTCF PKNOX1 ZNF644 RAD21 YY1 ZNF335 ZNF143 SMC3 ZBTB20 GATAD2A POU2AF1 COLCA1 COLCA2 MIR34B MIR34C BTG4 C11orf88 RNU2-60P LAYN LOC100132078
GH11F111427 0.3 FANTOM5 10.6 +87.1 87101 0.4 PKNOX1 NFIA BHLHE40 OVOL3 FEZF1 ZNF843 OSR2 GATA3 ZNF366 GATA2 COLCA1 POU2AF1 COLCA2 BTG4 C11orf88 MIR34B MIR34C RNU2-60P LAYN LOC100132078
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BTG4 on UCSC Golden Path with GeneCards custom track

Promoters for BTG4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001772164 -67 401 CTCF RFX1 PRDM10 BMI1

Genomic Location for BTG4 Gene

111,384,095 bp from pter
111,514,733 bp from pter
130,639 bases
Minus strand

Genomic View for BTG4 Gene

Genes around BTG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTG4 Gene

Proteins for BTG4 Gene

  • Protein details for BTG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein BTG4
    Protein Accession:
    Secondary Accessions:
    • Q8NEH7

    Protein attributes for BTG4 Gene

    223 amino acids
    Molecular mass:
    25970 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTG4 Gene


neXtProt entry for BTG4 Gene

Post-translational modifications for BTG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTG4 Gene

Antibody Products

  • Abcam antibodies for BTG4
  • Santa Cruz Biotechnology (SCBT) Antibodies for BTG4

No data available for DME Specific Peptides for BTG4 Gene

Domains & Families for BTG4 Gene

Gene Families for BTG4 Gene

Protein Domains for BTG4 Gene

Suggested Antigen Peptide Sequences for BTG4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BTG family.
  • Belongs to the BTG family.
genes like me logo Genes that share domains with BTG4: view

Function for BTG4 Gene

Molecular function for BTG4 Gene

UniProtKB/Swiss-Prot Function:
Shows marked antiproliferative activity, being able to induce G(1) arrest.
genes like me logo Genes that share phenotypes with BTG4: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BTG4 Gene

Localization for BTG4 Gene

Subcellular locations from

Jensen Localization Image for BTG4 Gene COMPARTMENTS Subcellular localization image for BTG4 gene
Compartment Confidence
cytosol 3
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BTG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with BTG4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BTG4 Gene

Pathways & Interactions for BTG4 Gene

SuperPathways for BTG4 Gene

SuperPathway Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with BTG4: view

Pathways by source for BTG4 Gene

1 KEGG pathway for BTG4 Gene

Interacting Proteins for BTG4 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000348300 Q9NY30-BTG4_HUMAN for BTG4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for BTG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS 10995567
GO:0008285 negative regulation of cell proliferation IEA,TAS 10995567
GO:0030182 neuron differentiation TAS 10995567
GO:0045930 negative regulation of mitotic cell cycle IEA --
genes like me logo Genes that share ontologies with BTG4: view

No data available for SIGNOR curated interactions for BTG4 Gene

Transcripts for BTG4 Gene

mRNA/cDNA for BTG4 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTG4 Gene

B-cell translocation gene 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTG4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP3: -

Relevant External Links for BTG4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTG4 Gene

mRNA expression in normal human tissues for BTG4 Gene

mRNA differential expression in normal tissues according to GTEx for BTG4 Gene

This gene is overexpressed in Testis (x47.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTG4 Gene

Protein tissue co-expression partners for BTG4 Gene

NURSA nuclear receptor signaling pathways regulating expression of BTG4 Gene:


SOURCE GeneReport for Unigene cluster for BTG4 Gene:


mRNA Expression by UniProt/SwissProt for BTG4 Gene:

Tissue specificity: Highly expressed in testis and in olfactory epithelium.
genes like me logo Genes that share expression patterns with BTG4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for BTG4 Gene

Orthologs for BTG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTG4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTG4 34 35
  • 99.55 (n)
(Canis familiaris)
Mammalia BTG4 34 35
  • 87.33 (n)
(Bos Taurus)
Mammalia BTG4 34 35
  • 87.03 (n)
(Mus musculus)
Mammalia Btg4 34 16 35
  • 77.98 (n)
(Monodelphis domestica)
Mammalia BTG4 35
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia BTG4 35
  • 52 (a)
(Gallus gallus)
Aves BTG4 34 35
  • 64.63 (n)
(Anolis carolinensis)
Reptilia BTG4 35
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia btg4 34
  • 63.52 (n)
Str.3682 34
African clawed frog
(Xenopus laevis)
Amphibia LOC397913 34
(Danio rerio)
Actinopterygii btg4 34 35
  • 58.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tob 35
  • 9 (a)
Species where no ortholog for BTG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTG4 Gene

Gene Tree for BTG4 (if available)
Gene Tree for BTG4 (if available)

Paralogs for BTG4 Gene

Paralogs for BTG4 Gene

(4) SIMAP similar genes for BTG4 Gene using alignment to 2 proteins: Pseudogenes for BTG4 Gene

genes like me logo Genes that share paralogs with BTG4: view

Variants for BTG4 Gene

Sequence variations from dbSNP and Humsavar for BTG4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000995 -- 111,397,870(+) TGATG(C/T)TTTGG intron-variant
rs10400383 -- 111,413,921(+) CTGGC(A/G)TAGCT intron-variant
rs10444326 -- 111,442,513(+) gtata(C/T)acaca intron-variant
rs10444327 -- 111,442,607(+) aacaa(A/C)aacaa intron-variant
rs10450620 -- 111,424,766(+) CAGCC(C/T)GACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTG4 Gene

Variant ID Type Subtype PubMed ID
nsv472582 CNV novel sequence insertion 20440878
nsv832268 CNV loss 17160897

Variation tolerance for BTG4 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTG4 Gene

Disorders for BTG4 Gene

Relevant External Links for BTG4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BTG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTG4 Gene

Publications for BTG4 Gene

  1. Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium. (PMID: 10995567) Buanne P. … Tirone F. (Genomics 2000) 2 3 4 64
  2. A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. (PMID: 20309940) Xu Y. … Hu Z. (Int. J. Cancer 2011) 3 46 64
  3. Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. (PMID: 15672409) Auer R.L. … Cotter F.E. (Genes Chromosomes Cancer 2005) 3 22 64
  4. Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer. (PMID: 19576178) Dong W. … Wang L. (Biochem. Biophys. Res. Commun. 2009) 3 64
  5. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. (PMID: 18519671) Toyota M. … Tokino T. (Cancer Res. 2008) 3 64

Products for BTG4 Gene

Sources for BTG4 Gene

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