BTG4 Gene
protein-coding GIFtS: 53
GCID: GC11M111372
|
|
B-cell translocation gene 4
| |
Aliases
for BTG4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| B-Cell Translocation Gene 41 2 | | PC3B1 2 3 5 | | Protein PC3b2 3 | | BTG Family Member 42 3 | | Protein BTG42 |
Export aliases for BTG4 gene to outside databasesPrevious GC identifers: GC11M113691 GC11M112850 GC11M110875 GC11M110843 GC11M107262 |
Summaries
for BTG4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BTG4:
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins thatappear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: BTG4_HUMAN, Q9NY30Function: Shows marked antiproliferative activity, being able to induce G(1) arrest
Gene Wiki entry for BTG4
|
Genomic Views
for BTG4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BTG4 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU2F2 C/EBPalpha POU2F1 Nkx6-1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for BTG4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTG4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.1 HGNC cytogenetic band: 11q23BTG4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M111372: view genomic region
(about GC identifiers)
Start:
|
111,338,251 bp from pter |
End:
|
111,383,079 bp from pter |
Size:
|
44,829 bases |
Orientation:
|
minus strand |
|
Proteins
for BTG4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BTG4_HUMAN, Q9NY30 (See
protein sequence)Recommended Name: Protein BTG4 Size: 223 amino acids; 25970 DaExplore the universe of human proteins at neXtProt for BTG4: NX_Q9NY30
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NY30
BTG4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060059.1
ENSEMBL proteins: ENSP00000348300 ENSP00000432018 ENSP00000392358
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
BTG4 for ontologies About GeneDecksing
BTG4 Antibody Products:
Assay Products for BTG4: |
Protein
Domains /
Families
for BTG4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BTG4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NY30ProtoNet protein and cluster: Q9NY30 1 Blocks protein family: IPB002087 Anti-proliferative protein
UniProtKB/Swiss-Prot: BTG4_HUMAN, Q9NY30Similarity: Belongs to the BTG family |
Function
for BTG4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BTG4_HUMAN, Q9NY30Function: Shows marked antiproliferative activity, being able to induce G(1) arrest
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTG4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTG4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BTG4 (NM_017589) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BTG4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTG4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG4 |
|
Pathways & Interactions
for BTG4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Deadenylation-dependent mRNA decay | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for BTG4):
BTG4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BTG4
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for BTG4 (Q9NY303 ENSP000003483004) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
BTG4 for ontologies About GeneDecksing
|
Drugs & Compounds
for BTG4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BTG4
Search CenterWatch for drugs/clinical trials and news about BTG4
|
Transcripts
for BTG4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BTG4 gene: NM_017589.3 Unigene Clusters for BTG4: B-cell translocation gene 4 Hs.128180 [show with all ESTs], Hs.734027 [show with all ESTs]Unigene Representative Sequences: NM_017589, BC0310453 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000356018(uc001plj.3) ENST00000525791(uc001plk.3) ENST00000456861
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTG4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTG4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BTG4 (NM_017589) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BTG4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTG4 |
Additional cDNA sequence: BC031045.1 2 DOTS entries: DT.40127299 DT.99997052 9 AceView cDNA sequences: AI028546 BX099301 AJ271351 NM_017589 BC031045 AI798233 AA972143 AI827608 BI462306
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for BTG4 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for BTG4
|
Expression
for BTG4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BTG4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACAGTGCT
About this image
See BTG4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BTG4
SOURCE GeneReport for Unigene clusters: Hs.128180 Hs.734027
UniProtKB/Swiss-Prot: BTG4_HUMAN, Q9NY30Tissue specificity: Highly expressed in testis and in olfactory epithelium
SABiosciences Custom PCR Arrays for BTG4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BTG4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BTG4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTG4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTG4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG4 |
Orthologs
for BTG4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BTG4 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for BTG4 (if available)
TreeFam Gene Tree for BTG4 (if available) |
Paralogs
for BTG4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BTG4 gene
- TOB12 TOB22 BTG32 BTG12 BTG22
4 SIMAP similar genes for BTG4 using alignment to 3 protein entries: BTG4_HUMAN (see all proteins):BTG3 BTG1 TOB2 BTG2
BTG4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for BTG4
PGOHUM00000235166
|
Genomic Variants
for BTG4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BTG4 (111338251 - 111383079 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BTG4
1 CNV: 86042 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTG4 |
|
Disorders
/ Diseases
for BTG4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BTG4 for disorders About GeneDecksing
OMIM gene information: 605673
OMIM disorders: --
7  diseases for BTG4: About MalaCardschronic lymphocytic leukemia lymphocytic leukemia gastric cancer colorectal cancer
leukemia neuronitis carcinoma
Human Genome Epidemiology (HuGE) Navigator: BTG4 (1 document)
Export disorders for BTG4 gene to outside databases
|
Publications
for BTG4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BTG4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with BTG4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium. (PubMed id 10995567)1, 2, 3 Buanne P....Tirone F. (2000)
- Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. (PubMed id 15672409)1, 9 Auer R.L....Cotter F.E. (2005)
- A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocel lular carcinoma. (PubMed id 20309940)1 Xu Y....Hu Z. (2010)
- Frequent promoter hypermethylation and transcriptiona l downregulation of BTG4 gene in gastric cancer. (PubMed id 19576178)1 Dong W....Wang L. (2009)
- Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. (PubMed id 18519671)1 Toyota M....Tokino T. (2008)
- NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PubMed id 16709802)1 Fortier J.M. and Kornbluth J. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PubMed id 11429045)1 Yoshida Y....Yamamoto T. (2001)
- The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair? (PubMed id 11267995)1 Tirone F. (2001)
|
External Searches for BTG4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BTG4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BTG4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BTG4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for BTG4 gene:
Search GeneIP for patents involving BTG4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BTG4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BTG4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BTG4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BTG4 | | | OriGene Protein Over-expression Lysate for BTG4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BTG4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTG4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTG4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BTG4 | | OriGene Custom Protein Services for BTG4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BTG4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTG4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTG4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BTG4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTG4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTG4 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for BTG4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | BTG4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG4 |
|  |  |  | | | | Search ThermoFisher Antibodies for BTG4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTG4 |
|
|
|
|
