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Aliases for BTG3 Gene

Aliases for BTG3 Gene

  • BTG Family, Member 3 2 3
  • TOB5 3 4 6
  • ANA 3 4 6
  • Abundant In Neuroepithelium Area Protein 3 4
  • Protein Tob5 3 4
  • B-Cell Translocation Gene 3 3
  • BTG Family Member 3 4
  • Protein BTG3 3
  • TOB55 3
  • TOFA 3

External Ids for BTG3 Gene

Previous GeneCards Identifiers for BTG3 Gene

  • GC21M015630
  • GC21M017887
  • GC21M018965
  • GC21M004351

Summaries for BTG3 Gene

Entrez Gene Summary for BTG3 Gene

  • The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for BTG3 Gene

BTG3 (BTG Family, Member 3) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. An important paralog of this gene is TOB1.

UniProtKB/Swiss-Prot for BTG3 Gene

  • Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase

Gene Wiki entry for BTG3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTG3 Gene

Genomics for BTG3 Gene

Regulatory Elements for BTG3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BTG3 Gene

Start:
17,593,650 bp from pter
End:
17,612,950 bp from pter
Size:
19,301 bases
Orientation:
Minus strand

Genomic View for BTG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTG3 Gene

Proteins for BTG3 Gene

  • Protein details for BTG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14201-BTG3_HUMAN
    Recommended name:
    Protein BTG3
    Protein Accession:
    Q14201
    Secondary Accessions:
    • D3DSC4
    • Q53XV1
    • Q96ET7

    Protein attributes for BTG3 Gene

    Size:
    252 amino acids
    Molecular mass:
    29116 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTG3 Gene

Proteomics data for BTG3 Gene at MOPED

Post-translational modifications for BTG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTG3 Gene

No data available for DME Specific Peptides for BTG3 Gene

Domains for BTG3 Gene

Protein Domains for BTG3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BTG3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14201

UniProtKB/Swiss-Prot:

BTG3_HUMAN :
  • Q14201
Family:
  • Belongs to the BTG family.
genes like me logo Genes that share domains with BTG3: view

No data available for Gene Families for BTG3 Gene

Function for BTG3 Gene

Molecular function for BTG3 Gene

GENATLAS Biochemistry: B cell transcription gene 3,antiproliferative,predominantly expressed in ovary,testis,prostate,thymus,lung,putatively involved in neurogenesis in the central nervous system,Tob/BTG1 family
UniProtKB/Swiss-Prot Function: Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase

Gene Ontology (GO) - Molecular Function for BTG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17690688
genes like me logo Genes that share ontologies with BTG3: view

Phenotypes for BTG3 Gene

MGI mutant phenotypes for BTG3:
inferred from 1 alleles
GenomeRNAi human phenotypes for BTG3:
genes like me logo Genes that share phenotypes with BTG3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BTG3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BTG3 Gene

Localization for BTG3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTG3 Gene COMPARTMENTS Subcellular localization image for BTG3 gene
Compartment Confidence
cytosol 3
extracellular 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BTG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 9632145
genes like me logo Genes that share ontologies with BTG3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BTG3 Gene

Pathways for BTG3 Gene

SuperPathways for BTG3 Gene

Superpath Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with BTG3: view

Pathways by source for BTG3 Gene

1 KEGG pathway for BTG3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BTG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS 9632145
GO:0045930 negative regulation of mitotic cell cycle IDA 9632145
genes like me logo Genes that share ontologies with BTG3: view

Transcripts for BTG3 Gene

mRNA/cDNA for BTG3 Gene

(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTG3 Gene

BTG family, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BTG3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTG3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - - - -
SP2: - -
SP3: - - -
SP4:
SP5: - - - -
SP6:
SP7:

Relevant External Links for BTG3 Gene

GeneLoc Exon Structure for
BTG3
ECgene alternative splicing isoforms for
BTG3

Expression for BTG3 Gene

mRNA expression in normal human tissues for BTG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BTG3 Gene

SOURCE GeneReport for Unigene cluster for BTG3 Gene Hs.473420

mRNA Expression by UniProt/SwissProt for BTG3 Gene

Q14201-BTG3_HUMAN
Tissue specificity: Ubiquitous. High expression in the ventricular zone of the developing central nervous system. High in ovary, testis, prostate, thymus and lung.
genes like me logo Genes that share expressions with BTG3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BTG3 Gene

Orthologs for BTG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BTG3 35
  • 99.55 (n)
  • 98.99 (a)
BTG3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BTG3 35
  • 92.46 (n)
  • 94.84 (a)
BTG3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTG3 36
  • 98 (a)
OneToOne
LOC487695 35
  • 93.92 (n)
  • 97.62 (a)
mouse
(Mus musculus)
Mammalia Btg3 35
  • 91.4 (n)
  • 94.05 (a)
Btg3 16
Btg3 36
  • 94 (a)
OneToMany
Gm7334 36
  • 94 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia BTG3 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btg3 35
  • 90.87 (n)
  • 92.06 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.31129 35
tropical clawed frog
(Silurana tropicalis)
Amphibia btg3 35
  • 61.92 (n)
  • 53.56 (a)
Str.6608 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
btg3 35
  • 65.03 (n)
  • 62.94 (a)
btg3 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tob 36
  • 11 (a)
OneToMany
Species with no ortholog for BTG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTG3 Gene

ENSEMBL:
Gene Tree for BTG3 (if available)
TreeFam:
Gene Tree for BTG3 (if available)

Paralogs for BTG3 Gene

Paralogs for BTG3 Gene

Selected SIMAP similar genes for BTG3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for BTG3 Gene

genes like me logo Genes that share paralogs with BTG3: view

Variants for BTG3 Gene

Sequence variations from dbSNP and Humsavar for BTG3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs928248 -- 17,614,409(+) AAAAA(A/G)TACAG upstream-variant-2KB
rs2824387 -- 17,594,465(+) TCAGG(G/T)CTAAA intron-variant
rs2824388 -- 17,605,049(+) ATAAA(C/T)GCCGT intron-variant
rs2824389 -- 17,605,858(+) TCCTA(C/G)TATTT intron-variant
rs2824390 -- 17,606,098(+) TAATA(A/T)Taaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTG3 Gene

Variant ID Type Subtype PubMed ID
esv2723192 CNV Deletion 23290073

Relevant External Links for BTG3 Gene

HapMap Linkage Disequilibrium report
BTG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTG3 Gene

Disorders for BTG3 Gene

(1) Novoseek inferred disease relationships for BTG3 Gene

Disease -log(P) Hits PubMed IDs
tumors 8.26 3

Relevant External Links for BTG3

Genetic Association Database (GAD)
BTG3
Human Genome Epidemiology (HuGE) Navigator
BTG3
genes like me logo Genes that share disorders with BTG3: view

No data available for UniProtKB/Swiss-Prot for BTG3 Gene

Publications for BTG3 Gene

  1. Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle. (PMID: 9067576) Guehenneux F. … Rouault J.-P. (Leukemia 1997) 3 4 23
  2. ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system. (PMID: 9632145) Yoshida Y. … Yamamoto T. (Oncogene 1998) 2 3 4
  3. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PMID: 11429045) Yoshida Y. … Yamamoto T. (Jpn. J. Cancer Res. 2001) 3 23
  4. BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. (PMID: 19221000) Majid S. … Dahiya R. (Carcinogenesis 2009) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for BTG3 Gene

Sources for BTG3 Gene

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