Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BTG3 Gene

Aliases for BTG3 Gene

  • BTG Family Member 3 2 3 4 5
  • Abundant In Neuroepithelium Area Protein 3 4
  • BTG Family, Member 3 2 3
  • Protein Tob5 3 4
  • TOB5 3 4
  • ANA 3 4
  • B-Cell Translocation Gene 3 3
  • TOB55 3
  • TOFA 3

External Ids for BTG3 Gene

Previous GeneCards Identifiers for BTG3 Gene

  • GC21M015630
  • GC21M017887
  • GC21M018965
  • GC21M004351

Summaries for BTG3 Gene

Entrez Gene Summary for BTG3 Gene

  • The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for BTG3 Gene

BTG3 (BTG Family Member 3) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. An important paralog of this gene is TOB1.

UniProtKB/Swiss-Prot for BTG3 Gene

  • Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.

Gene Wiki entry for BTG3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTG3 Gene

Genomics for BTG3 Gene

Regulatory Elements for BTG3 Gene

Enhancers for BTG3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BTG3 on UCSC Golden Path with GeneCards custom track

Promoters for BTG3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BTG3 on UCSC Golden Path with GeneCards custom track

Genomic Location for BTG3 Gene

Chromosome:
21
Start:
17,593,650 bp from pter
End:
17,612,950 bp from pter
Size:
19,301 bases
Orientation:
Minus strand

Genomic View for BTG3 Gene

Genes around BTG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTG3 Gene

Proteins for BTG3 Gene

  • Protein details for BTG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14201-BTG3_HUMAN
    Recommended name:
    Protein BTG3
    Protein Accession:
    Q14201
    Secondary Accessions:
    • D3DSC4
    • Q53XV1
    • Q96ET7

    Protein attributes for BTG3 Gene

    Size:
    252 amino acids
    Molecular mass:
    29116 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTG3 Gene

Proteomics data for BTG3 Gene at MOPED

Post-translational modifications for BTG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTG3 Gene

No data available for DME Specific Peptides for BTG3 Gene

Domains & Families for BTG3 Gene

Protein Domains for BTG3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BTG3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14201

UniProtKB/Swiss-Prot:

BTG3_HUMAN :
  • Belongs to the BTG family.
Family:
  • Belongs to the BTG family.
genes like me logo Genes that share domains with BTG3: view

No data available for Gene Families for BTG3 Gene

Function for BTG3 Gene

Molecular function for BTG3 Gene

GENATLAS Biochemistry:
B cell transcription gene 3,antiproliferative,predominantly expressed in ovary,testis,prostate,thymus,lung,putatively involved in neurogenesis in the central nervous system,Tob/BTG1 family
UniProtKB/Swiss-Prot Function:
Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.

Phenotypes for BTG3 Gene

genes like me logo Genes that share phenotypes with BTG3: view

Animal Models for BTG3 Gene

MGI Knock Outs for BTG3:

Animal Model Products

  • Taconic Biosciences Mouse Models for BTG3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BTG3 Gene

Localization for BTG3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTG3 Gene COMPARTMENTS Subcellular localization image for BTG3 gene
Compartment Confidence
cytosol 3
extracellular 2
mitochondrion 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BTG3 Gene

Pathways & Interactions for BTG3 Gene

SuperPathways for BTG3 Gene

Superpath Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with BTG3: view

Pathways by source for BTG3 Gene

1 KEGG pathway for BTG3 Gene

Gene Ontology (GO) - Biological Process for BTG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS 9632145
genes like me logo Genes that share ontologies with BTG3: view

No data available for SIGNOR curated interactions for BTG3 Gene

Drugs & Compounds for BTG3 Gene

No Compound Related Data Available

Transcripts for BTG3 Gene

mRNA/cDNA for BTG3 Gene

Unigene Clusters for BTG3 Gene

BTG family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTG3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - - - -
SP2: - -
SP3: - - -
SP4:
SP5: - - - -
SP6:
SP7:

Relevant External Links for BTG3 Gene

GeneLoc Exon Structure for
BTG3
ECgene alternative splicing isoforms for
BTG3

Expression for BTG3 Gene

mRNA expression in normal human tissues for BTG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BTG3 Gene

This gene is overexpressed in Spinal cord (38.5), CD8 Tcells (15.9), Urinary Bladder (7.8), and Retina (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BTG3 Gene



SOURCE GeneReport for Unigene cluster for BTG3 Gene Hs.473420

mRNA Expression by UniProt/SwissProt for BTG3 Gene

Q14201-BTG3_HUMAN
Tissue specificity: Ubiquitous. High expression in the ventricular zone of the developing central nervous system. High in ovary, testis, prostate, thymus and lung.
genes like me logo Genes that share expression patterns with BTG3: view

Protein tissue co-expression partners for BTG3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BTG3 Gene

Orthologs for BTG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTG3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BTG3 35
  • 92.46 (n)
  • 94.84 (a)
BTG3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC487695 35
  • 93.92 (n)
  • 97.62 (a)
BTG3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btg3 35
  • 91.4 (n)
  • 94.05 (a)
Btg3 16
Btg3 36
  • 94 (a)
OneToMany
Gm7334 36
  • 94 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia BTG3 35
  • 99.55 (n)
  • 98.99 (a)
BTG3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btg3 35
  • 90.87 (n)
  • 92.06 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia BTG3 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia btg3 35
  • 61.92 (n)
  • 53.56 (a)
Str.6608 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.31129 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
btg3 35
  • 65.03 (n)
  • 62.94 (a)
btg3 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tob 36
  • 11 (a)
OneToMany
Species with no ortholog for BTG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTG3 Gene

ENSEMBL:
Gene Tree for BTG3 (if available)
TreeFam:
Gene Tree for BTG3 (if available)

Paralogs for BTG3 Gene

Paralogs for BTG3 Gene

(3) SIMAP similar genes for BTG3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for BTG3 Gene

genes like me logo Genes that share paralogs with BTG3: view

Variants for BTG3 Gene

Structural Variations from Database of Genomic Variants (DGV) for BTG3 Gene

Variant ID Type Subtype PubMed ID
esv2723192 CNV Deletion 23290073

Variation tolerance for BTG3 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTG3 Gene

HapMap Linkage Disequilibrium report
BTG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for BTG3 Gene

Disorders for BTG3 Gene

Relevant External Links for BTG3

Genetic Association Database (GAD)
BTG3
Human Genome Epidemiology (HuGE) Navigator
BTG3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BTG3

No disorders were found for BTG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTG3 Gene

Publications for BTG3 Gene

  1. ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system. (PMID: 9632145) Yoshida Y. … Yamamoto T. (Oncogene 1998) 2 3 4 67
  2. BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. (PMID: 19221000) Majid S. … Dahiya R. (Carcinogenesis 2009) 3 23
  3. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PMID: 11429045) Yoshida Y. … Yamamoto T. (Jpn. J. Cancer Res. 2001) 3 23
  4. Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle. (PMID: 9067576) Guehenneux F. … Rouault J.-P. (Leukemia 1997) 3 23
  5. Down-regulation of BTG3 promotes cell proliferation, migration and invasion and predicts survival in gastric cancer. (PMID: 25238703) Ren X.L. … Liang L. (J. Cancer Res. Clin. Oncol. 2015) 3

Products for BTG3 Gene

Sources for BTG3 Gene

Content