BTG3 Gene
protein-coding GIFtS: 57
GCID: GC21M018965
|
|
BTG family, member 3
| |
Aliases
for BTG3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
|
| Aliases |
|---|
| BTG Family, Member 31 2 | | B-Cell Translocation Gene11 | | ANA1 2 3 5 | | TOB552 | | TOB52 3 5 | | TOFA2 | | Abundant In Neuroepithelium Area Protein2 3 | | B-Cell Translocation Gene 32 | | Protein Tob52 3 | | Protein BTG32 | | Tob551 | | BTG Family Member 33 |
Export aliases for BTG3 gene to outside databasesPrevious GC identifers: GC21M015630 GC21M017887 GC21M004351 |
Summaries
for BTG3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BTG3:
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins thatappear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the centralnervous system. Two transcript variants encoding different isoforms have been found for this gene. (provided byRefSeq, Aug 2008)
UniProtKB/Swiss-Prot: BTG3_HUMAN, Q14201Function: Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase
Gene Wiki entry for BTG3
|
Genomic Views
for BTG3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics, Whole Chromsome Sequence According to
Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
|
| GC21M018965: |
GeneLoc |
Nature:405,311-319 |
Start:
|
18,965,968 bp from pter |
4,630,458 bp from centromere |
End:
|
18,985,268 bp from pter |
4,649,509 bp from centromere |
Size:
|
19,301 bases |
19,052 bases |
Orientation:
|
minus strand |
minus strand |
Proteins
for BTG3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BTG3_HUMAN, Q14201 (See
protein sequence)Recommended Name: Protein BTG3 Size: 252 amino acids; 29116 Da
Developmental stage: Expression is cell cycle dependent with the highest levels at the end of G1 phase, peaking at theG1-S transition
Secondary accessions: D3DSC4 Q53XV1 Q96ET7Alternative splicing: 2 isoforms: Q14201-1 Q14201-2 Explore the universe of human proteins at neXtProt for BTG3: NX_Q14201
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14201
BTG3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001124386.1 NP_006797.3
ENSEMBL proteins: ENSP00000344609 ENSP00000284879 ENSP00000413799
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
BTG3 for ontologies About GeneDecksing
BTG3 Antibody Products:
Assay Products for BTG3: |
Protein
Domains /
Families
for BTG3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BTG3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q14201ProtoNet protein and cluster: Q14201 1 Blocks protein family: IPB002087 Anti-proliferative protein
UniProtKB/Swiss-Prot: BTG3_HUMAN, Q14201Similarity: Belongs to the BTG family |
Function
for BTG3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BTG3_HUMAN, Q14201Function: Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase Genatlas biochemistry entry for BTG3:B cell transcription gene 3,antiproliferative,predominantly expressed in ovary,testis,prostate,thymus,lung,putativelyinvolved in neurogenesis in the central nervous system,Tob/BTG1 family
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTG3 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG3 |
1 GenomeRNAi human phenotype for BTG3:
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Btg3):
BTG3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for BTG3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Deadenylation-dependent mRNA decay | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for BTG3):
BTG3 for pathways About GeneDecksing
Interactions:
 SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BTG3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/7 Interacting proteins for BTG3 (Q142012, 3 ENSP000003446094) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
BTG3 for ontologies About GeneDecksing
|
Drugs & Compounds
for BTG3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BTG3
Search CenterWatch for drugs/clinical trials and news about BTG3
|
Transcripts
for BTG3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BTG3 gene (2 alternative transcripts): NM_001130914.1 NM_006806.4 Unigene Cluster for BTG3: BTG family, member 3 Hs.473420 [show with all ESTs]Unigene Representative Sequence: NM_0011309146 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000339775(uc002ykl.3) ENST00000348354(uc002ykk.3) ENST00000471860
ENST00000496601 ENST00000464058 ENST00000457956
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTG3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTG3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): BTG3 (NM_006806) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BTG3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTG3 |
Additional cDNA sequence: AK289408.1 BC011957.1 BT007276.1 CR457061.1 D64110.1 10 DOTS entries: DT.215678 DT.100757082 DT.100814202 DT.100814204 DT.40242889 DT.97846043 DT.100028740 DT.121139656 DT.91820940 DT.95174003 10 AceView cDNA sequences: AI648620 BC028229 BU674227 BX101397 AW665615 AI830363 BG255148 BI912970 BX404773 CB960723
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for BTG3 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for BTG3
|
Expression
for BTG3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BTG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGTTGCAAA
About this image
See BTG3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BTG3
SOURCE GeneReport for Unigene cluster: Hs.473420
UniProtKB/Swiss-Prot: BTG3_HUMAN, Q14201Tissue specificity: Ubiquitous. High expression in the ventricular zone of the developing central nervous system. Highin ovary, testis, prostate, thymus and lung
SABiosciences Expression via Pathway-Focused PCR Array including BTG3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BTG3
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG3 |
Orthologs
for BTG3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BTG3 gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.311292 |
Xenopus laevis transcribed sequence with weak similarity more |
72.47(n) |
|
AW640676.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BM265186.12 |
-- |
74.82(n) |
|
386764 BM265186.1 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
28(a) |
1 → many |
Group1.51(826082-827008) |
ENSEMBL Gene Tree for BTG3 (if available)
TreeFam Gene Tree for BTG3 (if available) |
Paralogs
for BTG3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BTG3 gene
- BTG42 TOB12 TOB22 BTG12 BTG22
3 SIMAP similar genes for BTG3 using alignment to 3 protein entries: BTG3_HUMAN (see all proteins):BTG4 BTG1 BTG2
BTG3 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for BTG3
PGOHUM00000243397 PGOHUM00000242002
|
Genomic Variants
for BTG3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BTG3 (18965968 - 18985268 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BTG3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTG3 |
|
Disorders
/ Diseases
for BTG3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BTG3 for disorders About GeneDecksing
OMIM gene information: 605674
OMIM disorders: --
11  diseases for BTG3: About MalaCardscapillariasis macular degeneration noma oral cancer
lung carcinoma influenza prostate cancer breast cancer
ataxia prostatitis carcinoma
1 Novoseek disease relationship for BTG3 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
8.26 |
3 |
19221000 (2), 19885928 (1) |
Human Genome Epidemiology (HuGE) Navigator: BTG3 (1 document)
Export disorders for BTG3 gene to outside databases
|
Publications
for BTG3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BTG3 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with BTG3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system. (PubMed id 9632145)1, 2, 3 Yoshida Y.... Yamamoto T. (1998)
- Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle. (PubMed id 9067576)1, 2, 9 Guehenneux F....Rouault J.-P. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PubMed id 11429045)1, 9 Yoshida Y....Yamamoto T. (2001)
- BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. (PubMed id 19221000)1, 9 Majid S....Dahiya R. (2009)
- Loss of the candidate tumor suppressor BTG3 triggers a cute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis. (PubMed id 22020331)1 Lin T.Y....Shieh S.Y. (2012)
- Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
|
External Searches for BTG3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BTG3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BTG3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BTG3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for BTG3 gene:
Search GeneIP for patents involving BTG3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BTG3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BTG3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BTG3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BTG3 | | | OriGene Protein Over-expression Lysate for BTG3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BTG3 | | OriGene 3'-UTR Clone for BTG3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTG3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTG3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BTG3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTG3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTG3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BTG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTG3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for BTG3 |
| |  |  |  |  | | | | |
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 | | | BTG3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG3 |
|  |  |  | | | | Search ThermoFisher Antibodies for BTG3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTG3 |
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