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BTG3 Gene

protein-coding   GIFtS: 61
GCID: GC21M018965

BTG Family, Member 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
BTG Family, Member 31 2     TOB552
ANA2 3 5     TOFA2
TOB52 3 5     B-Cell Translocation Gene 32
Abundant In Neuroepithelium Area Protein2 3     Protein BTG32
Protein Tob52 3     BTG Family Member 33
B-Cell Translocation Gene11     

External Ids:    HGNC: 11321   Entrez Gene: 109502   Ensembl: ENSG000001546407   OMIM: 6056745   UniProtKB: Q142013   

Export aliases for BTG3 gene to outside databases

Previous GC identifers: GC21M015630 GC21M017887 GC21M004351


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BTG3 Gene:
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins
that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the
central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Aug 2008)

GeneCards Summary for BTG3 Gene:
BTG3 (BTG family, member 3) is a protein-coding gene. Diseases associated with BTG3 include capillariasis, and labyrinthitis. An important paralog of this gene is BTG4.

UniProtKB/Swiss-Prot: BTG3_HUMAN, Q14201
Function: Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase

Gene Wiki entry for BTG3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  NT_187627.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the BTG3 gene promoter:
         HOXA9B   STAT1   AML1a   p53   STAT1beta   STAT5A   STAT1alpha   FOXO4   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBTG3 promoter sequence

   Search Chromatin IP Primers for BTG3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BTG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.1   Ensembl cytogenetic band:  21q21.1   HGNC cytogenetic band: 21q21.1
Nature(405: 311-319) cytogenetic band:   21q21.1
BTG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTG3 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M018965:   GeneLoc Nature:405,311-319
Start:
18,965,968 bp from pter       4,630,458 bp from centromere
End:
18,985,268 bp from pter 4,649,509 bp from centromere
Size:
19,301 bases 19,052 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: D64110
genomic clones: R877L16 R396A17


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BTG3_HUMAN, Q14201 (See protein sequence)
Recommended Name: Protein BTG3  
Size: 252 amino acids; 29116 Da
Developmental stage: Expression is cell cycle dependent with the highest levels at the end of G1 phase, peaking at
the G1-S transition
Secondary accessions: D3DSC4 Q53XV1 Q96ET7
Alternative splicing: 2 isoforms:  Q14201-1   Q14201-2   

Explore the universe of human proteins at neXtProt for BTG3: NX_Q14201

Explore proteomics data for BTG3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BTG3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001124386.1  NP_006797.3  

    ENSEMBL proteins: 
     ENSP00000344609   ENSP00000284879   ENSP00000413799  

    BTG3 Human Recombinant Protein Products:

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    Novus Biologicals BTG3 Protein
    Novus Biologicals BTG3 Lysate
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    Cloud-Clone Corp. Proteins for BTG3

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    Cloud-Clone Corp. CLIAs for BTG3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002087 Anti_prolifrtn

    Graphical View of Domain Structure for InterPro Entry Q14201

    ProtoNet protein and cluster: Q14201

    1 Blocks protein domain: IPB002087 Anti-proliferative protein

    UniProtKB/Swiss-Prot: BTG3_HUMAN, Q14201
    Similarity: Belongs to the BTG family


    BTG3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BTG3_HUMAN, Q14201
    Function: Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase

         Genatlas biochemistry entry for BTG3:
    B cell transcription gene 3,antiproliferative,predominantly expressed in
    ovary,testis,prostate,thymus,lung,putatively involved in neurogenesis in the central nervous system,Tob/BTG1
    family

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17690688
         
    BTG3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BTG3:
     Increased G1 DNA content 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Btg3):
     skeleton  tumorigenesis 

    BTG3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BTG3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BTG3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BTG3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BTG3

    miRNA
    Products:
        
    miRTarBase miRNAs that target BTG3:
    hsa-mir-106b-5p (MIRT020477), hsa-mir-340-5p (MIRT019633), hsa-mir-615-3p (MIRT039982), hsa-mir-93-5p (MIRT028053), hsa-mir-124-3p (MIRT002592), hsa-mir-130b-3p (MIRT020163)

    Block miRNA regulation of human, mouse, rat BTG3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BTG3 (see all 48):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-106a hsa-miR-139-5p hsa-miR-3074-3p hsa-miR-3653 hsa-miR-371-5p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidBTG3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BTG3
    Predesigned siRNA for gene silencing in human, mouse, rat BTG3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for BTG3

    Clone
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    OriGene ORF clones in mouse, rat for BTG3
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    GenScript: all cDNA clones in your preferred vector (see all 2): BTG3 (NM_006806)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTG3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTG3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for BTG3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular2
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA9632145

    BTG3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BTG3 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for BTG3):
        RNA degradation


    BTG3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including BTG3: 
              Leukemia in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BTG3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for BTG3 (Q142011, 2, 3 ENSP000003446094) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    E2F1Q010941, 2, 3, ENSP000003455714EBI-948192,EBI-448924 MINT-5226290 MINT-5226306 MINT-5226261 I2D: score=1 STRING: ENSP00000345571
    ATXN1P542532, 3, ENSP000002447694MINT-2868836 MINT-2868855 I2D: score=3 STRING: ENSP00000244769
    BANPQ8N9N53, ENSP000003769034I2D: score=2 STRING: ENSP00000376903
    CNOT7Q9UIV13, ENSP000003552794I2D: score=1 STRING: ENSP00000355279
    CACNA1AO005553I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008285negative regulation of cell proliferation TAS9632145
    GO:0045930negative regulation of mitotic cell cycle IDA9632145

    BTG3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BTG3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BTG3 gene (2 alternative transcripts): 
    NM_001130914.1  NM_006806.4  

    Unigene Cluster for BTG3:

    BTG family, member 3
    Hs.473420  [show with all ESTs]
    Unigene Representative Sequence: NM_001130914
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339775(uc002ykl.3) ENST00000348354(uc002ykk.3) ENST00000471860
    ENST00000496601 ENST00000464058 ENST00000457956
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BTG3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BTG3 (see all 48):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-106a hsa-miR-139-5p hsa-miR-3074-3p hsa-miR-3653 hsa-miR-371-5p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidBTG3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BTG3
    Predesigned siRNA for gene silencing in human, mouse, rat BTG3
    Clone
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    OriGene clones in human, mouse for BTG3 (see all 11)
    OriGene ORF clones in mouse, rat for BTG3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BTG3 (NM_006806)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTG3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTG3
    Primer
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    OriGene qPCR primer pairs and template standards for BTG3
    OriGene qSTAR qPCR primer pairs in human, mouse for BTG3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BTG3
      QuantiTect SYBR Green Assays in human, mouse, rat BTG3
      QuantiFast Probe-based Assays in human, mouse, rat BTG3

    Additional mRNA sequence: 

    AK289408.1 BC011957.1 BT007276.1 CR457061.1 D64110.1 

    10 DOTS entries:

    DT.215678  DT.100757082  DT.100814202  DT.100814204  DT.40242889  DT.97846043  DT.100028740  DT.121139656 
    DT.91820940  DT.95174003 

    10 AceView cDNA sequences:

    BC028229 BU674227 AI648620 BX101397 AW665615 CB960723 BI912970 AI830363 
    BG255148 BX404773 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BTG3 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c
    SP1:                    -     -                       -                 -                                 
    SP2:                                                  -                 -                                 
    SP3:                                                  -           -     -                                 
    SP4:                                                                                                      
    SP5:                                                  -     -     -     -                                 


    ECgene alternative splicing isoforms for BTG3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BTG3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTTGCAAA
    BTG3 Expression
    About this image


    BTG3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
     
     Lower Urinary Tract (Urinary System)
             Ureter
    BTG3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BTG3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473420

    UniProtKB/Swiss-Prot: BTG3_HUMAN, Q14201
    Tissue specificity: Ubiquitous. High expression in the ventricular zone of the developing central nervous system.
    High in ovary, testis, prostate, thymus and lung

        Pathway & Disease-focused RT2 Profiler PCR Array including BTG3: 
              Leukemia in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BTG3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BTG3
    QuantiTect SYBR Green Assays in human, mouse, rat BTG3
    QuantiFast Probe-based Assays in human, mouse, rat BTG3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BTG3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Btg31 , 5 B cell translocation gene 31, 5 91.4(n)1
    94.05(a)1
      16 (45.36 cM)5
    122281  NM_009770.21  NP_033900.11 
     783598605 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    31(a)
    many ↔ many
    12(3293874-3295013) ENSGALG00000004676
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    50(a)
    many ↔ many
    GL343604.1(329430-351485)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.311292 Xenopus laevis transcribed sequence with weak similarity more 72.47(n)    AW640676.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM265186.12   -- 74.82(n)   386764  BM265186.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tob6
    Tob
    11(a)
    1 → many
    X(15969396-15985528)


    ENSEMBL Gene Tree for BTG3 (if available)
    TreeFam Gene Tree for BTG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BTG3 gene
    BTG42  TOB12  TOB22  BTG12  BTG22  
    3 SIMAP similar genes for BTG3 using alignment to 3 protein entries:     BTG3_HUMAN (see all proteins):
    BTG4    BTG1    BTG2

    BTG3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for BTG3
    PGOHUM00000243397 PGOHUM00000242002


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BTG3 (see all 384)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs743827011,2
    C--18966406(+) AAAAAC/TGAAGT 2 -- ut312Minor allele frequency- T:0.01EA EU 1443
    rs1925936801,2
    C--18966545(+) TGGAAC/TAGGAG 4 I V mis10--------
    rs2001702101,2
    --18966546(+) GGAACA/GGGAGG 4 P syn10--------
    rs1825232221,2
    --18966575(+) GCCATC/TCCCTC 4 N D mis10--------
    rs58426491,2
    C--18966725(+) TAAAGACAA/-  
            
    ACAAA
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs2020934491,2
    C--18966728(-) TTTGTC/TTGTCT 2 -- int10--------
    rs2013930651,2
    --18966731(+) CAAAC-/AAAGTT 2 -- int10--------
    rs28243871,2
    C,F,O,H--18966783(+) TCAGGT/GCTAAA 2 -- int118Minor allele frequency- G:0.09NA NS EA 2336
    rs1470313161,2
    --18966945(+) TAAGGA/GCATGC 2 -- int10--------
    rs1383322481,2
    --18967021(+) AAACAC/TTGGAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for BTG3 (18965968 - 18985268 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BTG3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723192CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BTG3
    DNA2.0 Custom Variant and Variant Library Synthesis for BTG3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605674    OMIM disorders: --

    11 diseases for BTG3:    
    About MalaCards
    capillariasis    labyrinthitis    pulmonary function    oral cancer
    influenza    ataxia    prostate cancer    prostatitis
    cerebritis    breast cancer    leukemia


    BTG3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for BTG3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 8.26 3 19221000 (2), 19885928 (1)

    Genetic Association Database (GAD): BTG3
    Human Genome Epidemiology (HuGE) Navigator: BTG3 (1 document)

    Export disorders for BTG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BTG3 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with BTG3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system. (PubMed id 9632145)1, 2, 3 Yoshida Y.... Yamamoto T. (Oncogene 1998)
    2. Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle. (PubMed id 9067576)1, 2, 9 Guehenneux F....Rouault J.-P. (Leukemia 1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PubMed id 11429045)1, 9 Yoshida Y....Yamamoto T. (Jpn. J. Cancer Res. 2001)
    5. BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. (PubMed id 19221000)1, 9 Majid S....Dahiya R. (Carcinogenesis 2009)
    6. Decreased expression of BTG3 was linked to carcinogenesis, aggressiveness, and prognosis of ovarian carcinoma. (PubMed id 23657964)1 Deng B....Zheng H. (Tumour Biol. 2013)
    7. Downregulation of BTG3 in non-small cell lung cancer. (PubMed id 23810394)1 Chen X....Wei S. (Biochem. Biophys. Res. Commun. 2013)
    8. Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1. (PubMed id 23533280)1 Cheng Y.C....Shieh S.Y. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    9. Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis. (PubMed id 22020331)1 Lin T.Y....Shieh S.Y. (Oncogene 2012)
    10. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (Hum. Mol. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10950 HGNC: 1132 AceView: BTG3.1 Ensembl:ENSG00000154640 euGenes: HUgn10950
    ECgene: BTG3 Kegg: 10950 H-InvDB: BTG3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BTG3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BTG3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BTG3 gene:
    Search GeneIP for patents involving BTG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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