Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BTG3 Gene

Aliases for BTG3 Gene

  • BTG Anti-Proliferation Factor 3 2 3 5
  • BTG Family Member 3 2 3 4
  • Abundant In Neuroepithelium Area Protein 3 4
  • Protein Tob5 3 4
  • TOB5 3 4
  • ANA 3 4
  • B-Cell Translocation Gene 3 3
  • BTG Family, Member 3 2
  • Protein BTG3 3
  • APRO4 3
  • TOB55 3
  • TOFA 3

External Ids for BTG3 Gene

Previous GeneCards Identifiers for BTG3 Gene

  • GC21M015630
  • GC21M017887
  • GC21M018965
  • GC21M004351

Summaries for BTG3 Gene

Entrez Gene Summary for BTG3 Gene

  • The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for BTG3 Gene

BTG3 (BTG Anti-Proliferation Factor 3) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. An important paralog of this gene is BTG4.

UniProtKB/Swiss-Prot for BTG3 Gene

  • Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.

Gene Wiki entry for BTG3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTG3 Gene

Genomics for BTG3 Gene

Regulatory Elements for BTG3 Gene

Enhancers for BTG3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F017660 0.6 ENCODE 16.2 -47.7 -47708 0.2 CEBPB BTG3 ENSG00000226956 GC21M017663
GH21F017779 0.9 FANTOM5 Ensembl ENCODE 5.4 -170.8 -170808 8.7 HDGF TBP TBL1XR1 WRNIP1 BMI1 YY1 CBX5 ZNF143 ETV6 FOS C21orf91-OT1 C21orf91 BTG3 LOC105372741
GH21F017607 1.4 Ensembl ENCODE 5.3 +4.9 4875 1.9 TRIM28 BTG3 ENSG00000280594 ENSG00000199962
GH21F017610 0.6 ENCODE 0.8 +0.8 799 3.4 ATF1 BRCA1 YY1 GLIS2 ELK1 CBX5 ZNF207 FOS GTF2B JUNB BTG3 GC21P017612
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BTG3 on UCSC Golden Path with GeneCards custom track

Promoters for BTG3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000185373 949 3200 ATF1 BRCA1 YY1 ELK1 CBX5 FOS GTF2B JUNB TSHZ1 TBX21

Genomic Location for BTG3 Gene

Chromosome:
21
Start:
17,593,650 bp from pter
End:
17,612,950 bp from pter
Size:
19,301 bases
Orientation:
Minus strand

Genomic View for BTG3 Gene

Genes around BTG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTG3 Gene

Proteins for BTG3 Gene

  • Protein details for BTG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14201-BTG3_HUMAN
    Recommended name:
    Protein BTG3
    Protein Accession:
    Q14201
    Secondary Accessions:
    • D3DSC4
    • Q53XV1
    • Q96ET7

    Protein attributes for BTG3 Gene

    Size:
    252 amino acids
    Molecular mass:
    29116 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTG3 Gene

Post-translational modifications for BTG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTG3 Gene

No data available for DME Specific Peptides for BTG3 Gene

Domains & Families for BTG3 Gene

Gene Families for BTG3 Gene

Protein Domains for BTG3 Gene

Suggested Antigen Peptide Sequences for BTG3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14201

UniProtKB/Swiss-Prot:

BTG3_HUMAN :
  • Belongs to the BTG family.
Family:
  • Belongs to the BTG family.
genes like me logo Genes that share domains with BTG3: view

Function for BTG3 Gene

Molecular function for BTG3 Gene

GENATLAS Biochemistry:
B cell transcription gene 3,antiproliferative,predominantly expressed in ovary,testis,prostate,thymus,lung,putatively involved in neurogenesis in the central nervous system,Tob/BTG1 family
UniProtKB/Swiss-Prot Function:
Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.

Gene Ontology (GO) - Molecular Function for BTG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17690688
genes like me logo Genes that share ontologies with BTG3: view

Phenotypes for BTG3 Gene

genes like me logo Genes that share phenotypes with BTG3: view

Animal Models for BTG3 Gene

MGI Knock Outs for BTG3:

Animal Model Products

  • Taconic Biosciences Mouse Models for BTG3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BTG3 Gene

Localization for BTG3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTG3 Gene COMPARTMENTS Subcellular localization image for BTG3 gene
Compartment Confidence
cytosol 3
extracellular 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for BTG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 9632145
genes like me logo Genes that share ontologies with BTG3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BTG3 Gene

Pathways & Interactions for BTG3 Gene

SuperPathways for BTG3 Gene

SuperPathway Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with BTG3: view

Pathways by source for BTG3 Gene

1 KEGG pathway for BTG3 Gene

Gene Ontology (GO) - Biological Process for BTG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS 9632145
GO:0045930 negative regulation of mitotic cell cycle IDA 9632145
genes like me logo Genes that share ontologies with BTG3: view

No data available for SIGNOR curated interactions for BTG3 Gene

Transcripts for BTG3 Gene

mRNA/cDNA for BTG3 Gene

Unigene Clusters for BTG3 Gene

BTG family, member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTG3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - - - -
SP2: - -
SP3: - - -
SP4:
SP5: - - - -
SP6:
SP7:

Relevant External Links for BTG3 Gene

GeneLoc Exon Structure for
BTG3
ECgene alternative splicing isoforms for
BTG3

Expression for BTG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BTG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BTG3 Gene

This gene is overexpressed in Spinal cord (38.5), CD8 Tcells (15.9), Urinary Bladder (7.8), and Retina (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BTG3 Gene



Protein tissue co-expression partners for BTG3 Gene

NURSA nuclear receptor signaling pathways regulating expression of BTG3 Gene:

BTG3

SOURCE GeneReport for Unigene cluster for BTG3 Gene:

Hs.473420

mRNA Expression by UniProt/SwissProt for BTG3 Gene:

Q14201-BTG3_HUMAN
Tissue specificity: Ubiquitous. High expression in the ventricular zone of the developing central nervous system. High in ovary, testis, prostate, thymus and lung.
genes like me logo Genes that share expression patterns with BTG3: view

Primer Products

No data available for mRNA differential expression in normal tissues for BTG3 Gene

Orthologs for BTG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BTG3 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia BTG3 35
  • 98 (a)
OneToOne
LOC487695 34
  • 93.92 (n)
mouse
(Mus musculus)
Mammalia Gm7334 35
  • 94 (a)
OneToMany
Btg3 34 16 35
  • 91.4 (n)
cow
(Bos Taurus)
Mammalia BTG3 34 35
  • 92.46 (n)
rat
(Rattus norvegicus)
Mammalia Btg3 34
  • 90.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BTG3 35
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 34 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 50 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia btg3 34
  • 61.92 (n)
Str.6608 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.31129 34
zebrafish
(Danio rerio)
Actinopterygii btg3 34 35
  • 65.03 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Tob 35
  • 11 (a)
OneToMany
Species where no ortholog for BTG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTG3 Gene

ENSEMBL:
Gene Tree for BTG3 (if available)
TreeFam:
Gene Tree for BTG3 (if available)

Paralogs for BTG3 Gene

Paralogs for BTG3 Gene

(3) SIMAP similar genes for BTG3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for BTG3 Gene

genes like me logo Genes that share paralogs with BTG3: view

Variants for BTG3 Gene

Sequence variations from dbSNP and Humsavar for BTG3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs10685951 -- 17,614,113(+) AAAAA(-/A/AA)AAAAA intron-variant, upstream-variant-2KB
rs111268387 -- 17,594,186(+) CGATA(A/C/T)GGTTT intron-variant, reference, synonymous-codon, utr-variant-3-prime
rs111419352 -- 17,598,178(+) GACAA(C/T)GTTTC intron-variant
rs111446804 -- 17,609,245(+) CTCCC(C/G)TTCCT intron-variant
rs111838240 -- 17,607,399(+) AAAAA(A/T)TTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTG3 Gene

Variant ID Type Subtype PubMed ID
dgv4391n100 CNV gain 25217958
esv2723192 CNV deletion 23290073
esv3575381 CNV gain 25503493
esv3893382 CNV gain 25118596

Variation tolerance for BTG3 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BTG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTG3 Gene

Disorders for BTG3 Gene

Relevant External Links for BTG3

Genetic Association Database (GAD)
BTG3
Human Genome Epidemiology (HuGE) Navigator
BTG3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BTG3

No disorders were found for BTG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTG3 Gene

Publications for BTG3 Gene

  1. ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system. (PMID: 9632145) Yoshida Y. … Yamamoto T. (Oncogene 1998) 2 3 4 64
  2. Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle. (PMID: 9067576) Guehenneux F. … Rouault J.-P. (Leukemia 1997) 3 4 22 64
  3. BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. (PMID: 19221000) Majid S. … Dahiya R. (Carcinogenesis 2009) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PMID: 11429045) Yoshida Y. … Yamamoto T. (Jpn. J. Cancer Res. 2001) 3 22 64

Products for BTG3 Gene

Sources for BTG3 Gene

Content
Loading form....