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Aliases for BTG2 Gene

Aliases for BTG2 Gene

  • BTG Family Member 2 2 3 4 5
  • NGF-Inducible Anti-Proliferative Protein PC3 2 3 4
  • Nerve Growth Factor-Inducible Anti-Proliferative 2 3
  • B-Cell Translocation Gene 2 2 3
  • Pheochromacytoma Cell-3 2 3
  • BTG Family, Member 2 2 3
  • PC3 3 4
  • TIS21 3

External Ids for BTG2 Gene

Previous GeneCards Identifiers for BTG2 Gene

  • GC01P200954
  • GC01P198712
  • GC01P199741
  • GC01P200562
  • GC01P200006
  • GC01P201542
  • GC01P203274
  • GC01P174439

Summaries for BTG2 Gene

Entrez Gene Summary for BTG2 Gene

  • The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for BTG2 Gene

BTG2 (BTG Family Member 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Spinal Cord Injury. GO annotations related to this gene include transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is TOB1.

UniProtKB/Swiss-Prot for BTG2 Gene

  • Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.

Gene Wiki entry for BTG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTG2 Gene

Genomics for BTG2 Gene

Regulatory Elements for BTG2 Gene

Promoters for BTG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BTG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BTG2 Gene

Chromosome:
1
Start:
203,305,491 bp from pter
End:
203,309,602 bp from pter
Size:
4,112 bases
Orientation:
Plus strand

Genomic View for BTG2 Gene

Genes around BTG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTG2 Gene

Proteins for BTG2 Gene

  • Protein details for BTG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78543-BTG2_HUMAN
    Recommended name:
    Protein BTG2
    Protein Accession:
    P78543
    Secondary Accessions:
    • A0A024R986
    • Q3KR25
    • Q5VUT0

    Protein attributes for BTG2 Gene

    Size:
    158 amino acids
    Molecular mass:
    17416 Da
    Quaternary structure:
    • Interacts with PRKCABP (By similarity). Interacts with CNOT7 and CNOT8; indicative for an asscociation with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization.

    Three dimensional structures from OCA and Proteopedia for BTG2 Gene

neXtProt entry for BTG2 Gene

Proteomics data for BTG2 Gene at MOPED

Post-translational modifications for BTG2 Gene

  • Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BTG2 Gene

Domains & Families for BTG2 Gene

Protein Domains for BTG2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BTG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78543

UniProtKB/Swiss-Prot:

BTG2_HUMAN :
  • Belongs to the BTG family.
Family:
  • Belongs to the BTG family.
genes like me logo Genes that share domains with BTG2: view

No data available for Gene Families for BTG2 Gene

Function for BTG2 Gene

Molecular function for BTG2 Gene

GENATLAS Biochemistry:
B cell transition gene 2,preferentially expressed in quiescent cells,antiproliferative p53 dependent component of the DNA damage cellular response pathway,homolog to murine Pc3/Tis21 and human BTG1 (see symbol),at the onset of neurogenesis in single neuroepithelial cells that switch from proliferative to neuron-generating division,Tob/BTG1 family
UniProtKB/Swiss-Prot Function:
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.
genes like me logo Genes that share phenotypes with BTG2: view

Animal Models for BTG2 Gene

MGI Knock Outs for BTG2:

Animal Model Products

miRNA for BTG2 Gene

miRTarBase miRNAs that target BTG2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BTG2 Gene

Localization for BTG2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTG2 Gene COMPARTMENTS Subcellular localization image for BTG2 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
mitochondrion 2
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BTG2 Gene

Pathways & Interactions for BTG2 Gene

genes like me logo Genes that share pathways with BTG2: view

Gene Ontology (GO) - Biological Process for BTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006281 DNA repair TAS 8944033
GO:0006479 protein methylation IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 8944033
GO:0008306 associative learning IEA --
genes like me logo Genes that share ontologies with BTG2: view

No data available for SIGNOR curated interactions for BTG2 Gene

Drugs & Compounds for BTG2 Gene

(1) Drugs for BTG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for BTG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BTG2: view

Transcripts for BTG2 Gene

mRNA/cDNA for BTG2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(470) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTG2 Gene

BTG family, member 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTG2 Gene

No ASD Table

Relevant External Links for BTG2 Gene

GeneLoc Exon Structure for
BTG2
ECgene alternative splicing isoforms for
BTG2

Expression for BTG2 Gene

mRNA expression in normal human tissues for BTG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTG2 Gene

This gene is overexpressed in Fallopian Tube (x4.2).

SOURCE GeneReport for Unigene cluster for BTG2 Gene Hs.519162

genes like me logo Genes that share expression patterns with BTG2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BTG2 Gene

Orthologs for BTG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTG2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BTG2 35
  • 88.67 (n)
  • 91.33 (a)
BTG2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTG2 35
  • 90.72 (n)
  • 90.51 (a)
BTG2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btg2 35
  • 89.87 (n)
  • 93.67 (a)
Btg2 16
Btg2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BTG2 35
  • 99.79 (n)
  • 100 (a)
BTG2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btg2 35
  • 89.66 (n)
  • 92.41 (a)
oppossum
(Monodelphis domestica)
Mammalia BTG2 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves BTG2 35
  • 80.38 (n)
  • 82.28 (a)
BTG2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTG2 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btg2 35
  • 61.45 (n)
  • 65.31 (a)
MGC75753 35
zebrafish
(Danio rerio)
Actinopterygii btg2 35
  • 65.19 (n)
  • 61.39 (a)
btg2 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tob 36
  • 10 (a)
OneToMany
Species with no ortholog for BTG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTG2 Gene

ENSEMBL:
Gene Tree for BTG2 (if available)
TreeFam:
Gene Tree for BTG2 (if available)

Paralogs for BTG2 Gene

Paralogs for BTG2 Gene

(5) SIMAP similar genes for BTG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BTG2: view

Variants for BTG2 Gene

Sequence variations from dbSNP and Humsavar for BTG2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12039961 - 203,307,418(+) ACTAC(A/G)TGATG reference, missense
rs1130691 -- 203,309,486(+) CTATT(C/T)TGACA utr-variant-3-prime
rs1804734 -- 203,309,478(+) TTTGT(A/G)AGCTA utr-variant-3-prime
rs1804735 -- 203,309,343(+) CCTCA(C/T)GGTCT utr-variant-3-prime
rs1804736 -- 203,309,264(+) TTGAA(A/G)CAAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BTG2 Gene

Variant ID Type Subtype PubMed ID
esv2721696 CNV Deletion 23290073

Variation tolerance for BTG2 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTG2 Gene

HapMap Linkage Disequilibrium report
BTG2
Human Gene Mutation Database (HGMD)
BTG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTG2 Gene

Disorders for BTG2 Gene

Relevant External Links for BTG2

Genetic Association Database (GAD)
BTG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BTG2

No disorders were found for BTG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTG2 Gene

Publications for BTG2 Gene

  1. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. (PMID: 8944033) Rouault J.-P. … Puisieux A. (Nat. Genet. 1996) 2 3 4 23 67
  2. Skp2 enhances polyubiquitination and degradation of TIS21/BTG2/PC3, tumor suppressor protein, at the downstream of FoxM1. (PMID: 19615363) Park T.J. … Lim I.K. (Exp. Cell Res. 2009) 3 23
  3. Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen receptor-alpha and the REA corepressor. (PMID: 19117054) Karmakar S. … Smith C.L. (Int. J. Cancer 2009) 3 23
  4. Up-regulation of the BTG2 gene in TPA- or RA-treated HL-60 cell lines. (PMID: 18288394) Cho B.O. … Park J.C. (Oncol. Rep. 2008) 3 23
  5. The BTG2 protein is a general activator of mRNA deadenylation. (PMID: 18337750) Mauxion F. … Seraphin B. (EMBO J. 2008) 3 23

Products for BTG2 Gene

Sources for BTG2 Gene

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