Aliases for BTG2 Gene
External Ids for BTG2 Gene
Previous GeneCards Identifiers for BTG2 Gene
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]
GeneCards Summary for BTG2 Gene
BTG2 (BTG Anti-Proliferation Factor 2) is a Protein Coding gene. Diseases associated with BTG2 include Estrogen-Receptor Positive Breast Cancer. Among its related pathways are p53 Pathway (RnD) and TP53 Regulates Transcription of Cell Cycle Genes. GO annotations related to this gene include transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is BTG1.
UniProtKB/Swiss-Prot for BTG2 Gene
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.