Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BTG2 Gene

protein-coding   GIFtS: 59
GCID: GC01P203274

BTG Family, Member 2

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
BTG Family, Member 21 2     Pheochromacytoma Cell-31 2
NGF-Inducible Anti-Proliferative Protein PC31 2 3     TIS212
PC32 3 5     Protein BTG22
B-Cell Translocation Gene 21 2     BTG Family Member 23
Nerve Growth Factor-Inducible Anti-Proliferative1 2     

External Ids:    HGNC: 11311   Entrez Gene: 78322   Ensembl: ENSG000001593887   OMIM: 6015975   UniProtKB: P785433   

Export aliases for BTG2 gene to outside databases

Previous GC identifers: GC01P200954 GC01P198712 GC01P199741 GC01P200562 GC01P200006 GC01P201542 GC01P174439


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for BTG2 Gene:
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins
that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S
transition of the cell cycle. (provided by RefSeq, Jul 2008)

GeneCards Summary for BTG2 Gene:
BTG2 (BTG family, member 2) is a protein-coding gene. Diseases associated with BTG2 include atrophy of prostate, and advanced sleep phase syndrome. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is BTG4.

UniProtKB/Swiss-Prot: BTG2_HUMAN, P78543
Function: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the
CCR4-NOT complex. Activates mRNA deadenyltion in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit
deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth
arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation
mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth

Gene Wiki entry for BTG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the BTG2 gene promoter:
         SRF   STAT1   p53   SRF (504 AA)   STAT1beta   NF-kappaB   NF-kappaB1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBTG2 promoter sequence
   Search Chromatin IP Primers for BTG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BTG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

BTG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTG2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P203274:  view genomic region     (about GC identifiers)

Start:
203,274,619 bp from pter      End:
203,278,730 bp from pter
Size:
4,112 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BTG2_HUMAN, P78543 (See protein sequence)
Recommended Name: Protein BTG2  
Size: 158 amino acids; 17416 Da
Subunit: Interacts with PRKCABP (By similarity). Interacts with CNOT7 and CNOT8; indicative for an asscociation
with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization
2 PDB 3D structures from and Proteopedia for BTG2:
3DJU (3D)        3E9V (3D)    
Secondary accessions: Q3KR25 Q5VUT0

Explore the universe of human proteins at neXtProt for BTG2: NX_P78543

Explore proteomics data for BTG2 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and
    mitochondrial depolarization1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BTG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006754.1  
    ENSEMBL proteins: 
     ENSP00000433553   ENSP00000290551  

    BTG2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BTG2
    OriGene Protein Over-expression Lysate for BTG2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for BTG2
    GenScript Custom Purified and Recombinant Proteins Services for BTG2
    Novus Biologicals BTG2 Proteins
    Novus Biologicals BTG2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BTG2

    BTG2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for BTG2
    OriGene Custom Antibody Services for BTG2
    Novus Biologicals BTG2 Antibodies
    Abcam antibodies for BTG2
    Cloud-Clone Corp. Antibodies for BTG2
    ThermoFisher Antibodies for BTG2
    LSBio Antibodies in human, mouse, rat for BTG2

    BTG2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BTG2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BTG2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BTG2
    Cloud-Clone Corp. CLIAs for BTG2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR002087 Anti_prolifrtn

    Graphical View of Domain Structure for InterPro Entry P78543

    ProtoNet protein and cluster: P78543

    1 Blocks protein domain: IPB002087 Anti-proliferative protein

    UniProtKB/Swiss-Prot: BTG2_HUMAN, P78543
    Similarity: Belongs to the BTG family


    BTG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BTG2_HUMAN, P78543
    Function: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the
    CCR4-NOT complex. Activates mRNA deadenyltion in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit
    deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth
    arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation
    mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth

         Genatlas biochemistry entry for BTG2:
    B cell transition gene 2,preferentially expressed in quiescent cells,antiproliferative p53 dependent component of
    the DNA damage cellular response pathway,homolog to murine Pc3/Tis21 and human BTG1 (see symbol),at the onset of
    neurogenesis in single neuroepithelial cells that switch from proliferative to neuron-generating
    division,Tob/BTG1 family

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0005515protein binding IPI11136725
         
    BTG2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Btg2):
     nervous system  skeleton 

    BTG2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Btg2tm1Spo for BTG2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BTG2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BTG2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BTG2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BTG2

    miRNA
    Products:
        
    miRTarBase miRNAs that target BTG2:
    hsa-mir-101-3p (MIRT027327), hsa-mir-7-5p (MIRT025795), hsa-let-7b-5p (MIRT052067), hsa-mir-21-5p (MIRT002416), hsa-mir-26b-5p (MIRT029618), hsa-mir-16-5p (MIRT031792)

    Block miRNA regulation of human, mouse, rat BTG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BTG2 (see all 94):
    hsa-miR-548j hsa-miR-579 hsa-miR-146a hsa-miR-15a hsa-miR-218-1* hsa-miR-128 hsa-miR-4267 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidBTG2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BTG2
    Predesigned siRNA for gene silencing in human, mouse, rat BTG2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BTG2

    Clone
    Products:
         
    OriGene clones in human, mouse for BTG2 (see all 7)
    OriGene ORF clones in mouse, rat for BTG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BTG2 (NM_006763)
    Sino Biological Human cDNA Clone for BTG2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTG2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BTG2
    Browse ESI BIO Cell Lines and PureStem Progenitors for BTG2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular2
    nucleus2
    lysosome1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070062extracellular vesicular exosome IDA19056867

    BTG2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for BTG2 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.48
    2Cyclins and Cell Cycle Regulation
    Cell Cycle Control by BTG Proteins0.36
    3Spinal Cord Injury
    Spinal Cord Injury
    4Direct p53 effectors
    Direct p53 effectors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for BTG2
        Cell Cycle Control by BTG Proteins

    2 BioSystems Pathways for BTG2
        Spinal Cord Injury
    Direct p53 effectors



    1 Kegg Pathway  (Kegg details for BTG2):
        RNA degradation


    BTG2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BTG2: 
              Nephrotoxicity in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Hepatotoxicity in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BTG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for BTG2 (P785431, 2, 3 ENSP000002905514) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNOT8Q9UFF91, 3, ENSP000002858964EBI-1047576,EBI-742299 I2D: score=4 STRING: ENSP00000285896
    CNOT7Q9UIV11, 3, ENSP000003552794EBI-1047576,EBI-2105113 I2D: score=3 STRING: ENSP00000355279
    POPDC2Q9HBU92, 3, ENSP000002642314MINT-6544482 I2D: score=1 STRING: ENSP00000264231
    CNOT1A5YKK63, ENSP000003209494STRING: ENSP00000320949 I2D: score=2 
    CNOT6LQ96LI53, ENSP000002649034I2D: score=2 STRING: ENSP00000264903
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS8944033
    GO:0006479protein methylation IEA--
    GO:0006974cellular response to DNA damage stimulus IDA8944033
    GO:0008285negative regulation of cell proliferation IMP--
    GO:0008306associative learning IEA--

    BTG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BTG2

    2 Novoseek inferred chemical compound relationships for BTG2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 16.6 12 19117054 (2), 15378000 (2), 16849553 (1), 11136725 (1)
    oligonucleotide 0 1 12470596 (1)



    BTG2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BTG2 gene: 
    NM_006763.2  

    Unigene Cluster for BTG2:

    BTG family, member 2
    Hs.519162  [show with all ESTs]
    Unigene Representative Sequence: NM_006763
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475157 ENST00000290551(uc001gzq.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BTG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BTG2 (see all 94):
    hsa-miR-548j hsa-miR-579 hsa-miR-146a hsa-miR-15a hsa-miR-218-1* hsa-miR-128 hsa-miR-4267 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidBTG2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BTG2
    Predesigned siRNA for gene silencing in human, mouse, rat BTG2
    Clone
    Products:
         
    OriGene clones in human, mouse for BTG2 (see all 7)
    OriGene ORF clones in mouse, rat for BTG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BTG2 (NM_006763)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTG2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BTG2
    OriGene qSTAR qPCR primer pairs in human, mouse for BTG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BTG2
      QuantiTect SYBR Green Assays in human, mouse, rat BTG2
      QuantiFast Probe-based Assays in human, mouse, rat BTG2

    Additional mRNA sequence: 

    BC105948.1 BC105949.1 U72649.1 Y09943.1 

    10 DOTS entries:

    DT.444301  DT.100854554  DT.100789605  DT.100789607  DT.101975460  DT.97760005  DT.100730619  DT.100775835 
    DT.95122825  DT.95166015 

    Selected AceView cDNA sequences (see all 470):

    BQ071990 AA128906 BU741862 T32412 BU633190 AA662709 AI766364 AI356112 
    BE465354 BM996280 BQ062439 AA505284 BU145947 AA504880 CA442655 AW631446 
    AA693674 BQ057115 BM678134 BU150495 AA505981 BM662824 AL553608 AW263342 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BTG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTAATCTTG
    BTG2 Expression
    About this image


    BTG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced 7SMOO32 cells
     
     Thymus (Hematopoietic System)
             Double Negative 3 Thymocytes Thymus
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
    BTG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BTG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519162
        Pathway & Disease-focused RT2 Profiler PCR Arrays including BTG2: 
              Nephrotoxicity in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Hepatotoxicity in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BTG2
    OriGene qSTAR qPCR primer pairs in human, mouse for BTG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BTG2
    QuantiTect SYBR Green Assays in human, mouse, rat BTG2
    QuantiFast Probe-based Assays in human, mouse, rat BTG2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for BTG2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Btg21 , 5 B cell translocation gene 2, anti-proliferative1, 5 89.87(n)1
    93.67(a)1
      1 (58.10 cM)5
    122271  NM_007570.21  NP_031596.11 
     1340751705 
    chicken
    (Gallus gallus)
    Aves BTG21 BTG family, member 2 80.38(n)
    82.28(a)
      419932  XM_418053.4  XP_418053.3 
    lizard
    (Anolis carolinensis)
    Reptilia BTG26
    BTG family, member 2
    74(a)
    1 ↔ 1
    4(118853386-118857385)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC757532 hypothetical protein MGC75753 71.5(n)    BC059748.1 
    zebrafish
    (Danio rerio)
    Actinopterygii btg21 B-cell translocation gene 2 65.19(n)
    61.39(a)
      30079  NM_130922.2  NP_570997.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tob6
    Tob
    10(a)
    1 → many
    X(15969396-15985528)


    ENSEMBL Gene Tree for BTG2 (if available)
    TreeFam Gene Tree for BTG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for BTG2 gene
    BTG42  TOB12  TOB22  BTG12  BTG32  
    5 SIMAP similar genes for BTG2 using alignment to 1 protein entry:     BTG2_HUMAN:
    BTG1    TOB1    TOB2    BTG3    BTG4

    BTG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BTG2 (see all 66)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1443598131,2
    C,F--203276470(+) GCCCCA/CCTGGC 2 P syn11Minor allele frequency- C:0.00NA 4502
    rs1425533401,2
    C,F--203276476(+) CTGGCC/TGCCTC 2 A syn11Minor allele frequency- T:0.00NA 4480
    rs1995652981,2
    --203276511(+) CCAAGA/TGCTGC 2 E V mis10--------
    rs1838204791,2
    --203276528(+) GGAGCA/GGCCCC 2 S G mis10--------
    rs120399611,2,,4
    C,F,H--203276546(+) ACTACG/ATGATG 2 /M /V mis1 ese313Minor allele frequency- A:0.00NS EA NA EU 6437
    rs2014621151,2
    --203276580(+) GCCCCC/GGCCCT 1 -- ut310--------
    rs1405612431,2
    --203276651(+) CTGTAC/TTTTTA 1 -- ut310--------
    rs1458835161,2
    --203276730(+) AAGAAA/GAAAAA 1 -- ut310--------
    rs120637291,2
    C--203276998(+) CTCCCC/GCAGCC 1 -- ut31 ese35Minor allele frequency- G:0.12NA CSA WA EA 361
    rs120854171,2
    C,F,H--203277053(+) GCCTGA/GACTTA 1 -- ut31 ese330Minor allele frequency- N:0.00NS EA NA WA 3402

    HapMap Linkage Disequilibrium report for BTG2 (203274619 - 203278730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BTG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721696CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BTG2
    DNA2.0 Custom Variant and Variant Library Synthesis for BTG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601597    OMIM disorders: --

    19 diseases for BTG2:    
    About MalaCards
    atrophy of prostate    advanced sleep phase syndrome    chronic pain    clear cell renal cell carcinoma
    nicotine dependence    laryngeal carcinoma    renal cell carcinoma    laryngitis
    spinal cord injury    medulloblastoma    prostatitis    prostate cancer
    neuroblastoma    cerebritis    hepatocellular carcinoma    breast cancer
    lung cancer    neuronitis    leukemia


    BTG2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for BTG2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperalgesia 34.4 2 8544993 (1), 16110328 (1)
    breast carcinoma 28.6 5 16849553 (2), 16418486 (1)
    tumors 11.6 21 16456675 (4), 16849553 (2), 11470758 (2), 16418486 (2) (see all 8)
    atrophy 0 2 11470758 (1)
    cancer lung 0 1 9766435 (1)
    inflammation 0 2 16110328 (1), 12890505 (1)
    breast cancer 0 10 15378000 (4), 16849553 (2), 19117054 (1)
    prostate cancer 0 2 11470758 (2)
    cancer 0 5 16456675 (2), 9766435 (1), 19551855 (1)

    Genetic Association Database (GAD): BTG2

    Export disorders for BTG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BTG2 gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with BTG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. (PubMed id 8944033)1, 2, 3, 9 Rouault J.-P....Puisieux A. (Nat. Genet. 1996)
    2. Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity. (PubMed id 18974182)1, 2, 9 Yang X.... Rao Z. (Nucleic Acids Res. 2008)
    3. The BTG2 protein is a general activator of mRNA deadenylation. (PubMed id 18337750)1, 2, 9 Mauxion F.... Seraphin B. (EMBO J. 2008)
    4. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. (PubMed id 11136725)1, 2, 9 Prevot D.... Corbo L. (J. Biol. Chem. 2001)
    5. BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms. (PubMed id 12771185)1, 2, 9 Morel A.-P.... Corbo L. (J. Cell Sci. 2003)
    6. PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells. (PubMed id 18773938)1, 2 Miyata S.... Tohyama M. (Neurosci. Lett. 2008)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death. (PubMed id 15788397)1, 2 Hong J.W.... Lim I.K. (J. Biol. Chem. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene. (PubMed id 11814693)1, 2 Duriez C.... Puisieux A. (Gene 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7832 HGNC: 1131 AceView: BTG2 Ensembl:ENSG00000159388 euGenes: HUgn7832
    ECgene: BTG2 Kegg: 7832 H-InvDB: BTG2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BTG2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BTG2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BTG2 gene:
    Search GeneIP for patents involving BTG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for BTG2   OriGene RNAi products in human, mouse, rat for BTG2  
     OriGene qPCR primer pairs and template standards for BTG2   OriGene Protein Over-expression Lysate for BTG2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for BTG2  
     OriGene qSTAR qPCR primer pairs in human, mouse for BTG2   OriGene Purified Protein for BTG2  
     OriGene ORF clones in mouse, rat for BTG2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BTG2   OriGene Custom Protein Services for BTG2  

     
     
     Block miRNA regulation of human, mouse, rat BTG2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BTG2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BTG2 Predesigned siRNA for gene silencing in human, mouse, rat BTG2
     QuantiFast Probe-based Assays in human, mouse, rat BTG2 QuantiTect SYBR Green Assays in human, mouse, rat BTG2
     PCR Arrays including human, mouse, rat BTG2 Search Chromatin IP Primers for BTG2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BTG2  GeneGlobe Interaction Network for BTG2
     Regulatory tfbs in BTG2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for BTG2 GenScript cDNA clones with any tag delivered in your preferred vector for BTG2
     GenScript Custom Assay Services for BTG2 GenScript Custom overexpressing Cell Line Services for BTG2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for BTG2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for BTG2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BTG2 antibodies
     BTG2 proteins
     BTG2 lysates
     Antibodies for BTG2
     See all of Abcam's Antibodies, Kits and Proteins for BTG2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for BTG2
     Antibodies for BTG2
     ELISAs for BTG2
     CLIAs for BTG2



     Browse ESI BIO Cell Lines and PureStem Progenitors for BTG2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG2
     SwitchGear 3'UTR luciferase reporter plasmids for BTG2
     SwitchGear Promoter luciferase reporter plasmids for BTG2
     ThermoFisher Antibodies for BTG2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTG2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BTG2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BTG2
     LSBio Antibodies in human, mouse, rat for BTG2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BTG2 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4