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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BTG2 Gene

protein-coding   GIFtS: 56
GCID: GC01P203274

BTG family, member 2
 Explore 23 diseases affiliated with
BTG2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BTG2    

Aliases
for BTG2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
BTG Family, Member 21 2     B-Cell Translocation Gene 22
PC31 2 3 5     Nerve Growth Factor-Inducible Anti-Proliferative2
TIS211 2     Pheochromacytoma Cell-32
NGF-Inducible Anti-Proliferative Protein PC32 3     Protein BTG22
MGC1260631     BTG Family Member 23
MGC1260641     

External Ids:    HGNC: 11311   Entrez Gene: 78322   Ensembl: ENSG000001593887   OMIM: 6015975   UniProtKB: P785433   

Export aliases for BTG2 gene to outside databases

Previous GC identifers: GC01P200954 GC01P198712 GC01P199741 GC01P200562 GC01P200006 GC01P201542 GC01P174439


Summaries
for BTG2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BTG2:
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that
appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition
of the cell cycle. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BTG2_HUMAN, P78543
Function: Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal
precursors (By similarity). Anti-proliferative protein. Modulates transcription regulation mediated by ESR1. Involved
in mitochondrial depolarization and neurite outgrowth

Gene Wiki entry for BTG2


Genomic Views
for BTG2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BTG2 gene promoter:
         SRF   STAT1   p53   SRF (504 AA)   STAT1beta   NF-kappaB   NF-kappaB1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BTG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BTG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

BTG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTG2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P203274:  view genomic region     (about GC identifiers)

Start:
 203,274,619 bp from pter      End:
 203,278,730 bp from pter
Size:
 4,112 bases      Orientation:
 plus strand

Proteins
for BTG2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BTG2_HUMAN, P78543 (See protein sequence)
Recommended Name: Protein BTG2  
Size: 158 amino acids; 17416 Da
Subunit: Interacts with PRKCABP (By similarity). Binds the CCR4-NOT complex. Interacts with PIN1, inducing
mitochondrial depolarization
2 PDB 3D structures from and Proteopedia for BTG2:
3DJU (3D)        3E9V (3D)    
Secondary accessions: Q3KR25 Q5VUT0

Explore the universe of human proteins at neXtProt for BTG2: NX_P78543

Post-translational modifications:

  • Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and
    • mitochondrial depolarization1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P78543

    • BTG2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006754.1  
    ENSEMBL proteins: 
     ENSP00000433553   ENSP00000290551  

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    Uscn Proteins for BTG2


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    Uscn ELISAs and CLIAs for BTG2

    Protein Domains /
    Families
    for BTG2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BTG2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002087 Anti_prolifrtn

    Graphical View of Domain Structure for InterPro Entry P78543

    ProtoNet protein and cluster: P78543

    1 Blocks protein family: IPB002087 Anti-proliferative protein

    UniProtKB/Swiss-Prot: BTG2_HUMAN, P78543
    Similarity: Belongs to the BTG family


    Function
    for BTG2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BTG2_HUMAN, P78543
    Function: Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal
    precursors (By similarity). Anti-proliferative protein. Modulates transcription regulation mediated by ESR1. Involved
    in mitochondrial depolarization and neurite outgrowth

         Genatlas biochemistry entry for BTG2:
    B cell transition gene 2,preferentially expressed in quiescent cells,antiproliferative p53 dependent component of the
    DNA damage cellular response pathway,homolog to murine Pc3/Tis21 and human BTG1 (see symbol),at the onset of
    neurogenesis in single neuroepithelial cells that switch from proliferative to neuron-generating division,Tob/BTG1
    family

    miRNA
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    hsa-mir-21 (MIRT002416)

    OriGene 3'-UTR Clone: BTG2
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BTG2
    8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate BTG2 (see all 94):
    hsa-miR-548j hsa-miR-579 hsa-miR-146a hsa-miR-15a hsa-miR-218-1* hsa-miR-128 hsa-miR-4267 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: BTG2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BTG2 (see all 7)
    OriGene shRNA RFP: BTG2
    OriGene siRNA: BTG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BTG2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for BTG2

    Clone
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    Search LifeMap BioReagents cell lines for BTG2

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0005515protein binding IPI--


    BTG2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Btg2tm1Spo for BTG2
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Btg2):
     nervous system  skeleton 

    BTG2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BTG2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Direct p53 effectors
    		Direct p53 effectors1.00
    2Deadenylation-dependent mRNA decay
    		RNA degradation0.50
    3Cyclins and Cell Cycle Regulation
    		Cell Cycle Control by BTG Proteins0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for BTG2
        Cell Cycle Control by BTG Proteins

    1 BioSystems Pathway for BTG2 
        Direct p53 effectors


    1         Kegg Pathway  (Kegg details for BTG2):
        RNA degradation


    BTG2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BTG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/19 Interacting proteins for BTG2 (P785431, 2, 3 ENSP000002905514) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POPDC2Q9HBU92, 3, ENSP000002642314MINT-6544482 I2D: score=1 STRING: ENSP00000264231
    CNOT8Q9UFF93, ENSP000002858964I2D: score=4 STRING: ENSP00000285896
    CNOT1A5YKK63, ENSP000003209494STRING: ENSP00000320949 I2D: score=2 
    CNOT6LQ96LI53, ENSP000002649034I2D: score=2 STRING: ENSP00000264903
    HMGN1P051143, ENSP000003701254I2D: score=1 STRING: ENSP00000370125
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS8944033
    GO:0006479protein methylation IEA--
    GO:0006974response to DNA damage stimulus IDA8944033
    GO:0008285negative regulation of cell proliferation TAS8944033
    GO:0008306associative learning IEA--


    BTG2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BTG2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BTG2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BTG2
    2 Novoseek chemical compound relationships for BTG2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 16.6 12 19117054 (2), 15378000 (2), 16849553 (1), 11136725 (1)
    oligonucleotide 0 1 12470596 (1)

    Search CenterWatch for drugs/clinical trials and news about BTG2 

    Transcripts
    for BTG2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BTG2 gene: 
    NM_006763.2  

    Unigene Cluster for BTG2:

    BTG family, member 2
    Hs.519162  [show with all ESTs]
    Unigene Representative Sequence: NM_006763
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475157 ENST00000290551(uc001gzq.3)

    miRNA
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    8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate BTG2 (see all 94):
    hsa-miR-548j hsa-miR-579 hsa-miR-146a hsa-miR-15a hsa-miR-218-1* hsa-miR-128 hsa-miR-4267 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: BTG2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BTG2 (see all 7)
    OriGene shRNA RFP: BTG2
    OriGene siRNA: BTG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BTG2
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTG2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTG2

    Additional cDNA sequence: 

    BC105948.1 BC105949.1 U72649.1 Y09943.1 

    10 DOTS entries:

    DT.444301  DT.100854554  DT.100789605  DT.100789607  DT.101975460  DT.97760005  DT.100730619  DT.100775835 
    DT.95122825  DT.95166015 

    24/470 AceView cDNA sequences (see all 470):

    BG058564 F30533 BQ062439 CR595352 BG055824 BQ055700 BU633190 T85468 
    BU687883 AI268682 AW512044 BE465354 AI440076 AI439127 AA504932 BF222208 
    BM725500 BG235944 BM708202 BU429197 BQ065794 BM975108 AL553608 BQ924212 

    GeneLoc Exon Structure


    Expression
    for BTG2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BTG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTAATCTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BTG2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleMature Granulosa CellsOvary
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BTG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BTG2

    SOURCE GeneReport for Unigene cluster: Hs.519162
        SABiosciences Expression via Pathway-Focused PCR Arrays including BTG2: 
              Nephrotoxicity in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Hepatotoxicity in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG2

    Orthologs
    for BTG2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for BTG2 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BTG21 BTG family, member 2 81.02(n)
    84.11(a)    		   419932  XM_418053.3  XP_418053.3 
    lizard
    (Anolis carolinensis)    		 Reptilia BTG26
    		 --
    		 74(a)
    		 1 ↔ 1
    		 4(118853386-118857060)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia MGC757532 hypothetical protein MGC75753 71.5(n)    BC059748.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii btg21 B-cell translocation gene 2 65.4(n)
    61.39(a)    		   30079  NM_130922.1  NP_570997.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 38(a)
    		 1 → many
    		 Group2.31(38923-39474)


    ENSEMBL Gene Tree for BTG2 (if available)
    TreeFam Gene Tree for BTG2 (if available) 

    Paralogs
    for BTG2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BTG2 gene
    BTG42  TOB12  TOB22  BTG32  BTG12  
    5 SIMAP similar genes for BTG2 using alignment to 1 protein entry:     BTG2_HUMAN:
    BTG1    TOB1    TOB2    BTG3    BTG4

    BTG2 for paralogs           About GeneDecksing



    Genomic Variants
    for BTG2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/138 NCBI SNPs in BTG2 are shown (see all 138)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs168512681,2
    		C,F,H,--203272902(+) TGGAGC/TACAAA 3 -- int1 us2k132Minor allele frequency- T:0.22NA EA NS WA 3408
    rs346525481,2
    		F--203272964(+) CATTAG/AGCAAA 3 -- us2k1 int11Minor allele frequency- A:0.33NA 6
    rs1142265721,2
    		--203272999(+) CGAATG/AGGGGA 3 -- us2k1 int11Minor allele frequency- A:0.01WA 118
    rs1842105721,2
    		--203273033(+) GCAAGA/TGAAGA 3 -- int1 us2k10--------
    rs125673301,2
    		H--203273060(+) TTTTAG/AGAAGG 3 -- int1 us2k1 tfbs3 trp34Minor allele frequency- A:0.00NS EA 420
    rs1510716971,2
    		--203273149(+) GCAGCC/TGATTT 3 -- int1 us2k10--------
    rs1409231901,2
    		--203273175(+) GGAGCA/TAAGTA 3 -- us2k1 int10--------
    rs109206061,2
    		C,F,A,H,--203273221(+) GGAAAT/CGATGG 3 -- int1 us2k121Minor allele frequency- C:0.10NS EA NA WA 2764
    rs1890137911,2
    		--203273268(+) AGACAA/CTGGGC 3 -- int1 us2k10--------
    rs49712341,2
    		C,F,H,--203273366(+) AGACTG/ATGCAG 3 -- us2k1 int135Minor allele frequency- A:0.19NS EA NA WA CSA 3208

    HapMap Linkage Disequilibrium report for BTG2 (203274619 - 203278730 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BTG2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTG2
    DNA2.0 Custom Variant and Variant Library Synthesis for BTG2

    Disorders / Diseases
    for BTG2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BTG2 for disorders           About GeneDecksing

    OMIM gene information: 601597    OMIM disorders: --

    20/23 diseases for BTG2 (see all 23):    About MalaCards
    advanced sleep phase syndrome    clear cell renal cell carcinoma    nicotine dependence    renal cell carcinoma
    chronic pain    laryngitis    laryngeal carcinoma    breast carcinoma
    carcinoma    prostate cancer    breast cancer    prostatitis
    medulloblastoma    hepatocellular carcinoma    atrophy of prostate    neurodegeneration
    gastric cancer    prostate carcinoma    lung cancer    cerebritis

    9 Novoseek disease relationships for BTG2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperalgesia 34.4 2 8544993 (1), 16110328 (1)
    breast carcinoma 28.6 5 16849553 (2), 16418486 (1)
    tumors 11.6 21 16456675 (4), 16849553 (2), 11470758 (2), 16418486 (2) (see all 8)
    atrophy 0 2 11470758 (1)
    cancer lung 0 1 9766435 (1)
    inflammation 0 2 16110328 (1), 12890505 (1)
    breast cancer 0 10 15378000 (4), 16849553 (2), 19117054 (1)
    prostate cancer 0 2 11470758 (2)
    cancer 0 5 16456675 (2), 9766435 (1), 19551855 (1)


    Export disorders for BTG2 gene to outside databases

    Publications
    for BTG2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BTG2 gene, integrated from 9 sources (see all 107):
    (articles sorted by number of sources associating them with BTG2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. (PubMed id 8944033)1, 2, 3, 9 Rouault J.-P....Puisieux A. (1996)
    2. BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms. (PubMed id 12771185)1, 2, 9 Morel A.-P.... Corbo L. (2003)
    3. PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells. (PubMed id 18773938)1, 2 Miyata S....Tohyama M. (2008)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death. (PubMed id 15788397)1, 2 Hong J.W....Lim I.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene. (PubMed id 11814693)1, 2 Duriez C.... Puisieux A. (2002)
    8. The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair? (PubMed id 11267995)1, 2 Tirone F. (2001)
    9. Expression of the NF-kappaB-responsive gene BTG2 is aberrantly regulated in breast cancer. (PubMed id 15378000)1, 9 Kawakubo H....Maheswaran S. (2004)
    10. Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription. (PubMed id 10669755)1, 9 Guardavaccaro D....Tirone F. (2000)

    External Searches for BTG2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing BTG2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7832 HGNC: 1131 AceView: BTG2 Ensembl:ENSG00000159388 euGenes: HUgn7832
    ECgene: BTG2 Kegg: 7832 H-InvDB: BTG2

    Other Databases showing BTG2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BTG2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BTG2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BTG2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for BTG2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BTG2 gene:
    Search GeneIP for patents involving BTG2

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