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Aliases for BTG1 Gene

Aliases for BTG1 Gene

  • B-Cell Translocation Gene 1, Anti-Proliferative 2 3 5
  • B-Cell Translocation Gene 1 Protein 4

External Ids for BTG1 Gene

Previous GeneCards Identifiers for BTG1 Gene

  • GC12M091929
  • GC12M092827
  • GC12M092469
  • GC12M091039
  • GC12M089601

Summaries for BTG1 Gene

Entrez Gene Summary for BTG1 Gene

  • This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]

GeneCards Summary for BTG1 Gene

BTG1 (B-Cell Translocation Gene 1, Anti-Proliferative) is a Protein Coding gene. Diseases associated with BTG1 include chronic lymphocytic leukemia. Among its related pathways are Deadenylation-dependent mRNA decay and Cyclins and Cell Cycle Regulation. GO annotations related to this gene include enzyme binding and transcription cofactor activity. An important paralog of this gene is TOB1.

UniProtKB/Swiss-Prot for BTG1 Gene

  • Anti-proliferative protein.

Gene Wiki entry for BTG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTG1 Gene

Genomics for BTG1 Gene

Regulatory Elements for BTG1 Gene

Enhancers for BTG1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BTG1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the BTG1 gene promoter:

Genomic Location for BTG1 Gene

Chromosome:
12
Start:
92,140,278 bp from pter
End:
92,145,897 bp from pter
Size:
5,620 bases
Orientation:
Minus strand

Genomic View for BTG1 Gene

Genes around BTG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTG1 Gene

Proteins for BTG1 Gene

  • Protein details for BTG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62324-BTG1_HUMAN
    Recommended name:
    Protein BTG1
    Protein Accession:
    P62324
    Secondary Accessions:
    • P31607

    Protein attributes for BTG1 Gene

    Size:
    171 amino acids
    Molecular mass:
    19209 Da
    Quaternary structure:
    • Interacts with CNOT7 and CNOT8.

neXtProt entry for BTG1 Gene

Proteomics data for BTG1 Gene at MOPED

Post-translational modifications for BTG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BTG1 Gene

Domains & Families for BTG1 Gene

Protein Domains for BTG1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P62324

UniProtKB/Swiss-Prot:

BTG1_HUMAN :
  • Belongs to the BTG family.
Family:
  • Belongs to the BTG family.
genes like me logo Genes that share domains with BTG1: view

No data available for Gene Families for BTG1 Gene

Function for BTG1 Gene

Molecular function for BTG1 Gene

GENATLAS Biochemistry:
B cell translocation gene 1,widely expressed except in brain and muscle,maximally expressed in the G0/G1 phases of the cell cycle,involved in B cell lymphocytic leukemia with translocation t(8;12)(q24;q22),negative regulator of cell proliferation (antiproliferative),putative tumor suppressor gene,Tob/BTG1 family
UniProtKB/Swiss-Prot Function:
Anti-proliferative protein.
genes like me logo Genes that share phenotypes with BTG1: view

Animal Model Products

miRNA for BTG1 Gene

miRTarBase miRNAs that target BTG1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTG1 Gene

Localization for BTG1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTG1 Gene COMPARTMENTS Subcellular localization image for BTG1 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 3
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BTG1 Gene

Pathways & Interactions for BTG1 Gene

genes like me logo Genes that share pathways with BTG1: view

Pathways by source for BTG1 Gene

1 BioSystems pathway for BTG1 Gene
1 KEGG pathway for BTG1 Gene
1 Qiagen pathway for BTG1 Gene

Gene Ontology (GO) - Biological Process for BTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 1373383
GO:0030308 negative regulation of cell growth NAS 15033446
GO:0045663 positive regulation of myoblast differentiation NAS 15033446
GO:0045766 positive regulation of angiogenesis IMP 15033446
GO:2000271 positive regulation of fibroblast apoptotic process IMP 9690562
genes like me logo Genes that share ontologies with BTG1: view

No data available for SIGNOR curated interactions for BTG1 Gene

Drugs & Compounds for BTG1 Gene

(1) Drugs for BTG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for BTG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BTG1: view

Transcripts for BTG1 Gene

mRNA/cDNA for BTG1 Gene

Unigene Clusters for BTG1 Gene

B-cell translocation gene 1, anti-proliferative:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTG1 Gene

No ASD Table

Relevant External Links for BTG1 Gene

GeneLoc Exon Structure for
BTG1
ECgene alternative splicing isoforms for
BTG1

Expression for BTG1 Gene

mRNA expression in normal human tissues for BTG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTG1 Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for BTG1 Gene

This gene is overexpressed in CD8 Tcells (52.2) and Placenta (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTG1 Gene



SOURCE GeneReport for Unigene cluster for BTG1 Gene Hs.255935

genes like me logo Genes that share expression patterns with BTG1: view

Protein tissue co-expression partners for BTG1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for BTG1 Gene

Orthologs for BTG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BTG1 35
  • 96.3 (n)
  • 99.42 (a)
BTG1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btg1 35
  • 96.88 (n)
  • 100 (a)
Btg1 16
4930430D24Rik 36
  • 83 (a)
OneToMany
4930525M21RIK 36
  • 85 (a)
OneToMany
Btg1 36
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia BTG1 35
  • 100 (n)
  • 100 (a)
BTG1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btg1 35
  • 96.3 (n)
  • 99.42 (a)
dog
(Canis familiaris)
Mammalia BTG1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BTG1 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves BTG1 35
  • 91.12 (n)
  • 93.49 (a)
BTG1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTG1 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btg1 35
  • 74.16 (n)
  • 77.51 (a)
MGC75680 35
African clawed frog
(Xenopus laevis)
Amphibia btg1-prov 35
zebrafish
(Danio rerio)
Actinopterygii btg1 35
  • 70.63 (n)
  • 73.81 (a)
wufb14h05 35
btg1 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tob 36
  • 9 (a)
OneToMany
Species with no ortholog for BTG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTG1 Gene

ENSEMBL:
Gene Tree for BTG1 (if available)
TreeFam:
Gene Tree for BTG1 (if available)

Paralogs for BTG1 Gene

Paralogs for BTG1 Gene

(5) SIMAP similar genes for BTG1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for BTG1 Gene

genes like me logo Genes that share paralogs with BTG1: view

Variants for BTG1 Gene

Sequence variations from dbSNP and Humsavar for BTG1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_021345 -
VAR_021346 -

Structural Variations from Database of Genomic Variants (DGV) for BTG1 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
dgv1480n71 CNV Loss 21882294
nsv899434 CNV Loss 21882294
nsv899436 CNV Loss 21882294

Variation tolerance for BTG1 Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTG1 Gene

HapMap Linkage Disequilibrium report
BTG1
Human Gene Mutation Database (HGMD)
BTG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTG1 Gene

Disorders for BTG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BTG1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search BTG1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

BTG1_HUMAN
  • Note=A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC. {ECO:0000269 PubMed:2069907}.

Relevant External Links for BTG1

Genetic Association Database (GAD)
BTG1
Human Genome Epidemiology (HuGE) Navigator
BTG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BTG1
genes like me logo Genes that share disorders with BTG1: view

No data available for Genatlas for BTG1 Gene

Publications for BTG1 Gene

  1. An anti-proliferative gene BTG1 regulates angiogenesis in vitro. (PMID: 15033446) Iwai K. … Yokoyama M. (Biochem. Biophys. Res. Commun. 2004) 2 3 23 67
  2. Genetic association between polymorphisms in the BTG1 gene and multiple sclerosis. (PMID: 19515430) CamiA+a-Tato M. … Comabella M. (J. Neuroimmunol. 2009) 3 23
  3. Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. (PMID: 15674337) Busson M. … Cabello G. (Oncogene 2005) 3 23
  4. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. (PMID: 11136725) Prevot D. … Corbo L. (J. Biol. Chem. 2001) 3 23
  5. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PMID: 11429045) Yoshida Y. … Yamamoto T. (Jpn. J. Cancer Res. 2001) 3 23

Products for BTG1 Gene

Sources for BTG1 Gene

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