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BTG1 Gene

protein-coding   GIFtS: 58
GCID: GC12M092469

B-Cell Translocation Gene 1, Anti-Proliferative

  See BTG1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
B-Cell Translocation Gene 1, Anti-Proliferative1 2
B-Cell Translocation Gene 1 Protein2 3
Protein BTG12

External Ids:    HGNC: 11301   Entrez Gene: 6942   Ensembl: ENSG000001336397   OMIM: 1095805   UniProtKB: P623243   

Export aliases for BTG1 gene to outside databases

Previous GC identifers: GC12M091929 GC12M092827 GC12M091039 GC12M089601


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BTG1 Gene:
This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation.
Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed
through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell
differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a
case of B-cell chronic lymphocytic leukemia. (provided by RefSeq, Oct 2008)

GeneCards Summary for BTG1 Gene:
BTG1 (B-cell translocation gene 1, anti-proliferative) is a protein-coding gene. Diseases associated with BTG1 include chronic lymphocytic leukemia, and b-cell chronic lymphocytic leukemia. GO annotations related to this gene include kinase binding and enzyme binding. An important paralog of this gene is BTG4.

UniProtKB/Swiss-Prot: BTG1_HUMAN, P62324
Function: Anti-proliferative protein

Gene Wiki entry for BTG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the BTG1 gene promoter:
         AML1a   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BTG1 promoter sequence
   Search Chromatin IP Primers for BTG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BTG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22   Ensembl cytogenetic band:  12q21.33   HGNC cytogenetic band: 12q21.33

BTG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTG1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M092469:  view genomic region     (about GC identifiers)

Start:
92,534,054 bp from pter      End:
92,539,673 bp from pter
Size:
5,620 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BTG1_HUMAN, P62324 (See protein sequence)
Recommended Name: Protein BTG1  
Size: 171 amino acids; 19209 Da
Subunit: Interacts with CNOT7 and CNOT8
Developmental stage: Its expression is associated with the early G1 phase of the cell cycle
Secondary accessions: P31607

Explore the universe of human proteins at neXtProt for BTG1: NX_P62324

Explore proteomics data for BTG1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BTG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001722.1  
    ENSEMBL proteins: 
     ENSP00000256015   ENSP00000447551  

    BTG1 Human Recombinant Protein Products:

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    antibodies-online proteins for BTG1 (6 products) 

     
    antibodies-online peptides for BTG1

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    antibodies-online antibodies for BTG1 (29 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002087 Anti_prolifrtn

    Graphical View of Domain Structure for InterPro Entry P62324

    ProtoNet protein and cluster: P62324

    UniProtKB/Swiss-Prot: BTG1_HUMAN, P62324
    Similarity: Belongs to the BTG family


    Find genes that share domains with BTG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BTG1_HUMAN, P62324
    Function: Anti-proliferative protein

         Genatlas biochemistry entry for BTG1:
    B cell translocation gene 1,widely expressed except in brain and muscle,maximally expressed in the G0/G1 phases of
    the cell cycle,involved in B cell lymphocytic leukemia with translocation t(8;12)(q24;q22),negative regulator of
    cell proliferation (antiproliferative),putative tumor suppressor gene,Tob/BTG1 family

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003712transcription cofactor activity NAS11420681
    GO:0005515protein binding IPI10617598
    GO:0019899enzyme binding IPI8663146
    GO:0019900kinase binding NAS9820826
         
    Find genes that share ontologies with BTG1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for BTG1

    miRNA
    Products:
        
    miRTarBase miRNAs that target BTG1:
    hsa-mir-484 (MIRT041705), hsa-mir-26b-5p (MIRT028939)

    Block miRNA regulation of human, mouse, rat BTG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BTG1 (see all 152):
    hsa-miR-640 hsa-miR-1245 hsa-miR-3653 hsa-miR-519a hsa-miR-3622b-3p hsa-miR-208b hsa-miR-510 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidBTG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BTG1
    Predesigned siRNA for gene silencing in human, mouse, rat BTG1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: BTG1 (NM_001731)
    Sino Biological Human cDNA Clone for BTG1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTG1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular3
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IMP11420681
    GO:0005737cytoplasm IMP11420681

    Find genes that share ontologies with BTG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BTG1 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.48
    2Cyclins and Cell Cycle Regulation
    Cell Cycle Control by BTG Proteins0.36
    3Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    Find genes that share SuperPaths with BTG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for BTG1
        Cell Cycle Control by BTG Proteins

    1 BioSystems Pathway for BTG1
        Diurnally regulated genes with circadian orthologs



    1 Kegg Pathway  (Kegg details for BTG1):
        RNA degradation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BTG1: 
              Angiogenic Growth Factors in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BTG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for BTG1 (P623241, 2, 3 ENSP000002560154) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNOT8Q9UFF91, 2, 3, ENSP000002858964EBI-742279,EBI-742299 MINT-66250 MINT-8249674 I2D: score=7 STRING: ENSP00000285896
    TUBA1AQ71U362, 3MINT-8249685 I2D: score=2 
    XRCC6P129562, 3MINT-8249696 I2D: score=2 
    CNOT7Q9UIV11, 2, 3, ENSP000003552794EBI-742279,EBI-2105113 MINT-8249663 I2D: score=4 STRING: ENSP00000355279
    RARAP102763, ENSP000002540664I2D: score=3 STRING: ENSP00000254066
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated NAS11420681
    GO:0008285negative regulation of cell proliferation IDA11420681
    GO:0016477cell migration NAS15033446
    GO:0030308negative regulation of cell growth NAS15033446
    GO:0045603positive regulation of endothelial cell differentiation IMP15033446

    Find genes that share ontologies with BTG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BTG1

    2 Novoseek inferred chemical compound relationships for BTG1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 27.4 6 15674337 (2), 15449376 (1), 18288394 (1)
    arginine 5.39 2 17264152 (1)



    Find genes that share compounds with BTG1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BTG1 gene: 
    NM_001731.2  

    Unigene Cluster for BTG1:

    B-cell translocation gene 1, anti-proliferative
    Hs.255935  [show with all ESTs]
    Unigene Representative Sequence: NM_001731
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256015(uc001tby.3) ENST00000552315
    miRNA
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    Block miRNA regulation of human, mouse, rat BTG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BTG1 (see all 152):
    hsa-miR-640 hsa-miR-1245 hsa-miR-3653 hsa-miR-519a hsa-miR-3622b-3p hsa-miR-208b hsa-miR-510 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidBTG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BTG1
    Predesigned siRNA for gene silencing in human, mouse, rat BTG1
    Clone
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    Primer
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    OriGene qPCR primer pairs and template standards for BTG1
    OriGene qSTAR qPCR primer pairs in human, mouse for BTG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BTG1
      QuantiTect SYBR Green Assays in human, mouse, rat BTG1
      QuantiFast Probe-based Assays in human, mouse, rat BTG1

    Additional mRNA sequence: 

    AK307057.1 AK313309.1 BC009050.1 BC016759.2 BC064953.1 BT019839.1 BT019840.1 BT019841.1 
    CR456876.1 CR541782.1 X61123.1 

    23 DOTS entries:

    DT.91764653  DT.100726802  DT.100879582  DT.121175635  DT.100034894  DT.100879592  DT.91812649  DT.104387 
    DT.100879593  DT.100879584  DT.100879586  DT.95260209  DT.91684602  DT.100879578  DT.100879595  DT.121175646 
    DT.91764664  DT.95260226  DT.100682624  DT.121175597  DT.121175640  DT.91764652  DT.121175653 

    Selected AceView cDNA sequences (see all 1028):

    BM311527 BQ006025 BQ129982 CR606339 BM875599 AI050042 BM309988 AI923521 
    CA431923 BQ029749 AL046975 BU789954 BQ286605 BQ582164 CB528475 BQ002143 
    BC029844 AA505735 CB045653 AA345187 AA041258 BQ581185 CA308745 BC009050 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BTG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACAGCTGT
    BTG1 Expression
    About this image


    BTG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Liver (Hepatobiliary System)
    BTG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BTG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.255935
        Pathway & Disease-focused RT2 Profiler PCR Arrays including BTG1: 
              Angiogenic Growth Factors in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BTG1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Btg11 , 5 B cell translocation gene 1, anti-proliferative1, 5 96.88(n)1
    100(a)1
      10 (49.89 cM)5
    122261  NM_007569.21  NP_031595.11 
     966170015 
    chicken
    (Gallus gallus)
    Aves BTG11 B-cell translocation gene 1, anti-proliferative 91.12(n)
    93.49(a)
      396295  NM_205350.1  NP_990681.1 
    lizard
    (Anolis carolinensis)
    Reptilia BTG16
    B-cell translocation gene 1, anti-proliferative
    89(a)
    1 ↔ 1
    5(31906127-31915528)
    African clawed frog
    (Xenopus laevis)
    Amphibia btg1-prov2 B-cell translocation gene 1, anti-proliferative 85.07(n)    BC053755.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb14h052 wufb14h05 75.28(n)   336608  BC056691.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tob6
    Tob
    9(a)
    1 → many
    X(15969396-15985528)


    ENSEMBL Gene Tree for BTG1 (if available)
    TreeFam Gene Tree for BTG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BTG1 gene
    BTG42  TOB12  TOB22  BTG32  BTG22  
    5 SIMAP similar genes for BTG1 using alignment to 3 protein entries:     BTG1_HUMAN (see all proteins):
    BTG2    TOB1    TOB2    BTG4    BTG3

    Find genes that share paralogs with BTG1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for BTG1
    PGOHUM00000239657


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BTG1 (see all 78)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154457021,2
    C,F--92538476(+) CAGGCG/ACGCAG 1 -- int11Minor allele frequency- A:0.04WA 118
    rs1481460251,2
    --92538585(+) TGGAGA/CTGAGA 1 -- int10--------
    rs283995391,2
    C,F--92538651(-) CTGCCC/GAGAGC 1 -- int11Minor allele frequency- G:0.01NS 172
    rs283995381,2
    C,F--92538673(-) GTCACC/TGGCAC 1 -- int11Minor allele frequency- T:0.01NS 172
    rs7316521,2
    C,F,A,H--92538809(-) CTCAGC/TCCCCT 1 -- int17Minor allele frequency- T:0.18MN NS NA WA EA 596
    rs283995351,2
    C,F--92538840(-) TGGGGC/TTGGGG 1 -- int14Minor allele frequency- T:0.09NS NA WA 410
    rs283995341,2
    C,F--92538945(-) CAAAAC/TGGAGA 1 -- int12Minor allele frequency- T:0.02NS NA 270
    rs1502733391,2
    --92538970(+) GGGGGA/CGCCCT 1 -- int10--------
    rs2017317001,2
    C--92539146(+) TCCGAC/TGCCCT 1 -- int10--------
    rs2006230211,2
    --92539174(+) AGCAGC/TTCCTG 2 E syn10--------

    HapMap Linkage Disequilibrium report for BTG1 (92534054 - 92539673 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BTG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899434CNV Loss21882294
    nsv899436CNV Loss21882294
    dgv1480n71CNV Loss21882294
    nsv7234OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BTG1
    DNA2.0 Custom Variant and Variant Library Synthesis for BTG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 109580    OMIM disorders: --

    UniProtKB/Swiss-Prot: BTG1_HUMAN, P62324
  • Note=A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic
    leukemia. Translocation t(8;12)(q24;q22) with MYC

  • 2 diseases for BTG1:    
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    chronic lymphocytic leukemia    b-cell chronic lymphocytic leukemia


    Find genes that share disorders with BTG1           About GenesLikeMe

    3 Novoseek inferred disease relationships for BTG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukaemia lymphocytic 38.7 1 15674337 (1)
    breast cancer 0 3 16818519 (2), 16786164 (1)
    cancer 0 1 16281084 (1)

    Genetic Association Database (GAD): BTG1
    Human Genome Epidemiology (HuGE) Navigator: BTG1 (2 documents)

    Export disorders for BTG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BTG1 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with BTG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An anti-proliferative gene BTG1 regulates angiogenesis in vitro. (PubMed id 15033446)1, 3, 9 Iwai K....Yokoyama M. (Biochem. Biophys. Res. Commun. 2004)
    2. BTG1, a member of a new family of antiproliferative genes. (PubMed id 1373383)1, 2, 9 Rouault J.-P.... Magaud J.-P. (EMBO J. 1992)
    3. Genetic association between polymorphisms in the BTG1 gene and multiple sclerosis. (PubMed id 19515430)1, 4, 9 CamiA+a-Tato M....Comabella M. (J. Neuroimmunol. 2009)
    4. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. (PubMed id 11136725)1, 2, 9 Prevot D.... Corbo L. (J. Biol. Chem. 2001)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex. (PubMed id 9712883)1, 2 Rouault J.P.... Corbo L. (J. Biol. Chem. 1998)
    7. Identification of functional domains involved in BTG1 cell localization. (PubMed id 11420681)1, 9 Rodier A....Cabello G. (Oncogene 2001)
    8. Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. (PubMed id 15674337)1, 9 Busson M....Cabello G. (Oncogene 2005)
    9. Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human. (PubMed id 9690562)1, 9 Corjay M.H....Stoltenborg J.K. ( a journal of technical methods and pathology 1998)
    10. Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. (PubMed id 9820826)1, 9 Bogdan J.A.... Dicker I.B. (Biochem. J. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 694 HGNC: 1130 AceView: BTG1 Ensembl:ENSG00000133639 euGenes: HUgn694
    ECgene: BTG1 Kegg: 694 H-InvDB: BTG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BTG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BTG1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/btg1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BTG1 gene:
    Search GeneIP for patents involving BTG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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