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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BTG1 Gene

protein-coding   GIFtS: 56
GCID: GC12M092469

B-cell translocation gene 1, anti-proliferative
 Explore 18 diseases affiliated with
BTG1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BTG1    

Aliases
for BTG1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
B-Cell Translocation Gene 1, Anti-Proliferative1 2
B-Cell Translocation Gene 1 Protein2 3
Protein BTG12

External Ids:    HGNC: 11301   Entrez Gene: 6942   Ensembl: ENSG000001336397   OMIM: 1095805   UniProtKB: P623243   

Export aliases for BTG1 gene to outside databases

Previous GC identifers: GC12M091929 GC12M092827 GC12M091039 GC12M089601


Summaries
for BTG1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BTG1:
This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression
of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The
encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This
locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic
lymphocytic leukemia. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: BTG1_HUMAN, P62324
Function: Anti-proliferative protein

Gene Wiki entry for BTG1


Genomic Views
for BTG1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BTG1 gene promoter:
         AML1a   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BTG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for BTG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22   Ensembl cytogenetic band:  12q21.33   HGNC cytogenetic band: 12q21.33

BTG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTG1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M092469:  view genomic region     (about GC identifiers)

Start:
 92,534,054 bp from pter      End:
 92,539,673 bp from pter
Size:
 5,620 bases      Orientation:
 minus strand

Proteins
for BTG1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BTG1_HUMAN, P62324 (See protein sequence)
Recommended Name: Protein BTG1  
Size: 171 amino acids; 19209 Da
Developmental stage: Its expression is associated with the early G1 phase of the cell cycle
Secondary accessions: P31607

Explore the universe of human proteins at neXtProt for BTG1: NX_P62324

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62324

    • BTG1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001722.1  
    ENSEMBL proteins: 
     ENSP00000256015   ENSP00000447551  

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    Novus Biologicals BTG1 Protein
    Novus Biologicals BTG1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BTG1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IMP11420681
    GO:0005737cytoplasm IMP11420681


    BTG1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for BTG1

    Protein Domains /
    Families
    for BTG1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BTG1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002087 Anti_prolifrtn

    Graphical View of Domain Structure for InterPro Entry P62324

    ProtoNet protein and cluster: P62324

    UniProtKB/Swiss-Prot: BTG1_HUMAN, P62324
    Similarity: Belongs to the BTG family


    Function
    for BTG1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BTG1_HUMAN, P62324
    Function: Anti-proliferative protein

         Genatlas biochemistry entry for BTG1:
    B cell translocation gene 1,widely expressed except in brain and muscle,maximally expressed in the G0/G1 phases of the
    cell cycle,involved in B cell lymphocytic leukemia with translocation t(8;12)(q24;q22),negative regulator of cell
    proliferation (antiproliferative),putative tumor suppressor gene,Tob/BTG1 family

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BTG1
    8/152 QIAGEN miScript miRNA Assays for microRNAs that regulate BTG1 (see all 152):
    hsa-miR-640 hsa-miR-1245 hsa-miR-3653 hsa-miR-519a hsa-miR-3622b-3p hsa-miR-208b hsa-miR-510 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: BTG1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BTG1 (see all 7)
    OriGene shRNA RFP: BTG1
    OriGene siRNA: BTG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BTG1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for BTG1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTG1 (see all 4)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTG1 

    Cell Line
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    Search LifeMap BioReagents cell lines for BTG1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003712transcription cofactor activity NAS11420681
    GO:0005515protein binding IPI10617598
    GO:0019899enzyme binding IPI8663146
    GO:0019900kinase binding NAS9820826


    BTG1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for BTG1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Diurnally regulated genes with circadian orthologs
    		Diurnally regulated genes with circadian orthologs1.00
    2Deadenylation-dependent mRNA decay
    		RNA degradation0.50
    3Cyclins and Cell Cycle Regulation
    		Cell Cycle Control by BTG Proteins0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for BTG1
        Cell Cycle Control by BTG Proteins

    1 BioSystems Pathway for BTG1 
        Diurnally regulated genes with circadian orthologs


    1         Kegg Pathway  (Kegg details for BTG1):
        RNA degradation


    BTG1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BTG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/19 Interacting proteins for BTG1 (P623242, 3 ENSP000002560154) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNOT8Q9UFF92, 3, ENSP000002858964MINT-66250 MINT-8249674 I2D: score=7 STRING: ENSP00000285896
    TUBA1AQ71U362, 3MINT-8249685 I2D: score=2 
    XRCC6P129562, 3MINT-8249696 I2D: score=2 
    CNOT7Q9UIV12, 3, ENSP000003552794MINT-8249663 I2D: score=4 STRING: ENSP00000355279
    RARAP102763, ENSP000002540664I2D: score=3 STRING: ENSP00000254066
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent NAS11420681
    GO:0006479protein methylation ----
    GO:0006979response to oxidative stress ----
    GO:0007283spermatogenesis ----
    GO:0008285negative regulation of cell proliferation IDA11420681


    BTG1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BTG1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BTG1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BTG1
    2 Novoseek chemical compound relationships for BTG1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 27.4 6 15674337 (2), 15449376 (1), 18288394 (1)
    arginine 5.39 2 17264152 (1)

    Search CenterWatch for drugs/clinical trials and news about BTG1 

    Transcripts
    for BTG1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BTG1 gene: 
    NM_001731.2  

    Unigene Cluster for BTG1:

    B-cell translocation gene 1, anti-proliferative
    Hs.255935  [show with all ESTs]
    Unigene Representative Sequence: NM_001731
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256015(uc001tby.3) ENST00000552315

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BTG1
    8/152 QIAGEN miScript miRNA Assays for microRNAs that regulate BTG1 (see all 152):
    hsa-miR-640 hsa-miR-1245 hsa-miR-3653 hsa-miR-519a hsa-miR-3622b-3p hsa-miR-208b hsa-miR-510 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: BTG1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BTG1 (see all 7)
    OriGene shRNA RFP: BTG1
    OriGene siRNA: BTG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BTG1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTG1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTG1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: BTG1 (NM_001731)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTG1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BTG1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BTG1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTG1

    Additional cDNA sequence: 

    AK307057.1 AK313309.1 BC009050.1 BC016759.2 BC064953.1 BT019839.1 BT019840.1 BT019841.1 
    CR456876.1 CR541782.1 X61123.1 

    23 DOTS entries:

    DT.91764653  DT.100726802  DT.100879582  DT.121175635  DT.100034894  DT.100879592  DT.91812649  DT.104387 
    DT.100879593  DT.100879584  DT.100879586  DT.95260209  DT.91684602  DT.100879578  DT.100879595  DT.121175646 
    DT.91764664  DT.95260226  DT.100682624  DT.121175597  DT.121175640  DT.91764652  DT.121175653 

    24/1028 AceView cDNA sequences (see all 1028):

    AI052710 AI085694 BU684692 BM699994 BC029844 BU633142 CA432418 BM511336 
    BE222860 BQ286701 CB107658 AA345102 CR617798 BU679153 BU633103 BE218967 
    BF941278 CR604248 BF196443 AA679521 CB045653 BM511062 BG153410 AA234359 

    GeneLoc Exon Structure


    Expression
    for BTG1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BTG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCACAGCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BTG1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Paraxial Mesoderm CellsBone, Skeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See BTG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BTG1

    SOURCE GeneReport for Unigene cluster: Hs.255935
        SABiosciences Expression via Pathway-Focused PCR Arrays including BTG1: 
              Angiogenic Growth Factors in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTG1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTG1

    Orthologs
    for BTG1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for BTG1 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Btg11 , 5 B cell translocation gene 1, anti-proliferative1, 5 96.88(n)1
    100(a)1    		   10 (49.89 cM)5
    122261  NM_007569.21  NP_031595.11 
     966170015 
    chicken
    (Gallus gallus)    		 Aves BTG11 B-cell translocation gene 1, anti-proliferative 89.02(n)
    91.18(a)    		   396295  NM_205350.1  NP_990681.1 
    lizard
    (Anolis carolinensis)    		 Reptilia BTG16
    		 --
    		 86(a)
    		 1 ↔ 1
    		 5(31906401-31910862)
    African clawed frog
    (Xenopus laevis)    		 Amphibia btg1-prov2 B-cell translocation gene 1, anti-proliferative 85.07(n)    BC053755.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb14h052 wufb14h05 75.28(n)   336608  BC056691.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 39(a)
    		 1 → many
    		 Group2.31(38923-39474)


    ENSEMBL Gene Tree for BTG1 (if available)
    TreeFam Gene Tree for BTG1 (if available) 

    Paralogs
    for BTG1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BTG1 gene
    BTG42  TOB12  TOB22  BTG32  BTG22  
    5 SIMAP similar genes for BTG1 using alignment to 3 protein entries:     BTG1_HUMAN (see all proteins):
    BTG2    TOB1    TOB2    BTG4    BTG3

    BTG1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BTG1
    PGOHUM00000239657


    Genomic Variants
    for BTG1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/138 NCBI SNPs in BTG1 are shown (see all 138)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1383187871,2
    		--92533679(+) ACCTGC/TACTAC 6 -- int1 ds50010--------
    rs1496477051,2
    		--92533715(+) ACAAAC/TTGAAT 6 -- int1 ds50010--------
    rs1862596161,2
    		--92533764(+) CAGAGG/TAGAGA 6 -- int1 ds50010--------
    rs1904895971,2
    		C,--92533965(+) NNNNTC/TTAAGC 6 -- int1 ds50010--------
    rs1833905431,2
    		--92533969(+) TCTAAC/GCATAC 6 -- int1 ds50010--------
    rs1442181311,2
    		--92534099(+) CAATAC/TGAAAA 6 -- int1 ut310--------
    rs586369991,2
    		C,--92534100(+) AATACG/AAAAAG 6 -- ut31 int12Minor allele frequency- A:0.04WA 120
    rs1999776951,2
    		--92534131(+) CAGTC-/AAAAAA 6 -- int1 ut310--------
    rs1886535711,2
    		--92534147(+) TGGTGA/TCAATC 6 -- int1 ut310--------
    rs1910848811,2
    		--92534295(+) ATCTAA/TAGGCA 6 -- int1 ut310--------

    HapMap Linkage Disequilibrium report for BTG1 (92534054 - 92539673 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BTG1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTG1
    DNA2.0 Custom Variant and Variant Library Synthesis for BTG1

    Disorders / Diseases
    for BTG1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BTG1 for disorders           About GeneDecksing

    OMIM gene information: 109580    OMIM disorders: --

    UniProtKB/Swiss-Prot: BTG1_HUMAN, P62324
  • Note=A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia.
    • Translocation t(8;12)(q24;q22) with MYC

    18 diseases for BTG1:    About MalaCards
    chronic lymphocytic leukemia    lymphocytic leukemia    charcot-marie-tooth disease    leukemia
    b-cell lymphomas    tooth disease    acute lymphoblastic leukemia    lymphoblastic leukemia
    acute myeloid leukemia    myeloid leukemia    multiple myeloma    multiple sclerosis
    breast cancer    myeloma    prostate cancer    prostatitis
    schizophrenia    neuronitis

    3 Novoseek disease relationships for BTG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukaemia lymphocytic 38.7 1 15674337 (1)
    breast cancer 0 3 16818519 (2), 16786164 (1)
    cancer 0 1 16281084 (1)

    Human Genome Epidemiology (HuGE) Navigator: BTG1 (2 documents)

    Export disorders for BTG1 gene to outside databases

    Publications
    for BTG1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BTG1 gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with BTG1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. An anti-proliferative gene BTG1 regulates angiogenesis in vitro. (PubMed id 15033446)1, 3, 9 Iwai K....Yokoyama M. (2004)
    2. BTG1, a member of a new family of antiproliferative genes. (PubMed id 1373383)1, 2, 9 Rouault J.-P.... Magaud J.-P. (1992)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of functional domains involved in BTG1 cell localization. (PubMed id 11420681)1, 9 Rodier A....Cabello G. (2001)
    5. Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. (PubMed id 15674337)1, 9 Busson M....Cabello G. (2005)
    6. Genetic association between polymorphisms in the BTG1 gene and multiple sclerosis. (PubMed id 19515430)1, 9 CamiA+a-Tato M....Comabella M. (2009)
    7. Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human. (PubMed id 9690562)1, 9 Corjay M.H....Stoltenborg J.K. (1998)
    8. Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. (PubMed id 9820826)1, 9 Bogdan J.A.... Dicker I.B. (1998)
    9. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. (PubMed id 11136725)1, 9 Prevot D....Corbo L. (2001)
    10. The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. (PubMed id 8663146)1, 9 Lin W.J....Herschman H.R. (1996)

    External Searches for BTG1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing BTG1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 694 HGNC: 1130 AceView: BTG1 Ensembl:ENSG00000133639 euGenes: HUgn694
    ECgene: BTG1 Kegg: 694 H-InvDB: BTG1

    Other Databases showing BTG1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BTG1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BTG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BTG1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/btg1/

    Intellectual Property
    for BTG1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BTG1 gene:
    Search GeneIP for patents involving BTG1

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