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Aliases for BTF3L4 Gene

Aliases for BTF3L4 Gene

  • Basic Transcription Factor 3 Like 4 2 3 5
  • Basic Transcription Factor 3-Like 4 4

External Ids for BTF3L4 Gene

Previous GeneCards Identifiers for BTF3L4 Gene

  • GC01P052234
  • GC01P052294
  • GC01P052521
  • GC01P050639

Summaries for BTF3L4 Gene

GeneCards Summary for BTF3L4 Gene

BTF3L4 (Basic Transcription Factor 3 Like 4) is a Protein Coding gene. An important paralog of this gene is BTF3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTF3L4 Gene

Genomics for BTF3L4 Gene

Regulatory Elements for BTF3L4 Gene

Enhancers for BTF3L4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F052032 1.1 ENCODE 11.9 -22.7 -22730 2.4 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 PAF1 CC2D1B ZCCHC11 ENSG00000266993 BTF3L4 TXNDC12 ENSG00000272100 LOC100190934 ENSG00000223390 KTI12
GH01F052550 1.4 FANTOM5 ENCODE 1.4 +496.8 496774 5.6 HDGF CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ENSG00000228838 CC2D1B GPX7 LOC100652967 TXNDC12-AS1 LOC105378729 GAPDHP51 SLC25A6P3 ZCCHC11 MAGOH
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BTF3L4 on UCSC Golden Path with GeneCards custom track

Promoters for BTF3L4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000669988 -425 3801 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for BTF3L4 Gene

Chromosome:
1
Start:
52,056,125 bp from pter
End:
52,090,716 bp from pter
Size:
34,592 bases
Orientation:
Plus strand

Genomic View for BTF3L4 Gene

Genes around BTF3L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTF3L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTF3L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTF3L4 Gene

Proteins for BTF3L4 Gene

  • Protein details for BTF3L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K17-BT3L4_HUMAN
    Recommended name:
    Transcription factor BTF3 homolog 4
    Protein Accession:
    Q96K17
    Secondary Accessions:
    • B3KNJ1
    • D3DQ32
    • G3V1C6

    Protein attributes for BTF3L4 Gene

    Size:
    158 amino acids
    Molecular mass:
    17271 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTF3L4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTF3L4 Gene

Post-translational modifications for BTF3L4 Gene

  • Ubiquitination at Lys 115
  • Modification sites at PhosphoSitePlus

Other Protein References for BTF3L4 Gene

No data available for DME Specific Peptides for BTF3L4 Gene

Domains & Families for BTF3L4 Gene

Protein Domains for BTF3L4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96K17

UniProtKB/Swiss-Prot:

BT3L4_HUMAN :
  • Contains 1 NAC-A/B (NAC-alpha/beta) domain.
  • Belongs to the NAC-beta family.
Domain:
  • Contains 1 NAC-A/B (NAC-alpha/beta) domain.
Family:
  • Belongs to the NAC-beta family.
genes like me logo Genes that share domains with BTF3L4: view

No data available for Gene Families for BTF3L4 Gene

Function for BTF3L4 Gene

Gene Ontology (GO) - Molecular Function for BTF3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BTF3L4: view
genes like me logo Genes that share phenotypes with BTF3L4: view

Animal Model Products

miRNA for BTF3L4 Gene

miRTarBase miRNAs that target BTF3L4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTF3L4 Gene

Localization for BTF3L4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTF3L4 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BTF3L4 Gene

Pathways & Interactions for BTF3L4 Gene

SuperPathways for BTF3L4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BTF3L4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BTF3L4 Gene

Transcripts for BTF3L4 Gene

Unigene Clusters for BTF3L4 Gene

Basic transcription factor 3-like 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTF3L4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: -
SP3:
SP4: -

Relevant External Links for BTF3L4 Gene

GeneLoc Exon Structure for
BTF3L4
ECgene alternative splicing isoforms for
BTF3L4

Expression for BTF3L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BTF3L4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BTF3L4 Gene

This gene is overexpressed in Fetal ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BTF3L4 Gene



Protein tissue co-expression partners for BTF3L4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BTF3L4 Gene:

BTF3L4

SOURCE GeneReport for Unigene cluster for BTF3L4 Gene:

Hs.429839
genes like me logo Genes that share expression patterns with BTF3L4: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BTF3L4 Gene

Orthologs for BTF3L4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BTF3L4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia BTF3L4 35
  • 100 (a)
OneToOne
LOC100687058 34
  • 97.26 (n)
oppossum
(Monodelphis domestica)
Mammalia BTF3L4 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BTF3L4 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BTF3L4 34 35
  • 99.79 (n)
cow
(Bos Taurus)
Mammalia BTF3L4 34 35
  • 95.78 (n)
mouse
(Mus musculus)
Mammalia Btf3l4 34 16 35
  • 93.88 (n)
rat
(Rattus norvegicus)
Mammalia Btf3l4 34
  • 93.88 (n)
chicken
(Gallus gallus)
Aves BTF3L4 34 35
  • 88.19 (n)
lizard
(Anolis carolinensis)
Reptilia BTF3L4 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btf3l4 34
  • 82.49 (n)
zebrafish
(Danio rerio)
Actinopterygii btf3l4 35 35
  • 96 (a)
OneToMany
LOC100006097 34
  • 80.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta bic 35
  • 61 (a)
ManyToMany
CG11835 35
  • 13 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea icd-1 34 35
  • 65.29 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EGD1 35 37
  • 38 (a)
ManyToMany
BTT1 35
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1484 35
  • 72 (a)
OneToMany
Species where no ortholog for BTF3L4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BTF3L4 Gene

ENSEMBL:
Gene Tree for BTF3L4 (if available)
TreeFam:
Gene Tree for BTF3L4 (if available)

Paralogs for BTF3L4 Gene

Paralogs for BTF3L4 Gene

(1) SIMAP similar genes for BTF3L4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with BTF3L4: view

Variants for BTF3L4 Gene

Sequence variations from dbSNP and Humsavar for BTF3L4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10493163 -- 52,059,965(+) ATTTC(A/G)GATTT intron-variant
rs1051986 -- 52,087,804(+) ATAGA(A/C)TCATC utr-variant-3-prime
rs1056644 -- 52,090,244(-) AGGTA(C/T)CATTT utr-variant-3-prime
rs10788937 -- 52,069,985(+) GCCAA(A/G)GCAGG intron-variant
rs10788938 -- 52,080,966(+) TCCCA(A/G)GTAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTF3L4 Gene

Variant ID Type Subtype PubMed ID
nsv945944 CNV duplication 23825009
nsv945943 CNV duplication 23825009
nsv829848 CNV loss 17160897
nsv1004103 CNV loss 25217958

Variation tolerance for BTF3L4 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTF3L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BTF3L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTF3L4 Gene

Disorders for BTF3L4 Gene

Relevant External Links for BTF3L4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BTF3L4

No disorders were found for BTF3L4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTF3L4 Gene

Publications for BTF3L4 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for BTF3L4 Gene

Sources for BTF3L4 Gene

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