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Aliases for BTF3 Gene

Aliases for BTF3 Gene

  • Basic Transcription Factor 3 2 3 5
  • Nascent-Polypeptide-Associated Complex Beta Polypeptide 2 3
  • Nascent Polypeptide-Associated Complex Subunit Beta 3 4
  • RNA Polymerase B Transcription Factor 3 3 4
  • NAC-Beta 3 4
  • NACB 3 4
  • Transcription Factor BTF3 3
  • BETA-NAC 3
  • BTF3a 3
  • BTF3b 3

External Ids for BTF3 Gene

Previous HGNC Symbols for BTF3 Gene

  • NACB

Previous GeneCards Identifiers for BTF3 Gene

  • GC05P071599
  • GC05P073027
  • GC05P072832
  • GC05P072878
  • GC05P072830
  • GC05P072794
  • GC05P067999

Summaries for BTF3 Gene

Entrez Gene Summary for BTF3 Gene

  • This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for BTF3 Gene

BTF3 (Basic Transcription Factor 3) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is BTF3L4.

UniProtKB/Swiss-Prot for BTF3 Gene

  • When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.

Gene Wiki entry for BTF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTF3 Gene

Genomics for BTF3 Gene

Regulatory Elements for BTF3 Gene

Enhancers for BTF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F073519 1.2 Ensembl ENCODE 17.7 +21.4 21393 0.8 HDGF ATF1 ZNF133 ARID4B ZNF2 RAD21 YY1 RFX5 ZNF121 EGR1 BTF3 ANKRA2 FUNDC2P1 UTP15
GH05F073435 1.2 Ensembl ENCODE 8.5 -61.2 -61169 3.1 ATF1 PKNOX1 SIN3A FEZF1 ZNF48 ZNF2 GLIS2 KLF7 ZNF202 ZNF263 ANKRA2 UTP15 BTF3 FOXD1-AS1 GC05P073385
GH05F073337 2 Ensembl ENCODE 5.1 -159.8 -159827 1.2 FEZF1 ZIC2 ZFHX2 ZBTB48 SCRT2 FOS ZNF600 MAFK ZBTB20 EGR2 BTF3 GC05P073339 ENSG00000249149
GH05F073523 0.8 ENCODE 11.1 +24.8 24785 0.1 CTCF PKNOX1 SIN3A RAD21 ZNF316 ZNF766 CTBP1 PATZ1 ZNF143 SMC3 BTF3 FUNDC2P1 UTP15
GH05F073443 1 ENCODE 8.5 -52.1 -52131 6.3 ATF1 PKNOX1 CREB3L1 SIN3A ZNF2 GLIS2 ZNF202 ZNF263 SP3 YY2 ANKRA2 LINC01385 LINC01386 LOC105379033 LINC01335 ENSG00000223497 LINC01333 UTP15 BTF3 FOXD1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BTF3 on UCSC Golden Path with GeneCards custom track

Promoters for BTF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001282686 392 2801 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 KLF13

Genomic Location for BTF3 Gene

Chromosome:
5
Start:
73,498,408 bp from pter
End:
73,505,635 bp from pter
Size:
7,228 bases
Orientation:
Plus strand

Genomic View for BTF3 Gene

Genes around BTF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTF3 Gene

Proteins for BTF3 Gene

  • Protein details for BTF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20290-BTF3_HUMAN
    Recommended name:
    Transcription factor BTF3
    Protein Accession:
    P20290
    Secondary Accessions:
    • A8K510
    • Q13893
    • Q76M56

    Protein attributes for BTF3 Gene

    Size:
    206 amino acids
    Molecular mass:
    22168 Da
    Quaternary structure:
    • Part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of NACA and BTF3 (via NAC-A/B domains). NAC associates with ribosomes through the BTF3/NACB subunit. Both subunits can contact nascent polypeptide chains.

    Three dimensional structures from OCA and Proteopedia for BTF3 Gene

    Alternative splice isoforms for BTF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTF3 Gene

Post-translational modifications for BTF3 Gene

  • Ubiquitination at Lys 54, Lys 94, and Lys 171
  • Modification sites at PhosphoSitePlus

Other Protein References for BTF3 Gene

No data available for DME Specific Peptides for BTF3 Gene

Domains & Families for BTF3 Gene

Protein Domains for BTF3 Gene

Suggested Antigen Peptide Sequences for BTF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20290

UniProtKB/Swiss-Prot:

BTF3_HUMAN :
  • Contains 1 NAC-A/B (NAC-alpha/beta) domain.
  • Belongs to the NAC-beta family.
Domain:
  • Contains 1 NAC-A/B (NAC-alpha/beta) domain.
Family:
  • Belongs to the NAC-beta family.
genes like me logo Genes that share domains with BTF3: view

No data available for Gene Families for BTF3 Gene

Function for BTF3 Gene

Molecular function for BTF3 Gene

GENATLAS Biochemistry:
general transcription factor BTF3,forming a stable complex with RNA polymerase II, required for initiation of transcription
UniProtKB/Swiss-Prot Function:
When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.

Gene Ontology (GO) - Molecular Function for BTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with BTF3: view
genes like me logo Genes that share phenotypes with BTF3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BTF3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTF3 Gene

Localization for BTF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTF3 Gene

Cytoplasm. Nucleus. Note=The heterodimer with NACA is cytoplasmic.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTF3 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BTF3: view

Pathways & Interactions for BTF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 2320128
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with BTF3: view

No data available for Pathways by source and SIGNOR curated interactions for BTF3 Gene

Transcripts for BTF3 Gene

Unigene Clusters for BTF3 Gene

Basic transcription factor 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BTF3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b
SP1: - - -
SP2: -
SP3: - -
SP4: - - - - -
SP5: -

Relevant External Links for BTF3 Gene

GeneLoc Exon Structure for
BTF3
ECgene alternative splicing isoforms for
BTF3

Expression for BTF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BTF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BTF3 Gene



Protein tissue co-expression partners for BTF3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BTF3 Gene:

BTF3

SOURCE GeneReport for Unigene cluster for BTF3 Gene:

Hs.591768
genes like me logo Genes that share expression patterns with BTF3: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BTF3 Gene

Orthologs for BTF3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BTF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BTF3 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia BTF3 34 35
  • 96.3 (n)
dog
(Canis familiaris)
Mammalia BTF3 34 35
  • 95.68 (n)
rat
(Rattus norvegicus)
Mammalia Btf3 34
  • 94.65 (n)
mouse
(Mus musculus)
Mammalia Btf3 34 16 35
  • 92.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BTF3 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BTF3 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves BTF3 34 35
  • 86.71 (n)
lizard
(Anolis carolinensis)
Reptilia BTF3 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btf3 34
  • 82.19 (n)
Str.17152 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3536 34
zebrafish
(Danio rerio)
Actinopterygii btf3 34 35
  • 84.36 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10091 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006614 34
  • 66.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta bic 36 35
  • 63 (a)
CG11835 36 34 35
  • 61.62 (n)
worm
(Caenorhabditis elegans)
Secernentea C56C10.8 36
  • 65 (a)
icd-1 35
  • 60 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EGD1 35
  • 36 (a)
ManyToMany
BTT1 35 37
  • 32 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons BTF3 34
  • 59.57 (n)
soybean
(Glycine max)
eudicotyledons Gma.11133 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.67 34
rice
(Oryza sativa)
Liliopsida Os03g0851000 34
  • 58.99 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.3012 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1484 35
  • 68 (a)
OneToMany
Species where no ortholog for BTF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BTF3 Gene

ENSEMBL:
Gene Tree for BTF3 (if available)
TreeFam:
Gene Tree for BTF3 (if available)

Paralogs for BTF3 Gene

Variants for BTF3 Gene

Sequence variations from dbSNP and Humsavar for BTF3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10068771 -- 73,504,295(+) tttGG(G/T)GAATA intron-variant
rs111355958 -- 73,505,338(+) CTGAT(A/T)AAATC utr-variant-3-prime
rs111466500 -- 73,501,020(+) ATATA(A/C)AATTT intron-variant
rs111548701 -- 73,500,091(+) CACTT(A/G)GACTT intron-variant
rs111757484 -- 73,502,954(+) CACTT(C/T)AACAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for BTF3 Gene

Variant ID Type Subtype PubMed ID
nsv830346 CNV loss 17160897
nsv968944 CNV duplication 23825009

Variation tolerance for BTF3 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BTF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTF3 Gene

Disorders for BTF3 Gene

Relevant External Links for BTF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BTF3

No disorders were found for BTF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTF3 Gene

Publications for BTF3 Gene

  1. Genomic structure of the putative BTF3 transcription factor. (PMID: 1386332) Kanno M. … Egly J.-M. (Gene 1992) 2 3 4 22 64
  2. Sequencing and expression of complementary DNA for the general transcription factor BTF3. (PMID: 2320128) Zheng X.M. … Egly J.-M. (Nature 1990) 2 3 4 64
  3. Crystal structures of NAC domains of human nascent polypeptide- associated complex (NAC) and its alphaNAC subunit. (PMID: 21203952) Wang L. … Rao Z. (Protein Cell 2010) 3 4 64
  4. Basic transcription factor 3 (BTF3) regulates transcription of tumor- associated genes in pancreatic cancer cells. (PMID: 17312387) Kusumawidjaja G. … Kleeff J. (Cancer Biol. Ther. 2007) 3 22 64
  5. Translation initiation factor (iso) 4E interacts with BTF3, the beta subunit of the nascent polypeptide-associated complex. (PMID: 15716105) Freire M.A. (Gene 2005) 2 3 64

Products for BTF3 Gene

Sources for BTF3 Gene

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