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Aliases for BTF3 Gene

Aliases for BTF3 Gene

  • Basic Transcription Factor 3 2 3
  • Nascent-Polypeptide-Associated Complex Beta Polypeptide 2 3
  • Nascent Polypeptide-Associated Complex Subunit Beta 3 4
  • RNA Polymerase B Transcription Factor 3 3 4
  • NAC-Beta 3 4
  • NACB 3 4
  • Transcription Factor BTF3 3
  • BETA-NAC 3
  • BTF3a 3
  • BTF3b 3

External Ids for BTF3 Gene

Previous Symbols for BTF3 Gene

  • NACB

Summaries for BTF3 Gene

Entrez Gene Summary for BTF3 Gene

  • This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for BTF3 Gene

BTF3 (Basic Transcription Factor 3) is a Protein Coding gene. An important paralog of this gene is BTF3L4.

UniProtKB/Swiss-Prot for BTF3 Gene

  • When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.

Gene Wiki entry for BTF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTF3 Gene

Genomics for BTF3 Gene

Genomic Location for BTF3 Gene

Start:
73,498,408 bp from pter
End:
73,505,635 bp from pter
Size:
7,228 bases
Orientation:
Plus strand

Genomic View for BTF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTF3 Gene

Regulatory Elements for BTF3 Gene

Proteins for BTF3 Gene

  • Protein details for BTF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20290-BTF3_HUMAN
    Recommended name:
    Transcription factor BTF3
    Protein Accession:
    P20290
    Secondary Accessions:
    • A8K510
    • Q13893
    • Q76M56

    Protein attributes for BTF3 Gene

    Size:
    206 amino acids
    Molecular mass:
    22168 Da
    Quaternary structure:
    • Part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of NACA and BTF3 (via NAC-A/B domains). NAC associates with ribosomes through the BTF3/NACB subunit. Both subunits can contact nascent polypeptide chains.

    Three dimensional structures from OCA and Proteopedia for BTF3 Gene

    Alternative splice isoforms for BTF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTF3 Gene

Proteomics data for BTF3 Gene at MOPED

Post-translational modifications for BTF3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys46, Lys54, Lys57, Lys94, and Lys171

Other Protein References for BTF3 Gene

No data available for DME Specific Peptides for BTF3 Gene

Domains for BTF3 Gene

Protein Domains for BTF3 Gene

UniProtKB/Swiss-Prot:

BTF3_HUMAN
Domain:
  • Contains 1 NAC-A/B (NAC-alpha/beta) domain.:
    • P20290
Family:
  • Belongs to the NAC-beta family.:
    • P20290
genes like me logo Genes that share domains with BTF3: view

No data available for Gene Families for BTF3 Gene

Function for BTF3 Gene

Molecular function for BTF3 Gene

GENATLAS Biochemistry: general transcription factor BTF3,forming a stable complex with RNA polymerase II, required for initiation of transcription
UniProtKB/Swiss-Prot Function: When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.

Gene Ontology (GO) - Molecular Function for BTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18025262
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with BTF3: view

Phenotypes for BTF3 Gene

MGI mutant phenotypes for BTF3:
inferred from 1 alleles
GenomeRNAi human phenotypes for BTF3:
genes like me logo Genes that share phenotypes with BTF3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BTF3 Gene

Localization for BTF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTF3 Gene

Cytoplasm. Nucleus. Note=The heterodimer with NACA is cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTF3 Gene COMPARTMENTS Subcellular localization image for BTF3 gene
Compartment Confidence
nucleus 5
chloroplast 1
cytosol 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BTF3: view

Pathways for BTF3 Gene

SuperPathways for BTF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 2320128
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with BTF3: view

No data available for Pathways by source for BTF3 Gene

Transcripts for BTF3 Gene

Unigene Clusters for BTF3 Gene

Basic transcription factor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b
SP1: - - -
SP2: -
SP3: - -
SP4: - - - - -
SP5: -

Relevant External Links for BTF3 Gene

GeneLoc Exon Structure for
BTF3
ECgene alternative splicing isoforms for
BTF3

Expression for BTF3 Gene

mRNA expression in normal human tissues for BTF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BTF3 Gene

SOURCE GeneReport for Unigene cluster for BTF3 Gene Hs.591768

genes like me logo Genes that share expressions with BTF3: view

Orthologs for BTF3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BTF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BTF3 36
  • 99.84 (n)
  • 100 (a)
BTF3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BTF3 36
  • 96.3 (n)
  • 99.38 (a)
BTF3 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTF3 36
  • 95.68 (n)
  • 100 (a)
BTF3 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btf3 36
  • 92.65 (n)
  • 95.59 (a)
Btf3 16
Btf3 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BTF3 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BTF3 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btf3 36
  • 94.65 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves BTF3 36
  • 86.71 (n)
  • 98.77 (a)
BTF3 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTF3 37
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3536 36
tropical clawed frog
(Silurana tropicalis)
Amphibia btf3 36
  • 82.19 (n)
  • 96.89 (a)
Str.17152 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10091 36
zebrafish
(Danio rerio)
Actinopterygii btf3 36
  • 84.36 (n)
  • 96.91 (a)
btf3 37
  • 97 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006614 36
  • 66.43 (n)
  • 67.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta bic 37
  • 56 (a)
ManyToMany
CG11835 36
  • 61.62 (n)
  • 65.79 (a)
CG11835 37
  • 12 (a)
ManyToMany
bic 38
  • 63 (a)
CG11835 38
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea icd-1 37
  • 60 (a)
OneToMany
C56C10.8 38
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BTT1 37
  • 32 (a)
ManyToMany
BTT1 39
EGD1 37
  • 36 (a)
ManyToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.67 36
soybean
(Glycine max)
eudicotyledons Gma.11133 36
thale cress
(Arabidopsis thaliana)
eudicotyledons BTF3 36
  • 59.57 (n)
  • 56.13 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3012 36
rice
(Oryza sativa)
Liliopsida Os03g0851000 36
  • 58.99 (n)
  • 53.95 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1484 37
  • 68 (a)
OneToMany
Species with no ortholog for BTF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BTF3 Gene

ENSEMBL:
Gene Tree for BTF3 (if available)
TreeFam:
Gene Tree for BTF3 (if available)

Paralogs for BTF3 Gene

Paralogs for BTF3 Gene

Selected SIMAP similar genes for BTF3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BTF3: view

Variants for BTF3 Gene

Sequence variations from dbSNP and Humsavar for BTF3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs2979 -- 73,505,334(+) GGATC(G/T)GATAA utr-variant-3-prime
rs14010 -- 73,503,020(+) GAGAC(A/G)AAGCA reference, synonymous-codon
rs347233 -- 73,502,899(-) AGAAA(A/C)ATTTA intron-variant
rs347245 -- 73,497,226(+) TCATT(A/G)GGAAG upstream-variant-2KB
rs703882 -- 73,504,583(-) CAAGC(C/G)AAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTF3 Gene

Variant ID Type Subtype PubMed ID
nsv830346 CNV Loss 17160897

Relevant External Links for BTF3 Gene

HapMap Linkage Disequilibrium report
BTF3

Disorders for BTF3 Gene

No disorders were found for BTF3 Gene.

No data available for UniProtKB/Swiss-Prot for BTF3 Gene

Publications for BTF3 Gene

  1. Genomic structure of the putative BTF3 transcription factor. (PMID: 1386332) Kanno M. … Egly J.-M. (Gene 1992) 2 3 4 23
  2. Sequencing and expression of complementary DNA for the general transcription factor BTF3. (PMID: 2320128) Zheng X.M. … Egly J.-M. (Nature 1990) 2 3 4
  3. Basic transcription factor 3 (BTF3) regulates transcription of tumor- associated genes in pancreatic cancer cells. (PMID: 17312387) Kusumawidjaja G. … Kleeff J. (Cancer Biol. Ther. 2007) 3 23
  4. The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions. (PMID: 10982809) Beatrix B. … Wiedmann M. (J. Biol. Chem. 2000) 3 4
  5. Translation initiation factor (iso) 4E interacts with BTF3, the beta subunit of the nascent polypeptide-associated complex. (PMID: 15716105) Freire M.A. (Gene 2005) 2 3

Products for BTF3 Gene

  • Addgene plasmids for BTF3

Sources for BTF3 Gene

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