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BTF3 Gene

protein-coding   GIFtS: 60
GCID: GC05P072794

Basic Transcription Factor 3

(Previous name: nascent-polypeptide-associated complex beta polypeptide)
(Previous symbol: NACB)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Basic Transcription Factor 31 2     RNA Polymerase B Transcription Factor 32 3
NACB1 2 3     BETA-NAC2
Nascent-Polypeptide-Associated Complex Beta Polypeptide1 2     BTF3a2
Nascent Polypeptide-Associated Complex Subunit Beta2 3     BTF3b2
NAC-beta2 3     Transcription Factor BTF32

External Ids:    HGNC: 11251   Entrez Gene: 6892   Ensembl: ENSG000001457417   OMIM: 6025425   UniProtKB: P202903   

Export aliases for BTF3 gene to outside databases

Previous GC identifers: GC05P071599 GC05P073027 GC05P072832 GC05P072878 GC05P072830 GC05P067999


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BTF3 Gene:
This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB
and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants
encoding different isoforms. This gene has multiple pseudogenes. (provided by RefSeq, Jul 2008)

GeneCards Summary for BTF3 Gene:
BTF3 (basic transcription factor 3) is a protein-coding gene. An important paralog of this gene is BTF3L4.

UniProtKB/Swiss-Prot: BTF3_HUMAN, P20290
Function: When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the
endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their
interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the
ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required
for the initiation of transcription

Gene Wiki entry for BTF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the BTF3 gene promoter:
         Nkx3-1   Egr-3   TBP   Pax-5   GCNF   SRY   TFIID   GCNF-1   Sox9   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBTF3 promoter sequence
   Search Chromatin IP Primers for BTF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BTF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.3

BTF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTF3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P072794:  view genomic region     (about GC identifiers)

Start:
72,794,233 bp from pter      End:
72,801,460 bp from pter
Size:
7,228 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BTF3_HUMAN, P20290 (See protein sequence)
Recommended Name: Transcription factor BTF3  
Size: 206 amino acids; 22168 Da
Subunit: Part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of NACA and BTF3 (via
NAC-A/B domains). NAC associates with ribosomes through the BTF3/NACB subunit. Both subunits can contact nascent
polypeptide chains
2 PDB 3D structures from and Proteopedia for BTF3:
3LKX (3D)        3MCB (3D)    
Secondary accessions: A8K510 Q13893 Q76M56
Alternative splicing: 2 isoforms:  P20290-1   P20290-2   

Explore the universe of human proteins at neXtProt for BTF3: NX_P20290

Explore proteomics data for BTF3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys46, Lys54, Lys57, Lys94, Lys171
  • Modification sites at PhosphoSitePlus

  • See BTF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001032726.1  NP_001198.2  

    ENSEMBL proteins: 
     ENSP00000338516   ENSP00000369965   ENSP00000420978   ENSP00000425490  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002715 Nas_poly-pep-assoc_cplx_dom

    Graphical View of Domain Structure for InterPro Entry P20290

    ProtoNet protein and cluster: P20290

    1 Blocks protein domain: IPB002715 Nascent polypeptide-associated complex NAC

    UniProtKB/Swiss-Prot: BTF3_HUMAN, P20290
    Similarity: Belongs to the NAC-beta family
    Similarity: Contains 1 NAC-A/B (NAC-alpha/beta) domain


    Find genes that share domains with BTF3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BTF3_HUMAN, P20290
    Function: When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the
    endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their
    interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the
    ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required
    for the initiation of transcription

         Genatlas biochemistry entry for BTF3:
    general transcription factor BTF3,forming a stable complex with RNA polymerase II, required for initiation of
    transcription

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18025262
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with BTF3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BTF3:
     Increased cell death HMECs cel 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Btf3):
     mortality/aging  reproductive system 

    Find genes that share phenotypes with BTF3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for BTF3

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    hsa-let-7a-3p (MIRT039000), hsa-mir-22-3p (MIRT030634), hsa-mir-455-3p (MIRT037856), hsa-mir-16-5p (MIRT031986), hsa-mir-186-5p (MIRT021187), hsa-mir-92a-3p (MIRT049443), hsa-mir-652-3p (MIRT039540)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BTF3_HUMAN, P20290: Cytoplasm. Nucleus. Note=The heterodimer with NACA is cytoplasmic
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    chloroplast1
    cytosol1
    golgi apparatus1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with BTF3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BTF3
    Interactions:

        GeneGlobe Interaction Network for BTF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BTF3 (P202901, 3 ENSP000003699654) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678703, ENSP000003650254I2D: score=2 STRING: ENSP00000365025
    ENSG00000224774P678703, ENSP000004156154I2D: score=2 STRING: ENSP00000415615
    ENSG00000206406P678703I2D: score=2 
    ENSG00000224398P678703I2D: score=2 
    ENSG00000228875P678703I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS2320128
    GO:0015031protein transport IEA--

    Find genes that share ontologies with BTF3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for BTF3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BTF3 gene (2 alternative transcripts): 
    NM_001037637.1  NM_001207.4  

    Unigene Cluster for BTF3:

    Basic transcription factor 3
    Hs.591768  [show with all ESTs]
    Unigene Representative Sequence: BQ923254
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335895 ENST00000512257(uc010izd.1) ENST00000514505 ENST00000514360
    ENST00000380591(uc003kcr.1 uc003kcq.1) ENST00000510787 ENST00000508901
    ENST00000507081 ENST00000509708
    miRNA
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    hsa-miR-3163 hsa-miR-4274 hsa-miR-518a-5p hsa-miR-558 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidBTF3 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for BTF3 
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    Additional mRNA sequence: 

    AB062126.1 AK225964.1 AK291125.1 AK310919.1 BC008062.2 BT007120.1 X53280.1 X74070.1 

    Selected DOTS entries (see all 51):

    DT.100890045  DT.100842455  DT.97864272  DT.91711433  DT.415447  DT.100890008  DT.99989204  DT.91776539 
    DT.100890002  DT.91730781  DT.120878609  DT.100045248  DT.100045246  DT.100700480  DT.100890034  DT.121152528 
    DT.91839297  DT.120878611  DT.120909440  DT.120878555  DT.208129  DT.208130  DT.100890018  DT.100890027 

    Selected AceView cDNA sequences (see all 1382):

    BX407832 BM910786 BM975790 BU729782 BF515204 BM461777 AB062126 AI928965 
    BM768324 AI754221 CA390834 CB111839 BM562704 CA947075 BU170933 BI856815 
    BG697270 BM800753 BI862510 AA353314 AA310329 CR612512 CB177242 BU784870 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BTF3    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b
    SP1:                    -           -                                   -               
    SP2:                                -                                                   
    SP3:                    -           -                                                   
    SP4:                    -           -           -     -                 -               
    SP5:                    -                                                               


    ECgene alternative splicing isoforms for BTF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BTF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGACAAA
    BTF3 Expression
    About this image


    BTF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
    BTF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BTF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591768
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BTF3 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Btf31 , 5 basic transcription factor 31, 5 92.65(n)1
    95.59(a)1
      13 (51.92 cM)5
    2184901  NM_145455.31  NP_663430.21 
     983098965 
    chicken
    (Gallus gallus)
    Aves BTF31 basic transcription factor 3 86.71(n)
    98.77(a)
      426154  XM_423823.4  XP_423823.4 
    lizard
    (Anolis carolinensis)
    Reptilia BTF36
    basic transcription factor 3
    98(a)
    1 ↔ 1
    2(15925881-15934597)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.35362 Xenopus laevis transcribed sequence with strong similarity more 83.38(n)    BJ059914.1 
    zebrafish
    (Danio rerio)
    Actinopterygii btf31 basic transcription factor 3 84.36(n)
    96.91(a)
      556625  NM_001076558.1  NP_001070026.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bic3
    CG118351
    transcription factor3
    CG118351
    63(a)
    (best of 2)3
    61.62(n)1
    65.79(a)1
      2 49D63
    332321  NM_134688.31  NP_608532.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C56C10.83 Transcription factor BTF3 (human) 65(a)   II(6587862-6588799)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BTT1(YDR252W)4 Beta3 subunit of the heterotrimeric nascent polypeptide-associated more   --   4(963412-963861) 851839  NP_010538.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons BTF31 BTF3 59.57(n)
    56.13(a)
      838367  NM_101651.3  NP_173230.1 
    rice
    (Oryza sativa)
    Liliopsida AK121674.12   -- 75.15(n)    AK121674.1 


    ENSEMBL Gene Tree for BTF3 (if available)
    TreeFam Gene Tree for BTF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BTF3 gene
    BTF3L42  
    1 SIMAP similar gene for BTF3 using alignment to 3 protein entries:     BTF3_HUMAN (see all proteins):
    BTF3L4

    Find genes that share paralogs with BTF3           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for BTF3 (see all 18)
    PGOHUM00000238915 PGOHUM00000248635 PGOHUM00000247752 PGOHUM00000236912 PGOHUM00000251147


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BTF3 (see all 232)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469607221,2
    --72792543(+) GCCAGA/GGAAAG 2 -- us2k10--------
    rs1816571241,2
    --72792544(+) CCAGGA/GAAAGT 2 -- us2k10--------
    rs1851236731,2
    --72792718(+) TCCCTA/GGTTTC 2 -- us2k10--------
    rs756763471,2
    C,F--72792828(+) AAAAAA/GGGTGG 2 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1895897281,2
    C--72792855(+) AATCTC/TGTCTC 2 -- us2k10--------
    rs1813379541,2
    --72792915(+) AATATA/GACATG 2 -- us2k10--------
    rs1861172971,2
    --72792954(+) AAAGAC/TACACA 2 -- us2k10--------
    rs794501591,2
    C--72793011(+) AGAGCA/TCAGCA 2 -- us2k10--------
    rs782562841,2
    C--72793012(+) GAGCAC/TAGCAT 2 -- us2k10--------
    rs768300011,2
    C,F--72793041(+) TTGGCC/TTTTGT 2 -- us2k11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for BTF3 (72794233 - 72801460 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BTF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830346CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BTF3
    DNA2.0 Custom Variant and Variant Library Synthesis for BTF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602542    OMIM disorders: --


    Find genes that share disorders with BTF3           About GenesLikeMe


    Export disorders for BTF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BTF3 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with BTF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure of the putative BTF3 transcription factor. (PubMed id 1386332)1, 2, 3, 9 Kanno M.... Egly J.-M. (Gene 1992)
    2. Sequencing and expression of complementary DNA for the general transcription factor BTF3. (PubMed id 2320128)1, 2, 3 Zheng X.M.... Egly J.-M. (Nature 1990)
    3. Translation initiation factor (iso) 4E interacts with BTF3, the beta subunit of the nascent polypeptide-associated complex. (PubMed id 15716105)1, 3 Freire M.A. (Gene 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Basic transcription factor 3 (BTF3) regulates transcription of tumor- associated genes in pancreatic cancer cells. (PubMed id 17312387)1, 9 Kusumawidjaja G.... Kleeff J. (Cancer Biol. Ther. 2007)
    6. Clinicopathological significance of BTF3 expression in colorectal cancer. (PubMed id 23532689)1 Wang C.J....Sun X.F. (Tumour Biol. 2013)
    7. Fine-mapping of 5q12.1-13.3 unveils new genetic contributors to caries. (PubMed id 23363935)1 Shimizu T....Vieira A.R. (Caries Res. 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Basic transcription factor 3 is involved in gastric cancer development and progression. (PubMed id 23901224)1 Liu Q....Nie S.L. (World J. Gastroenterol. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 689 HGNC: 1125 AceView: BTF3 Ensembl:ENSG00000145741 euGenes: HUgn689
    ECgene: BTF3 H-InvDB: BTF3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BTF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BTF3 gene:
    Search GeneIP for patents involving BTF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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