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Aliases for BTF3 Gene

Aliases for BTF3 Gene

  • Basic Transcription Factor 3 2 3 5
  • Nascent-Polypeptide-Associated Complex Beta Polypeptide 2 3
  • Nascent Polypeptide-Associated Complex Subunit Beta 3 4
  • RNA Polymerase B Transcription Factor 3 3 4
  • NAC-Beta 3 4
  • NACB 3 4
  • Transcription Factor BTF3 3
  • BETA-NAC 3
  • BTF3a 3
  • BTF3b 3

External Ids for BTF3 Gene

Previous HGNC Symbols for BTF3 Gene

  • NACB

Previous GeneCards Identifiers for BTF3 Gene

  • GC05P071599
  • GC05P073027
  • GC05P072832
  • GC05P072878
  • GC05P072830
  • GC05P072794
  • GC05P067999

Summaries for BTF3 Gene

Entrez Gene Summary for BTF3 Gene

  • This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for BTF3 Gene

BTF3 (Basic Transcription Factor 3) is a Protein Coding gene. Diseases associated with BTF3 include Deafness, Autosomal Recessive 49 and Nonsyndromic Deafness. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is BTF3L4.

UniProtKB/Swiss-Prot for BTF3 Gene

  • When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.

Gene Wiki entry for BTF3 Gene

Additional gene information for BTF3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTF3 Gene

Genomics for BTF3 Gene

Regulatory Elements for BTF3 Gene

Enhancers for BTF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H073519 1.2 Ensembl ENCODE 17.8 +21.4 21393 0 HDGF ZSCAN4 ARID4B ZNF2 RAD21 RFX5 ZNF121 ZNF143 ZNF391 RUNX3 BTF3 ANKRA2 FUNDC2P1 UTP15
GH05H073387 1.1 Ensembl ENCODE 15.9 -110.4 -110399 1 PKNOX1 FEZF1 RUNX3 IKZF2 ZNF362 ZNF488 ZEB2 ELF1 ZNF843 SP1 BTF3 TNPO1 ANKRA2 FCHO2 UTP15 GC05P073385 FOXD1-AS1
GH05H073435 1.5 Ensembl ENCODE dbSUPER 8.5 -61.2 -61169 3 PKNOX1 ATF1 SIN3A FEZF1 ZNF2 GLIS2 KLF7 ZNF202 ZNF610 SMARCA4 ANKRA2 UTP15 TNPO1 BTF3 FOXD1-AS1 GC05P073385
GH05H073443 1.2 ENCODE dbSUPER 8.5 -52.1 -52131 6 PKNOX1 ATF1 SIN3A ZNF2 GLIS2 ZNF202 SP3 YY2 SMARCA4 GLIS1 ANKRA2 LINC01385 LINC01386 LINC02230 ENSG00000223497 LINC01335 LINC01333 UTP15 TNPO1 BTF3
GH05H073337 1.9 Ensembl ENCODE 5.2 -159.8 -159827 1 GFI1B FEZF1 ZBTB8A RAD21 ZIC2 PRDM6 GLIS1 BCL6B ZNF600 MAFK BTF3 GC05P073340 ENSG00000249149
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BTF3 on UCSC Golden Path with GeneCards custom track

Promoters for BTF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000182425 392 2001 HDGF PKNOX1 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B YY1 ZNF143

Genomic Location for BTF3 Gene

Chromosome:
5
Start:
73,498,408 bp from pter
End:
73,505,635 bp from pter
Size:
7,228 bases
Orientation:
Plus strand

Genomic View for BTF3 Gene

Genes around BTF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTF3 Gene

Proteins for BTF3 Gene

  • Protein details for BTF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20290-BTF3_HUMAN
    Recommended name:
    Transcription factor BTF3
    Protein Accession:
    P20290
    Secondary Accessions:
    • A8K510
    • Q13893
    • Q76M56

    Protein attributes for BTF3 Gene

    Size:
    206 amino acids
    Molecular mass:
    22168 Da
    Quaternary structure:
    • Part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of NACA and BTF3 (via NAC-A/B domains). NAC associates with ribosomes through the BTF3/NACB subunit. Both subunits can contact nascent polypeptide chains.

    Three dimensional structures from OCA and Proteopedia for BTF3 Gene

    Alternative splice isoforms for BTF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTF3 Gene

Post-translational modifications for BTF3 Gene

  • Ubiquitination at posLast=5454, posLast=9494, and posLast=171171
  • Modification sites at PhosphoSitePlus

Other Protein References for BTF3 Gene

No data available for DME Specific Peptides for BTF3 Gene

Domains & Families for BTF3 Gene

Gene Families for BTF3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for BTF3 Gene

Suggested Antigen Peptide Sequences for BTF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20290

UniProtKB/Swiss-Prot:

BTF3_HUMAN :
  • Belongs to the NAC-beta family.
Family:
  • Belongs to the NAC-beta family.
genes like me logo Genes that share domains with BTF3: view

Function for BTF3 Gene

Molecular function for BTF3 Gene

GENATLAS Biochemistry:
general transcription factor BTF3,forming a stable complex with RNA polymerase II, required for initiation of transcription
UniProtKB/Swiss-Prot Function:
When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.

Phenotypes From GWAS Catalog for BTF3 Gene

Gene Ontology (GO) - Molecular Function for BTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BTF3: view
genes like me logo Genes that share phenotypes with BTF3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BTF3
  • Applied Biological Materials Clones for BTF3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTF3 Gene

Localization for BTF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTF3 Gene

Cytoplasm. Nucleus. Note=The heterodimer with NACA is cytoplasmic.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTF3 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with BTF3: view

Pathways & Interactions for BTF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 2320128
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with BTF3: view

No data available for Pathways by source and SIGNOR curated interactions for BTF3 Gene

Drugs & Compounds for BTF3 Gene

No Compound Related Data Available

Transcripts for BTF3 Gene

Unigene Clusters for BTF3 Gene

Basic transcription factor 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BTF3
  • Applied Biological Materials Clones for BTF3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for BTF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b
SP1: - - -
SP2: -
SP3: - -
SP4: - - - - -
SP5: -

Relevant External Links for BTF3 Gene

GeneLoc Exon Structure for
BTF3
ECgene alternative splicing isoforms for
BTF3

Expression for BTF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BTF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BTF3 Gene



Protein tissue co-expression partners for BTF3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BTF3 Gene:

BTF3

SOURCE GeneReport for Unigene cluster for BTF3 Gene:

Hs.591768

Evidence on tissue expression from TISSUES for BTF3 Gene

  • Liver(4.8)
  • Blood(4.7)
  • Skin(4.7)
  • Nervous system(4.6)
  • Pancreas(4.5)
  • Lung(4.3)
  • Intestine(4)
  • Stomach(3.2)
  • Heart(3.1)
  • Thyroid gland(3.1)
  • Eye(3)
  • Muscle(2.7)
  • Bone(2.6)
  • Kidney(2.6)
  • Lymph node(2.4)
  • Adrenal gland(2.3)
  • Bone marrow(2.3)
  • Gall bladder(2.3)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with BTF3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTF3 Gene

Orthologs for BTF3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BTF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BTF3 33 34
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia BTF3 33 34
  • 96.3 (n)
dog
(Canis familiaris)
Mammalia BTF3 33 34
  • 95.68 (n)
rat
(Rattus norvegicus)
Mammalia Btf3 33
  • 94.65 (n)
mouse
(Mus musculus)
Mammalia Btf3 33 16 34
  • 92.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BTF3 34
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BTF3 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves BTF3 33 34
  • 86.71 (n)
lizard
(Anolis carolinensis)
Reptilia BTF3 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btf3 33
  • 82.19 (n)
Str.17152 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3536 33
zebrafish
(Danio rerio)
Actinopterygii btf3 33 34
  • 84.36 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10091 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006614 33
  • 66.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta bic 35 34
  • 63 (a)
CG11835 35 33 34
  • 61.62 (n)
worm
(Caenorhabditis elegans)
Secernentea C56C10.8 35
  • 65 (a)
icd-1 34
  • 60 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EGD1 34
  • 36 (a)
ManyToMany
BTT1 34 36
  • 32 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons BTF3 33
  • 59.57 (n)
soybean
(Glycine max)
eudicotyledons Gma.11133 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.67 33
rice
(Oryza sativa)
Liliopsida Os03g0851000 33
  • 58.99 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.3012 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1484 34
  • 68 (a)
OneToMany
Species where no ortholog for BTF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BTF3 Gene

ENSEMBL:
Gene Tree for BTF3 (if available)
TreeFam:
Gene Tree for BTF3 (if available)

Paralogs for BTF3 Gene

Variants for BTF3 Gene

Sequence variations from dbSNP and Humsavar for BTF3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000146189 -- 73,496,851(+) TTTAT(A/G)TTTTT upstream-variant-2KB
rs1000678847 -- 73,502,434(+) GAAAA(A/G)TATCT intron-variant
rs1000921866 -- 73,499,703(+) AAATA(C/T)AACCC intron-variant
rs1001116991 -- 73,497,827(+) TTAGT(C/T)ATCTG upstream-variant-2KB
rs1001148339 -- 73,498,289(+) TAGGG(C/T)CTACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BTF3 Gene

Variant ID Type Subtype PubMed ID
nsv830346 CNV loss 17160897
nsv968944 CNV duplication 23825009

Variation tolerance for BTF3 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BTF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTF3 Gene

Disorders for BTF3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BTF3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal recessive 49
  • autosomal recessive nonsyndromic deafness 49
nonsyndromic deafness
  • nonsyndromic hearing loss
- elite association - COSMIC cancer census association via MalaCards
Search BTF3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BTF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BTF3
genes like me logo Genes that share disorders with BTF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BTF3 Gene

Publications for BTF3 Gene

  1. Genomic structure of the putative BTF3 transcription factor. (PMID: 1386332) Kanno M … Egly JM (Gene 1992) 2 3 4 22 60
  2. Sequencing and expression of complementary DNA for the general transcription factor BTF3. (PMID: 2320128) Zheng XM … Egly JM (Nature 1990) 2 3 4 60
  3. Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its αNAC subunit. (PMID: 21203952) Wang L … Rao Z (Protein & cell 2010) 3 4 60
  4. Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells. (PMID: 17312387) Kusumawidjaja G … Kleeff J (Cancer biology & therapy 2007) 3 22 60
  5. Translation initiation factor (iso) 4E interacts with BTF3, the beta subunit of the nascent polypeptide-associated complex. (PMID: 15716105) Freire MA (Gene 2005) 2 3 60

Products for BTF3 Gene

  • Addgene plasmids for BTF3

Sources for BTF3 Gene

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