Aliases for BTF3 Gene
External Ids for BTF3 Gene
Previous HGNC Symbols for BTF3 Gene
Previous GeneCards Identifiers for BTF3 Gene
This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
GeneCards Summary for BTF3 Gene
BTF3 (Basic Transcription Factor 3) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is BTF3L4.
UniProtKB/Swiss-Prot for BTF3 Gene
When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.