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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BTC Gene

protein-coding   GIFtS: 62
GCID: GC04M075669

betacellulin
 Explore 26 diseases affiliated with
BTC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BTC    

Aliases
for BTC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Betacellulin1
Probetacellulin1

External Ids:    HGNC: 11211   Entrez Gene: 6852   Ensembl: ENSG000001748087   OMIM: 6003455   UniProtKB: P350703   

Export aliases for BTC gene to outside databases

Previous GC identifers: GC04M075557 GC04M075843 GC04M076062 GC04M076128 GC04M076129 GC04M076027 GC04M075889 GC04M071418


Summaries
for BTC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BTC:
The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a
transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand
for the EGF receptor. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BTC_HUMAN, P35070
Function: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal
pigment epithelial cells and vascular smooth muscle cells

Gene Wiki entry for BTC (Betacellulin)


Genomic Views
for BTC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BTC gene promoter:
         FOXI1   HFH-3   CREB   FOXO4   deltaCREB   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BTC promoter sequence
   Search SABiosciences Chromatin IP Primers for BTC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

BTC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M075669:  view genomic region     (about GC identifiers)

Start:
 75,669,969 bp from pter      End:
 75,719,896 bp from pter
Size:
 49,928 bases      Orientation:
 minus strand

Proteins
for BTC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BTC_HUMAN, P35070 (See protein sequence)
Recommended Name: Probetacellulin precursor  
Size: 178 amino acids; 19746 Da
Subunit: Monomer. Interacts with EGFR and ERBB4
Subcellular location: Betacellulin: Secreted, extracellular space
Subcellular location: Probetacellulin: Cell membrane; Single-pass type I membrane protein
2 PDB 3D structures from and Proteopedia for BTC:
1IOX (3D)        1IP0 (3D)    
Secondary accessions: Q96F48

Explore the universe of human proteins at neXtProt for BTC: NX_P35070

BTC Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_001720.1  
ENSEMBL proteins: 
 ENSP00000379092   ENSP00000421747  
Reactome Protein details: P35070
Human Recombinant Protein Products: 
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R&D Systems Recombinant & Natural Proteins for BTC (Betacellulin/BTC)
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Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: BTC
OriGene Custom Protein Services for BTC 
GenScript Purified and Recombinant Proteins for BTC
Novus Biologicals BTC Proteins
Novus Biologicals BTC Lysates
Sino Biological Recombinant Protein for BTC
ProSpec Recombinant Protein for BTC
Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--
GO:0005625soluble fraction ----
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--


BTC for ontologies           About GeneDecksing



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ThermoFisher Antibodies for BTC

Assay Products for BTC: 
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Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for BTC gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
BTC for domains           About GeneDecksing

3 InterPro domains/families:
 IPR015497 EGF_rcpt_ligand
 IPR000742 EG-like_dom
 IPR013032 EGF-like_CS

Graphical View of Domain Structure for InterPro Entry P35070

ProtoNet protein and cluster: P35070

2 Blocks protein families:
IPB001336 Type I EGF signature
IPB006210 Type I EGF


UniProtKB/Swiss-Prot: BTC_HUMAN, P35070
Similarity: Contains 1 EGF-like domain


Function
for BTC gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: BTC_HUMAN, P35070
Function: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal
pigment epithelial cells and vascular smooth muscle cells

     Genatlas biochemistry entry for BTC:
betacellulin,ECF family

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BTC
8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate BTC (see all 16):
hsa-miR-548j hsa-miR-548w hsa-miR-4324 hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-4299
SwitchGear 3'UTR luciferase reporter plasmid: BTC 3' UTR sequence
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BTC (see all 7)
OriGene shRNA RFP: BTC
OriGene siRNA: BTC
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BTC

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for BTC

Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTC (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: BTC (NM_001729)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTC 

Cell Line
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Search LifeMap BioReagents cell lines for BTC

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTC

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005154epidermal growth factor receptor binding TAS8144591
GO:0008083growth factor activity IEA--


BTC for ontologies           About GeneDecksing


1 GenomeRNAi human phenotype for BTC:
 Increased circadian rhythm amp 

Animal Models:
     Mouse knock-out Btctm1Dcl for BTC
     7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Btc):
 cardiovascular system  growth/size  homeostasis/metabolism  mortality/aging  muscle 
 normal  skeleton 

BTC for phenotypes           About GeneDecksing


Pathways & Interactions
for BTC gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Apoptotic Pathways in Synovial Fibroblasts
8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts1.00
ERK5 Signaling0.61
p53 Mediated Apoptosis0.84
eIF2 Pathway0.60
Mitochondrial Apoptosis0.73
Rac1 Pathway0.58
Telomerase Components in Cell Signaling0.72
Nuclear Receptor Activation by Vitamin-A0.57
2Signaling by FGFR
8/12 pathways (see all 12)
Signaling by FGFR1.00
DAP12 signaling0.83
Downstream signaling of activated FGFR0.92
Signaling by EGFR in Cancer0.83
Signaling by FGFR in disease0.91
DAP12 interactions0.76
Signaling by ERBB20.89
Signaling by PDGF0.72
3PIP3 activates AKT signaling
8/10 pathways (see all 10)
PIP3 activates AKT signaling1.00
PI3K/AKT activation0.97
PI3K/AKT Signaling in Cancer1.00
GAB1 signalosome0.96
PI3K events in ERBB2 signaling1.00
Constitutive PI3K/AKT Signaling in Cancer0.88
PI3K events in ERBB4 signaling1.00
Signaling by SCF-KIT0.72
4GPCR Pathway
GPCR Pathway1.00
Estrogen Pathway0.55
Ras Pathway0.62
Pancreatic Adenocarcinoma0.55
Breast Cancer Regulation by Stathmin10.58
Paxillin Interactions0.53
NFAT in Immune Response0.58
5Rho Family GTPases
Rho Family GTPases1.00
MAPK Signaling0.51
ERK Signaling0.61
ILK Signaling0.45
Molecular Mechanisms of Cancer0.51

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for BTC
    Development ERBB-family signaling
Development EGFR signaling pathway

5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BTC (see all 55)
    Nuclear Receptor Activation by Vitamin-A
Paxillin Interactions
Telomerase Components in Cell Signaling
Mitochondrial Apoptosis
Molecular Mechanisms of Cancer

2 GeneGo (Thomson Reuters) Pathways for BTC
    Development ERBB-family signaling
Development EGFR signaling pathway

3 BioSystems Pathways for BTC 
    ErbB signaling pathway
ErbB4 signaling events
ErbB receptor signaling network

5/33        Reactome Pathways for BTC (see all 33)
    Signaling by EGFR in Cancer
Downstream signal transduction
Signal Transduction
Signaling by PDGF
Downstream Signaling Events Of B Cell Receptor (BCR)

1 PharmGKB Pathway for BTC
    EGFR Inhibitor Pathway, Pharmacodynamics

1         Kegg Pathway  (Kegg details for BTC):
    ErbB signaling pathway


BTC for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BTC

5 Interacting proteins for BTC (P350702, 3) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
S100A4P264472, 3MINT-7256512 MINT-7256593 I2D: score=1 
EGFRP005333I2D: score=2 
ERBB2P046263I2D: score=1 
ERBB4Q153033I2D: score=1 
MMP9P147803I2D: score=1 
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008284positive regulation of cell proliferation IEA--
GO:0043066negative regulation of apoptotic process IEA--
GO:0051781positive regulation of cell division IEA--


BTC for ontologies           About GeneDecksing



Drugs & Compounds
for BTC gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BTC for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BTC
10/15 Novoseek chemical compound relationships for BTC gene (see all 15)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
ag 1478 58.8 1 10601546 (1)
tyrosine 53.9 15 15192046 (3), 9334263 (2), 9662041 (1), 10579352 (1) (see all 10)
heparin 40 15 17673511 (3), 11218236 (2), 12612292 (1), 16962163 (1) (see all 9)
wortmannin 39.5 2 12475887 (2)
pd 98,059 39.4 2 12475887 (2)
phosphatidylinositol 36.8 3 8626392 (1), 12475887 (1), 16487738 (1)
nicotinamide 34.1 5 18060872 (3), 14514635 (1), 16132961 (1)
matrigel 25.3 1 12475887 (1)
c-peptide 12.8 1 15939230 (1)
cycloheximide 12.8 1 11072245 (1)

Search CenterWatch for drugs/clinical trials and news about BTC 

Transcripts
for BTC gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for BTC gene: 
NM_001729.2  

Unigene Cluster for BTC:

Betacellulin
Hs.710156  [show with all ESTs]
Unigene Representative Sequence: NM_001729
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000395743(uc003hig.2) ENST00000512743

miRNA
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8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate BTC (see all 16):
hsa-miR-548j hsa-miR-548w hsa-miR-4324 hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-4299
SwitchGear 3'UTR luciferase reporter plasmid: BTC 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BTC (see all 7)
OriGene shRNA RFP: BTC
OriGene siRNA: BTC
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BTC
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTC
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GenScript: all cDNA clones in your preferred vector: BTC (NM_001729)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTC 
Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTC
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTC

Additional cDNA sequence: 

AB109441.1 S55606.1 

2 DOTS entries:

DT.204260  DT.92416550 

18 AceView cDNA sequences:

AA917900 BX493533 AB109441 NM_001729 AI822020 BC011618 BE899442 S55606 
CB121982 BX646859 AI792829 AI277656 BF382080 BG194271 AI766016 BI552049 
BI758136 AW129759 

GeneLoc Exon Structure


Expression
for BTC gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BTC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGATAGCTAT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

BTC expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
2 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
OvaryAntral FollicleMural Granulosa CellsOvary
HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

Genevestigator expression for BTC

SOURCE GeneReport for Unigene cluster: Hs.710156

UniProtKB/Swiss-Prot: BTC_HUMAN, P35070
Tissue specificity: Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small
intestine

    SABiosciences Custom PCR Arrays for BTC
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTC
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTC

Orthologs
for BTC gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for BTC gene from 3/7 species (see all 7)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Btc1 , 5 betacellulin, epidermal growth factor family member1, 5 80.41(n)1
79.66(a)1		   5 (44.78 cM)5
122231  NM_007568.51  NP_031594.11 
 913572615 
chicken
(Gallus gallus)		 Aves BTC1 betacellulin 62.08(n)
59.37(a)		   448833  NM_001004769.1  NP_001004769.1 
zebrafish
(Danio rerio)		 Actinopterygii zgc:1532531 betacellulin-like 52.83(n)
39.62(a)		   767639  NM_001160823.1  NP_001154295.1 


ENSEMBL Gene Tree for BTC (if available)
TreeFam Gene Tree for BTC (if available) 

Paralogs
for BTC gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for BTC gene
MSANTD3-TMEFF12  TGFA2  TMEFF22  TMEFF12  
1 SIMAP similar gene for BTC using alignment to 2 protein entries:     BTC_HUMAN (see all proteins):
TGFA

BTC for paralogs           About GeneDecksing



Genomic Variants
for BTC gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Human Gene Mutation Database (HGMD): BTC
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTC
DNA2.0 Custom Variant and Variant Library Synthesis for BTC

Disorders / Diseases
for BTC gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
BTC for disorders           About GeneDecksing

OMIM gene information: 600345    OMIM disorders: --

20/26 diseases for BTC (see all 26):    About MalaCards
erythropoietic protoporphyria    fibrous histiocytoma    malignant fibrous histiocytoma    type 1 diabetes mellitus
glucose intolerance    chronic obstructive pulmonary disease    biliary tract cancer    histiocytoma
diabetes mellitus    basal cell carcinoma    malignant mesothelioma    insulinoma
endometrial cancer    pulmonary disease    pancreatic cancer    breast carcinoma
breast cancer    carcinoma    obesity    hepatocellular carcinoma

10/15 Novoseek disease relationships for BTC gene (see all 15)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
insulinoma 55.6 14 8439318 (2), 10724350 (2), 8283650 (1), 17260022 (1) (see all 6)
hnscc 51.4 8 15197768 (3), 11072245 (1), 10706134 (1), 11235991 (1)
gastrointestinal tumor 35.9 2 14530681 (1), 12790326 (1)
carcinoma squamous cell 18 3 15197768 (1), 8144591 (1), 10706134 (1)
tumors 15.6 13 16949929 (5), 10601546 (2), 18289051 (1), 10797281 (1) (see all 5)
breast carcinoma 15.5 1 9312020 (1)
pancreatic cancer 9.68 9 10601546 (6), 8980184 (1)
endometrial cancer 8.08 2 16962163 (1), 10537356 (1)
breast cancer 4.53 4 18949710 (1), 10022523 (1), 19026613 (1), 17962208 (1)
carcinoma 2.98 6 9648926 (1), 11439355 (1), 8144591 (1), 8630011 (1) (see all 5)

Genetic Association Database (GAD): BTC
Human Genome Epidemiology (HuGE) Navigator: BTC (8 documents)

Export disorders for BTC gene to outside databases

Publications
for BTC gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for BTC gene, integrated from 9 sources (see all 149):
(articles sorted by number of sources associating them with BTC)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family. (PubMed id 8439318)1, 2, 3, 9 Sasada R.... Igarashi K. (1993)
  2. Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form. (PubMed id 8919026)1, 2, 9 Seno M.... Yamada H. (1996)
  3. Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction. (PubMed id 8144591)1, 2, 9 Watanabe T....Sasada R. (1994)
  4. The exon 1 Cys7Gly polymorphism within the betacellulin gene is associated with type 2 diabetes in African Americans. (PubMed id 15793259)1, 4, 9 Silver K....Mitchell B.D. (2005)
  5. Molecular scanning of the betacellulin gene for mutations in type 2 diabetic patients. (PubMed id 15936459)1, 4, 9 Nakagawa T....Nanjo K. (2005)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  7. Solution structure of betacellulin, a new member of EGF-family ligands. (PubMed id 12074582)1, 2 Miura K.... Kawano K. (2002)
  8. Novel betacellulin derivatives. Separation of the differentiation activity from the mitogenic activity. (PubMed id 11522793)1, 3 Itoh T....Fujino M. (2001)
  9. Changes in the expression and cytological localization of betacellulin and its receptors (ErbB-1 and ErbB-4) in the trophoblasts in human placenta over the course of pregnancy. (PubMed id 15248827)1, 9 Tanimura K....Maruo T. (2004)
  10. Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF. (PubMed id 15192046)1, 9 Saito T....Mori M. (2004)

External Searches for BTC gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing BTC gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 685 HGNC: 1121 AceView: BTC Ensembl:ENSG00000174808 euGenes: HUgn685
ECgene: BTC Kegg: 685 H-InvDB: BTC

Other Databases showing BTC gene

(According to HUGE)
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Specialized Databases showing BTC gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for BTC Pharmacogenomics, SNPs, Pathways

Intellectual Property
for BTC gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for BTC gene:
Search GeneIP for patents involving BTC

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for BTC gene

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In Situ Hybridization Assays from
Advanced Cell Diagnostics
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