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BTC Gene

protein-coding GIFtS: 62

GC04M075889

betacellulin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
OTTHUMP00000160600 ^²
betacellulin ^²

External Ids
HGNC: 1121¹
Entrez Gene: 685²
UniProtKB: P35070³
Ensembl: ENSG00000174808⁷

Search outside databases for aliases for BTC gene

Previous GC identifers: GC04M075557 GC04M075843 GC04M076062 GC04M076128 GC04M076129 GC04M076027

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BTC:

The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized

primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic

events. This protein is a ligand for the EGF receptor. [provided by RefSeq]

UniProtKB/Swiss-Prot: BTC_HUMAN, P35070

Function: Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. The

effects of betacellulin are probably mediated by the EGF receptor and other related receptors

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BTC gene

Entrez Gene cytogenetic band: 4q13-q21 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13-q21

BTC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M075889: (about GC identifiers)

Start:	75,888,993 bp from pter
End:	75,938,920 bp from pter
Size:	49,928 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BTC_HUMAN, P35070 (See protein sequence)

Recommended Name: Probetacellulin precursor

Size: 178 amino acids; 19746 Da

Subunit: Monomer

Subcellular location: Betacellulin: Secreted, extracellular space

Subcellular location: Probetacellulin: Cell membrane; Single-pass type I membrane protein

PDB structure from and Proteopedia :

1IOX (3D)

1IP0 (3D)

Secondary accessions: Q96F48

REFSEQ proteins: NP_001720.1

ENSEMBL proteins:

ENSP00000379092 ENSP00000312050

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for BTC
	R&D Systems Recombinant & Natural Proteins for BTC (Betacellulin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Betacellulin)
	Human Recombinant Proteins from Abnova (BTC)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005625	soluble fraction	TAS	8144591
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for BTC:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for BTC
	R&D Systems Antibodies for BTC (Betacellulin)
	Antibodies from Abcam (Betacellulin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BTC)
	Novus Biologicals Antibodies for BTC

Assays for BTC:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for BTC (Betacellulin) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P35070

ProtoNet protein and cluster: P35070

2 Blocks protein families:

IPB001336 Type I EGF signature

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: BTC_HUMAN, P35070

Similarity: Contains 1 EGF-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BTC)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001729

Applied Biosystems Silencer® siRNAs for BTC

Sigma-Aldrich siRNA and siRNA Panels for BTC

Sigma-Aldrich shRNA for BTC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BTC
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001729
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001729
untagged cDNA clone in CMV expression vector: NM_001729

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001729

UniProtKB/Swiss-Prot: BTC_HUMAN, P35070

Function: Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. The

effects of betacellulin are probably mediated by the EGF receptor and other related receptors

Genatlas biochemistry entry for BTC:

betacellulin,ECF family

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Btc):

	growth/size	homeostasis/metabolism	life span-post-weaning/aging	muscle
normal	skeleton

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005154	epidermal growth factor receptor binding	TAS	8144591
GO:0008083	growth factor activity	TAS	8439318

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for BTC (Your Favorite Gene powered by Ingenuity)

Neuregulin Signaling

GeneDecks BTC for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for BTC

5/11 Interacting proteins for BTC (ENSP00000312050³) via UniProtKB, MINT, and/or STRING (see all 11 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EGFR	ENSP00000275493³	STRING (score=.999)
ERBB4	ENSP00000342235³	STRING (score=.997)
ERBB2	ENSP00000269571³	STRING (score=.902)
ERBB3	ENSP00000267101³	STRING (score=.819)
EGFLAM	ENSP00000346964³	STRING (score=.816)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008284	positive regulation of cell proliferation	TAS	8144591
GO:0043066	negative regulation of apoptosis	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BTC
10 Novoseek chemical compound relationships for BTC gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	55.23	15	15192046 (3), 9334263 (2), 9662041 (1), 10579352 (1) (see all 10)
pd 98,059	41.11	2	12475887 (2)
wortmannin	40.92	2	12475887 (2)
phosphatidylinositol	38.35	3	8626392 (1), 12475887 (1), 16487738 (1)
matrigel	27.53	1	12475887 (1)
c-peptide	14.56	1	15939230 (1)
glucose	9.02	11	17479438 (2), 11118003 (2), 15939230 (1), 17989064 (1) (see all 6)
progesterone	3.17	2	16543407 (1)
calcium	0.00	1	8144591 (1)
thymidine	0.00	1	11254912 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BTC)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001729

Sigma-Aldrich siRNA and siRNA Panels for BTC

Sigma-Aldrich shRNA for BTC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001729

REFSEQ mRNAs for BTC gene:

NM_001729.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001729

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001729
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001729
                                 untagged cDNA clone in CMV expression vector: NM_001729

Additional cDNA sequence:

AB109441.1 S55606.1

2 DOTS entries:

DT.204260 DT.92416550

18 AceView cDNA sequences:

AB109441 BX493533 AA917900 BE899442 NM_001729 AI822020 CB121982 S55606

BC011618 AI792829 BX646859 AI277656 BG194271 AI766016 BF382080 BI552049

AW129759 BI758136

highest scoring ESTs for BTC:

S55606 AA917900 AB109441 AI766016 AI792829 AI822020 BC011618 BE899442 BX493533 AA148418

Unigene Cluster for BTC:

Betacellulin

Hs.710156 [show with all ESTs]

Unigene Representative Sequence: NM_001729

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000395743 ENST00000311727

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BTC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BTC

¹ / ² / ³

6 probe-sets matching BTC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
83477_at²^{, 3}	U95-E	1	1.00	1.00	0.92	1.47	AW003768	0.60	1.00	0.82	1
33975_at²^{, 3}	U95-A	1	1.00	1.00	0.90	0.55	S55606	1.00	1.00	1.00	1
241412_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI620677	0.40	1.00	0.76	1
207326_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001729	0.60	1.00	0.82	1
207326_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
241412_at²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--

GeneDecks BTC for binary patterns associated with the probe-sets selected above

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About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGATAGCTAT

SOURCE GeneReport for Unigene cluster: Hs.710156
Expression variation in blood from EXPOLDB for BTC
UniProtKB/Swiss-Prot: BTC_HUMAN, P35070
Tissue specificity: Synthesized in several tissues and tumor cells. Predominantly expressed in
pancreas and small intestine

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BTC gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BTC¹	--	betacellulin	83.74(n) 81.71(a)	482682 XM_539798.2 XP_539798.2
chimpanzee (Pan troglodytes)	BTC¹	--	betacellulin	99.25(n) 97.75(a)	461250 XM_517223.2 XP_517223.2
cow (Bos taurus)	BTC¹	--	betacellulin	89.51(n) 88.2(a)	280737 NM_173896.1 NP_776321.1
rat (Rattus norvegicus)	Btc¹	--	betacellulin	80.23(n) 78.53(a)	64022 NM_022256.1 NP_071592.1
mouse (Mus musculus)	Btc^{1, 5}	5 (51.00 cM)⁵	betacellulin, epidermal growth factor family member^{1, 5}	80.41(n)¹ 79.66(a)¹	12223¹ NM_007568.3¹ NP_031594.1¹ AF368017⁵ AF368018⁵ (see all 16)

About this table Species with no ortholog for BTC

ENSEMBL Gene Tree for BTC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BTC gene

TGFA² C9orf30² TMEFF2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/360 NCBI SNPs in BTC are shown (see all 360 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 140)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1452308^1,2	C,F,H	75939175(-)	`CCACAA/GTGAAT`	1	--	ng3¹		4		EU EA WA	394
	rs11938093^1,2	C,F,H	75894865(+)	`TATCAA/TACAAA`	1	L/M	mis¹		9		EU EA WA NA	898
	rs2278862^1,2	C,F	75938785(-)	`GGGATA/GAATAG`	1	--	ut5¹		3		EA NA	1664
--	rs6856455^1,2	A,C	75938970(+)	`TCCCTA/CCCCCC`	1	--	ng3¹		0	--	--	--	--
	rs28549760^1,2	C,F	75938541(+)	`GCTGCA/CCCGGG`	1	C/G	mis¹ ese³		5		NA EU EA WA	494
--	rs1377031^1,2	A,C	75939495(-)	`cttttC/Tttttt`	1	--	ng3¹ trp³		0	--	--	--	--
	rs13101336^1,2	A,C	75939947(+)	`GTTAAA/GTAAAT`	1	--	ng3¹		0	--	--	--	--
--	rs11733938^1,2	A,C	75940718(+)	`TTTTTC/TCCCTC`	1	--	ng3¹ trp³		0	--	--	--	--
	rs1452306^1,2	C,O	75939567(-)	`TTTTAC/TGAATT`	1	--	ng3¹		0	--	--	--	--
	rs28690341^1,2	C	75938792(+)	`TCCCCC/GCTCCT`	1	--	ut5¹ trp³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for BTC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600345

UniProtKB/Swiss-Prot: BTC_HUMAN, P35070

Betacellulin from beta cells could play a role in the vascular complications associated

with diabetes

10/15 Novoseek disease relationships for BTC gene (see all 15 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
insulinoma	56.78	14	8439318 (2), 10724350 (2), 8283650 (1), 17260022 (1) (see all 6)
hnscc	53.73	8	15197768 (3), 11072245 (1), 10706134 (1), 11235991 (1)
gastrointestinal tumor	37.52	2	14530681 (1), 12790326 (1)
carcinoma squamous cell	20.00	3	15197768 (1), 8144591 (1), 10706134 (1)
breast carcinoma	17.19	1	9312020 (1)
tumors	14.84	13	16949929 (5), 10601546 (2), 18289051 (1), 10797281 (1) (see all 5)
pancreatic cancer	12.28	9	10601546 (6), 8980184 (1)
endometrial cancer	10.28	2	16962163 (1), 10537356 (1)
breast cancer	7.01	4	18949710 (1), 10022523 (1), 19026613 (1), 17962208 (1)
carcinoma	4.76	6	9648926 (1), 11439355 (1), 8144591 (1), 8630011 (1) (see all 5)

About this table

Human Gene Mutation Database: BTC
Genetic Association Database: BTC
Human Genome Epidemiology Navigator: BTC (7 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/138 PubMed articles for BTC gene (see all 138 ):

Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family. (PubMed id 8439318)^{1, 2, 3, 4} Sasada R.... Igarashi K. (1993)
Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form. (PubMed id 8919026)^{1, 3, 4} Seno M.... Yamada H. (1996)
The exon 1 Cys7Gly polymorphism within the betacellulin gene is associated with type 2 diabetes in African Americans. (PubMed id 15793259)^{1, 3, 6} Silver K....Mitchell B.D. (2005)
Molecular scanning of the betacellulin gene for mutations in type 2 diabetic patients. (PubMed id 15936459)^{1, 3, 6} Nakagawa T....Nanjo K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Solution structure of betacellulin, a new member of EGF-family ligands. (PubMed id 12074582)^{3, 4} Miura K.... Kawano K. (2002)
Novel betacellulin derivatives. Separation of the differentiation activity from the mitogenic activity. (PubMed id 11522793)^{2, 3} Itoh T....Fujino M. (2001)
Changes in the expression and cytological localization of betacellulin and its receptors (ErbB-1 and ErbB-4) in the trophoblasts in human placenta over the course of pregnancy. (PubMed id 15248827)^{1, 3} Tanimura K....Maruo T. (2004)
Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF. (PubMed id 15192046)^{1, 3} Saito T....Mori M. (2004)
Immunohistochemical localization of Betacellulin, a member of epidermal growth factor family, in atherosclerotic plaques of human aorta. (PubMed id 11254912)^{1, 3} Tamura R....Matsuzawa Y. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 685	HGNC: 1121	AceView: BTC	Ensembl:ENSG00000174808	euGenes: HUgn685
ECgene: BTC	H-InvDB: BTC

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for BTC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BTC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
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	Lentivirus-delivered shRNAs for BTC		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BTC)
	Antibodies (BTC)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Betacellulin)
	Antibodies (Betacellulin)

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Search Tocris compounds for BTC

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BTC

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BTC Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for BTC

Summaries
for BTC

Genomic Location
for BTC

Proteins
for BTC

Protein Domains/
Families
for BTC

Gene Function
for BTC

Pathways & Interactions
for BTC

Drugs & Compounds
for BTC

Transcripts
for BTC

Expression
for BTC

Orthologs
for BTC

Paralogs
for BTC

SNPs/Variants
for BTC

Disorders & Mutations
for BTC

Medical News
for BTC

Publications
for BTC

Search for BTC

Genome Databases showing BTC

Other Databases showing BTC

Specialized Databases showing BTC

Licensable Technologies
for BTC

Services
for BTC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BTC Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor BTC

Summariesfor BTC

Genomic Locationfor BTC

Proteinsfor BTC

Protein Domains/Familiesfor BTC

Gene Functionfor BTC

Pathways & Interactionsfor BTC

Drugs & Compoundsfor BTC

Transcriptsfor BTC

Expression for BTC

Orthologsfor BTC

Paralogsfor BTC

SNPs/Variantsfor BTC

Disorders & Mutationsfor BTC

Medical Newsfor BTC

Publicationsfor BTC

Search for BTC

Genome Databases showing BTC

Other Databases showing BTC

Specialized Databases showing BTC

Licensable Technologiesfor BTC

Servicesfor BTC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BTC

Summaries
for BTC

Genomic Location
for BTC

Proteins
for BTC

Protein Domains/
Families
for BTC

Gene Function
for BTC

Pathways & Interactions
for BTC

Drugs & Compounds
for BTC

Transcripts
for BTC

Expression
for BTC

Orthologs
for BTC

Paralogs
for BTC

SNPs/Variants
for BTC

Disorders & Mutations
for BTC

Medical News
for BTC

Publications
for BTC

Licensable Technologies
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