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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BTC Gene

protein-coding   GIFtS: 63
GCID: GC04M075669

Betacellulin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
betacellulin1 2
probetacellulin2

External Ids:    HGNC: 11211   Entrez Gene: 6852   Ensembl: ENSG000001748087   OMIM: 6003455   UniProtKB: P350703   

Export aliases for BTC gene to outside databases

Previous GC identifers: GC04M075557 GC04M075843 GC04M076062 GC04M076128 GC04M076129 GC04M076027 GC04M075889 GC04M071418


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BTC Gene:
The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a
transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a
ligand for the EGF receptor. (provided by RefSeq, Jul 2008)

GeneCards Summary for BTC Gene: 
BTC (betacellulin) is a protein-coding gene. Diseases associated with BTC include erythropoietic protoporphyria, and insulinoma, and among its related super-pathways are ErbB signaling pathway and GRB2 events in ERBB2 signaling. GO annotations related to this gene include epidermal growth factor receptor binding and growth factor activity. An important paralog of this gene is TGFA.

UniProtKB/Swiss-Prot: BTC_HUMAN, P35070
Function: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for
retinal pigment epithelial cells and vascular smooth muscle cells

Gene Wiki entry for BTC (Betacellulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BTC gene promoter:
         FOXI1   HFH-3   CREB   FOXO4   deltaCREB   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBTC promoter sequence
   Search SABiosciences Chromatin IP Primers for BTC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

BTC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M075669:  view genomic region     (about GC identifiers)

Start:
75,669,969 bp from pter      End:
75,719,896 bp from pter
Size:
49,928 bases      Orientation:
minus strand

1 alternative location:
Chr4-,NW_003571035 229,746-239,493     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BTC_HUMAN, P35070 (See protein sequence)
Recommended Name: Probetacellulin precursor  
Size: 178 amino acids; 19746 Da
Subunit: Monomer. Interacts with EGFR and ERBB4
Subcellular location: Betacellulin: Secreted, extracellular space
Subcellular location: Probetacellulin: Cell membrane; Single-pass type I membrane protein
2 PDB 3D structures from and Proteopedia for BTC:
1IOX (3D)        1IP0 (3D)    
Secondary accessions: Q96F48

Explore the universe of human proteins at neXtProt for BTC: NX_P35070

BTC Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001720.1  
ENSEMBL proteins: 
 ENSP00000379092   ENSP00000421747  
Reactome Protein details: P35070
Human Recombinant Protein Products for BTC: 
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OriGene Protein Over-expression Lysate for BTC
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Novus Biologicals BTC Proteins
Novus Biologicals BTC Lysates
Sino Biological Recombinant Protein for BTC
Sino Biological Cell Lysate for BTC 
ProSpec Recombinant Protein for BTC
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--

BTC for ontologies           About GeneDecksing



BTC Antibody Products: 
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LSBio Antibodies in human, mouse, rat for BTC 

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR015497 EGF_rcpt_ligand
 IPR000742 EG-like_dom
 IPR013032 EGF-like_CS

Graphical View of Domain Structure for InterPro Entry P35070

ProtoNet protein and cluster: P35070

2 Blocks protein domains:
IPB001336 Type I EGF signature
IPB006210 Type I EGF


UniProtKB/Swiss-Prot: BTC_HUMAN, P35070
Similarity: Contains 1 EGF-like domain


BTC for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: BTC_HUMAN, P35070
Function: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for
retinal pigment epithelial cells and vascular smooth muscle cells

     Genatlas biochemistry entry for BTC:
betacellulin,ECF family

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005154epidermal growth factor receptor binding TAS8144591
GO:0005515protein binding IPI19740107
GO:0008083growth factor activity IEA--
     
BTC for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for BTC:
 Increased circadian rhythm amp 

     7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Btc):
 cardiovascular system  growth/size  homeostasis/metabolism  mortality/aging  muscle 
 normal  skeleton 

BTC for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Btctm1Dcl for BTC

   inGenious Targeting Laboratory - Custom generated mouse model solutions for BTC 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BTC

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BTC 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BTC 

miRNA
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8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate BTC (see all 16):
hsa-miR-548j hsa-miR-548w hsa-miR-4324 hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-4299
SwitchGear 3'UTR luciferase reporter plasmidBTC 3' UTR sequence
Inhib. RNA
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Gene Editing
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Clone
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GenScript: all cDNA clones in your preferred vector: BTC (NM_001729)
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTC


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for BTC About   (see all 26)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1ErbB signaling pathway
ErbB signaling pathway0.52
EGFR Inhibitor Pathway, Pharmacodynamics0.49
ErbB signaling pathway0.52
2SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling0.92
SHC1 events in ERBB4 signaling0.84
GRB2 events in ERBB2 signaling0.92
ErbB receptor signaling network0.34
3Apoptotic Pathways in Synovial Fibroblasts
Mitochondrial Apoptosis0.85
Rac1 Pathway0.65
Cellular Apoptosis Pathway0.85
Glioma Invasiveness0.64
Apoptotic Pathways in Synovial Fibroblasts0.84
Actin-Based Motility by Rho Family GTPases0.62
p53 Mediated Apoptosis0.84
ERK5 Signaling0.61
4Signaling by FGFR
Downstream signaling of activated FGFR0.92
Downstream signal transduction0.90
Signaling by FGFR0.92
Signaling by PDGF0.85
Signaling by FGFR in disease0.91
Signaling by EGFR0.84
DAP12 signaling0.91
Signaling by EGFR in Cancer0.83
5PIP3 activates AKT signaling
GAB1 signalosome0.93
PI3K events in ERBB2 signaling0.88
PI3K/AKT activation0.93
PI3K events in ERBB4 signaling0.88
PIP3 activates AKT signaling0.88
Constitutive PI3K/AKT Signaling in Cancer0.88
PI3K/AKT Signaling in Cancer0.88
Signaling by SCF-KIT0.72

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 EMD Millipore Pathways for BTC
    Development ERBB-family signaling
Development EGFR signaling pathway

5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BTC (see all 55)
    Nuclear Receptor Activation by Vitamin-A
Paxillin Interactions
Telomerase Components in Cell Signaling
Mitochondrial Apoptosis
Molecular Mechanisms of Cancer

2 GeneGo (Thomson Reuters) Pathways for BTC
    Development ERBB-family signaling
Development EGFR signaling pathway

3 BioSystems Pathways for BTC
    ErbB signaling pathway
ErbB receptor signaling network
ErbB4 signaling events

1 Sino Biological Pathway for BTC 
    EGFR Signaling Pathway

5/35        Reactome Pathways for BTC (see all 35)
    Signaling by EGFR in Cancer
Downstream signal transduction
Signal Transduction
Signaling by PDGF
Downstream Signaling Events Of B Cell Receptor (BCR)

1 PharmGKB Pathway for BTC
    EGFR Inhibitor Pathway, Pharmacodynamics

1         Kegg Pathway  (Kegg details for BTC):
    ErbB signaling pathway


BTC for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BTC

5 Interacting proteins for BTC (P350702, 3) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
S100A4P264472, 3MINT-7256512 MINT-7256593 I2D: score=1 
EGFRP005333I2D: score=2 
ERBB2P046263I2D: score=1 
ERBB4Q153033I2D: score=1 
MMP9P147803I2D: score=1 
About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007173epidermal growth factor receptor signaling pathway TAS--
GO:0008284positive regulation of cell proliferation IEA--
GO:0008543fibroblast growth factor receptor signaling pathway TAS--
GO:0038095Fc-epsilon receptor signaling pathway TAS--
GO:0043066negative regulation of apoptotic process IEA--

BTC for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BTC for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BTC

10/15 Novoseek inferred chemical compound relationships for BTC gene (see all 15)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
ag 1478 58.8 1 10601546 (1)
tyrosine 53.9 15 15192046 (3), 9334263 (2), 9662041 (1), 10579352 (1) (see all 10)
heparin 40 15 17673511 (3), 11218236 (2), 12612292 (1), 16962163 (1) (see all 9)
wortmannin 39.5 2 12475887 (2)
pd 98,059 39.4 2 12475887 (2)
phosphatidylinositol 36.8 3 8626392 (1), 12475887 (1), 16487738 (1)
nicotinamide 34.1 5 18060872 (3), 14514635 (1), 16132961 (1)
matrigel 25.3 1 12475887 (1)
c-peptide 12.8 1 15939230 (1)
cycloheximide 12.8 1 11072245 (1)

Search CenterWatch for drugs/clinical trials and news about BTC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BTC gene: 
NM_001729.2  

Unigene Cluster for BTC:

Betacellulin
Hs.710156  [show with all ESTs]
Unigene Representative Sequence: NM_001729
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000395743(uc003hig.2) ENST00000512743
miRNA
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hsa-miR-548j hsa-miR-548w hsa-miR-4324 hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-4299
SwitchGear 3'UTR luciferase reporter plasmidBTC 3' UTR sequence
Inhib. RNA
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Primer
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Additional mRNA sequence: 

AB109441.1 S55606.1 

2 DOTS entries:

DT.204260  DT.92416550 

18 AceView cDNA sequences:

AB109441 AA917900 BX493533 S55606 AI822020 BE899442 BC011618 CB121982 
NM_001729 AI277656 AI792829 BX646859 BG194271 BF382080 AI766016 BI758136 
AW129759 BI552049 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BTC expression in normal human tissues (normalized intensities)      BTC embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGATAGCTAT
BTC Expression
About this image


BTC expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Heart (Cardiovascular System)
         Atrioventricular Canal Cells Atrioventricular Canal
 
 Ovary (Reproductive System)
         Mural Granulosa Cells Antral Follicle
 
 Endothelium (Cardiovascular System)
         aorta   
 
 Bone (Muscoskeletal System)
         Bone marrow-derived mesenchymal stem cells
 
 Mesenchymal Stem Cells
         Bone marrow-derived mesenchymal stem cells

Genevestigator expression for BTC

SOURCE GeneReport for Unigene cluster: Hs.710156

UniProtKB/Swiss-Prot: BTC_HUMAN, P35070
Tissue specificity: Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small
intestine

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTC

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BTC gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Btc1 , 5 betacellulin, epidermal growth factor family member1, 5 80.41(n)1
79.66(a)1
  5 (44.78 cM)5
122231  NM_007568.51  NP_031594.11 
 913572615 
chicken
(Gallus gallus)
Aves BTC1 betacellulin 62.08(n)
59.37(a)
  448833  NM_001004769.1  NP_001004769.1 
zebrafish
(Danio rerio)
Actinopterygii zgc:1532531 betacellulin-like 52.83(n)
39.62(a)
  767639  NM_001160823.1  NP_001154295.1 


ENSEMBL Gene Tree for BTC (if available)
TreeFam Gene Tree for BTC (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for BTC gene
TGFA2  
1 SIMAP similar gene for BTC using alignment to 2 protein entries:     BTC_HUMAN (see all proteins):
TGFA

BTC for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1228 SNPs in BTC are shown (see all 1228)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs716573381,2
C--75493770(+) TCTGC-/AAAAAA 1 -- int11Minor allele frequency- A:0.50NA 2
rs726591981,2
C,F--75670976(+) ATTTAT/CATTTT 1 -- ds50013Minor allele frequency- C:0.29WA NA 240
rs1409240511,2
--75671022(+) GCCAAA/GCATTT 1 -- ds50010--------
rs1827692301,2
--75671064(+) TGGGGA/CCAATC 1 -- ds50010--------
rs1142962051,2
C,F--75671106(+) CATCAT/CTGAGA 1 -- ds50011Minor allele frequency- C:0.05WA 118
rs1497642521,2
--75671318(+) ATGATC/GGTTAA 1 -- ds50010--------
rs1142408961,2
C,F--75671355(+) CTTGAT/GTTCTA 1 -- ds50011Minor allele frequency- G:0.03NA 120
rs1164547501,2
F--75671364(+) TAGTCT/AGTCTC 1 -- ds50011Minor allele frequency- A:0.03NA 120
rs1479072331,2
--75671385(+) CAACTA/CTCTAA 1 -- ds50010--------
rs1416049751,2
C--75671429(+) GCCCTA/GTTTCC 1 -- ds50010--------

HapMap Linkage Disequilibrium report for BTC (75669969 - 75719896 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for BTC:    About this table     
Variant IDTypeSubtypePubMed ID
nsv4390CNV Loss18451855
nsv7363OTHER Inversion18451855


Human Gene Mutation Database (HGMD): BTC
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing BTC
DNA2.0 Custom Variant and Variant Library Synthesis for BTC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 600345    OMIM disorders: --

20/24 diseases for BTC (see all 24):    About MalaCards
erythropoietic protoporphyria    insulinoma    biliary tract cancer    fibrous histiocytoma
histiocytoma    glucose intolerance    type 1 diabetes mellitus    malignant mesothelioma
type 1 diabetes    pancreatic cancer    chronic obstructive pulmonary disease    basal cell carcinoma
obesity    diabetes mellitus    pancreatitis    breast cancer
retinitis    adenocarcinoma    hepatocellular carcinoma    gastric cancer


BTC for disorders           About GeneDecksing

10/15 Novoseek inferred disease relationships for BTC gene (see all 15)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
insulinoma 55.6 14 8439318 (2), 10724350 (2), 8283650 (1), 17260022 (1) (see all 6)
hnscc 51.4 8 15197768 (3), 11072245 (1), 10706134 (1), 11235991 (1)
gastrointestinal tumor 35.9 2 14530681 (1), 12790326 (1)
carcinoma squamous cell 18 3 15197768 (1), 8144591 (1), 10706134 (1)
tumors 15.6 13 16949929 (5), 10601546 (2), 18289051 (1), 10797281 (1) (see all 5)
breast carcinoma 15.5 1 9312020 (1)
pancreatic cancer 9.68 9 10601546 (6), 8980184 (1)
endometrial cancer 8.08 2 16962163 (1), 10537356 (1)
breast cancer 4.53 4 18949710 (1), 10022523 (1), 19026613 (1), 17962208 (1)
carcinoma 2.98 6 9648926 (1), 11439355 (1), 8144591 (1), 8630011 (1) (see all 5)

Genetic Association Database (GAD): BTC
Human Genome Epidemiology (HuGE) Navigator: BTC (8 documents)

Export disorders for BTC gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for BTC gene, integrated from 9 sources (see all 150):
(articles sorted by number of sources associating them with BTC)
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world of online information

  1. Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family. (PubMed id 8439318)1, 2, 3, 9 Sasada R.... Igarashi K. (1993)
  2. Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form. (PubMed id 8919026)1, 2, 9 Seno M.... Yamada H. (1996)
  3. Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction. (PubMed id 8144591)1, 2, 9 Watanabe T....Sasada R. (1994)
  4. The exon 1 Cys7Gly polymorphism within the betacellulin gene is associated with type 2 diabetes in African Americans. (PubMed id 15793259)1, 4, 9 Silver K....Mitchell B.D. (2005)
  5. A functional variant in the human betacellulin gene promoter is associated with type 2 diabetes. (PubMed id 16306376)1, 4, 9 Nakano Y....Nanjo K. (2005)
  6. Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects. (PubMed id 16869959)1, 4, 9 Elbein S.C....Silver K.D. (2006)
  7. Association of a polymorphism in the betacellulin gene with type 1 diabetes mellitus in two populations. (PubMed id 16683131)1, 4, 9 Silver K.D....Mitchell B.D. (2006)
  8. Molecular scanning of the betacellulin gene for mutations in type 2 diabetic patients. (PubMed id 15936459)1, 4, 9 Nakagawa T....Nanjo K. (2005)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  10. Solution structure of betacellulin, a new member of EGF-family ligands. (PubMed id 12074582)1, 2 Miura K.... Kawano K. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 685 HGNC: 1121 AceView: BTC Ensembl:ENSG00000174808 euGenes: HUgn685
ECgene: BTC Kegg: 685 H-InvDB: BTC

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for BTC Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for BTC gene:
Search GeneIP for patents involving BTC

GeneCards and IP:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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