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BTC Gene

protein-coding   GIFtS: 62
GCID: GC04M075669

Betacellulin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
betacellulin1 2
probetacellulin2

External Ids:    HGNC: 11211   Entrez Gene: 6852   Ensembl: ENSG000001748087   OMIM: 6003455   UniProtKB: P350703   

Export aliases for BTC gene to outside databases

Previous GC identifers: GC04M075557 GC04M075843 GC04M076062 GC04M076128 GC04M076129 GC04M076027 GC04M075889 GC04M071418


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BTC Gene:
The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a
transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a
ligand for the EGF receptor. (provided by RefSeq, Jul 2008)

GeneCards Summary for BTC Gene:
BTC (betacellulin) is a protein-coding gene. Diseases associated with BTC include erythropoietic protoporphyria, and insulinoma. GO annotations related to this gene include epidermal growth factor receptor binding and growth factor activity. An important paralog of this gene is TGFA.

UniProtKB/Swiss-Prot: BTC_HUMAN, P35070
Function: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for
retinal pigment epithelial cells and vascular smooth muscle cells

Gene Wiki entry for BTC (Betacellulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the BTC gene promoter:
         FOXI1   HFH-3   CREB   FOXO4   deltaCREB   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBTC promoter sequence
   Search Chromatin IP Primers for BTC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BTC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

BTC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M075669:  view genomic region     (about GC identifiers)

Start:
75,669,969 bp from pter      End:
75,719,896 bp from pter
Size:
49,928 bases      Orientation:
minus strand

1 alternative location:
Chr4-,NW_003571035 229,746-239,493     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BTC_HUMAN, P35070 (See protein sequence)
Recommended Name: Probetacellulin precursor  
Size: 178 amino acids; 19746 Da
Subunit: Monomer. Interacts with EGFR and ERBB4
2 PDB 3D structures from and Proteopedia for BTC:
1IOX (3D)        1IP0 (3D)    
Secondary accessions: Q96F48

Explore the universe of human proteins at neXtProt for BTC: NX_P35070

Explore proteomics data for BTC at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn34
  • Modification sites at PhosphoSitePlus

  • See BTC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001720.1  
    ENSEMBL proteins: 
     ENSP00000379092   ENSP00000421747  
    Reactome Protein details: P35070

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR015497 EGF_rcpt_ligand
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry P35070

    ProtoNet protein and cluster: P35070

    2 Blocks protein domains:
    IPB001336 Type I EGF signature
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: BTC_HUMAN, P35070
    Similarity: Contains 1 EGF-like domain


    BTC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BTC_HUMAN, P35070
    Function: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for
    retinal pigment epithelial cells and vascular smooth muscle cells

         Genatlas biochemistry entry for BTC:
    betacellulin,ECF family

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005154epidermal growth factor receptor binding IEA--
    GO:0005515protein binding IPI19740107
    GO:0008083growth factor activity IEA--
         
    BTC for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BTC:
     Increased circadian rhythm amp 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Btc):
     cardiovascular system  growth/size/body  homeostasis/metabolism  mortality/aging  muscle 
     normal  skeleton 

    BTC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Btctm1Dcl for BTC

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BTC
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BTC

    miRNA
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    miRTarBase miRNAs that target BTC:
    hsa-mir-1 (MIRT023635), hsa-mir-192-5p (MIRT026321), hsa-mir-124-3p (MIRT022504), hsa-mir-215-5p (MIRT024368)

    Block miRNA regulation of human, mouse, rat BTC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BTC (see all 16):
    hsa-miR-548j hsa-miR-548w hsa-miR-4324 hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-4299
    SwitchGear 3'UTR luciferase reporter plasmidBTC 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTC

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BTC_HUMAN, P35070: Betacellulin: Secreted, extracellular space
    BTC_HUMAN, P35070: Probetacellulin: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    BTC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BTC About   (see all 25)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    ErbB receptor signaling network0.00
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    4Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    5GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BTC (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 GeneGo (Thomson Reuters) Pathways for BTC
        Development ERBB-family signaling
    Development EGFR signaling pathway

    3 BioSystems Pathways for BTC
        ErbB signaling pathway
    ErbB4 signaling events
    ErbB receptor signaling network

    1 Sino Biological Pathway for BTC
        EGFR Signaling Pathway

    Selected Reactome Pathways for BTC (see all 10)
        GRB2 events in ERBB2 signaling
    PI3K events in ERBB2 signaling
    SHC1 events in ERBB2 signaling
    Signaling by ERBB2
    SHC1 events in ERBB4 signaling

    1 PharmGKB Pathway for BTC
        EGFR Inhibitor Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for BTC):
        ErbB signaling pathway


    BTC for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BTC
    Interactions:

        GeneGlobe Interaction Network for BTC

    5 Interacting proteins for BTC (P350701, 2, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    S100A4P264471, 2, 3EBI-6590057,EBI-717058 MINT-7256512 MINT-7256593 I2D: score=1 
    EGFRP005333I2D: score=2 
    ERBB2P046263I2D: score=1 
    ERBB4Q153033I2D: score=1 
    MMP9P147803I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008284positive regulation of cell proliferation TAS8144591
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0035810positive regulation of urine volume IEA--
    GO:0038095Fc-epsilon receptor signaling pathway TAS--

    BTC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BTC

    Selected Novoseek inferred chemical compound relationships for BTC gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ag 1478 58.8 1 10601546 (1)
    tyrosine 53.9 15 15192046 (3), 9334263 (2), 9662041 (1), 10579352 (1) (see all 10)
    heparin 40 15 17673511 (3), 11218236 (2), 12612292 (1), 16962163 (1) (see all 9)
    wortmannin 39.5 2 12475887 (2)
    pd 98,059 39.4 2 12475887 (2)
    phosphatidylinositol 36.8 3 8626392 (1), 12475887 (1), 16487738 (1)
    nicotinamide 34.1 5 18060872 (3), 14514635 (1), 16132961 (1)
    matrigel 25.3 1 12475887 (1)
    c-peptide 12.8 1 15939230 (1)
    cycloheximide 12.8 1 11072245 (1)



    BTC for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BTC gene: 
    NM_001729.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395743(uc003hig.2) ENST00000512743
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BTC (see all 16):
    hsa-miR-548j hsa-miR-548w hsa-miR-4324 hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-4299
    SwitchGear 3'UTR luciferase reporter plasmidBTC 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat BTC
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    18 AceView cDNA sequences:

    AA917900 BX493533 AB109441 BC011618 S55606 AI822020 BE899442 NM_001729 
    CB121982 BX646859 AI792829 AI277656 BG194271 AI766016 BF382080 BI758136 
    BI552049 AW129759 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BTC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATAGCTAT
    BTC Expression
    About this image


    BTC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
    BTC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BTC Protein Expression

    UniProtKB/Swiss-Prot: BTC_HUMAN, P35070
    Tissue specificity: Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small
    intestine

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for BTC gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Btc1 , 5 betacellulin, epidermal growth factor family member1, 5 78.53(n)1
    77.4(a)1
      5 (44.78 cM)5
    122231  NM_007568.51  NP_031594.11 
     913572615 
    chicken
    (Gallus gallus)
    Aves BTC1 betacellulin 60.28(n)
    58.87(a)
      448833  NM_001004769.1  NP_001004769.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004976101 probetacellulin-like 60.87(n)
    56.52(a)
      100497610  XM_002941767.2  XP_002941813.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1532531 betacellulin-like 56.05(n)
    43.36(a)
      767639  NM_001160823.1  NP_001154295.1 


    ENSEMBL Gene Tree for BTC (if available)
    TreeFam Gene Tree for BTC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BTC gene
    TGFA2  
    1 SIMAP similar gene for BTC using alignment to 2 protein entries:     BTC_HUMAN (see all proteins):
    TGFA

    BTC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BTC (see all 1228)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs716573381,2
    C--75493770(+) TCTGC-/AAAAAA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs726591981,2
    C,F--75670976(+) ATTTAT/CATTTT 1 -- ds50013Minor allele frequency- C:0.29WA NA 240
    rs1409240511,2
    --75671022(+) GCCAAA/GCATTT 1 -- ds50010--------
    rs1827692301,2
    --75671064(+) TGGGGA/CCAATC 1 -- ds50010--------
    rs1142962051,2
    C,F--75671106(+) CATCAT/CTGAGA 1 -- ds50011Minor allele frequency- C:0.05WA 118
    rs1497642521,2
    --75671318(+) ATGATC/GGTTAA 1 -- ds50010--------
    rs1142408961,2
    C,F--75671355(+) CTTGAT/GTTCTA 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1164547501,2
    F--75671364(+) TAGTCT/AGTCTC 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1479072331,2
    --75671385(+) CAACTA/CTCTAA 1 -- ds50010--------
    rs1416049751,2
    C--75671429(+) GCCCTA/GTTTCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for BTC (75669969 - 75719896 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BTC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4390CNV Loss18451855
    nsv7363OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): BTC
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BTC
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600345    OMIM disorders: --

    Selected diseases for BTC (see all 21):    
    About MalaCards
    erythropoietic protoporphyria    insulinoma    glucose intolerance    fibrous histiocytoma
    histiocytoma    type 1 diabetes mellitus    malignant mesothelioma    type 1 diabetes
    basal cell carcinoma    pancreatic cancer    diabetes mellitus    obesity
    pancreatitis    breast cancer    retinitis    adenocarcinoma
    hepatocellular carcinoma    prostatitis    thyroiditis    prostate cancer


    BTC for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for BTC gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulinoma 55.6 14 8439318 (2), 10724350 (2), 8283650 (1), 17260022 (1) (see all 6)
    hnscc 51.4 8 15197768 (3), 11072245 (1), 10706134 (1), 11235991 (1)
    gastrointestinal tumor 35.9 2 14530681 (1), 12790326 (1)
    carcinoma squamous cell 18 3 15197768 (1), 8144591 (1), 10706134 (1)
    tumors 15.6 13 16949929 (5), 10601546 (2), 18289051 (1), 10797281 (1) (see all 5)
    breast carcinoma 15.5 1 9312020 (1)
    pancreatic cancer 9.68 9 10601546 (6), 8980184 (1)
    endometrial cancer 8.08 2 16962163 (1), 10537356 (1)
    breast cancer 4.53 4 18949710 (1), 10022523 (1), 19026613 (1), 17962208 (1)
    carcinoma 2.98 6 9648926 (1), 11439355 (1), 8144591 (1), 8630011 (1) (see all 5)

    Genetic Association Database (GAD): BTC
    Human Genome Epidemiology (HuGE) Navigator: BTC (8 documents)

    Export disorders for BTC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BTC gene, integrated from 10 sources (see all 150):
    (articles sorted by number of sources associating them with BTC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family. (PubMed id 8439318)1, 2, 3, 9 Sasada R.... Igarashi K. (Biochem. Biophys. Res. Commun. 1993)
    2. Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form. (PubMed id 8919026)1, 2, 9 Seno M.... Yamada H. (Growth Factors 1996)
    3. Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction. (PubMed id 8144591)1, 2, 9 Watanabe T.... Sasada R. (J. Biol. Chem. 1994)
    4. The exon 1 Cys7Gly polymorphism within the betacellulin gene is associated with type 2 diabetes in African Americans. (PubMed id 15793259)1, 4, 9 Silver K....Mitchell B.D. (Diabetes 2005)
    5. A functional variant in the human betacellulin gene promoter is associated with type 2 diabetes. (PubMed id 16306376)1, 4, 9 Nakano Y....Nanjo K. (Diabetes 2005)
    6. Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects. (PubMed id 16869959)1, 4, 9 Elbein S.C....Silver K.D. (BMC Med. Genet. 2006)
    7. Association of a polymorphism in the betacellulin gene with type 1 diabetes mellitus in two populations. (PubMed id 16683131)1, 4, 9 Silver K.D....Mitchell B.D. (J. Mol. Med. 2006)
    8. Molecular scanning of the betacellulin gene for mutations in type 2 diabetic patients. (PubMed id 15936459)1, 4, 9 Nakagawa T....Nanjo K. (Diabetes Res. Clin. Pract. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Solution structure of betacellulin, a new member of EGF-family ligands. (PubMed id 12074582)1, 2 Miura K.... Kawano K. (Biochem. Biophys. Res. Commun. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 685 HGNC: 1121 AceView: BTC Ensembl:ENSG00000174808 euGenes: HUgn685
    ECgene: BTC Kegg: 685 H-InvDB: BTC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BTC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BTC gene:
    Search GeneIP for patents involving BTC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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