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Aliases for BTC Gene

Aliases for BTC Gene

  • Betacellulin 2 3
  • Probetacellulin 3

External Ids for BTC Gene

Previous GeneCards Identifiers for BTC Gene

  • GC04M075557
  • GC04M075843
  • GC04M076062
  • GC04M076128
  • GC04M076129
  • GC04M076027
  • GC04M075889
  • GC04M075669
  • GC04M071418

Summaries for BTC Gene

Entrez Gene Summary for BTC Gene

  • The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for BTC Gene

BTC (Betacellulin) is a Protein Coding gene. Diseases associated with BTC include endometrial cancer and pancreatic cancer. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include growth factor activity and epidermal growth factor receptor binding. An important paralog of this gene is TGFA.

UniProtKB/Swiss-Prot for BTC Gene

  • Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Gene Wiki entry for BTC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTC Gene

Genomics for BTC Gene

Regulatory Elements for BTC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BTC Gene

74,744,759 bp from pter
74,794,686 bp from pter
49,928 bases
Minus strand

Genomic View for BTC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTC Gene

Proteins for BTC Gene

  • Protein details for BTC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q96F48

    Protein attributes for BTC Gene

    178 amino acids
    Molecular mass:
    19746 Da
    Quaternary structure:
    • Monomer. Interacts with EGFR and ERBB4.

    Three dimensional structures from OCA and Proteopedia for BTC Gene

neXtProt entry for BTC Gene

Proteomics data for BTC Gene at MOPED

Post-translational modifications for BTC Gene

  • Glycosylation at Asn34
  • Modification sites at PhosphoSitePlus

Other Protein References for BTC Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for BTC (Betacellulin/BTC)

No data available for DME Specific Peptides for BTC Gene

Domains for BTC Gene

Protein Domains for BTC Gene

Suggested Antigen Peptide Sequences for BTC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P35070
  • Contains 1 EGF-like domain.
genes like me logo Genes that share domains with BTC: view

No data available for Gene Families for BTC Gene

Function for BTC Gene

Molecular function for BTC Gene

GENATLAS Biochemistry: betacellulin,ECF family
UniProtKB/Swiss-Prot Function: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Gene Ontology (GO) - Molecular Function for BTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005154 epidermal growth factor receptor binding IEA --
GO:0005515 protein binding IPI 19740107
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with BTC: view
genes like me logo Genes that share phenotypes with BTC: view

Animal Models for BTC Gene

MGI Knock Outs for BTC:

Animal Model Products

CRISPR Products

miRNA for BTC Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BTC Gene

Localization for BTC Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTC Gene

Betacellulin: Secreted, extracellular space.
Probetacellulin: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for BTC Gene COMPARTMENTS Subcellular localization image for BTC gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BTC: view

Pathways for BTC Gene

SuperPathways for BTC Gene

Superpath Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
2 PI-3K cascade
3 Signaling by FGFR
4 GPCR Pathway
5 ERK Signaling
genes like me logo Genes that share pathways with BTC: view

Gene Ontology (GO) - Biological Process for BTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0008284 positive regulation of cell proliferation TAS 8144591
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0035810 positive regulation of urine volume IEA --
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with BTC: view

Compounds for BTC Gene

(15) Novoseek inferred chemical compound relationships for BTC Gene

Compound -log(P) Hits PubMed IDs
ag 1478 58.8 1
tyrosine 53.9 13
heparin 40 12
wortmannin 39.5 2
pd 98,059 39.4 2
genes like me logo Genes that share compounds with BTC: view

Transcripts for BTC Gene

mRNA/cDNA for BTC Gene

(18) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTC Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BTC

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for BTC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTC Gene

No ASD Table

Relevant External Links for BTC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTC Gene

mRNA expression in normal human tissues for BTC Gene

mRNA differential expression in normal tissues according to GTEx for BTC Gene

This gene is overexpressed in Colon - Sigmoid (7.9), Esophagus - Muscularis (6.5), and Esophagus - Gastroesophageal Junction (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BTC Gene

SOURCE GeneReport for Unigene cluster for BTC Gene Hs.710156

mRNA Expression by UniProt/SwissProt for BTC Gene

Tissue specificity: Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.
genes like me logo Genes that share expressions with BTC: view

In Situ Assay Products

Orthologs for BTC Gene

This gene was present in the common ancestor of chordates.

Orthologs for BTC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTC 35
  • 99.25 (n)
  • 97.75 (a)
BTC 36
  • 98 (a)
(Bos Taurus)
Mammalia BTC 35
  • 89.14 (n)
  • 87.64 (a)
BTC 36
  • 88 (a)
(Canis familiaris)
Mammalia BTC 36
  • 74 (a)
LOC482682 35
  • 85.56 (n)
  • 84.71 (a)
(Mus musculus)
Mammalia Btc 35
  • 78.53 (n)
  • 77.4 (a)
Btc 16
Btc 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia BTC 36
  • 55 (a)
(Rattus norvegicus)
Mammalia Btc 35
  • 78.53 (n)
  • 76.27 (a)
(Gallus gallus)
Aves BTC 35
  • 60.28 (n)
  • 58.87 (a)
BTC 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497610 35
  • 60.87 (n)
  • 56.52 (a)
(Danio rerio)
Actinopterygii btc 36
  • 31 (a)
zgc:153253 35
  • 56.05 (n)
  • 43.36 (a)
Species with no ortholog for BTC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTC Gene

Gene Tree for BTC (if available)
Gene Tree for BTC (if available)

Paralogs for BTC Gene

Paralogs for BTC Gene

Selected SIMAP similar genes for BTC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BTC: view

Variants for BTC Gene

Sequence variations from dbSNP and Humsavar for BTC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs967874 -- 74,792,894(-) TTGGA(A/T)ATGCA intron-variant
rs967875 -- 74,792,857(-) ATTCA(C/T)GGAAT intron-variant
rs977266 -- 74,792,391(-) GCAGA(A/G)GTGTC intron-variant
rs982427 -- 74,787,910(-) TCATG(A/T)TTCTT intron-variant
rs1349633 -- 74,793,561(-) AAAGC(A/T)TGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTC Gene

Variant ID Type Subtype PubMed ID
nsv4390 CNV Loss 18451855
nsv7363 OTHER Inversion 18451855

Relevant External Links for BTC Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTC Gene

Disorders for BTC Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for BTC Gene including...

Search for BTC Gene in MalaCards »

(15) Novoseek inferred disease relationships for BTC Gene

Disease -log(P) Hits PubMed IDs
insulinoma 55.6 8
hnscc 51.4 6
gastrointestinal tumor 35.9 2
carcinoma squamous cell 18 3
tumors 15.6 10

Relevant External Links for BTC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BTC: view

No data available for UniProtKB/Swiss-Prot for BTC Gene

Publications for BTC Gene

  1. Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family. (PMID: 8439318) Sasada R. … Igarashi K. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 23
  2. Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction. (PMID: 8144591) Watanabe T. … Sasada R. (J. Biol. Chem. 1994) 3 4 23
  3. Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form. (PMID: 8919026) Seno M. … Yamada H. (Growth Factors 1996) 3 4 23
  4. The exon 1 Cys7Gly polymorphism within the betacellulin gene is associated with type 2 diabetes in African Americans. (PMID: 15793259) Silver K. … Mitchell B.D. (Diabetes 2005) 3 23 48
  5. Molecular scanning of the betacellulin gene for mutations in type 2 diabetic patients. (PMID: 15936459) Nakagawa T. … Nanjo K. (Diabetes Res. Clin. Pract. 2005) 3 23 48

Products for BTC Gene

Sources for BTC Gene

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