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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BTBD9 Gene

protein-coding   GIFtS: 55
GCID: GC06M038136

BTB (POZ) Domain Containing 9

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BTB (POZ) Domain Containing 91 2
KIAA18803 5
BTB/POZ Domain-Containing Protein 92
dJ322I12.12

External Ids:    HGNC: 212281   Entrez Gene: 1147812   Ensembl: ENSG000001838267   OMIM: 6112375   UniProtKB: Q96Q073   

Export aliases for BTBD9 gene to outside databases

Previous GC identifers: GC06M038140 GC06M038189 GC06M038250 GC06M037854


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BTBD9 Gene:
This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein
interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless
Legs Syndrome and may also be associated with Tourette Syndrome. Alternatively spliced transcript variants have
been described. (provided by RefSeq, Aug 2011)

GeneCards Summary for BTBD9 Gene: 
BTBD9 (BTB (POZ) domain containing 9) is a protein-coding gene. Diseases associated with BTBD9 include restless legs syndrome, and essential tremor. An important paralog of this gene is BTBD2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BTBD9 gene promoter:
         Evi-1   PPAR-gamma1   POU2F1   POU2F1a   POU2F1b   PPAR-gamma2   POU2F1c   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BTBD9 promoter sequence
   Search SABiosciences Chromatin IP Primers for BTBD9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTBD9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21

BTBD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTBD9 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M038136:  view genomic region     (about GC identifiers)

Start:
38,136,227 bp from pter      End:
38,607,924 bp from pter
Size:
471,698 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BTBD9_HUMAN, Q96Q07 (See protein sequence)
Recommended Name: BTB/POZ domain-containing protein 9  
Size: 612 amino acids; 69188 Da
Sequence caution: Sequence=BAB67773.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q494V9 Q494W1 Q96M00
Alternative splicing: 3 isoforms:  Q96Q07-1   Q96Q07-2   Q96Q07-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BTBD9: NX_Q96Q07

Explore proteomics data for BTBD9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96Q07

  • BTBD9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BTBD9 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001092742.1  NP_001165889.1  NP_443125.1  NP_689946.2  

    ENSEMBL proteins: 
     ENSP00000323408   ENSP00000418751   ENSP00000415365   ENSP00000328328   ENSP00000418201  
     ENSP00000419382   ENSP00000386121   ENSP00000386211  

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    Cloud-Clone Corp. Proteins for BTBD9 


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing

    5/6 InterPro protein domains (see all 6):
     IPR011333 BTB/POZ_fold
     IPR000421 Coagulation_fac_5/8-C_type_dom
     IPR013069 BTB_POZ
     IPR011705 BACK
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q96Q07

    ProtoNet protein and cluster: Q96Q07

    3 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB000421 Coagulation factor 5/8 type C domain (FA58C)
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: BTBD9_HUMAN, Q96Q07
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain


    BTBD9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    BTBD9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BTBD9:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Btbd9):
     behavior/neurological  homeostasis/metabolism  nervous system 

    BTBD9 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BTBD9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BTBD9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BTBD9 
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    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate BTBD9 (see all 92):
    hsa-miR-124* hsa-miR-549 hsa-miR-579 hsa-miR-4254 hsa-miR-1321 hsa-miR-520e hsa-miR-374a hsa-miR-138-2*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BTBD9

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for BTBD9 (Q96Q073 ENSP000003861214) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS6Q7L5N13, ENSP000003041024I2D: score=2 STRING: ENSP00000304102
    USP25Q9UHP33, ENSP000002856794I2D: score=2 STRING: ENSP00000285679
    FBXO11Q86XK23, ENSP000003238224I2D: score=5 STRING: ENSP00000323822
    GALNT2Q104713I2D: score=4 
    USP21ENSP000002898654STRING: ENSP00000289865
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007616long-term memory IEA--
    GO:0008344adult locomotory behavior IEA--
    GO:0042428serotonin metabolic process IEA--
    GO:0042748circadian sleep/wake cycle, non-REM sleep IEA--

    BTBD9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BTBD9

    Search CenterWatch for drugs/clinical trials and news about BTBD9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BTBD9 gene (4 alternative transcripts): 
    NM_001099272.1  NM_001172418.1  NM_052893.1  NM_152733.2  

    Unigene Cluster for BTBD9:

    BTB (POZ) domain containing 9
    Hs.603858  [show with all ESTs]
    Unigene Representative Sequence: NM_052893
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314100(uc010jwv.3 uc003ony.4 uc010jww.3) ENST00000481247(uc003ooa.4 uc010jwx.3)
    ENST00000419706 ENST00000328403 ENST00000497373 ENST00000498633 ENST00000403056
    ENST00000408958
    miRNA
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    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate BTBD9 (see all 92):
    hsa-miR-124* hsa-miR-549 hsa-miR-579 hsa-miR-4254 hsa-miR-1321 hsa-miR-520e hsa-miR-374a hsa-miR-138-2*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTBD9
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTBD9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTBD9

    Additional mRNA sequence: 

    AK057507.1 AK090930.1 AK126242.1 AL157476.1 BC035667.1 BC101354.2 BC101355.1 BC101356.2 
    BC101357.1 BX537534.1 

    5 DOTS entries:

    DT.97774578  DT.95197071  DT.212249  DT.100000171  DT.121359443 

    24/80 AceView cDNA sequences (see all 80):

    CR616810 F10886 CB155212 AI732925 AI700921 AI474779 N53643 AI824328 
    AI984662 CR596814 BX279596 AA486863 AA896980 BX451662 AL567269 AI197834 
    BX109492 BC035667 BX377450 AI220033 R51295 AA894437 BM976766 BX114302 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BTBD9    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
    SP1:                                                  -                                                   
    SP2:                    -                                   -                                             
    SP3:        -     -     -                             -     -                                             
    SP4:        -     -     -                             -     -                                             
    SP5:                    -                             -     -                                             


    ECgene alternative splicing isoforms for BTBD9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BTBD9 expression in normal human tissues (normalized intensities)      BTBD9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTGAAAA
    BTBD9 Expression
    About this image


    BTBD9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod

    See BTBD9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BTBD9

    SOURCE GeneReport for Unigene cluster: Hs.603858

    UniProtKB/Swiss-Prot: BTBD9_HUMAN, Q96Q07
    Tissue specificity: Highly expressed in kidney and moderately expressed in all other adult and fetal tissues.
    Moderately expressed in all specific brain regions examined

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTBD9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BTBD9 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Btbd91 , 5 BTB (POZ) domain containing 91, 5 88.56(n)1
    95.75(a)1
      17 (15.62 cM)5
    2246711  NM_172618.21  NP_766206.11 
     302155245 
    chicken
    (Gallus gallus)
    Aves BTBD91 BTB (POZ) domain containing 9 79.45(n)
    90.33(a)
      421429  NM_001008459.1  NP_001008459.1 
    lizard
    (Anolis carolinensis)
    Reptilia BTBD96
    BTB (POZ) domain containing 9
    92(a)
    1 ↔ 1
    1(229817993-229988698)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BQ396730.12   -- 76.46(n)    BQ396730.1 
    zebrafish
    (Danio rerio)
    Actinopterygii btbd91 BTB (POZ) domain containing 9 65.32(n)
    72.27(a)
      557659  NM_001002198.1  NP_001002198.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18261 CG1826 54.33(n)
    53.58(a)
      32000  NM_132421.2  NP_572649.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hpo-91 Protein HPO-9 49.9(n)
    42.99(a)
      179117  NM_072438.3  NP_504839.1 


    ENSEMBL Gene Tree for BTBD9 (if available)
    TreeFam Gene Tree for BTBD9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BTBD9 gene
    BTBD22  BTBD12  BTBD62  BTBD192  BTBD32  
    6 SIMAP similar genes for BTBD9 using alignment to 4 protein entries:     BTBD9_HUMAN (see all proteins):
    KLHL26    KBTBD4    KLHL36    RHOBTB3    KLHL24    KLHL7

    BTBD9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9187 SNPs in BTBD9 are shown (see all 9187)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs671222121,2
    C--37857851(+) TCTCA-/AAAAA/AAAAAAAAAA/AAAAA
    AAAAAAAAA
    /AAAAAAAAAAAAAAA
    AAAAA
    20 -- ut31 cds11NA 2
    rs357372431,2
    C,F--37868909(+) TTTTTT/-CCAAT 4 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs1869871101,2
    --37869248(+) ACAGGC/TGTGAG 4 -- int10--------
    rs1928025771,2
    --37869249(+) CAGGTA/GTGAGC 4 -- int10--------
    rs1842693951,2
    --37869250(+) AGGTGG/TGAGCC 4 -- int10--------
    rs345038621,2
    C--37879055(+) AAAAA-/AGTGCG 4 -- int11Minor allele frequency- A:0.50CSA 2
    rs114608341,2
    C--37879735(+) CTGCTG/-GGAAG 4 -- int13Minor allele frequency- -:0.17NA CSA 6
    rs2003463851,2
    --37894477(+) ATTAC-/TGTGTTT 4 -- int10--------
    rs106566461,2
    C--37894479(+) TACTGTGT/-TTTAA 4 -- cds11Minor allele frequency- -:0.50NA 2
    rs559516101,2
    C--37894480(+) ACTGT-/GT    
       T
    /TGT
    TTAAC
    8 -- cds10--------

    HapMap Linkage Disequilibrium report for BTBD9 (38136227 - 38386227 bp, first 250kb of BTBD9)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for BTBD9 (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674905CNV Deletion23128226
    esv2731950CNV Deletion23290073
    esv2421878CNV Deletion20811451
    nsv5268CNV Insertion18451855
    esv269996CNV Insertion20981092
    esv267992CNV Insertion20981092
    nsv507325CNV Insertion20534489
    esv27105CNV Loss19812545
    nsv885817CNV Loss21882294
    nsv349297CNV Loss16902084


    Human Gene Mutation Database (HGMD): BTBD9
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611237    OMIM disorders: --

    UniProtKB/Swiss-Prot: BTBD9_HUMAN, Q96Q07
  • Restless legs syndrome 6 (RLS6) [MIM:611185]: A neurologic sleep/wake disorder characterized by
    uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an
    irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation.
    The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary,
    highly stereotypical, regularly occurring limb movements that occur during sleep. Note=Disease susceptibility may
    be associated with variations affecting the gene represented in this entry

  • 3 diseases for BTBD9:    About MalaCards
    restless legs syndrome    essential tremor    tremor

    1 disease from the University of Copenhagen DISEASES database for BTBD9:
    Gilles de la Tourette syndrome

    BTBD9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BTBD9
    Human Genome Epidemiology (HuGE) Navigator: BTBD9 (6 documents)

    Export disorders for BTBD9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BTBD9 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with BTBD9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genetic risk factor for periodic limb movements in sleep. (PubMed id 17634447)1, 2, 4 Stefansson H.... Stefansson K. (2007)
    2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2, 3 Nagase T....Ohara O. (2001)
    3. Genome-wide association study identifies novel restles s legs syndrome susceptibility loci on 2p14 and 16q12.1. (PubMed id 21779176)1, 4 Winkelmann J....Meitinger T. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Association of intronic variants of the BTBD9 gene wi th Tourette syndrome. (PubMed id 19822783)1, 4 RiviA"re J.B....Rouleau G.A. (2009)
    6. Replication of restless legs syndrome loci in three European populations. (PubMed id 19279021)1, 4 Kemlink D....Winkelmann J. (2009)
    7. Exploring the genetic link between RLS and ADHD. (PubMed id 19223043)1, 4 Schimmelmann B.G....Hebebrand J. (2009)
    8. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. (PubMed id 17637780)1, 4 Winkelmann J....Meitinger T. (2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. Analysis of the BTBD9 and HTR2C variants in Chinese Ha n patients with Tourette syndrome. (PubMed id 22914617)1 Guo Y....Deng H. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114781 HGNC: 21228 AceView: BTBD9 Ensembl:ENSG00000183826 euGenes: HUgn114781
    ECgene: BTBD9 H-InvDB: BTBD9

    (According to HUGE)
    About This Section
    HUGE: KIAA1880

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BTBD9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BTBD9 gene:
    Search GeneIP for patents involving BTBD9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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