Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BTBD8 Gene

Aliases for BTBD8 Gene

  • BTB (POZ) Domain Containing 8 2 3

External Ids for BTBD8 Gene

Summaries for BTBD8 Gene

GeneCards Summary for BTBD8 Gene

BTBD8 (BTB (POZ) Domain Containing 8) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTBD8 Gene

Genomics for BTBD8 Gene

Genomic Location for BTBD8 Gene

Start:
92,080,305 bp from pter
End:
92,147,840 bp from pter
Size:
67,536 bases
Orientation:
Plus strand

Genomic View for BTBD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTBD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTBD8 Gene

Regulatory Elements for BTBD8 Gene

Proteins for BTBD8 Gene

  • Protein details for BTBD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XKL5-BTBD8_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein 8
    Protein Accession:
    Q5XKL5
    Secondary Accessions:
    • Q6V9S5

    Protein attributes for BTBD8 Gene

    Size:
    378 amino acids
    Molecular mass:
    42793 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTBD8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTBD8 Gene

Proteomics data for BTBD8 Gene at MOPED

Post-translational modifications for BTBD8 Gene

No Post-translational modifications

Other Protein References for BTBD8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BTBD8 Gene

Domains for BTBD8 Gene

Gene Families for BTBD8 Gene

HGNC:
  • BTBD :BTB/POZ domain containing

Protein Domains for BTBD8 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

BTBD8_HUMAN
Domain:
  • Contains 2 BTB (POZ) domains.:
    • Q5XKL5
genes like me logo Genes that share domains with BTBD8: view

Function for BTBD8 Gene

Gene Ontology (GO) - Molecular Function for BTBD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with BTBD8: view

Phenotypes for BTBD8 Gene

GenomeRNAi human phenotypes for BTBD8:
genes like me logo Genes that share phenotypes with BTBD8: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BTBD8 Gene

Localization for BTBD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTBD8 Gene

Nucleus. Note=Localized to nucleus in fetal cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTBD8 Gene COMPARTMENTS Subcellular localization image for BTBD8 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BTBD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with BTBD8: view

Pathways for BTBD8 Gene

SuperPathways for BTBD8 Gene

No Data Available

Interacting Proteins for BTBD8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343686%0d%0a9606.ENSP00000288828%0d%0a
Selected Interacting proteins: ENSP00000343686 Q5XKL5-BTBD8_HUMAN for BTBD8 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for BTBD8 Gene

None

No data available for Pathways by source for BTBD8 Gene

Transcripts for BTBD8 Gene

mRNA/cDNA for BTBD8 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTBD8 Gene

BTB (POZ) domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTBD8 Gene

No ASD Table

Relevant External Links for BTBD8 Gene

GeneLoc Exon Structure for
BTBD8
ECgene alternative splicing isoforms for
BTBD8

Expression for BTBD8 Gene

mRNA expression in normal human tissues for BTBD8 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for BTBD8 Gene

SOURCE GeneReport for Unigene cluster for BTBD8 Gene Hs.676102

mRNA Expression by UniProt/SwissProt for BTBD8 Gene

Q5XKL5-BTBD8_HUMAN
Tissue specificity: Highly expressed in fetal brain. Weakly expressed in adult brain and prostate.
genes like me logo Genes that share expressions with BTBD8: view

Orthologs for BTBD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTBD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BTBD8 36
  • 99.91 (n)
  • 99.74 (a)
BTBD8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BTBD8 36
  • 89.74 (n)
  • 84.35 (a)
mouse
(Mus musculus)
Mammalia Btbd8 36
  • 80.37 (n)
  • 72.68 (a)
Btbd8 16
Btbd8 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BTBD8 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTBD8 37
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13917 37
  • 3 (a)
OneToOne
Species with no ortholog for BTBD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTBD8 Gene

ENSEMBL:
Gene Tree for BTBD8 (if available)
TreeFam:
Gene Tree for BTBD8 (if available)

Paralogs for BTBD8 Gene

No data available for Paralogs for BTBD8 Gene

Variants for BTBD8 Gene

Sequence variations from dbSNP and Humsavar for BTBD8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs481677 -- 92,109,900(-) aatat(A/G)taagt intron-variant
rs488288 -- 92,109,174(-) TAATG(A/T)TCAAT intron-variant
rs488849 -- 92,111,548(-) TAAAC(A/G)CAAAA intron-variant
rs490800 -- 92,127,348(-) AAGGA(G/T)GTACA intron-variant
rs492164 -- 92,146,450(-) tgtaa(C/T)tgtat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTBD8 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV Deletion 23290073
nsv462517 CNV Gain 19166990
nsv524845 CNV Gain 19592680
dgv264n71 CNV Gain 21882294
esv2750842 CNV Gain 17911159
nsv871508 CNV Gain 21882294
dgv265n71 CNV Loss 21882294
esv2674499 CNV Deletion 23128226
nsv441700 CNV CNV 18776908
nsv823531 CNV Gain 20364138

Relevant External Links for BTBD8 Gene

HapMap Linkage Disequilibrium report
BTBD8

Disorders for BTBD8 Gene

No disorders were found for BTBD8 Gene.

No data available for UniProtKB/Swiss-Prot for BTBD8 Gene

Publications for BTBD8 Gene

  1. Molecular cloning and characterization of a novel human BTBD8 gene containing double BTB/POZ domains. (PMID: 14654994) Xu J. … Mao Y. (Int. J. Mol. Med. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Network organization of the human autophagy system. (PMID: 20562859) Behrends C. … Harper J.W. (Nature 2010) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for BTBD8 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate BTBD8
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for BTBD8
    • Block miRNA regulation of BTBD8 using miScript Target Protectors

    Sources for BTBD8 Gene

    Back to Top

    Content