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Aliases for BTBD7 Gene

Aliases for BTBD7 Gene

  • BTB (POZ) Domain Containing 7 2 3
  • FUP1 3 6
  • BTB/POZ Domain-Containing Protein 7 3
  • KIAA1525 4

External Ids for BTBD7 Gene

Summaries for BTBD7 Gene

GeneCards Summary for BTBD7 Gene

BTBD7 (BTB (POZ) Domain Containing 7) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BTBD7 Gene

  • Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTBD7 Gene

Genomics for BTBD7 Gene

Genomic Location for BTBD7 Gene

Start:
93,237,550 bp from pter
End:
93,333,092 bp from pter
Size:
95,543 bases
Orientation:
Minus strand

Genomic View for BTBD7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTBD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTBD7 Gene

Regulatory Elements for BTBD7 Gene

Proteins for BTBD7 Gene

  • Protein details for BTBD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P203-BTBD7_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein 7
    Protein Accession:
    Q9P203
    Secondary Accessions:
    • A8K5V7
    • Q69Z05
    • Q7Z308
    • Q86TS0
    • Q9HAA4
    • Q9NVM0

    Protein attributes for BTBD7 Gene

    Size:
    1132 amino acids
    Molecular mass:
    126368 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA96049.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB13946.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13946.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAH10736.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for BTBD7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTBD7 Gene

Proteomics data for BTBD7 Gene at MOPED

Post-translational modifications for BTBD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BTBD7 Gene

Domains for BTBD7 Gene

Gene Families for BTBD7 Gene

HGNC:
  • BTBD :BTB/POZ domain containing

Protein Domains for BTBD7 Gene

Suggested Antigen Peptide Sequences for BTBD7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P203

UniProtKB/Swiss-Prot:

BTBD7_HUMAN
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.:
    • Q9P203
  • Contains 2 BTB (POZ) domains.:
    • Q9P203
genes like me logo Genes that share domains with BTBD7: view

Function for BTBD7 Gene

Molecular function for BTBD7 Gene

UniProtKB/Swiss-Prot Function: Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity).

Gene Ontology (GO) - Molecular Function for BTBD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with BTBD7: view

Phenotypes for BTBD7 Gene

genes like me logo Genes that share phenotypes with BTBD7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BTBD7 Gene

Localization for BTBD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTBD7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTBD7 Gene COMPARTMENTS Subcellular localization image for BTBD7 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for BTBD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with BTBD7: view

Pathways for BTBD7 Gene

SuperPathways for BTBD7 Gene

No Data Available

Interacting Proteins for BTBD7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000335615%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000335615 for BTBD7 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for BTBD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0060693 regulation of branching involved in salivary gland morphogenesis IEA --
genes like me logo Genes that share ontologies with BTBD7: view

No data available for Pathways by source for BTBD7 Gene

Transcripts for BTBD7 Gene

mRNA/cDNA for BTBD7 Gene

(5) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTBD7 Gene

BTB (POZ) domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTBD7 Gene

No ASD Table

Relevant External Links for BTBD7 Gene

GeneLoc Exon Structure for
BTBD7
ECgene alternative splicing isoforms for
BTBD7

Expression for BTBD7 Gene

mRNA expression in normal human tissues for BTBD7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BTBD7 Gene

SOURCE GeneReport for Unigene cluster for BTBD7 Gene Hs.525549

genes like me logo Genes that share expressions with BTBD7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BTBD7 Gene

Orthologs for BTBD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTBD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BTBD7 35
  • 99.73 (n)
  • 99.56 (a)
BTBD7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BTBD7 35
  • 93.01 (n)
  • 96.27 (a)
BTBD7 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTBD7 35
  • 93.22 (n)
  • 96.89 (a)
BTBD7 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btbd7 35
  • 90.43 (n)
  • 93.62 (a)
Btbd7 16
Btbd7 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BTBD7 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BTBD7 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btbd7 35
  • 91.67 (n)
  • 95.33 (a)
chicken
(Gallus gallus)
Aves BTBD7 35
  • 82.1 (n)
  • 88.85 (a)
BTBD7 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTBD7 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btbd7 35
  • 77.25 (n)
  • 84.66 (a)
zebrafish
(Danio rerio)
Actinopterygii btbd7 35
  • 67.62 (n)
  • 74.38 (a)
btbd7 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16952 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C39F7.5 36
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for BTBD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BTBD7 Gene

ENSEMBL:
Gene Tree for BTBD7 (if available)
TreeFam:
Gene Tree for BTBD7 (if available)

Paralogs for BTBD7 Gene

Pseudogenes.org Pseudogenes for BTBD7 Gene

genes like me logo Genes that share paralogs with BTBD7: view

No data available for Paralogs for BTBD7 Gene

Variants for BTBD7 Gene

Sequence variations from dbSNP and Humsavar for BTBD7 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs110742 -- 93,308,407(-) AACAT(C/T)TCCAC intron-variant
rs169523 -- 93,323,327(+) ATATA(C/G)AGTTA intron-variant
rs172225 -- 93,282,451(+) cctca(A/G)actcc intron-variant
rs205321 -- 93,300,282(+) agatg(C/G)actct intron-variant
rs205322 -- 93,300,327(+) atctc(A/C)gctca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTBD7 Gene

Variant ID Type Subtype PubMed ID
dgv383n67 CNV Gain 20364138
nsv820783 CNV Duplication 20802225
nsv820297 CNV Loss 19587683
esv26222 CNV Loss 19812545
nsv518613 CNV Loss 19592680

Relevant External Links for BTBD7 Gene

HapMap Linkage Disequilibrium report
BTBD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTBD7 Gene

Disorders for BTBD7 Gene

No disorders were found for BTBD7 Gene.

No data available for UniProtKB/Swiss-Prot for BTBD7 Gene

Publications for BTBD7 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. FUP1, a gene associated with hepatocellular carcinoma, stimulates NIH3T3 cell proliferation and tumor formation in nude mice. (PMID: 11527404) Pan W. … Li T.P. (Biochem. Biophys. Res. Commun. 2001) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for BTBD7 Gene

Sources for BTBD7 Gene

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