Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BTBD7 Gene

Aliases for BTBD7 Gene

  • BTB Domain Containing 7 2 3
  • BTB (POZ) Domain Containing 7 2 3 5
  • KIAA1525 4
  • FUP1 3

External Ids for BTBD7 Gene

Previous GeneCards Identifiers for BTBD7 Gene

  • GC14M091697
  • GC14M092776
  • GC14U900579
  • GC14M093703
  • GC14M073884

Summaries for BTBD7 Gene

GeneCards Summary for BTBD7 Gene

BTBD7 (BTB Domain Containing 7) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BTBD7 Gene

  • Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTBD7 Gene

Genomics for BTBD7 Gene

Regulatory Elements for BTBD7 Gene

Enhancers for BTBD7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BTBD7 on UCSC Golden Path with GeneCards custom track

Promoters for BTBD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BTBD7 on UCSC Golden Path with GeneCards custom track

Genomic Location for BTBD7 Gene

Chromosome:
14
Start:
93,237,550 bp from pter
End:
93,333,092 bp from pter
Size:
95,543 bases
Orientation:
Minus strand

Genomic View for BTBD7 Gene

Genes around BTBD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTBD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTBD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTBD7 Gene

Proteins for BTBD7 Gene

  • Protein details for BTBD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P203-BTBD7_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein 7
    Protein Accession:
    Q9P203
    Secondary Accessions:
    • A8K5V7
    • Q69Z05
    • Q7Z308
    • Q86TS0
    • Q9HAA4
    • Q9NVM0

    Protein attributes for BTBD7 Gene

    Size:
    1132 amino acids
    Molecular mass:
    126368 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA96049.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB13946.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13946.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAH10736.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for BTBD7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTBD7 Gene

Proteomics data for BTBD7 Gene at MOPED

Post-translational modifications for BTBD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BTBD7 Gene

Domains & Families for BTBD7 Gene

Gene Families for BTBD7 Gene

Protein Domains for BTBD7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BTBD7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P203

UniProtKB/Swiss-Prot:

BTBD7_HUMAN :
  • Contains 1 BACK (BTB/Kelch associated) domain.
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 2 BTB (POZ) domains.
genes like me logo Genes that share domains with BTBD7: view

Function for BTBD7 Gene

Molecular function for BTBD7 Gene

UniProtKB/Swiss-Prot Function:
Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity).
genes like me logo Genes that share phenotypes with BTBD7: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTBD7 Gene

Localization for BTBD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTBD7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTBD7 Gene COMPARTMENTS Subcellular localization image for BTBD7 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for BTBD7 Gene

Pathways & Interactions for BTBD7 Gene

SuperPathways for BTBD7 Gene

No Data Available

Interacting Proteins for BTBD7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000335615%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000335615 for BTBD7 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for BTBD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with BTBD7: view

No data available for Pathways by source and SIGNOR curated interactions for BTBD7 Gene

Drugs & Compounds for BTBD7 Gene

No Compound Related Data Available

Transcripts for BTBD7 Gene

mRNA/cDNA for BTBD7 Gene

(5) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTBD7 Gene

BTB (POZ) domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTBD7 Gene

No ASD Table

Relevant External Links for BTBD7 Gene

GeneLoc Exon Structure for
BTBD7
ECgene alternative splicing isoforms for
BTBD7

Expression for BTBD7 Gene

mRNA expression in normal human tissues for BTBD7 Gene

Protein differential expression in normal tissues from HIPED for BTBD7 Gene

This gene is overexpressed in Prostate (19.5), Rectum (16.6), Gallbladder (11.7), Urinary Bladder (8.7), and Fetal gut (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BTBD7 Gene



SOURCE GeneReport for Unigene cluster for BTBD7 Gene Hs.525549

genes like me logo Genes that share expression patterns with BTBD7: view

Protein tissue co-expression partners for BTBD7 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BTBD7 Gene

Orthologs for BTBD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTBD7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BTBD7 35
  • 93.01 (n)
  • 96.27 (a)
BTBD7 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTBD7 35
  • 93.22 (n)
  • 96.89 (a)
BTBD7 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btbd7 35
  • 90.43 (n)
  • 93.62 (a)
Btbd7 16
Btbd7 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BTBD7 35
  • 99.73 (n)
  • 99.56 (a)
BTBD7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btbd7 35
  • 91.67 (n)
  • 95.33 (a)
oppossum
(Monodelphis domestica)
Mammalia BTBD7 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BTBD7 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves BTBD7 35
  • 82.1 (n)
  • 88.85 (a)
BTBD7 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTBD7 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btbd7 35
  • 77.25 (n)
  • 84.66 (a)
zebrafish
(Danio rerio)
Actinopterygii btbd7 35
  • 67.62 (n)
  • 74.38 (a)
btbd7 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16952 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C39F7.5 36
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for BTBD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BTBD7 Gene

ENSEMBL:
Gene Tree for BTBD7 (if available)
TreeFam:
Gene Tree for BTBD7 (if available)

Paralogs for BTBD7 Gene

Pseudogenes.org Pseudogenes for BTBD7 Gene

genes like me logo Genes that share paralogs with BTBD7: view

No data available for Paralogs for BTBD7 Gene

Variants for BTBD7 Gene

Sequence variations from dbSNP and Humsavar for BTBD7 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs110742 -- 93,308,407(-) AACAT(C/T)TCCAC intron-variant
rs169523 -- 93,323,327(+) ATATA(C/G)AGTTA intron-variant
rs172225 -- 93,282,451(+) cctca(A/G)actcc intron-variant
rs205321 -- 93,300,282(+) agatg(C/G)actct intron-variant
rs205322 -- 93,300,327(+) atctc(A/C)gctca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTBD7 Gene

Variant ID Type Subtype PubMed ID
dgv383n67 CNV Gain 20364138
nsv820783 CNV Duplication 20802225
nsv820297 CNV Loss 19587683
esv26222 CNV Loss 19812545
nsv518613 CNV Loss 19592680

Variation tolerance for BTBD7 Gene

Residual Variation Intolerance Score: 7.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BTBD7 Gene

Disorders for BTBD7 Gene

Relevant External Links for BTBD7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BTBD7

No disorders were found for BTBD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTBD7 Gene

Publications for BTBD7 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. FUP1, a gene associated with hepatocellular carcinoma, stimulates NIH3T3 cell proliferation and tumor formation in nude mice. (PMID: 11527404) Pan W. … Li T.P. (Biochem. Biophys. Res. Commun. 2001) 2 3
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  4. Btbd7 contributes to reduced E-cadherin expression and predicts poor prognosis in non-small cell lung cancer. (PMID: 25253020) Fan C. … Wang E. (BMC Cancer 2014) 3
  5. BTB/POZ domain-containing protein 7: epithelial-mesenchymal transition promoter and prognostic biomarker of hepatocellular carcinoma. (PMID: 23325674) Tao Y.M. … Shen H. (Hepatology 2013) 3

Products for BTBD7 Gene

Sources for BTBD7 Gene

Content