BTBD6 Gene
protein-coding GIFtS: 41
GCID: GC14P105715
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BTB (POZ) domain containing 6
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Aliases
for BTBD6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BTB (POZ) Domain Containing 61 2 | | BDPL1 2 3 | | Lens BTB Domain Protein2 3 | | BTB Domain Protein BDPL2 | | BTB/POZ Domain-Containing Protein 62 | | Glucocorticoid Receptor AF-1 Coactivator-12 |
Export aliases for BTBD6 gene to outside databasesPrevious GC identifers: GC14U900160 GC14P103686 GC14P104786 GC14P085912 |
Summaries
for BTBD6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: BTBD6_HUMAN, Q96KE9Function: Adapter protein for the CUL3 E3 ubiquitin-protein ligase complex. Involved in late neuronal development andmuscle formation (By similarity)
|
Genomic Views
for BTBD6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BTBD6 gene promoter:
c-Fos TBP ISGF-3 C/EBPbeta AP-1 TFIID c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for BTBD6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTBD6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.33BTBD6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P105715: view genomic region
(about GC identifiers)
Start:
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105,714,827 bp from pter |
End:
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105,717,430 bp from pter |
Size:
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2,604 bases |
Orientation:
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plus strand |
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Proteins
for BTBD6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BTBD6_HUMAN, Q96KE9 (See
protein sequence)Recommended Name: BTB/POZ domain-containing protein 6 Size: 485 amino acids; 53411 Da
Subcellular location: Cytoplasm, P-body (By similarity). Note=Cytoplasmic bodies (By similarity)
Sequence caution: Sequence=AAK39520.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for BTBD6:2VKP (3D)
Secondary accessions: Q8IVQ7 Q9BR94Alternative splicing: 2 isoforms: Q96KE9-1 Q96KE9-2 Explore the universe of human proteins at neXtProt for BTBD6: NX_Q96KE9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96KE9
BTBD6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_150374.2
ENSEMBL proteins: ENSP00000446223 ENSP00000376337 ENSP00000418150 ENSP00000443091 ENSP00000329361
Human Recombinant Protein Products for BTBD6:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000932 | cytoplasmic mRNA processing body |
IEA | -- |
BTBD6 for ontologies About GeneDecksing
BTBD6 Antibody Products:
Assay Products for BTBD6: |
Protein
Domains /
Families
for BTBD6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BTBD6 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96KE9ProtoNet protein and cluster: Q96KE9 2 Blocks protein families: IPB000210 BTB/POZ domain IPB012983 PHR
UniProtKB/Swiss-Prot: BTBD6_HUMAN, Q96KE9Similarity: Contains 1 BTB (POZ) domain |
Function
for BTBD6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: BTBD6_HUMAN, Q96KE9Function: Adapter protein for the CUL3 E3 ubiquitin-protein ligase complex. Involved in late neuronal development andmuscle formation (By similarity)Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTBD6 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTBD6 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for BTBD6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTBD6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTBD6 |
|
Pathways & Interactions
for BTBD6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BTBD6
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for BTBD6 (ENSP000003293614) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for BTBD6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BTBD6
Search CenterWatch for drugs/clinical trials and news about BTBD6
|
Transcripts
for BTBD6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BTBD6 gene: NM_033271.2 Unigene Cluster for BTBD6: BTB (POZ) domain containing 6 Hs.7367 [show with all ESTs]Unigene Representative Sequence: NM_0332716 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000537513 ENST00000392554(uc010tyq.2) ENST00000463376 ENST00000392553
ENST00000536364 ENST00000327471
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTBD6 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTBD6 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BTBD6 (NM_152903) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BTBD6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTBD6 |
Additional cDNA sequence: AF086420.1 AF353674.1 BC006414.1 BC042525.1 8 DOTS entries: DT.443986 DT.91785381 DT.100644084 DT.91920755 DT.100644085 DT.75189946 DT.100789163 DT.95273817 24/87 AceView cDNA sequences (see all 87): CB243619 BU738186 F25178 BQ928269 W88594 BM466059 BM693745 AI553977 BM670142 T33693 AI380621 AI758641 BM977956 CB132544 BM711637 T08942 T23988 AI923896 BU730253 AA993708 BM700130 BC006414 CN480310 BM670994
GeneLoc Exon Structure
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Expression
for BTBD6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BTBD6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCACCTGCTT
About this image
See BTBD6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BTBD6
SOURCE GeneReport for Unigene cluster: Hs.7367
UniProtKB/Swiss-Prot: BTBD6_HUMAN, Q96KE9Tissue specificity: Expressed in lens
SABiosciences Custom PCR Arrays for BTBD6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BTBD6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BTBD6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTBD6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTBD6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTBD6 |
Orthologs
for BTBD6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BTBD6 gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for BTBD6 (if available)
TreeFam Gene Tree for BTBD6 (if available) |
Paralogs
for BTBD6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BTBD6 gene
- BTBD12 BTBD22 BTBD192 BTBD32 BTBD92
5 SIMAP similar genes for BTBD6 using alignment to 3 protein entries: BTBD6_HUMAN (see all proteins):DKFZp434B055 BTBD3 BTBD1 BCL6 BTBD2
BTBD6 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for BTBD6
PGOHUM00000243933
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Genomic Variants
for BTBD6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for BTBD6
5 CNVs: 3950 29968 23306 29967 29965 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTBD6 |
|
Disorders
/ Diseases
for BTBD6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BTBD6 for disorders About GeneDecksing
1  disease for BTBD6: About MalaCardsneuronitis
Export disorders for BTBD6 gene to outside databases
|
Publications
for BTBD6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BTBD6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with BTBD6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107413)1, 2 Wistow G.... Peterson K. (2002)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- FTH1 binds to Daxx and inhibits Daxx-mediated cell apo ptosis. (PubMed id 21573799)1 Liu F....Wang Y.X. (2012)
- A feedback loop mediated by degradation of an inhibit or is required to initiate neuronal differentiation. (PubMed id 20080956)1 Sobieszczuk D.F....Wilkinson D.G. (2010)
- A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for BTBD6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing BTBD6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BTBD6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BTBD6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BTBD6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BTBD6 gene:
Search GeneIP for patents involving BTBD6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BTBD6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BTBD6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BTBD6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BTBD6 | | | OriGene Protein Over-expression Lysate for BTBD6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for BTBD6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTBD6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTBD6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | BTBD6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTBD6 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for BTBD6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTBD6 |
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