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Aliases for BTBD6 Gene

Aliases for BTBD6 Gene

  • BTB (POZ) Domain Containing 6 2 3
  • Lens BTB Domain Protein 3 4
  • BDPL 3 4
  • Glucocorticoid Receptor AF-1 Coactivator-1 3
  • BTB/POZ Domain-Containing Protein 6 3
  • BTB Domain Protein BDPL 3

External Ids for BTBD6 Gene

Summaries for BTBD6 Gene

GeneCards Summary for BTBD6 Gene

BTBD6 (BTB (POZ) Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is BTBD9.

UniProtKB/Swiss-Prot for BTBD6 Gene

  • Adapter protein for the CUL3 E3 ubiquitin-protein ligase complex. Involved in late neuronal development and muscle formation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTBD6 Gene

Genomics for BTBD6 Gene

Genomic Location for BTBD6 Gene

Start:
105,248,490 bp from pter
End:
105,251,093 bp from pter
Size:
2,604 bases
Orientation:
Plus strand

Genomic View for BTBD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTBD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTBD6 Gene

Regulatory Elements for BTBD6 Gene

Proteins for BTBD6 Gene

  • Protein details for BTBD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KE9-BTBD6_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein 6
    Protein Accession:
    Q96KE9
    Secondary Accessions:
    • Q8IVQ7
    • Q9BR94

    Protein attributes for BTBD6 Gene

    Size:
    485 amino acids
    Molecular mass:
    53411 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK39520.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BTBD6 Gene

    Alternative splice isoforms for BTBD6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTBD6 Gene

Proteomics data for BTBD6 Gene at MOPED

Post-translational modifications for BTBD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTBD6 Gene

No data available for DME Specific Peptides for BTBD6 Gene

Domains for BTBD6 Gene

Gene Families for BTBD6 Gene

HGNC:
  • BTBD :BTB/POZ domain containing

Protein Domains for BTBD6 Gene

UniProtKB/Swiss-Prot:

BTBD6_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • Q96KE9
genes like me logo Genes that share domains with BTBD6: view

Function for BTBD6 Gene

Molecular function for BTBD6 Gene

UniProtKB/Swiss-Prot Function: Adapter protein for the CUL3 E3 ubiquitin-protein ligase complex. Involved in late neuronal development and muscle formation (By similarity).

Gene Ontology (GO) - Molecular Function for BTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with BTBD6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BTBD6 Gene

Localization for BTBD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTBD6 Gene

Cytoplasm, P-body. Note=Cytoplasmic bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTBD6 Gene COMPARTMENTS Subcellular localization image for BTBD6 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for BTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IEA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with BTBD6: view

Pathways for BTBD6 Gene

SuperPathways for BTBD6 Gene

No Data Available

Interacting Proteins for BTBD6 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000376337%0d%0a9606.ENSP00000338157%0d%0a9606.ENSP00000262630%0d%0a9606.ENSP00000262030%0d%0a
Selected Interacting proteins: ENSP00000376337 for BTBD6 Gene via STRING

Gene Ontology (GO) - Biological Process for BTBD6 Gene

None

No data available for Pathways by source for BTBD6 Gene

Transcripts for BTBD6 Gene

Unigene Clusters for BTBD6 Gene

BTB (POZ) domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTBD6 Gene

No ASD Table

Relevant External Links for BTBD6 Gene

GeneLoc Exon Structure for
BTBD6
ECgene alternative splicing isoforms for
BTBD6

Expression for BTBD6 Gene

mRNA expression in normal human tissues for BTBD6 Gene

SOURCE GeneReport for Unigene cluster for BTBD6 Gene Hs.7367

mRNA Expression by UniProt/SwissProt for BTBD6 Gene

Q96KE9-BTBD6_HUMAN
Tissue specificity: Expressed in lens.
genes like me logo Genes that share expressions with BTBD6: view

Orthologs for BTBD6 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTBD6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BTBD6 36
  • 88.21 (n)
  • 96.59 (a)
BTBD6 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTBD6 36
  • 88.78 (n)
  • 94.88 (a)
BTBD6 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btbd6 36
  • 86.65 (n)
  • 95.14 (a)
Btbd6 16
Btbd6 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BTBD6 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BTBD6 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btbd6 36
  • 86.65 (n)
  • 94.68 (a)
chicken
(Gallus gallus)
Aves BTBD6 36
  • 83.14 (n)
  • 92.18 (a)
BTBD6 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTBD6 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btbd6 36
  • 77.01 (n)
  • 89.89 (a)
zebrafish
(Danio rerio)
Actinopterygii btbd6a 37
  • 71 (a)
OneToMany
btbd6b 36
  • 76.04 (n)
  • 87.33 (a)
btbd6b 37
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta lute 37
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 66 (a)
OneToMany
Species with no ortholog for BTBD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTBD6 Gene

ENSEMBL:
Gene Tree for BTBD6 (if available)
TreeFam:
Gene Tree for BTBD6 (if available)

Paralogs for BTBD6 Gene

Paralogs for BTBD6 Gene

Selected SIMAP similar genes for BTBD6 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for BTBD6 Gene

genes like me logo Genes that share paralogs with BTBD6: view

Variants for BTBD6 Gene

Structural Variations from Database of Genomic Variants (DGV) for BTBD6 Gene

Variant ID Type Subtype PubMed ID
dgv2020n71 CNV Loss 21882294
nsv902424 CNV Loss 21882294
dgv659e1 CNV Complex 17122850
nsv470679 CNV Loss 18288195
nsv902433 CNV Loss 21882294
nsv902441 CNV Loss 21882294
dgv2024n71 CNV Loss 21882294
dgv2025n71 CNV Loss 21882294
nsv517055 CNV Gain+Loss 19592680
dgv2030n71 CNV Loss 21882294
nsv510651 CNV Loss 20534489
nsv902466 CNV Gain 21882294
esv29986 CNV Loss 17803354
dgv2031n71 CNV Loss 21882294
dgv26n68 CNV Loss 17160897

Relevant External Links for BTBD6 Gene

HapMap Linkage Disequilibrium report
BTBD6

No data available for Sequence variations from dbSNP and Humsavar for BTBD6 Gene

Disorders for BTBD6 Gene

No disorders were found for BTBD6 Gene.

No data available for UniProtKB/Swiss-Prot for BTBD6 Gene

Publications for BTBD6 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107413) Wistow G. … Peterson K. (Mol. Vis. 2002) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3

Products for BTBD6 Gene

  • Addgene plasmids for BTBD6

Sources for BTBD6 Gene

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