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Aliases for BTBD3 Gene

Aliases for BTBD3 Gene

  • BTB (POZ) Domain Containing 3 2 3
  • KIAA0952 4 6
  • BTB/POZ Domain-Containing Protein 3 3
  • DJ742J24.1 3

External Ids for BTBD3 Gene

Summaries for BTBD3 Gene

GeneCards Summary for BTBD3 Gene

BTBD3 (BTB (POZ) Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is BTBD9.

UniProtKB/Swiss-Prot for BTBD3 Gene

  • Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTBD3 Gene

Genomics for BTBD3 Gene

Genomic Location for BTBD3 Gene

Start:
11,890,723 bp from pter
End:
11,926,609 bp from pter
Size:
35,887 bases
Orientation:
Plus strand

Genomic View for BTBD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTBD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTBD3 Gene

Regulatory Elements for BTBD3 Gene

Proteins for BTBD3 Gene

  • Protein details for BTBD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2F9-BTBD3_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein 3
    Protein Accession:
    Q9Y2F9
    Secondary Accessions:
    • D3DW19
    • Q5JY73

    Protein attributes for BTBD3 Gene

    Size:
    522 amino acids
    Molecular mass:
    58420 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76796.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for BTBD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTBD3 Gene

Proteomics data for BTBD3 Gene at MOPED

Post-translational modifications for BTBD3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys315

No data available for DME Specific Peptides for BTBD3 Gene

Domains for BTBD3 Gene

Gene Families for BTBD3 Gene

HGNC:
  • BTBD :BTB/POZ domain containing

Protein Domains for BTBD3 Gene

UniProtKB/Swiss-Prot:

BTBD3_HUMAN
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.:
    • Q9Y2F9
  • Contains 1 BTB (POZ) domain.:
    • Q9Y2F9
genes like me logo Genes that share domains with BTBD3: view

Function for BTBD3 Gene

Molecular function for BTBD3 Gene

UniProtKB/Swiss-Prot Function: Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity).

Gene Ontology (GO) - Molecular Function for BTBD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with BTBD3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BTBD3 Gene

Localization for BTBD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTBD3 Gene

Cytoplasm, cytosol. Nucleus. Note=Translocates from the cytosol to the nucleus in response to neuronal activity. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTBD3 Gene COMPARTMENTS Subcellular localization image for BTBD3 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BTBD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with BTBD3: view

Pathways for BTBD3 Gene

SuperPathways for BTBD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BTBD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0021987 cerebral cortex development ISS --
GO:0048813 dendrite morphogenesis ISS --
genes like me logo Genes that share ontologies with BTBD3: view

No data available for Pathways by source for BTBD3 Gene

Transcripts for BTBD3 Gene

Unigene Clusters for BTBD3 Gene

BTB (POZ) domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTBD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - -
SP2: - -
SP3: -
SP4: - - - - - - - -
SP5: - -
SP6: - - - -
SP7: -
SP8: - -
SP9:

Relevant External Links for BTBD3 Gene

GeneLoc Exon Structure for
BTBD3
ECgene alternative splicing isoforms for
BTBD3

Expression for BTBD3 Gene

mRNA expression in normal human tissues for BTBD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTBD3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BTBD3 Gene

SOURCE GeneReport for Unigene cluster for BTBD3 Gene Hs.709366

genes like me logo Genes that share expressions with BTBD3: view

Orthologs for BTBD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTBD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BTBD3 36
  • 99.93 (n)
  • 99.8 (a)
BTBD3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BTBD3 36
  • 87.99 (n)
  • 97.7 (a)
BTBD3 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTBD3 36
  • 93.9 (n)
  • 98.21 (a)
BTBD3 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btbd3 36
  • 90.68 (n)
  • 97.7 (a)
Btbd3 16
Btbd3 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BTBD3 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 88 (a)
OneToMany
-- 37
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Btbd3 36
  • 91.57 (n)
  • 97.7 (a)
chicken
(Gallus gallus)
Aves BTBD3 36
  • 84.91 (n)
  • 96.15 (a)
BTBD3 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTBD3 37
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btbd3 36
  • 79.75 (n)
  • 91.49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7701 36
zebrafish
(Danio rerio)
Actinopterygii btbd3b 36
  • 74.61 (n)
  • 88.95 (a)
btbd3b 37
  • 86 (a)
OneToOne
sbcb776 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004234 36
  • 64.16 (n)
  • 72.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta lute 36
  • 64.24 (n)
  • 69.25 (a)
lute 37
  • 43 (a)
OneToMany
CG5319 38
  • 68 (a)
CG17068 38
  • 38 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9981 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 68 (a)
OneToMany
Species with no ortholog for BTBD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTBD3 Gene

ENSEMBL:
Gene Tree for BTBD3 (if available)
TreeFam:
Gene Tree for BTBD3 (if available)

Paralogs for BTBD3 Gene

Paralogs for BTBD3 Gene

genes like me logo Genes that share paralogs with BTBD3: view

Variants for BTBD3 Gene

Sequence variations from dbSNP and Humsavar for BTBD3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1625 -- 11,888,961(+) aaggt(A/T)acttt upstream-variant-2KB
rs6660 -- 11,926,410(+) TGTAG(C/T)CACTT utr-variant-3-prime
rs1043926 -- 11,925,532(+) ACAAC(A/G)TTCTA utr-variant-3-prime
rs1232480 -- 11,907,832(-) TCCCA(A/G)TTAGA intron-variant
rs1232481 -- 11,906,203(-) ATTTT(G/T)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTBD3 Gene

Variant ID Type Subtype PubMed ID
nsv7339 OTHER Inversion 18451855
dgv1307e1 CNV Complex 17122850
dgv1308e1 CNV Complex 17122850
dgv168e55 CNV Gain 17911159
nsv833921 CNV Gain 17160897
esv271822 CNV Insertion 20981092

Relevant External Links for BTBD3 Gene

HapMap Linkage Disequilibrium report
BTBD3

Disorders for BTBD3 Gene

Relevant External Links for BTBD3

Genetic Association Database (GAD)
BTBD3
Human Genome Epidemiology (HuGE) Navigator
BTBD3
genes like me logo Genes that share disorders with BTBD3: view

No data available for UniProtKB/Swiss-Prot for BTBD3 Gene

Publications for BTBD3 Gene

  1. Genome-wide examination of genetic variants associated with response to platinum-based chemotherapy in patients with small-cell lung cancer. (PMID: 20463552) Wu C. … Lin D. (Pharmacogenet. Genomics 2010) 3 49
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. (PMID: 12421765) Nakayama M. … Ohara O. (Genome Res. 2002) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for BTBD3 Gene

Sources for BTBD3 Gene

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