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Aliases for BTBD2 Gene

Aliases for BTBD2 Gene

  • BTB (POZ) Domain Containing 2 2 3

External Ids for BTBD2 Gene

Previous GeneCards Identifiers for BTBD2 Gene

  • GC19M002048
  • GC19M001925
  • GC19M001936
  • GC19M001934
  • GC19M001757

Summaries for BTBD2 Gene

Entrez Gene Summary for BTBD2 Gene

  • The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. [provided by RefSeq, Jul 2008]

GeneCards Summary for BTBD2 Gene

BTBD2 (BTB (POZ) Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is BTBD9.

Gene Wiki entry for BTBD2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTBD2 Gene

Genomics for BTBD2 Gene

Regulatory Elements for BTBD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BTBD2 Gene

Start:
1,985,438 bp from pter
End:
2,034,881 bp from pter
Size:
49,444 bases
Orientation:
Minus strand

Genomic View for BTBD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTBD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTBD2 Gene

Proteins for BTBD2 Gene

  • Protein details for BTBD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BX70-BTBD2_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein 2
    Protein Accession:
    Q9BX70
    Secondary Accessions:
    • O60418
    • O75248
    • Q4VBZ1
    • Q6IAC5
    • Q7Z5W0
    • Q96SX8
    • Q9NPS1
    • Q9NX81

    Protein attributes for BTBD2 Gene

    Size:
    525 amino acids
    Molecular mass:
    55931 Da
    Quaternary structure:
    • Interacts with topoisomerase 1 and with TRIM5 isoform Delta.
    SequenceCaution:
    • Sequence=AAC16070.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB55143.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BTBD2 Gene

    Alternative splice isoforms for BTBD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTBD2 Gene

Proteomics data for BTBD2 Gene at MOPED

Post-translational modifications for BTBD2 Gene

  • Ubiquitination at Lys100 and Lys312
  • Modification sites at PhosphoSitePlus

Other Protein References for BTBD2 Gene

Antibody Products

No data available for DME Specific Peptides for BTBD2 Gene

Domains for BTBD2 Gene

Gene Families for BTBD2 Gene

HGNC:
  • BTBD :BTB/POZ domain containing

Protein Domains for BTBD2 Gene

Suggested Antigen Peptide Sequences for BTBD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BX70

UniProtKB/Swiss-Prot:

BTBD2_HUMAN :
  • Q9BX70
Domain:
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with BTBD2: view

Function for BTBD2 Gene

Gene Ontology (GO) - Molecular Function for BTBD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12878161
genes like me logo Genes that share ontologies with BTBD2: view

Phenotypes for BTBD2 Gene

GenomeRNAi human phenotypes for BTBD2:
genes like me logo Genes that share phenotypes with BTBD2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BTBD2 Gene

Localization for BTBD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTBD2 Gene

Cytoplasm, P-body. Note=Cytoplasmic bodies.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTBD2 Gene COMPARTMENTS Subcellular localization image for BTBD2 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BTBD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 12878161
genes like me logo Genes that share ontologies with BTBD2: view

Pathways for BTBD2 Gene

SuperPathways for BTBD2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BTBD2 Gene

None

No data available for Pathways by source for BTBD2 Gene

Transcripts for BTBD2 Gene

Unigene Clusters for BTBD2 Gene

BTB (POZ) domain containing 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BTBD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTBD2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: -
SP3: - -
SP4:
SP5:

Relevant External Links for BTBD2 Gene

GeneLoc Exon Structure for
BTBD2
ECgene alternative splicing isoforms for
BTBD2

Expression for BTBD2 Gene

mRNA expression in normal human tissues for BTBD2 Gene

Protein differential expression in normal tissues for BTBD2 Gene

This gene is overexpressed in Heart (49.0) and Prostate (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BTBD2 Gene

SOURCE GeneReport for Unigene cluster for BTBD2 Gene Hs.465543

genes like me logo Genes that share expressions with BTBD2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for BTBD2 Gene

Orthologs for BTBD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTBD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BTBD2 35
  • 89.33 (n)
  • 96.91 (a)
BTBD2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btbd2 35
  • 88.36 (n)
  • 97.72 (a)
Btbd2 16
Btbd2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BTBD2 35
  • 97.78 (n)
  • 98.69 (a)
BTBD2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btbd2 35
  • 88.13 (n)
  • 97.72 (a)
dog
(Canis familiaris)
Mammalia BTBD2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BTBD2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BTBD2 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves BTBD2 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btbd2 35
  • 76.1 (n)
  • 93.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2618 35
zebrafish
(Danio rerio)
Actinopterygii btbd2a 35
  • 75.76 (n)
  • 91.74 (a)
Dr.11478 35
BTBD2 36
  • 71 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9078 35
fruit fly
(Drosophila melanogaster)
Insecta CG17068 36
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F38H4.7 37
  • 58 (a)
tag-30 35
  • 56.71 (n)
  • 60.47 (a)
tag-30 36
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToMany
Species with no ortholog for BTBD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BTBD2 Gene

ENSEMBL:
Gene Tree for BTBD2 (if available)
TreeFam:
Gene Tree for BTBD2 (if available)

Paralogs for BTBD2 Gene

Paralogs for BTBD2 Gene

genes like me logo Genes that share paralogs with BTBD2: view

Variants for BTBD2 Gene

Sequence variations from dbSNP and Humsavar for BTBD2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs881654 -- 1,999,339(+) GGGAA(G/T)GCTGG intron-variant
rs1046342 -- 1,985,557(-) TGTTT(C/T)TGCCC utr-variant-3-prime
rs1599856 -- 1,997,121(+) GTTGC(A/T)GTGAG intron-variant
rs1610045 -- 1,997,364(+) AAGGC(A/G)GCGGG synonymous-codon, reference
rs2009336 -- 2,007,842(+) TAAAA(C/T)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTBD2 Gene

Variant ID Type Subtype PubMed ID
esv32942 CNV Gain+Loss 17666407
nsv910499 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294
dgv3613n71 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
nsv470107 CNV Loss 18288195
nsv910569 CNV Loss 21882294
nsv910587 CNV Gain+Loss 21882294
nsv910588 CNV Loss 21882294
nsv910589 CNV Gain+Loss 21882294
dgv3621n71 CNV Loss 21882294
nsv910593 CNV Loss 21882294
nsv910594 CNV Loss 21882294
dgv3622n71 CNV Loss 21882294
dgv3623n71 CNV Loss 21882294
nsv910598 CNV Loss 21882294
esv2717868 CNV Deletion 23290073
esv2717869 CNV Deletion 23290073
nsv910599 CNV Loss 21882294
esv2717870 CNV Deletion 23290073
esv2661496 CNV Deletion 23128226
nsv910600 CNV Loss 21882294
dgv3624n71 CNV Loss 21882294
esv27612 CNV Gain 19812545

Relevant External Links for BTBD2 Gene

HapMap Linkage Disequilibrium report
BTBD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTBD2 Gene

Disorders for BTBD2 Gene

Relevant External Links for BTBD2

Genetic Association Database (GAD)
BTBD2
Human Genome Epidemiology (HuGE) Navigator
BTBD2

No disorders were found for BTBD2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for BTBD2 Gene

Publications for BTBD2 Gene

  1. Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24. (PMID: 11179693) Carim-Todd L. … Escarceller M. (Gene 2001) 2 3 23
  2. Characterization of BTBD1 and BTBD2, two similar BTB-domain- containing Kelch-like proteins that interact with topoisomerase I. (PMID: 11818025) Xu L. … D'Arpa P. (BMC Genomics 2002) 3 4 23
  3. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. (PMID: 12878161) Xu L. … D'Arpa P. (Exp. Cell Res. 2003) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. (PMID: 20610542) Liu Y. … Bondy M.L. (Carcinogenesis 2010) 3 48

Products for BTBD2 Gene

Sources for BTBD2 Gene

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