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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BTBD17 Gene

protein-coding GIFtS: 37
GCID: GC17M072352

BTB (POZ) domain containing 17

Search for BTBD17
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
BTB (POZ) Domain Containing 17¹ ²		BTB/POZ And BACK Domain-Containing Protein LOC388419²
BTBD17A¹ ²		BTB/POZ Domain-Containing Protein 17²
LGALS3BPL¹ ²		Transport And Golgi Organization 10 Homolog A²
TANGO10A¹ ²		Galectin-3-Binding Protein-Like³

External Ids:	HGNC: 33758¹	Entrez Gene: 388419²	Ensembl: ENSG00000204347⁷	UniProtKB: A6NE02³

Export aliases for BTBD17 gene to outside databases

Previous GC identifers: GC17M069865 GC17M067762

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BTBD17 gene promoter:
RFX1 NF-1/L NF-1 FOXO3 NF-kappaB c-Ets-1 AREB6 Max NF-kappaB1 c-Myc
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTBD17

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1

BTBD17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTBD17 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M072352: view genomic region (about GC identifiers)

Start:	72,352,555 bp from pter	End:	72,358,085 bp from pter
Size:	5,531 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BTBDH_HUMAN, A6NE02 (See protein sequence)

Recommended Name: BTB/POZ domain-containing protein 17 precursor

Size: 478 amino acids; 52471 Da

Subcellular location: Secreted (Potential)

Explore the universe of human proteins at neXtProt for BTBD17: NX_A6NE02

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A6NE02

BTBD17 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001073935.1

ENSEMBL proteins:

ENSP00000364515

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005737	colocalizes with cytoplasm	ISS	--
GO:0005886	plasma membrane	ISS	--

BTBD17 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BTBD17 for domains About GeneDecksing

4 InterPro domains/families:

IPR011333 BTB/POZ_fold

IPR013069 BTB_POZ

IPR011705 BACK

IPR000210 BTB/POZ-like

Graphical View of Domain Structure for InterPro Entry A6NE02

ProtoNet protein and cluster: A6NE02

UniProtKB/Swiss-Prot: BTBDH_HUMAN, A6NE02

Similarity: Contains 1 BACK (BTB/Kelch associated) domain

Similarity: Contains 1 BTB (POZ) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for BTBD17

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009615	response to virus	ISS	--
GO:0045071	negative regulation of viral genome replication	ISS	--

BTBD17 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for BTBD17 gene:

NM_001080466.1

Unigene Cluster for BTBD17:

BTB (POZ) domain containing 17

Hs.211870 [show with all ESTs]

Unigene Representative Sequence: NM_001080466

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000375366(uc002jkn.2)

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1 DOTS entry:

DT.120995993

24/30 AceView cDNA sequences (see all 30):

BF513472 AI569728 AI828151 AW135964 CA430895 AI590084 AI088747 BE858105

BF116017 AI885663 AW007054 BF115458 AI199676 AI498970 AI475044 BG394808

BI714844 BE223011 AI569769 BG470892 BF347984 AI939616 AI554692 AI199622

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BTBD17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCCCACCGG

About this image
See BTBD17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BTBD17

SOURCE GeneReport for Unigene cluster: Hs.211870

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for BTBD17 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BTBD17¹	BTB (POZ) domain containing 17	75.3(n) 68.95(a)		427813 XM_425385.3 XP_425385.2
lizard (Anolis carolinensis)	Reptilia	BTBD17⁶	--	63(a)	1 ↔ 1	2(98350403-98357926)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.10709²	Transcribed sequence with weak similarity to protein more	73.83(n)		142012844
zebrafish (Danio rerio)	Actinopterygii	LOC563672¹	BTB/POZ domain-containing protein 17-like	63.88(n) 59.78(a)		563672 XM_687031.1 XP_692123.1
fruit fly (Drosophila melanogaster)	Insecta	Tango10¹	Transport and Golgi organization 10	45.19(n) 29.33(a)		32125 NM_167302.2 NP_727555.1
worm (Caenorhabditis elegans)	Secernentea	W07A12.4⁶	--	16(a)	possible ortholog	II(9148294-9152250)

ENSEMBL Gene Tree for BTBD17 (if available)
TreeFam Gene Tree for BTBD17 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BTBD17 gene

LGALS3BP²

BTBD17 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183839794^1,2		--	72352527(+)	`TTTTAC/TCCAGA`	1	--	ds500¹		0	--	--	--	--
rs189203112^1,2		--	72352593(+)	`AAGAAC/TGTTCC`	1	--	ut3¹		0	--	--	--	--
rs111972317^1,2		--	72352636(+)	`CAGGCG/ATCTTG`	1	--	ut3¹		1		CSA	2
rs141172104^1,2	C,	--	72352637(+)	`GCATC-/TTTGTC`	1	--	ut3¹		0	--	--	--	--
rs55690660^1,2	C,F,	--	72352686(+)	`TGGCCG/AGCGCC`	1	--	ut3¹		5		NA WA EA	362
rs182170994^1,2	C,	--	72352782(+)	`TTATTC/TCCAGA`	1	--	ut3¹		0	--	--	--	--
rs201880257^1,2		--	72352833(+)	`CGGGCC/TTGACG`	2	K R	mis¹		0	--	--	--	--
rs140255309^1,2	C,F	--	72352891(+)	`CCGCTG/ACAGGT`	2	/Q /*	stg¹		2		NA EU	5739
rs201086520^1,2	C,	--	72352988(+)	`GCCCCC/GACCAG`	2	V	syn¹		0	--	--	--	--
rs144983232^1,2		--	72353191(+)	`GTCGTG/TGCCAC`	2	N H	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BTBD17 (72352555 - 72358085 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for BTBD17
6 CNVs: 34522 8852 53066 5336 5029 7171

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed article for BTBD17 gene integrated from 9 sources:
(articles sorted by number of sources associating them with BTBD17)

Utopia: connect your pdf to the dynamic
world of online information

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)^{1, 2} Zody M.C.... Nusbaum C. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 388419	HGNC: 33758	AceView: LOC388419	Ensembl:ENSG00000204347	euGenes: HUgn388419
ECgene: BTBD17	H-InvDB: BTBD17

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BTBD17	Pharmacogenomics, SNPs, Pathways

Intellectual Property for BTBD17 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for BTBD17 gene:
Search GeneIP for patents involving BTBD17

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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BTBD17 Gene

BTB (POZ) domain containing 17

Aliases
for BTBD17 gene

Summaries
for BTBD17 gene

Genomic Views
for BTBD17 gene

Proteins
for BTBD17 gene

Protein Domains /
Families
for BTBD17 gene

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for BTBD17 gene

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for BTBD17 gene

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for BTBD17 gene

Transcripts
for BTBD17 gene

Expression
for BTBD17 gene

Orthologs
for BTBD17 gene

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for BTBD17 gene

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for BTBD17 gene

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for BTBD17 gene

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for BTBD17 gene

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BTBD17 Gene

BTB (POZ) domain containing 17

Aliasesfor BTBD17 gene

Summariesfor BTBD17 gene

Genomic Viewsfor BTBD17 gene

Proteinsfor BTBD17 gene

Protein Domains /Familiesfor BTBD17 gene

Functionfor BTBD17 gene

Pathways & Interactionsfor BTBD17 gene

Drugs & Compoundsfor BTBD17 gene

Transcriptsfor BTBD17 gene

Expression for BTBD17 gene

Orthologsfor BTBD17 gene

Paralogsfor BTBD17 gene

Genomic Variantsfor BTBD17 gene

Disorders / Diseasesfor BTBD17 gene

Publicationsfor BTBD17 gene

External Searches for BTBD17 gene

Genome Databases showing BTBD17 gene

Other Databases showing BTBD17 gene

Specialized Databases showing BTBD17 gene

Intellectual Propertyfor BTBD17 gene

Productsfor BTBD17 gene

View Random Gene

Aliases
for BTBD17 gene

Summaries
for BTBD17 gene

Genomic Views
for BTBD17 gene

Proteins
for BTBD17 gene

Protein Domains /
Families
for BTBD17 gene

Function
for BTBD17 gene

Pathways & Interactions
for BTBD17 gene

Drugs & Compounds
for BTBD17 gene

Transcripts
for BTBD17 gene

Expression
for BTBD17 gene

Orthologs
for BTBD17 gene

Paralogs
for BTBD17 gene

Genomic Variants
for BTBD17 gene

Disorders / Diseases
for BTBD17 gene

Publications
for BTBD17 gene

Intellectual Property
for BTBD17 gene

Products
for BTBD17 gene