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Aliases for BTBD16 Gene

Aliases for BTBD16 Gene

  • BTB Domain Containing 16 2 3 5
  • BTB (POZ) Domain Containing 16 2 3
  • C10orf87 3 4
  • BTB/POZ Domain-Containing Protein 16 3
  • Chromosome 10 Open Reading Frame 87 2

External Ids for BTBD16 Gene

Previous HGNC Symbols for BTBD16 Gene

  • C10orf87

Previous GeneCards Identifiers for BTBD16 Gene

  • GC10P124022
  • GC10P117661

Summaries for BTBD16 Gene

GeneCards Summary for BTBD16 Gene

BTBD16 (BTB Domain Containing 16) is a Protein Coding gene. An important paralog of this gene is GMCL1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTBD16 Gene

Genomics for BTBD16 Gene

Regulatory Elements for BTBD16 Gene

Enhancers for BTBD16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around BTBD16 on UCSC Golden Path with GeneCards custom track

Genomic Location for BTBD16 Gene

122,270,828 bp from pter
122,338,162 bp from pter
67,335 bases
Plus strand

Genomic View for BTBD16 Gene

Genes around BTBD16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTBD16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTBD16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTBD16 Gene

Proteins for BTBD16 Gene

  • Protein details for BTBD16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein 16
    Protein Accession:
    Secondary Accessions:
    • A6NM63
    • Q4VXL1
    • Q96LN0

    Protein attributes for BTBD16 Gene

    506 amino acids
    Molecular mass:
    58481 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTBD16 Gene


neXtProt entry for BTBD16 Gene

Post-translational modifications for BTBD16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTBD16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BTBD16 Gene

Domains & Families for BTBD16 Gene

Gene Families for BTBD16 Gene

Protein Domains for BTBD16 Gene


Suggested Antigen Peptide Sequences for BTBD16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with BTBD16: view

Function for BTBD16 Gene

genes like me logo Genes that share phenotypes with BTBD16: view

Animal Models for BTBD16 Gene

MGI Knock Outs for BTBD16:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BTBD16 Gene

Localization for BTBD16 Gene

Subcellular locations from

Jensen Localization Image for BTBD16 Gene COMPARTMENTS Subcellular localization image for BTBD16 gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BTBD16 Gene

Pathways & Interactions for BTBD16 Gene

SuperPathways for BTBD16 Gene

No Data Available

Interacting Proteins for BTBD16 Gene

Selected Interacting proteins: Q32M84-BTBDG_HUMAN for BTBD16 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for BTBD16 Gene


No data available for Pathways by source and SIGNOR curated interactions for BTBD16 Gene

Drugs & Compounds for BTBD16 Gene

No Compound Related Data Available

Transcripts for BTBD16 Gene

mRNA/cDNA for BTBD16 Gene

(8) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTBD16 Gene

BTB (POZ) domain containing 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTBD16 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b

Relevant External Links for BTBD16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTBD16 Gene

mRNA expression in normal human tissues for BTBD16 Gene

mRNA differential expression in normal tissues according to GTEx for BTBD16 Gene

This gene is overexpressed in Bladder (x13.7), Skin - Sun Exposed (Lower leg) (x6.1), and Testis (x5.9).

Protein differential expression in normal tissues from HIPED for BTBD16 Gene

This gene is overexpressed in Stomach (27.1), Prostate (20.0), Ovary (9.8), and Testis (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTBD16 Gene

NURSA nuclear receptor signaling pathways regulating expression of BTBD16 Gene:


SOURCE GeneReport for Unigene cluster for BTBD16 Gene:

genes like me logo Genes that share expression patterns with BTBD16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for BTBD16 Gene

Orthologs for BTBD16 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTBD16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BTBD16 34
  • 82.16 (n)
  • 75.35 (a)
BTBD16 35
  • 75 (a)
(Canis familiaris)
Mammalia BTBD16 34
  • 83 (n)
  • 75 (a)
BTBD16 35
  • 74 (a)
(Mus musculus)
Mammalia Btbd16 34
  • 79.02 (n)
  • 70.34 (a)
Btbd16 16
Btbd16 35
  • 67 (a)
(Pan troglodytes)
Mammalia BTBD16 34
  • 98.68 (n)
  • 97.43 (a)
BTBD16 35
  • 96 (a)
(Rattus norvegicus)
Mammalia Btbd16 34
  • 78.92 (n)
  • 69.17 (a)
(Monodelphis domestica)
Mammalia BTBD16 35
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia BTBD16 35
  • 58 (a)
(Anolis carolinensis)
Reptilia BTBD16 35
  • 44 (a)
(Danio rerio)
Actinopterygii btbd16 34
  • 48.75 (n)
  • 37.38 (a)
btbd16 35
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta gcl 35
  • 14 (a)
(Caenorhabditis elegans)
Secernentea gcl-1 35
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
Species where no ortholog for BTBD16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for BTBD16 Gene

Gene Tree for BTBD16 (if available)
Gene Tree for BTBD16 (if available)

Paralogs for BTBD16 Gene

Paralogs for BTBD16 Gene

genes like me logo Genes that share paralogs with BTBD16: view

Variants for BTBD16 Gene

Sequence variations from dbSNP and Humsavar for BTBD16 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2421013 - 122,329,521(+) AGGAC(A/G)GAGCT reference, missense
rs986178 - 122,329,560(+) GCACG(A/G)CATCA reference, missense
rs1048347 - 122,336,546(+) CAACC(A/C)CGTCA reference, missense
rs10510108 - 122,336,645(+) CAAGC(A/G)GAAGT reference, missense
rs1923448 -- 122,332,893(-) TTGGC(A/G)TGGAG intron-variant

Variation tolerance for BTBD16 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.07; 80.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTBD16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BTBD16 Gene

Disorders for BTBD16 Gene

Relevant External Links for BTBD16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BTBD16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTBD16 Gene

Publications for BTBD16 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Genome-wide association study of bipolar disorder in European American and African American individuals. (PMID: 19488044) Smith E.N. … Kelsoe J.R. (Mol. Psychiatry 2009) 3 46 65
  3. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 46 65
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for BTBD16 Gene

Sources for BTBD16 Gene

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