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Aliases for BTBD11 Gene

Aliases for BTBD11 Gene

  • BTB (POZ) Domain Containing 11 2 3
  • BTB/POZ Domain-Containing Protein 11 3 4
  • Ankyrin Repeat And BTB/POZ Domain-Containing Protein BTBD11 3
  • ANK-Repeat BTB Domain Containing Protein 3
  • ABTB2B 3

External Ids for BTBD11 Gene

Summaries for BTBD11 Gene

GeneCards Summary for BTBD11 Gene

BTBD11 (BTB (POZ) Domain Containing 11) is a Protein Coding gene. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is ABTB2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTBD11 Gene

Genomics for BTBD11 Gene

Genomic Location for BTBD11 Gene

Start:
107,318,413 bp from pter
End:
107,659,642 bp from pter
Size:
341,230 bases
Orientation:
Plus strand

Genomic View for BTBD11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTBD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTBD11 Gene

Regulatory Elements for BTBD11 Gene

Proteins for BTBD11 Gene

  • Protein details for BTBD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6QL63-BTBDB_HUMAN
    Recommended name:
    Ankyrin repeat and BTB/POZ domain-containing protein BTBD11
    Protein Accession:
    A6QL63
    Secondary Accessions:
    • A4FU41
    • B3KXG3
    • C9J019
    • C9JK80
    • E9PHS4
    • Q3ZTQ4
    • Q52M89
    • Q6ZV99
    • Q8N245

    Protein attributes for BTBD11 Gene

    Size:
    1104 amino acids
    Molecular mass:
    120884 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI01562.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI01564.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI46825.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAR21078.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85963.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW97799.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for BTBD11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTBD11 Gene

Proteomics data for BTBD11 Gene at MOPED

Post-translational modifications for BTBD11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BTBD11 Gene

Domains for BTBD11 Gene

Gene Families for BTBD11 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • BTBD :BTB/POZ domain containing

Protein Domains for BTBD11 Gene

Suggested Antigen Peptide Sequences for BTBD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6QL63

UniProtKB/Swiss-Prot:

BTBDB_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • A6QL63
Similarity:
  • Contains 5 ANK repeats.:
    • A6QL63
genes like me logo Genes that share domains with BTBD11: view

Function for BTBD11 Gene

Molecular function for BTBD11 Gene

UniProtKB/Swiss-Prot Induction: By all-trans retinoic acid (ATRA)

Gene Ontology (GO) - Molecular Function for BTBD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with BTBD11: view

Phenotypes for BTBD11 Gene

genes like me logo Genes that share phenotypes with BTBD11: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BTBD11 Gene

Localization for BTBD11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTBD11 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTBD11 Gene COMPARTMENTS Subcellular localization image for BTBD11 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for BTBD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BTBD11: view

Pathways for BTBD11 Gene

SuperPathways for BTBD11 Gene

No Data Available

Interacting Proteins for BTBD11 Gene

Gene Ontology (GO) - Biological Process for BTBD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060395 SMAD protein signal transduction IEA --
genes like me logo Genes that share ontologies with BTBD11: view

No data available for Pathways by source for BTBD11 Gene

Transcripts for BTBD11 Gene

Unigene Clusters for BTBD11 Gene

BTB (POZ) domain containing 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTBD11 Gene

No ASD Table

Relevant External Links for BTBD11 Gene

GeneLoc Exon Structure for
BTBD11
ECgene alternative splicing isoforms for
BTBD11

Expression for BTBD11 Gene

mRNA expression in normal human tissues for BTBD11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTBD11 Gene

This gene is overexpressed in Esophagus - Mucosa (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BTBD11 Gene

SOURCE GeneReport for Unigene cluster for BTBD11 Gene Hs.271272

genes like me logo Genes that share expressions with BTBD11: view

No data available for mRNA Expression by UniProt/SwissProt for BTBD11 Gene

Orthologs for BTBD11 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTBD11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BTBD11 35
  • 98.91 (n)
  • 99 (a)
BTBD11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BTBD11 35
  • 93.12 (n)
  • 97.46 (a)
BTBD11 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTBD11 35
  • 94.81 (n)
  • 98.64 (a)
BTBD11 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btbd11 35
  • 89.86 (n)
  • 95.2 (a)
Btbd11 16
Btbd11 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BTBD11 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Btbd11 35
  • 91.57 (n)
  • 98.2 (a)
chicken
(Gallus gallus)
Aves BTBD11 35
  • 83.36 (n)
  • 93.3 (a)
BTBD11 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTBD11 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15727 35
tropical clawed frog
(Silurana tropicalis)
Amphibia btbd11 35
  • 76.86 (n)
  • 86.45 (a)
zebrafish
(Danio rerio)
Actinopterygii btbd11a 36
  • 73 (a)
OneToMany
btbd11b 35
  • 71.31 (n)
  • 75.42 (a)
btbd11b 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43980 36
  • 23 (a)
OneToMany
Species with no ortholog for BTBD11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTBD11 Gene

ENSEMBL:
Gene Tree for BTBD11 (if available)
TreeFam:
Gene Tree for BTBD11 (if available)

Paralogs for BTBD11 Gene

Paralogs for BTBD11 Gene

Selected SIMAP similar genes for BTBD11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BTBD11: view

Variants for BTBD11 Gene

Sequence variations from dbSNP and Humsavar for BTBD11 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11893 -- 107,659,442(-) GACAG(A/C)CGCAA utr-variant-3-prime
rs15607 -- 107,659,546(-) CTGGA(G/T)GCCCT utr-variant-3-prime
rs703685 -- 107,324,561(+) TGAAG(A/C)GGCAC intron-variant
rs703686 -- 107,325,210(+) AGCAC(A/G)GGCTT intron-variant
rs713459 -- 107,562,593(+) CCTTA(A/G)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTBD11 Gene

Variant ID Type Subtype PubMed ID
nsv872 CNV Insertion 18451855
nsv899506 CNV Gain 21882294
esv2746337 CNV Deletion 23290073
nsv873 CNV Loss 18451855
esv32768 CNV Gain 17666407
esv2746338 CNV Deletion 23290073
esv2025373 CNV Deletion 18987734
nsv899507 CNV Loss 21882294
nsv899508 CNV Gain 21882294
nsv874 CNV Insertion 18451855
esv2746339 CNV Deletion 23290073
esv1000854 CNV Deletion 20482838
esv1332246 CNV Deletion 17803354
nsv875 CNV Loss 18451855
nsv876 CNV Insertion 18451855
nsv524699 CNV Loss 19592680
nsv524835 CNV Loss 19592680
nsv455705 CNV Loss 19166990
nsv899509 CNV Gain 21882294
nsv528273 CNV Gain 19592680

Relevant External Links for BTBD11 Gene

HapMap Linkage Disequilibrium report
BTBD11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTBD11 Gene

Disorders for BTBD11 Gene

Relevant External Links for BTBD11

Genetic Association Database (GAD)
BTBD11
Human Genome Epidemiology (HuGE) Navigator
BTBD11
genes like me logo Genes that share disorders with BTBD11: view

No data available for UniProtKB/Swiss-Prot for BTBD11 Gene

Publications for BTBD11 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for BTBD11 Gene

Sources for BTBD11 Gene

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